An initial benchmark of the quality of the diagnosis and surgical treatment of breast cancer in South Africa by S Nietz, H Cubasch, I Buccimazza, S Čačala, B Phakathi, M Joffe, W C C Chen, S Norris, P Ruff

Get full text

Spatiotemporal variation in biomass abundance of different algal species in Lake Hulun using machine learning and Sentinel-3 images by Zhaojiang Yan, Chong Fang, Kaishan Song, Xiangyu Wang, Zhidan Wen, Yingxin Shang, Hui Tao, Yunfeng Lyu

“…The RF model demonstrated the highest accuracy for estimating Chlorophyta’s biomass abundance (R2 = 0.72, RMSE = 6.57%, MAPE = 50.8%), while the GBDT model exhibited the highest accuracy for estimating Bacillariophyta’s biomass abundance (R2 = 0.9, RMSE = 4.66%, MAPE = 47.87%). …”
Get full text

The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysis by Qingling Zeng, Yuhui Yang, Limin Zhang, Jiangyu Yan, Jian Wang, Jingmin Nie, Qingmei Wang, Yu Luo, Gaoming Li

“…The prevalence decreased from 22.8% (18.4–27.9) before 2010 to 17.0% (14.6–19.6) in 2010 and thereafter (R2 = 5.82%). Among PLHIV via homosexual transmission, the prevalence of syphilis was 24.9% (21.3–28.9), which significantly declined from 33.8% (27.5–40.8) to 21.4% (18.3–24.9) in 2010 and thereafter (R2 = 22.35%). …”
Get full text

Patterns of general and abdominal obesity and their association with hypertension control in the iranian hypertensive population: insights from a nationwide study by Fataneh Esmaeili, Keyvan Karimi, Samaneh Akbarpour, Mohammadreza Naderian, Shirin Djalalinia, Ozra Tabatabaei-Malazy, Ali Golestani, Nazila Rezaei

“…Abdominal obesity according to WC (1.30 [1.13–1.51]), WHR (1.31 [1.10–1.53]), and WHtR (1.39 [1.11–1.74]) was also associated with uncontrolled HTN. …”
Get full text

Association of social frailty, sarcopenia, and oral frailty with depressive symptoms in Chinese older adults: a cross-sectional study by Yuanhao Sun, Huan Liu, Xiangdong Li, Lin Zhang, Wenwen Xu, Hairong liu, Ting Yuan

“…Spearman correlation analysis indicated that depressive symptoms significantly correlated with sarcopenia (r = 0.415), oral frailty (r = 0.282), and social frailty (r = 0.410). …”
Get full text

Acinetobacter baumannii represses type VI secretion system through a manganese-dependent small RNA-mediated regulation by Somok Bhowmik, Avik Pathak, Shivam Pandey, Kuldip Devnath, Abhiroop Sett, Nishant Jyoti, Timsy Bhando, Jawed Akhter, Saurabh Chugh, Ramandeep Singh, Tarun Kumar Sharma, Ranjana Pathania

“…Here, we identified an Mn2+-dependent post-transcriptional regulation of T6SS mediated by a bonafide small RNA, AbsR28. A. baumannii utilizes MumT, an Mn2+-uptake inner membrane transporter, for the uptake of extracellular Mn2+ during oxidative stress. …”
Get full text

Single or multiple treatments with lusutrombopag in subjects with thrombocytopenia and chronic liver disease needing an invasive procedure by Davide Scalabrini, Paolo Sciuto, Cristina Felicani, Antonia Rudilosso, Pietro Andreone

“…In conclusion, second generation TpoR agonists can be considered the prophylactic treatment of choice to reduce the risk of bleeding in patients with liver cirrhosis and severe thrombocytopenia.…”
Get full text

Physical activity, fatigue severity, and health-related quality of life of community-dwelling stroke survivors: a cross-sectional study by Marufat Oluyemisi Odetunde, Ayomide Felix Makinde, Olamide Mary Jimoh, Chidozie Emmanuel Mbada, Faatihah Niyi-Odumosu, Francis Fatoye

“…There was a moderate and significant correlation (R = 0.426; p < 0.05) among PA, FS, and HRQL. Regression analysis revealed no significant associations with the socio-demographic/clinical variable except the side of affectation for HRQL, low (R = 0.223) level of prediction of socio-demographic/clinical variables for PA (F 8, 93 = 0.607; p > 0.05), and fair (R = 0.326) level of prediction for FS (F 8, 93 = 1.386; p > 0.05). …”
Get full text

Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

“…Objective Assess long-term safety, tolerability and efficacy of bimekizumab in ankylosing spondylitis (radiographic axial spondyloarthritis (r-axSpA)).Methods Patients with active r-axSpA completing the dose-ranging 48-week randomised controlled trial could enrol in the open-label extension, where patients received bimekizumab 160 mg every 4 weeks. …”
Get full text

The Effect of Laboratory Parameters on the Hospital Stay and Mortality in Pediatric Patients Who Underwent Lobectomy and Pneumonectomy by Ahmet Ulusan, Hilal Zehra Kumbasar Danaci, Bekir Elma, Maruf Sanli, Ahmet Feridun Isik

“…PIV showed a strong correlation with length of hospital stay, with an r value of 0.650 (<i>p</i> < 0.01). A significant relationship was also found between PLR and length of hospital stay (r = 0.500, <i>p</i> < 0.01). …”
Get full text

Efficacy and safety of the Russian protease inhibitor narlaprevir at treatment-naive and earlier treated noncirrhotic patients with the 1st genotype chronic hepatitis C (PIONEER st... by M. V. Mayevskaya, V. T. Ivashkin, O. O. Znoyko, Ye. A. Klimova, D. T. Abdurakhmanov, I. G. Bakulin, P. O. Bogomolov, E. Z. Burnevich, M. Yu. Galushko, N. I. Geyvandova, K. V. Zhdanov, Ye. V. Esaulenko, S. N. Kizhlo, D. Yu. Konstantinov, N. I. Mironova, V. G. Morozov, Ye. A. Strebkova, I. G. Nikitin, M. F. Osipenko, V. D. Pasechnikov, O. I. Sagalova, I. M. Khayertynova, V. P. Chulanov, A. A. Yakovlev, I. A. Vasyutin, Ye. P. Tarkhova, E. N. Krasavina, M. Yu. Samsonov

Get full text

Accurate space-based NO_<i>x</i> emission estimates with the flux divergence approach require fine-scale model information on local oxidation chemistry and profile shapes by F. Cifuentes, F. Cifuentes, H. Eskes, E. Dammers, E. Dammers, C. Bryan, F. Boersma, F. Boersma

Get full text

Efficacy and safety of jaktinib hydrochloride tablets in active axial spondyloarthritis: a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial by Xiaomei Li, Xiaoxia Wang, Jian Wu, Xiao Zhang, Chunde Bao, Shengqian Xu, Lingyun Sun, Juan Wang, Guixiu Shi, Xiaofei Wang, Qing Dai, Antao Xu, Huaxiang Wu, YongQing Wang, Yan Ye, Yongfu Wang, Huaxiang Liu, Chenyin Lv, Jun Miao, Weiqi Min, Kuanting Wang, Luan Xue, Shanhui Ye

“…Objective The objective of this study is to evaluate the efficacy and safety of jaktinib hydrochloride tablets (jaktinib), a Janus kinase inhibitor, in patients with active radiographic axial spondyloarthritis (r-axSpA).Methods Adults with active r-axSpA who met modified New York criteria and had an inadequate response to non-steroidal anti-inflammatory drugs were randomised 1:1:1 to receive jaktinib 75 mg two times per day, 100 mg two times per day, or placebo. …”
Get full text

A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients by M.-C. Boll, M. Alcaraz-Zubeldia, C. Rios, D. González-Esquivel, S. Montes

“…Changes in a functional scale score (ALSFRS-R) and survival rate were chosen as primary outcome variables. …”
Get full text

Endangered clonal plant Rosa persica: Limited genetic and clonal diversity, abundant leaf phenotypic variation by Xiaolong Zhang, Xueyun Zhang, Na Li, Chenyang Sun, Chenjie Zhang, Chao Yu, Qixiang Zhang, Le Luo

“…As a typical clonal plant, R. persica mainly utilizes horizontal roots for asexual reproduction. …”
Get full text

Hypoxia-driven mobilization of altruistic cancer stem cells in platinum-treated head and neck cancer by Lekhika Pathak, Lekhika Pathak, Lekhika Pathak, Bidisha Pal, Bidisha Pal, Joyeeta Talukdar, Partha Jyoti Saikia, Sorra Sandhya, Wale Tasabehji, Wale Tasabehji, Hong Li, Jyotirmoy Phukan, Jyotirmoy Phukan, Anjan Bhuyan, Sanjukta Patra, Bikul Das, Bikul Das, Bikul Das, Bikul Das, Bikul Das

“…We demonstrated the protection of R-CSCs by TSD+ CSCs. Notably, inhibiting hypoxia alone with tirapazamine did not reduce TSD+ CSCs, CTCs, or R-CSCs. …”
Get full text

Diffuse Ionized Gas in the Anticenter of the Milky Way by Shiming Wen, Wei Zhang, Lin Ma, Yunning Zhao, Man I. Lam, Chaojian Wu, Juanjuan Ren, Jianjun Chen, Yuzhong Wu, Guozhen Hu, Yonghui Hou, Yongheng Zhao, Hong Wu

“…[S ii ]/[N ii ] has a radial gradient of 0.1415 ± 0.0646 kpc ^−1 for the inner disk (8.34 <  R _gal  < 9.65 kpc) and remains nearly flat for the outer disk ( R _gal  > 9.65 kpc). …”
Get full text

Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators by Michael Hecker, Brit Fitzner, Isis Ludwig-Portugall, Friederike Bohne, Edmar Heyland, Juliane Klehmet, Matthias Grothe, Matthias Schwab, Alexander Winkelmann, Stefanie Meister, Ales Dudesek, Hannah Wurm, Ilya Ayzenberg, Ingo Kleiter, Ingo Kleiter, Corinna Trebst, Martin W. Hümmert, Bernhard Neumann, Bernhard Neumann, Klaus Eulitz, Dirk Koczan, Uwe K. Zettl

Get full text

Pregnancy and Lifestyle: Short- and Long-Term Effects on Mother's and Her Children's Health by Riitta Luoto, Michelle F. Mottola, Leena Hilakivi-Clarke

Get full text