AN EXPERIMENTAL STUDY OF THE EFFECT OF RARE POLYMORPHISMS OF HUMAN HBB, HBD AND F9 PROMOTER TATA BOXES ON THE KINETICS OF INTERACTION WITH THE TATA-BINDING PROTEIN by E. B. Sharypova, I. A. Drachkova, E. V. Kashina, D. A. Rasskazov, P. M. Ponomarenko, M. P. Ponomarenko, N. А. Kolchanov, L. K. Savinkova

“…The coefficient of linear correlation r = 0.94 (α < 0.0001). A comprehensive approach to the study of rare polymorphisms may lead to the identification of the most sensitive markers of orphan diseases, which will contribute to the development of reliable and rapid methods for their diagnosis and treatment.…”
Get full text

Quarantine nematode species and pathotypes potentially dangerous for domestic potato production: populations diversity and the genetics of potato resistance by N. V. Mironenko, T. A. Gavrilenko, A. V. Khiutti, O. S. Afanasenko

“…The review provides data on sources of potato resistance to parasitic nematodes identified in collections of wild and cultivated species. Data on identified R-gens and QTL of resistance that have been introduced into breeding varieties using different methods and approaches are analyzed. …”
Get full text

Longer disease progression milestone-free time in people with amyotrophic lateral sclerosis treated versus not treated with intravenous edaravone: results from an administrative cl... by James D Berry, Melissa Hagan, Jeffrey Zhang, Ying Liu, Malgorzata Ciepielewska

“…Aim: To estimate time-to-progression milestones in people with amyotrophic lateral sclerosis (PALS) treated versus not treated with intravenous (IV) edaravone (Radicava R IV, Mitsubishi Tanabe Pharma America [MTPA], hereafter ”IV edaravone”) in a real-world setting. …”

Deep learning model based prediction of vehicle CO2 emissions with eXplainable AI integration for sustainable environment by Gazi Mohammad Imdadul Alam, Sharia Arfin Tanim, Sumit Kanti Sarker, Yutaka Watanobe, Rashedul Islam, M. F. Mridha, Kamruddin Nur

“…The proposed model was optimized by hyperparameter tuning and achieved excellent performance metrics, such as a high R-squared value of 0.9938 and a low Mean Squared Error (MSE) of 0.0002. …”
Get full text

A Prospective Observational Study to Establish a Correlation Between Tinnitus and Hearing Loss by Anshu Chopra, Madhurima Bannerjee, Sanjoy Ghosh

“…We found that relative coefficient, ‘r’ being 0.309 on right side and 0.270 on left side. …”
Get full text

The Performance of Irrigation Schemes in Sudan Affected by Climate Variability and the Grand Ethiopian Renaissance Dam by Shamseddin M. Ahmed, Khalid G. Biro Turk, Hassan Ali Dinar

“…The analysis was carried out using R version 4.4.1 and spreadsheets. A dummy variable approach was employed to examine the effects of the GERD on the EVI, given the limited timeframe of the study, whilst Grey Relational Analysis was applied to investigate the influence of selected climate variables on the EVI. …”
Get full text

Molecular dynamics and machine learning unlock possibilities in beauty design—A perspective by Yuzhi Xu, Haowei Ni, Fanyu Zhao, Qinhui Gao, Ziqing Zhao, Chia-Hua Chang, Yanran Huo, Shiyu Hu, Yike Zhang, Radu Grovu, Hermione He, John Z. H. Zhang, Yuanqing Wang

Get full text

Efficient Dual Cas9 Nickase Correction of a Prevalent Pathogenic LAMB3 Variant for Junctional Epidermolysis Bullosa by Alex du Rand, John Hunt, Daniel Verdon, Ben Buttle, P. Rod Dunbar, Diana Purvis, Vaughan Feisst, Hilary Sheppard

“…Targeting a hotspot pathogenic variant (c.1903C>T, p.R635∗), we report perfect correction efficiencies of up to 54% based on standard next-generation sequencing. …”
Get full text

1990–2041 Global burden of Burkitt lymphoma with 20 years forecast: A systematic analysis using the global burden disease of study of 2021 by Chengyun Dou, Yidan Sang, Hongbo Zhu, Chuangjie Cao

“…Furthermore, the estimated annual percentage changes of incidence with Burkitt lymphoma were positively correlated with sociodemographic index (Pearson r  = 0.606; p  = 0.003). The Bayesian age-period-cohort model predicts a significant increase in the age-standardized incidence rates of Burkitt lymphoma over the next 20 years. …”
Get full text

پهنه‌بندی خطر وقوع زمین‌لغزش در منطقه کلور با استفاده از مدل ترکیبی قضیه بیز-ANP by فرنگیس نظری بیاتیانی, منصور جعفربیگلو, شیرین محمدخان, مهران مقصودی

“…همچنین، صحت نتایج با بررسی رابطه مساحت پهنه‌های خطر و مساحت سطوح لغزشی و R2 بیش از 93/0 در سطح خوبی مورد تأیید قرار گرفت؛ بنابراین، نتایج مدل ترکیبی قضیه بیز-ANP برای پهنه‌بندی خطر زمین‌لغزش در این نوع مناطق مناسب بوده و نقشه حاصل از آن همراه با شرح تفصیلی می‌تواند به‌عنوان ابزاری ارزشمند در برنامه‌ریزی محیطی و کاهش هزینه‌های رخ داد زمین‌لغزش مورد استفاده قرار گیرد.…”
Get full text

Serum cardiac and inflammatory biomarker levels following chemotherapy among female patients with breast cancer attending at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiop... by Muluabay Getie, Biset Asrade Mekonnen, Daniel Seifu, Yonas Mulugeta, Solomon Tebeje, Chernet Tafere, Asmare Amuamuta

“…An Elecsys 2010 Troponin-T immunoassay analyzer was used to measure serum levels of cardiac troponin T (cTnT), creatinine kinase-myocardial band (CK-MB), C-reactive protein (CRP), and R and D systemic luminex performance assays were used to measure serum Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF- α). …”
Get full text

Complete mitochondrial genome sequence analysis revealed double matrilineal components in Indian Ghoongroo pigs by Pranab Jyoti Das, Satish Kumar, Manasee Choudhury, Seema Rani Pegu, K. Meera, Rajib Deb, Sunil Kumar, Santanu Banik, Vivek Kumar Gupta

“…Furthermore, examination of tRNA genes and nucleotide composition of different genes namely rRNAs, COX1, COX2, ATP6, ND4, ND5, ND6, Cytb offered insights into genetic diversity within these pigs. …”
Get full text

The association of dietary approaches to stop hypertension measured by the food frequency questionnaire with metabolic syndrome and some inflammatory biomarkers in adolescents with... by Maryam Behrooz, Alireza Ostadrahimi, Samaneh Hajjarzadeh, Mirhadi Mousavi, Afshin Ghalegolab Behbahani, Siamak Shiva

“…To assess the correlation between the DASH score and dietary factor, the Pearson correlation coefficient (r) was used. Results Adolescents with a high DASH score had significantly higher intakes of potassium, magnesium, vitamin C, and vitamin K and lower intakes of sodium compared with those with a low DASH score (P < 0.05 ). …”
Get full text

Molecular Detection of Bartonella spp. in China and St. Kitts by Ke Huang, Patrick John Kelly, Jilei Zhang, Yi Yang, Weiguo Liu, Anwar Kalalah, Chengming Wang

“…By comparing highly conserved 16S rRNA sequences of the better-recognized Bartonella spp. on GenBank, we selected primers and probes for a genus-specific pan-Bartonella FRET-qPCR. …”
Get full text

Minimal clinical data sets for spine-related musculoskeletal disorders in primary care and outpatient settings: a scoping review protocol by Pierre Côté, Andrea C Tricco, Cesar A Hincapié, Léonie Hofstetter, Jérémie Mikhail, Isabelle Pagé

“…Findings will be synthesised and presented as a descriptive summary using PRISMA ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews).Ethics and dissemination Ethics review and approval is not required for this scoping review. …”
Get full text

The molecular prognostic scoring system for normal karyotype myelodysplastic syndromes by Wei Wang, Yudi Zhang, Wenli Yang, Xiaozhen Liu, Lingxu Jiang, Wei Lang, Yingwan Luo, Xinping Zhou, Lu Wang, Li Ye, Ying Xu, Liya Ma, Hongyan Tong

“…The performance of NK-PSS-M was comparable to that of the Molecular International Prognostic Scoring System (IPSS-M), and it significantly outperformed the Revised International Prognostic Scoring System for MDS (IPSS-R). Conclusions The NK-PSS-M model improved the risk stratification of non-molecular models and provided a reliable alternative to the IPSS-M. …”
Get full text

Siyasetin Meşruluğu Ya Da Meşruiyetin Siyaseti -Politics Legitimate or Legitimacy of Politics by N-erdal Fanid

“…Meşruiyet mekanizmalarının tarihsel deneyim &ccedil;er&ccedil;evesinde birbirinin yerine ge&ccedil;en ve d&ouml;n&uuml;şt&uuml;r&uuml;len egemenlik kavramı g&uuml;n&uuml;m&uuml;z toplumunda siyasetin her kuruma egemen olmasının zeminini de oluşturacaktır. …”
Get full text

A Five-Year Retrospective Study of Foot-and-Mouth Disease Outbreaks in Southern Africa, 2014 to 2018 by Elliot Mpolokang Fana, Sununguko Wata Mpoloka, Melvin Leteane, LaToya Seoke, Kelebogile Masoba, Mokganedi Mokopasetso, Aobakwe Rapharing, Tshephang Kabelo, Patricia Made, Joseph Hyera

“…Vaccine matching studies on the field FMDv isolates produced r1-values greater than or equal to 0.3 for the three SAT serotypes. …”
Get full text

The comprehensive assessment of epigenetics changes during skin development by Li Lei, Ling Jiang, Yibo Hu, Menglu Chen, Jinhua Huang, Jing Chen, Qinghai Zeng

“…The transcriptomes of human skin samples from different ages or irradiated with different types and doses of UV light were analyzed using R (version 4.0.3) software. The epigenetic landscape of the skin, including histone modifications, genetic imprinting and m6A modification, which are mainly involved in collagen formation, extracellular matrix organization, immune function and keratinization, underwent significant changes during neonatal to adult development. …”
Get full text

Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus by Haiyan Zhou, Bojiang Li, Jing Li, Tongqian Wu, Xiaoqian Jin, Rui Yuan, Ping Shi, Yan Zhou, Long Li, Fang Yu

“…The expression of HLA-DR+ T cells was positively correlated with SLEDAI (r=0.15, P<0.01). Furthermore, levels of serum IL-6, MCP-1, TNFRI, IL-10, IL-12, and CCL20 were higher in SLE patients compared with healthy controls. …”
Get full text