Aurora kinase as a putative target to tick control by Bruno Moraes, Helga Gomes, Luiz Saramago, Valdir Braz, Luís Fernando Parizi, Gloria Braz, Itabajara da Silva Vaz, Carlos Logullo, Jorge Moraes, Ala Tabor

“…Based on deduced amino acid sequences, it was possible to identify non-conserved threonine residues which are essential to AURK functions in vertebrates and which are not present in R. microplus sequences. A pan AURK inhibitor (CCT137690) caused cell viability decline in the BME26 tick embryonic cell line. …”
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Personality's Time Perspective as a Resource for Overcoming the Identity Crisis at Different Stages of Life Realization by E.M. Meshcheryakova, A.V. Seryy, M.S. Yanitskiy

“…Samoilik; questionnaire of crisis events and experiences by V.R. Manukyan; methodology for the study of professional identity and personal identity by L.B. …”
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Modulation of Caecal Microbiome in Obese Mice Associated with Administration of Amaranth or Soybean Protein Isolates by Diana Olguín-Calderón, Jorge L. González-Escobar, Rosalva Ríos-Villa, Elena Dibildox-Alvarado, Antonio De León-Rodríguez, Ana P. Barba de la Rosa

“…Microbiota was isolated from the caecum and 16S rRNA gene was sequenced. Caecal Short Chain Fatty Acids (SCFAs) were quantified by gas chromatography. …”
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An NMR Study of the Bortezomib Degradation under Clinical Use Conditions by Adele Bolognese, Anna Esposito, Michele Manfra, Lucio Catalano, Fara Petruzziello, Maria Carmen Martorelli, Raffaella Pagliuca, Vittoria Mazzarelli, Maria Ottiero, Melania Scalfaro, Bruno Rotoli

“…The (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl-boronic acid, bortezomib (BTZ), which binds the 20S proteasome subunit and causes a large inhibition of its activity, is a peptidomimetic boronic drug mainly used for the treatment of multiple myeloma. …”
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Cost Savings in Chronic Pain Patients Initiating Peripheral Nerve Stimulation (PNS) with a 60-Day PNS Treatment by David M. Dickerson, Hemant Kalia, Kevin E. Vorenkamp, Konstantin V. Slavin, Jonathan M. Hagedorn, Candace Gunnarsson, Eric L. Keuffel, Andrew J. Epstein, Mark Stultz, Nathan D. Crosby

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Spondias purpurea L. (Anacardiaceae) fruits flours at different maturation stages: Drying kinetics, mathematical modelling, characterization and correlation analysis by Álvaro Gustavo Ferreira da Silva, Franciscleudo Bezerra da Costa, Ana Marinho do Nascimento, Giuliana Naiara Barros Sales, Jéssica Leite da Silva, Alzira Maria de Sousa Silva Neta, Wellington Souto Ribeiro, Toshik Iarley da Silva, Bruno Fonsêca Feitosa

“…All employed mathematical models effectively characterized the drying process, exhibiting R2 values exceeding 0.99, MSD below 0.03, and X2 below 0.0009. …”
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Antrodia cinnamomea ameliorates neointimal formation by inhibiting inflammatory cell infiltration through downregulation of adhesion molecule expression in vitro and in vivo by Yan Zhang, Aijin Ma, Hao Xi, Ning Chen, Rong Wang, Chenhui Yang, Jinbang Chen, Pin Lv, Fuping Zheng, Wenyi Kang

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Mapping and Summarizing the Research on AI Systems for Automating Medical History Taking and Triage: Scoping Review by Elin Siira, Hanna Johansson, Jens Nygren

“…MethodsThe study was conducted following the framework proposed by Arksey and O’Malley and adhered to the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) guidelines. …”
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Transcriptome analysis reveals modulations in glycosylation profiles of the mucosal barrier and their potential interaction with gut microbiota in weaned piglets by Hao Cheng, Hao Li, Yujie Zhao, Kai Yang, Jing Wang, Bie Tan, Xiaokang Ma

“…The results of the correlation between intestinal differential bacteria and O-chain glycosylated DEG showed that C1GALT2, GALNT1 and KMT2 were associated with Lactobacillus_pontis showed a positive correlation (R = 0.67). Through comparative analysis of differentially glycosylated genes and their associated functions, this study highlights the potential role of reduced expression of GALNT1 and KMT2C genes, involved in O-linked protein and glycan reactions, in impairing the intestinal barrier function of DLY piglets. …”
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Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…In addition, bozitinib efficiently inhibits c-Met resistance-conferring mutations G1163R and Y1230H, although its potency is significantly decreased against the D1228N and Y1230C mutations. …”
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The Association between Polymorphisms of Vitamin D Metabolic-Related Genes and Vitamin D3 Supplementation in Type 2 Diabetic Patients by Zhiyong Hu, ShaSha Tao, Huaqing Liu, Guotao Pan, Bingyan Li, Zengli Zhang

“…Multiplex TaqMan genotyping was used to determine the distribution of eight candidate SNPs in genes of DHCR7, CYP2R1, CYP27B1, CYP24A1, and VDR, which are key genes in the vitamin D metabolic pathway, in diabetic patients. …”
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Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) by Shishi Yu, Jinya Wu, Yuan Jing, Ping Lin, Lang Lang, Yifan Xiong, Wangzhong Chen, Wenhua Liu, Changpeng Sun, Yuntao Lu

“…Bibliometric tools, including VOSviewer, CiteSpace, and R packages such as bibliometrix and ggplot2, were used to analyze co-authorship networks, keyword evolution, and citation bursts to identify collaboration patterns, thematic developments, and influential contributions.ResultsPublication output increased significantly between 2013 and 2022, peaking at 650 articles in 2022. …”
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Total immunoglobulin E levels in induced sputum reflect asthma control status by Wenhui Chen, Xiaofang Liu, Xiujuan Yao, Yanghe Hao, Zhuo Zhou, Chengshuo Wang, Ming Wang, Luo Zhang

“…Sputum total IgE levels showed a significant correlation with asthma control scores (r = 0.53, p < 0.001). Moreover, ROC analysis showed that the predictive value of sputum total IgE for patients with UCA was 0.82 (95% CI, 0.74–0.9). …”
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Characterizing the microstructural transition at the gray matter-white matter interface: Implementation and demonstration of age-associated differences by Joan Y Song, Roman Fleysher, Kenny Ye, Mimi Kim, Molly E Zimmerman, Richard B Lipton, Michael L Lipton

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Application of the DEB-TKTD model with multi-omics data: Prediction of life history traits of Chinese mitten crab (Eriocheir sinensis) under different salinities by Hanzun Zhang, Shipeng Dong, Hongwei Shan, Chao Yang, Fang Wang

“…DEB-TKTD model predictions fit well with the observed data, with high R2 values (0.9704 for survival, 0.9842 for carapace width, and 0.9283 for reproduction) and low NRMSE (0.0093, 0.1175, and 0.0778, respectively). …”
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Yiqi Juanshen decoction alleviates renal interstitial fibrosis by targeting the LOXL2/PI3K/AKT pathway to suppress EMT and inflammation by Kaiyue Tan, Jingwei Deng, Yi Liu, Yudi Zhang, Yu Xiong, Su Yuan, Jun Liu, Zhiwei Chen, Yuanyuan Liu, Wenfu Cao

“…Moreover, YQJSD can regulate the PI3K/AKT signaling pathway by decreasing the expression of LOXL2 and PIK3R1, along with p-AKT1/2/3. This modulation of the LOXL2/PI3K/AKT pathway contributes to the inhibition of both EMT and inflammation, highlighting a critical role in the therapeutic intervention against RIF. …”
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Formation of advanced glycation end products in raw and subsequently boiled broiler muscle: biological variation and effects of postmortem ageing and storage by Suhong Huang, Xiaoli Dong, Yali Zhang, Yuru Chen, Yajie Yu, Ming Huang, Yuandong Zheng

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Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study by Aaya Shahin, Yael Anne Leshem, Yossi Taieb, Sharon Baum, Aviv Barzilai, Danielle Jeddah, Efrat Sharon, Omry Koren, Rinat Tzach-Nahman, Shunit Coppenhagen-Glazer, Ronen Hazan, Yael Houri-Haddad, Shoshana Greenberger

“…A dentist assessed oral health status, and oral flora samples were collected and subjected to 16S rRNA sequencing for microbiome analysis. Results: Forty-five AD participants and 41 non-AD controls were recruited. …”
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Assessment of the genetic diversity of the alleles of gliadin-coding loci in common wheat (<i>Triticum aestivum</i> L.) collections in Kazakhstan and Russia by M. U. Utebayev, S. M. Dashkevich, O. O. Kradetskaya, I. V. Chilimova, N. A. Bome

“…Intrapopulation (μ ± Sμ) and genetic (H) diversity, the proportion of rare alleles (h ± Sh), identity criterion (I) and genetic similarity (r) of common wheat from eight breeding centers in Russia and Kazakhstan have been calculated. …”
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Determination of Polyphenol Components of Korean Prostrate Spurge (Euphorbia supina) by Using Liquid Chromatography—Tandem Mass Spectrometry: Overall Contribution to Antioxidant Ac... by Yi Song, Sung Woo Jeong, Won Sup Lee, Semin Park, Yun-Hi Kim, Gon-Sup Kim, Soo Jung Lee, Jong Sung Jin, Chi-Yeon Kim, Ji Eun Lee, Se Yun Ok, Ki-Min Bark, Sung Chul Shin

“…Correlation coefficients (r2) were >0.9907. The limit of detection and limit of quantification of the method were >0.028 mg/L and 0.094 mg/L, respectively. …”
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