Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency by Tim Heemskerk, Gerarda van de Kamp, Marta Rovituso, Roland Kanaar, Jeroen Essers

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Analysis of clinical and pathological prognostic factors of survival in rectal adenocarcinoma treated with preoperative radiochemotherapy by Sarhan Sydney Saad, Nora Forones, Gaspar Lopes Filho, Jaques Waisberg, Elesiario Caetano Júnior, Ricardo Artigiani-Neto, Delcio Matos

“…Methods: We studied 70 patients from the Discipline of Surgical Gastroenterology at Escola Paulista de Medicina from 2000 to 2019, with rectal cancer located up to 10 cm from the anal verge and with stages II or III, submitted to preoperative RCT and curative surgery (R0) and with follow-up of at least 12 months. Clinical restaging was performed four to six weeks after the end of neoadjuvant treatment to characterize the degree of clinical tumor regression. …”
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Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-naïve celiac disease by Prasenjit Das, Sudha Battu, Lalita Mehra, Alka Singh, Muzaffar Ahmad, Ashish Agarwal, Ashish Chauhan, Anam Ahmad, Sreenivas Vishnubhatla, Siddhartha Datta Gupta, Vineet Ahuja, Govind Makharia

“…Immunohistochemical markers were used to investigate ISC niche alterations, including LGR5 for crypt basal cells (CBC), Bmi1 for position 4+ cells, β-Defensin for Paneth cells, R-spondin1 as WNT activator, transcription factor-4 as WNT transcription factor, BMP receptor1A as WNT inhibitor, fibronectin-1 as periepithelial stromal cell marker, H2AX as apoptosis marker, and Ki67 as proliferation marker. …”
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Development and Application of an Indirect Enzyme‐Linked Immunosorbent Assay Based on a Recombinant Matrix Protein for the Serological Study of Porcine Deltacoronavirus in Mexican... by Francisco Jesus Castañeda Montes, José Luis Cerriteño Sánchez, Julieta Sandra Cuevas‐Romero, María Azucena Castañeda Montes, Susana Mendoza Elvira

“…In this study, for the first time, an indirect enzyme‐linked immunosorbent assay (iELISA) based on a recombinant M protein (rM‐PDCoV) was developed to evaluate the seroprevalence of PDCoV in four states in Mexico. …”
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Persistent functional and taxonomic groups dominate an 8,000-year sedimentary sequence from Lake Cadagno, Switzerland by Paula Rodriguez, Jasmine S. Berg, Longhui Deng, Longhui Deng, Hendrik Vogel, Michal Okoniewski, Mark A. Lever, Mark A. Lever, Cara Magnabosco

“…Here, we reconstruct the microbial functional and taxonomic composition of an 8,000-year Holocene sedimentary succession from meromictic Lake Cadagno (Switzerland) using shotgun metagenomics and 16S rRNA gene amplicon sequencing. While younger sediments (<1,000 years) are dominated by typical anaerobic surface sedimentary bacterial taxa (Deltaproteobacteria, Acidobacteria, and Firmicutes), older layers with lower organic matter concentrations and reduced terminal electron acceptor availability are dominated by taxa previously identified as “persistent populations” within deep anoxic marine sediments (Candidatus Bathyarchaeia, Chloroflexi, and Atribacteria). …”
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A Comparison of Resting Scapular Posture and the Davies Closed Kinetic Chain Upper Extremity Stability Test by John D Heick, Jenna Haggerty, Robert C Manske

“… # RESULTS One way analysis of variance (ANOVA) showed statistically significant differences in Type I and Type IV Kibler scapula classification for the CKCUEST power score, however when an ANCOVA controlled for body mass index, there was no statistically significant difference. A strong correlation r=.94 was observed between student and experienced physical therapist in evaluating all four types of Kibler scapular classification…”
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Productividad y eficiencia de ganaderías lecheras especializadas en el Valle del Cauca (Colombia) by F. Morales-Vallecilla, S. Ortiz-Grisales

“…Se determinó una relación lineal Y=Producción de leche (kg.día) = 5,6639 + 0,5513 X, R2=0,77, donde solo con pastoreo las vacas producen 5,66 l.vaca-1día y cada kg de concentrado adicional incrementó en 0. 5513 l.vaca-1día. …”
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Probing the potential of InDel polymorphisms on the molecular identification of cetaceans by Dafne Adriana Abreu dos Anjos, Rodrigo Goldenberg Barbosa, Anna Luiza dos Santos Donato, Elizeu Fagundes de Carvalho, Cesar Rogerio Leal do Amaral

“…We carried out an in silico analysis using previously published 16S rRNA and adjacent tRNA-Leu mitochondrial sequences obtained from the NCBI database and found that accurate identification of all species included in our assay could be obtained by combining the lengths of three InDel regions. …”
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Remote sensing assessment of dam impact on arid basins in Southern Saudi Arabia: A machine learning and space-for-time approach by Raid Almalki, Mehdi Khaki, Patricia M. Saco, Jose F. Rodriguez

“…Additionally, regression models showed a decrease in predictive accuracy from 2010 to 2020, as evidenced by lower R² values for NDVI (0.82–0.37), soil salinity (0.77–0.38), groundwater (0.98–0.34), and soil moisture (0.96–0.24).…”
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Asynchronous Realization of Algebraic Integer-Based 2D DCT Using Achronix Speedster SPD60 FPGA by Nilanka Rajapaksha, Amila Edirisuriya, Arjuna Madanayake, Renato J. Cintra, Dennis Onen, Ihab Amer, Vassil S. Dimitrov

“…Performance of AI DCT with HEVC is measured in terms of the accuracy of the transform coefficients and the overall rate-distortion (R-D) characteristics, using HM 7.1 reference software. …”
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Clima ético, estrés de conciencia y laboral de enfermeras y médicos que laboran en cuidados intensivos neonatal by María Magdalena Alonso Castillo, Nora Angélica Armendaríz Garcia, María Teresa De Jesús Alonso Castillo, Bertha Alicia Alonso Castillo, Karla Selene López García

“…Además, se identificó como hallazgo adicional que el clima ético predice el estrés relacionado con el trabajo, tanto en médicos como en enfermeras (R2=7.9, p=.004). La evidencia científica del presente estudio confirma que la bioética como ciencia debe ser competencia de todos los profesionales de la salud y, en particular, de la enfermería, debido a los desafíos éticos y morales de su práctica profesional, especialmente en áreas críticas debido a las políticas, la normatividad y los recursos con los que cuentan el lugar de trabajo. …”
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Discapacidad física, personalidad y competencias laborales. Estudio comparativo con población normativa by Sylvia Sylvia Lara Paredes, Marta Alzina Carreró, Begoña Mariné Basterra, Ariana Sabaté García

“…Los instrumentos estandarizados empleados para el estudio fueron el Inventario de Personalidad (NEO-PI-R) y el Cuestionario SOSIA para la Gestión por Competencias. …”
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Burnout among Nurses Working in Ethiopia by Abrha Hailay, Woldu Aberhe, Guesh Mebrahtom, Kidane Zereabruk, Guesh Gebreayezgi, Teklehaimanot Haile

“…All statistical analysis was done using R and RStudio software for Windows, and a random-effects model was applied to estimate the overall prevalence of burnout among nurses in Ethiopia. …”
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Hypericin-Mediated Photodynamic Therapy for Head and Neck Cancers: A Systematic Review by Jakub Fiegler-Rudol, Natalia Zięba, Radosław Turski, Maciej Misiołek, Rafał Wiench

“…Additionally, HY-PDT modulated the tumour microenvironment by altering cytokine profiles, such as by increasing IL-20 and sIL-6R levels, which may enhance antitumor immunity and reduce metastasis. …”
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Occupational Infections Among Workers in Europe: Protocol for a Scoping Review by Guglielmo Dini, Stefania Curti, Alborz Rahmani, Paolo Durando, Stefano Mattioli

“…MethodsThe review will be conducted following the Joanna Briggs Institute methodology for scoping reviews and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines. …”
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Evaluation of the Operational Simplified Surface Energy Balance Model for Pastureland Evapotranspiration Mapping and Drought Monitoring in North Central Kentucky by Maheteme Gebremedhin, Ian Ries, Gabriel B. Senay, Martin Matisoff, Ibukun Amusan, Jeremy Sandifer, Buddhi Gyawali

“…The mean bias error (MBE), root mean squared error (RMSE), mean absolute percentage error (MAPE), and coefficient of determination (R2) were 5.47, 21.49 mm mon−1, 30.94%, and 0.87, respectively. …”
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Clinical performance of real-time nanopore metagenomic sequencing for rapid identification of bacterial pathogens in cerebrospinal fluid: a pilot study by Yoon Hyun Sung, Yong Kuk Ju, Hak Jun Lee, Seung Min Park, Jin Woong Suh, Jeong Yeon Kim, Jang Wook Sohn, Young Kyung Yoon

“…Abstract This study aimed to evaluate the usefulness of amplicon-based real-time metagenomic sequencing applied to cerebrospinal fluid (CSF) for identifying the causative agents of bacterial meningitis. We conducted a 16S rRNA amplicon sequencing using a nanopore-based platform, alongside routine polymerase chain reaction (PCR) testing or bacterial culture, to compare its clinical performance in pathogen detection on CSF samples. …”
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Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment by Matthew Regier, Jiancong Liang, Alexander Choi, Kavita Verma, Jenny Libien, A. Iván Hernández

“…We proposed that the displacement of PARP-1 from the nucleolus results in downregulation of new rRNA expression and ribosome biogenesis, leading to cognitive impairment. …”
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Pharmaceuticals as emerging pollutants: Implications for water resource management in Malaysia by Asvinidevi Arumugam, Khai Ern Lee, Pei Yuen Ng, Aida Soraya Shamsuddin, Aziemah Zulkifli, Thian Lai Goh

“…This review aims to provide comprehensive insights into the occurrence of pharmaceuticals in Malaysian water bodies. Following PRISMA-ScR guidelines, a scoping review of studies from 2007 to 2024 was conducted using the Scopus, Web of Science and Google Scholar databases. …”
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Fecal microbiota transplantation alleviates radiation enteritis by modulating gut microbiota and metabolite profiles by Qin Ding, Jing Xue, Nan Li, Zhihui Hu, Jianbo Song

“…Gut microbiota alterations and fecal metabolism were analyzed via 16S rDNA sequencing and targeted metabolomics. The results demonstrated that FMT, particularly in the M-FMT group, effectively alleviated RE by reducing DAI scores, histological damage, and inflammatory markers while enhancing enzyme activity, superoxide dismutase (SOD) levels, and intestinal absorption. …”
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