Merck Open Global Health Library in vitro screening against Schistosoma mansoni identified two new substances with antischistosomal activities for further development by Monique Evelyn Ueberall, Martina Berchthold, Cécile Häberli, Sven Lindemann, Thomas Spangenberg, Jennifer Keiser, Christoph G. Grevelding

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The negative aspects of injury on motivation of sports and physical exercise practitioners by Hugo Enrico Souza Machado, Hugo Enrico Souza Machado, Andreza do Socorro Dantas Oliveira, Andreza do Socorro Dantas Oliveira, Eldimberg Souza da Cunha Júnior, Adriano Lopes Lemos, Eduardo Macedo Penna, Eduardo Macedo Penna, Daniel Alvarez Pires, Daniel Alvarez Pires

“…Also, the IG demonstrated higher median values of demotivation when compared to the NIG, with a small effect size (NIG median: 3.3; IG median: 5.8; p = 0.04, r = 0.26).ConclusionWe conclude that almost half of the injured practitioners demonstrated give-up thoughts as well as exhibit higher levels of demotivation compared to non-injured ones. …”
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Auricular Acupuncture for Perioperative Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Zhou Y, Bao Q, Yang C, Li S, Yin Z, Xiong J, Sun M, Yang J, Liu F, Liang F

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Immune-metabolic shifts in acute liver failure caused by HEV infection during pregnancy and their association with obstetric outcomes by Anoushka Saxena, Minal, Prabhjyoti Pahwa, Jaswinder Singh Maras, Hamda Siddiqui, Jayesh Kumar Sevak, Yedla Manikya Mala, Shakun Tyagi, Shiv K. Sarin, Nirupama Trehanpati

“…Both AVH-E and ALF-E had decreased choline, sn-glycero-3-phosphocholine, O-palmitoyl-r-carnitine, and increased taurocholic acid. However, patients with ALF-E had a 2–5-fold decline in these metabolites with raised taurochenodeoxycholic acid. …”
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Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

“…Additionally, we used flow cytometry, adeno-associated virus-mediated gene silence, parabiosis and single-cell RNA sequencing to uncover the specific roles and mechanisms of the HPA in colitis.Results: Our results indicate that colitis activates HPA secretion and increases α-MSH. α-MSH acts on the MC5R present on the surface of hematopoietic stem cells (HSCs) in the bone marrow, altering the bone marrow microenvironment and promoting HSCs proliferation and differentiation into neutrophils. …”
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Residual Characteristics and Dietary Risk Assessment of Dinotefuran and Tolfenpyrad in Tea Processing by LI Chunyong, LÜ Ying, JIN Jing, WANG Xia, QIN Shu

“…In the range of 0.005–0.500 µg/mL, a good linear relationship was obtained between the concentrations of dinotefuran and its metabolites as well as tolfenpyrad and their response peak areas (R2 > 0.99). The average recovery rates of dinotefuran and its metabolites 1-methyl-3-(tetrahydro-3-furylmethyl)guanidine (DN) and 1-methyl-3-(tetrahydro-3-furylmethyl)urea (UF) in fresh and dried tea leaves spiked at 0.05, 1.00, 20.00 and 50.00 mg/kg and in tea infusion spiked at 0.05, 0.10 and 5.00 mg/kg ranged from 74% to 103%, with relative standard deviations (RSDs) of 1%–9%. …”
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Biodesulfurization of high-sulfur oil from the Karazhanbas field of Kazakhstan with deep eutectic solvents by A.O. Akimbek, G.A. Jamalova, A.K. Yernazarova, G.K. Kaiyrmanova, B.K. Yelikbayev, M.C. Pagano, A.G. Zazybin, Kh. S. Rafikova

“…The research methodology was based on the application of the Koch methods to determine the total number of microorganisms; light microscopy – for the study of microbiological preparations; genetic identification of bacteria based on the analysis of the nucleotide sequence of a fragment of the 16S rRNA gene; synthesis of deep eutectic solvents; testing of isolated bacteria – for sensitivity to Cr (VI), for the ability of microorganisms to use hydrocarbons of high-sulfur oil, for activity in sulfur-containing crude oil, for determination of the mass fraction of sulfur. …”
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Effect of intraoperative noise isolation on postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery: protocol for a randomized controlled trial by Chong Fu, Fan Xia, Zihan Yan, Han-bing Xu, Wei-ming Zhao, Yi-shan Lei, Chang Xu, Wen-wen Huo, Duo-duo Tao, Juan Wang, Xi-sheng Shan, Ke Peng, Hong Liu, Fu-hai Ji, Hua-yue Liu

“…Secondary outcomes include PONV severity at 24 and 48 h, antiemetic use, pain scores, need for rescue analgesia, Quality of Recovery-15 (QoR-15) scores, Richards-Campbell Sleep Questionnaire (RCSQ) scores, hemodynamic interventions, extubation time, length of stay in PACU and hospital, adverse events (hypertension, hypotension, bradycardia, tachycardia, desaturation after extubation, postoperative shivering, emergence agitation, allergic reactions, severe arrhythmias arrhythmia, cardiac arrest, hypothermia), patient satisfaction, and postoperative complications based on the Postoperative Morbidity Survey (POMS). …”
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Early Changes in Tumor Perfusion from T1-Weighted Dynamic Contrast-Enhanced MRI following Neural Stem Cell-Mediated Therapy of Recurrent High-Grade Glioma Correlate with Overall Su... by Prativa Sahoo, Paul Frankel, Julie Ressler, Margarita Gutova, Alexander J. Annala, Behnam Badie, Jana Portnow, Karen S. Aboody, Massimo D’Apuzzo, Russell C. Rockne

“…All parameters were highly correlated, resulting in a multivariate model for OS including only CE at MRI#2 and Δ32Vp, with an R2 of 0.89. Conclusion. The change in perfusion parameter values from 1 week to 1 month following NSC-mediated therapy combined with contrast-enhancing volume may be a useful biomarker to predict overall survival in patients with recurrent high-grade glioma.…”
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Safeguarding in Sport: The Performative Compliance of International Sports Federations by Carole Gomez, Lucie Schoch

“…., Tiivas, A., & Budgett, R. (2016). International Olympic Committee consensus statement: Harassment and abuse (non-accidental violence) in sport. …”
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Iron(III)–Quercetin Complex: In Vivo Acute Toxicity and Biodistribution of Novel MRI Agent by Innuan P, Kongkarnka S, Thongtharb A, Kantapan J, Dechsupa N

“…For in vivo biodistribution, SD rats were administered an intravenous dose of IronQ (225 μmol Fe/kg BW), followed by MR imaging using a 1.5 T scanner and subsequent tissue-ICP analysis.Results: The longitudinal relaxivity (r1) of IronQ was measured to be 2.17 mm⁻¹s⁻¹ in ultrapure water and 3.56 mm⁻¹s⁻¹ in whole blood. …”
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Luteal Phase Stimulation in the Same Cycle Is an Effective Strategy to Rescue POSEIDON Poor Responders with No Embryos after the First Follicular Stimulation by Abha Majumdar, Gaurav Majumdar, Neeti Tiwari, Anu Singh, Shweta Mittal Gupta, Ruma Satwik

“…The analysis was conducted using R statistical environment 4.2. Results: The mean number of oocytes retrieved and the mean number of utilizable blastocysts frozen per stimulation cycle were found to be significantly higher in the luteal phase as compared to the follicular phase (5.71 ± 3.95 vs. 4.87 ± 2.79, P = 0.02, and 1.43 ± 1.22 vs. 0.95 ± 1, P = 0.001, respectively). …”
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The association of origin and environmental conditions with performance in professional IRONMAN triathletes by Beat Knechtle, Mabliny Thuany, David Valero, Elias Villiger, Pantelis T. Nikolaidis, Marilia S. Andrade, Ivan Cuk, Thomas Rosemann, Katja Weiss

“…The Decision Tree and the XG Boost models were the best performing models (r2 = 0.48) and rated the relative feature importances in the order gender, country of origin, water temperature, air temperature and event location. …”
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A framework for quantifying the multisectoral burden of animal disease to support decision making by Sara Lysholm, Sara Lysholm, Gemma L. Chaters, Gemma L. Chaters, Carlotta Di Bari, Carlotta Di Bari, Ellen C. Hughes, Ellen C. Hughes, Ben Huntington, Ben Huntington, Jonathan Rushton, Jonathan Rushton, Lian Thomas, Lian Thomas

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Porphyromonas gingivalis associates with the presence of anti-citrullinated protein antibodies, but not with the onset of arthritis: studies in an at-risk population by Helga Westerlind, Linda Mathsson-Alm, Alexandra Circiumaru, Aase Hensvold, Karin Lundberg, Jan Potempa, Yogan Kisten, Charlotte De Vries, Marina Dehara, Barbara Potempa

“…Data were analysed in GraphPad Prism and R using log-transformed antibody levels.Results 53% of Risk-RA and 26% of controls, p=0.003, were anti-Rgp IgG positive at baseline, with higher levels in Risk-RA compared with controls, p<0.0001. …”
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Cross-cultural insights into internet addiction and mental health: a network analysis from China and Malawi by Mengze Li, Yidi Wang, Bin Liu, Xiaoli Ni, Zhujing Ma, Fengzhan Li, Tifei Yuan, Hongyi Chen, Zhongying Wu, Qiannan Jia, Lei Song, Yinchuan Jin, Qun Yang

“…Network estimation, centrality, bridge estimation and network comparison, were conducted using R software. Results The prevalence of internet addiction and mental health was significantly higher in China than Malawi. …”
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Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan by Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou

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Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits by Luciane Angela Nottar Nesello, Maria Luisa Maes Lima Beleza, Marihá Mariot, Luísa Nathália Bolda Mariano, Priscila de Souza, Adriana Campos, Valdir Cechinel-Filho, Sérgio Faloni Andrade, Luísa Mota da Silva

“…These results confirm that M. nigra and R. niveus are berries with a gastroprotective value by strengthening of gastric protective factors.…”
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MAGICS. II. Seed Black Holes Stripped of Their Surrounding Stars Do Not Sink by Yihao Zhou, Diptajyoti Mukherjee, Nianyi Chen, Tiziana Di Matteo, Peter H. Johansson, Antti Rantala, Christian Partmann, Ugo Niccolò Di Carlo, Simeon Bird, Yueying Ni

“…After evolving all the systems for  ≈1.2 Gyr in three stages (MAGICS-2000, MAGICS-500, and MAGICS-K), we find in four of the six systems that the MBHs stall at separations Δ r  ≳ 200 pc. Only in two systems, the MBHs manage to sink further, and only in one of them a bound binary forms. …”
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Network meta-analysis of cadmium toxicity against Chlorella vulgaris and the role of growth stimulants and macronutrients by M. Iqhrammullah, S. Saudah, M. Monalisa, F. Fahrurrozi, S.A. Akbar, S.S. Lubis

“…Additionally, a linear regression analysis was performed to examine the dose-dependent impact of cadmium toxicity.FINDINGS: Dose-dependent toxic effects of cadmium on Chlorella vulgaris were evident (R-square of more than 0.90), particularly at a concentration of 1 part per million, deemed as the maximum tolerable threshold. …”
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