Association between airway microbiota and systemic inflammation markers in non-small cell lung cancer patients by DanHui Huang, QianNan Ren, LingYan Xie, YueHua Chen, Cui Li, XiaoFang Su, LiShan Lin, LaiYu Liu, Haijin Zhao, Tingyue Luo, JianHua Wu, Shaoxi Cai, Hangming Dong

“…The microbiota of spontaneous sputum samples from 51 non-small cell lung cancer (NSCLC) patients and 6 patients with lung benign nodules were sequenced via 16 S rRNA sequencing. Neutrophil-lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR) and C reactive protein (CRP) were used to represent systemic inflammation. …”
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Accumulation Mechanism of Marine Shale Gas Reservoir in Anticlines: A Case Study of the Southern Sichuan Basin and Xiuwu Basin in the Yangtze Region by Kun Zhang, Yan Song, Shu Jiang, Zhenxue Jiang, Chengzao Jia, Yizhou Huang, Ming Wen, Weiwei Liu, Pengfei Wang, Xin Li, Tianlin Liu, Xuelian Xie, Chang’an Shan, Xiaoxue Liu, Xin Wang

“…The regression equation of the fractured depth (H) and the horizontal stress (S) is presented as H=15.404S−754.41 (with a correlation coefficient R2=0.6834). The stratification plane and the organic pores form the migration channel of natural gas that is horizontal to the stratification plane in shale. …”
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Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic Overlapping Pain Conditions with Functional Gastrointestinal Disorders by Gisela Chelimsky, Pippa Simpson, Liyun Zhang, Doug Bierer, Steve Komas, Balaraman Kalyanaraman, Thomas Chelimsky

“…We measured 5 parameters of oxygen consumption using this methodology: basal respiration (BR), ATP linked oxygen consumption (ATP-LC), maximal oxygen consumption rate (max R), spare respiratory capacity (SRC), and extracellular acidification rate (ECAR), which reflect non-electron chain energy generation through glycolysis. …”
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Using stated-preferences methods to develop a summary metric to determine successful treatment of children with a surgical condition: a study protocol by Nigel Hall, Marian Knight, Nick Lansdale, Lisa Hinton, Charles Opondo, Simon Kenny, Stefano Giuliani, John Buckell, Oliver Rivero-Arias, Kokila Lakhoo, Alexander Macdonald, Crispin Jenkinson, Benjamin Allin, Rema Ramakrishnan, Gregor Walker, Timothy Bradnock, Karolina Kuberska, Benjamin M Craig, Goher Ayman, Anna May Long, Joanne Shepherd

“…A traffic light system to determine what combination of attributes and levels represent successful treatment will be created.Ethics and dissemination Ethics approval to conduct this study has been obtained from the Medical Sciences Inter-Divisional Research Ethics Committee (IDREC) at the University of Oxford (R59631/RE001-05). We will disseminate all of our results in peer-review publications and scientific presentations. …”
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Cyclopiazonic acid suppresses the function of Leydig cells in prepubertal male rats by disrupting mitofusin 1-mediated mitochondrial function by Hang Lin, Ming Su, He Zhu, Yang Yu, Jianmin Sang, Yiyan Wang, Qiqi Zhu, Yang Zhu, Xiaoheng Li, Xingwang Li, Ren-Shan Ge, Huitao Li

“…In vitro experiments corroborated these observations, demonstrating that CPA induced mitochondrial fragmentation by downregulating SIRT1, PGC1-α, MFN1, and OPA1, increase reactive oxygen species, and inhibit testosterone synthesis in R2C cells. The administration of leflunomide was shown to mitigate the detrimental effects of CPA on PLCs. …”
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Efficacy and safety of perioperative sintilimab plus platinum-based chemotherapy for potentially resectable stage IIIB non-small cell lung cancer (periSCOPE): an open-label, single... by Xiangyang Yu, Chujian Huang, Longde Du, Chunguang Wang, Yikun Yang, Xin Yu, Shengcheng Lin, Chenglin Yang, Hongbo Zhao, Songhua Cai, Zhe Wang, Lixu Wang, Xiaotong Guo, Baihua Zhang, Zhentao Yu, Jie He, Kai Ma

“…The key secondary endpoints included the objective response rate (ORR), radical resection (R0) rate, pathological complete response (pCR) rate, event-free survival (EFS), disease-free survival (DFS), OS, treatment-related adverse events (TRAEs), surgical complications, and surgery delay rate. …”
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Designing the entrepreneurial government model in attracting and selecting public sector human resources by Atieh sarayani, Vahid Pourshahabi, Nourmohammad yaghobi, Amin reza kamaliyan

“…The results showed that for seven hypotheses out of the total of nine formulated hypotheses based on the research model, no evidence of rejection at the 5% error level has been obtained, and it has a positive and significant effect, and also the results of the average common values ​​and the average values ​​of R Squares show that the value of GOF is equal to 0.790, which indicates the strong fit of the model. …”
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بررسی اثرات تغییرات اقلیم با استفاده از نتایج گزارش ششم هیات بین الدول بر میزان تولید رواناب و رسوب by محمدرضا شیخ ربیعی, حمید رضا پیروان, پیمان دانشکار آراسته, مهری اکبری, بهارک معتمدوزیری

“…سپس با توجه به مقادیر به‌دست‌آمده از معیارهای ارزیابی NS، R² و RMSE، مشخص شد که مدل اقلیمی CanESM5 از دقت و کارایی بهتری نسبت به مدل‌های اقلیمی MPI-ESM1.2-HR و NorESM2-MM برخوردار است. …”
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Steroid hormone receptors, exome sequencing and treatment responsiveness of breast cancer patient-derived xenografts originated in a South American country by Gabriela Pataccini, Andrés Elia, Gonzalo Sequeira, Luisa Ambrosio, Marcela Coianis, Caroline A. Lamb, Paola A. Rojas, Paula Martínez Vázquez, Javier Burruchaga, Eunice Spengler, Silvia I. Vanzulli, Martin Abba, Claudia Lanari

“…BC-AR687 carried a PIK3CA (C420R) mutation and was sensitive to alpelisib and mTOR inhibitors. …”
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Analysis of Polycyclic Aromatic Hydrocarbon in Airborne Particulate Matter Samples by Gas Chromatography in Combination with Tandem Mass Spectrometry (GC-MS/MS) by Nam Vu-Duc, Lan Anh Phung Thi, Thuy Le-Minh, Lan-Anh Nguyen, Huong Nguyen-Thi, Loan-Ha Pham-Thi, Van-Anh Doan-Thi, Huong Le-Quang, Hung Nguyen-Xuan, Thao Thi Nguyen, Phuong Thanh Nguyen, Dinh Binh Chu

“…The linearity range of all analyzed PAHs was from 5 to 2000 ng mL−1 with R2 ≥0.9990. Limit of detection (LOD) of PAHs in particulate matter sample was from 0.001 ng m−3 (Br-Naph) to 0.276 ng m−3 (Fln). …”
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Changes in Microbial Safety and Quality of High-Pressure Processed Camel Milk by Tareq M. Osaili, Dinesh Kumar Dhanasekaran, Fayeza Hasan, Reyad S. Obaid, Anas A. Al-Nabulsi, Amin N. Olaimat, Leila Cheikh Ismail, Nadia Alkalbani, Mutamed Ayyash, Gafar Babatunde Bamigbade, Richard Holley, Adan Shahzadi Cheema, Wael Ahmad Bani Odeh, Khalid Abdulla Mohd, Ayesha Khalid Haji Kamal

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Structural Vulnerability Factors and Gestational Weight Gain:  A Scoping Review on the Extent, Range, and Nature of the Literature by Labonté, Jocelyne M, Dumas, Alex, Clark, Emily, Savard, Claudia, Fournier, Karine, O’Connor, Sarah, Morisset, Anne-Sophie, Fontaine-Bisson, Bénédicte

“…Methods: Electronic searches were performed in October 2018 (updated in August 2019) in MEDLINE(R) ALL, EMBASE, PsycINFO, CINAHL, and Sociological Abstracts databases. …”
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Postoperative Outcomes After Robotic Liver Resection of Caudate Lobe: A Systematic Review by Gabriela Del Angel Millan, Gianluca Cassese, Fabio Giannone, Celeste Del Basso, Mariantonietta Alagia, Marco Lodin, Igor Monsellato, Marco Palucci, Federico Sangiuolo, Fabrizio Panaro

“…All the patients underwent R0 resection. In total, 24 out of 110 patients (21.8%) developed postoperative complications, with 1.8% of all patients developing a major complication (Clavien–Dindo classification ≥ III). …”
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Understanding phage BX-1 resistance in Vibrio alginolyticus AP-1 and the role of quorum-sensing regulation by Xiaoyu Li, Xin Liu, Tianyi Ma, Haochen Su, Bingrui Sui, Lili Wang, Bilal Murtaza, Yongping Xu, Na Li, Demeng Tan

“…Conversely, cells in a low-density state (ΔhapR) exhibit reduced susceptibility to phage BX-1 while still producing comparable phage progenies. …”
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Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment by Wenxiu Yuan, Jiaqi Liu, Zhenzhen Zhang, Chengxinyue Ye, Xueman Zhou, Yating Yi, Yange Wu, Yijun Li, Qinlanhui Zhang, Xin Xiong, Hengyi Xiao, Jin Liu, Jun Wang

“…Our results illustrate Alix’s crucial role in Sr-triggered miRNA loading, identifying miR-143-3p as a key anti-TMJOA exosomal component. …”
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Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

“…Secondary endpoints included duration of response (DoR), disease control rate, progression-free survival (PFS), overall survival (OS), and safety. …”
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Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer by Wang L, Deng X, Tang J, Gong Y, Bu S, Li Z, Liao B, Ding Y, Dai T, Liao Y, Li Y

“…Statistical analyses were conducted using R and GraphPad Prism software.Results: ERAS2 was overexpressed in CRC tissues compared to normal and adenoma tissues, with higher expression levels correlating with aberrant lactate metabolism and poorer patient prognosis. …”
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The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Statistical analysis was performed by using R software and complex heatmap and corrplot packages. …”
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Accelerating CO₂ Outgassing in the Equatorial Pacific from Satellite Remote Sensing by Yiwu Shang, Jingyuan Xi, Yi Yu, Wentao Ma, Shuangling Chen

“…We comprehensively analyzed the potential effects of different factors, such as sea surface temperature, sea surface wind speed, and Δ<i>p</i>CO₂ in driving CO₂ fluxes in the equatorial Pacific, and found that Δ<i>p</i>CO₂ had the highest correlation (<i>R</i> ≥ 0.80, at <i>p</i> ≤ 0.05), highlighting the importance of accurate estimates of <i>p</i>CO₂sw from satellites. …”
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Comparative Genomics Reveals Evidence of the Genome Reduction and Metabolic Potentials of <i>Aliineobacillus hadale</i> Isolated from Challenger Deep Sediment of the Mariana Trench by Shaofeng Yang, Jie Liu, Yang Liu, Weichao Wu, Jiahua Wang, Yuli Wei

“…Strain Lsc_1132^T contains heterogenous 16S rRNA genes, exhibiting the highest sequence similarities to the type strains of <i>Neobacillus drentensis</i> LMG 21831^T, <i>Neobacillus dielmonensis</i>, <i>Neobacillus drentensis</i> NBRC 102427^T, <i>Neobacillus rhizosphaerae</i>, and <i>Neobacillus soli</i> NBRC 102451^T, with a range of 98.60–99.10% identity. …”
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