Immune cells in thyroid adenoma and carcinoma: uncovering a hidden value of assessing tumor-host interplay and its potential application in thyroid cytopathology by Iryna Omelianenko, Iryna Omelianenko, Nazarii Kobyliak, Nazarii Kobyliak, Tetyana Falalyeyeva, Tetyana Falalyeyeva, Oleksii Seleznov, Pavlina Botsun, Lyudmila Ostapchenko, Oleksandr Korotkyi, Liudmyla Domylivska, Olena Tsyryuk, Galyna Mykhalchyshyn, Tetiana Shapochka, Oksana Sulaieva, Oksana Sulaieva

“…The number of immune cells in cytological specimens correlated with CD8+ (r = 0.693; p < 0.001) and CD163+ cells (r = 0.559; p < 0.001) in histological samples, reflecting the differences in the tumor immune microenvironment between benign and malignant thyroid neoplasms.ConclusionTC demonstrated high immunogenicity compared to TA, which correlated to the number of immune cells in cytological specimens. …”
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Phase II randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of MLC1501 in patients with stroke: the MLC1501 study Assessing Efficacy in post-STrOk... by Narayanaswamy Venketasubramanian, Deidre Anne De Silva, Christopher P L H Chen, Cyrus G Escabillas, John Harold Hiyadan, Johnny K Lokin, Romulo U Esagunde, Joel M Advincula, Christian Oliver C Co, Maria Epifania V Collantes, Annabelle Y Lao, Yeow-Hoay Koh, Carol Huilian Tham

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Artificial intelligence analysis of thermal energy for convectively heated ternary nanofluid flow in radiated channel considering viscous dissipations aspects by Hamid Qureshi, Amjad Ali Pasha, Muhammad Asif Zahoor Raja, Zahoor Shah, Salem Algarni, Talal Alqahtani, Waqar Azeem Khan, Moinul Haq

“…The profile of flow rate shows it increases with fluidity parameter R and decreases with increasing deviation parameter γ. …”
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Influence of Irradiance, Flow Rate, Reactor Geometry, and Photopromoter Concentration in Mineralization Kinetics of Methane in Air and in Aqueous Solutions by Photocatalytic Membra... by Ignazio Renato Bellobono, Mauro Rossi, Andrea Testino, Franca Morazzoni, Riccardo Bianchi, Giulia de Martini, Paola Maria Tozzi, Rodica Stanescu, Cristina Costache, Liliana Bobirica, Mauro Luigi Bonardi, Flavia Groppi

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NEWCOMBO PROBLEMA IR AMERIKIETIŠKAS KLAUSIMAS by Zenonas Norkus

“…However, some of them (evidentialists - E. Eells, R. Jeffrey) maintain that the classical decision theory if properly applied recommends the correct - "bad news, small benefit" - choice, whereas others (causalists - J. …”
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Effect of Exogenous of Transforming Growth Factor-β1 on Pregnancy Outcome in Mice with Recurrent Pregnancy Loss by Persistent Enhancement of Placental Tissue Indoleamine 2,3-Dioxyg... by Xinghui Wen, Xiaojuan Chen, Mei Li, Jinnian Zhou, Shouli Dao, Shixiang Li, Hui Cheng, Shuyun Zhao, Guanyou Huang

“…The expression of IDO, TGF-β1, and TGF-β3 were detected in the placenta using westernblotting and immunohistochemistry techniques.Results: The expression of IDO was positively correlated with TGF-β1 in the placental tissue of RPL mice (r=0.591,P<0.001). In all treatment groups, the embryo resorption rates were significantly lower than the control group andthe expression of IDO in the placental tissue of all treatment groups was significantly higher than the control group.The expression of TGF-β1 increased gradually from, 2, 20 to 200 ng/ml in treatment groups, and the concentrationof exogenous TGF-β1 positively correlated with the expression of TGF-β1, in placental tissues in treatment groups(r=0.372, P=0.018).Conclusion: Exogenous TGF-β1 improves pregnancy outcomes in RPL mice, and the possible therapeutic mechanismis that exogenous TGF-β1 induces the persistent expression of endogenous TGF-β1 and IDO due to mutuallyinduced expression of the other. …”
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Thermodynamics guided design and processing of a WC/HEA cermet tool for high temperature friction stir welding by Supreeth Gaddam, Surekha Yadav, Amit Kishan Behera, Noriaki Arai, Zaynab Mahbooba, Shikhar Krishn Jha, Qiaofu Zhang, Rajiv S. Mishra

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Assessment of Different Conventional and Biofortified Wheat Genotypes Based on Biology and Damage Pattern of <i>Rhyzopertha dominica</i> and <i>Trogoderma granarium</i> by Hafiz Muhammad Bilal Yousuf, Muhammad Yasin, Muhammad Asif Khan, Asim Abbasi, Muhammad Arshad, Muhammad Anjum Aqueel, Inzamam Ul Haq, Waleed A. A. Alsakkaf, Marwa I. Mackled, Nazih Y. Rebouh, Hayssam M. Ali

“…The longest developmental period was recorded in Akbar-2019, i.e., 44.33 and 58.83 days, for <i>R. dominica</i> and <i>T. granarium</i>, respectively. …”
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A rare deleterious missense mutation in the AXIN2 gene in Chinese women with polycystic ovary syndrome by Ying Zhang, Yu Chen, Fa-Ying Liu, Jing-Wen Fu, Xian-Xian Liu, Jun Tan, Ou-Ping Huang, Yang Zou

“…Among them, we find a rare deleterious missense variant [p.R714W (c.2140C > T)]. The allele frequencies of this variant were 0.82% and 0.17% in PCOS cases and matched controls, respectively. …”
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Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic live... by Nikolina Canová, Jana Šípková, Mahak Arora, Zuzana Pavlíková, Zuzana Pavlíková, Tomáš Kučera, Ondřej Šeda, Tijana Šopin, Tomáš Vacík, Ondřej Slanař

“…Quantitative gene expression originally showed significant regulation of galanin and all three of its receptors (GalR1/2/3) in the heart ventricles and only GalR2 in the liver of obese mice. …”
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AaMYB61-like and AabHLH137 jointly regulate anthocyanin biosynthesis in Actinidia arguta by Zhe Song, Yukuo Li, Xu Zhan, Xiaohan Li, Lingshuai Ye, Miaomiao Lin, Ran Wang, Leiming Sun, Jinyong Chen, Jinbao Fang, Feng Wei, Xiujuan Qi

“…Results Here, we demonstrated that a key R2R3-MYB transcription factor, AaMYB61-like, plays a crucial role in A. arguta anthocyanin biosynthesis. …”
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The incidence of outpatient care within 24 months from SARS-CoV-2 infection in the general population: a multicenter population-based cohort study by Federico Banchelli, Carlo Gagliotti, Angela De Paoli, Rossella Buttazzi, Elena Narne, Enrico Ricchizzi, Silvia Pierobon, Ugo Fedeli, Gisella Pitter, Elisa Fabbri, Michele Tonon, Elisa Gentilotti, Maurizia Rolli, Evelina Tacconelli, Maria Luisa Moro, Francesca Russo, Elena Berti

“…Results There were 27,140 subjects in E-R and 22,876 in Veneto who were included in the analysis. …”
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Machine vision-based detection of key traits in shiitake mushroom caps by Jiuxiao Zhao, Jiuxiao Zhao, Wengang Zheng, Wengang Zheng, Yibo Wei, Yibo Wei, Qian Zhao, Qian Zhao, Jing Dong, Jing Dong, Xin Zhang, Xin Zhang, Mingfei Wang, Mingfei Wang

“…Experimental results demonstrated that the R² between predicted values and true values was 0.97 with an RMSE as low as 0.049. …”
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Identification and Analysis of Components in Yizhi Granule and Cynomolgus Monkey Plasma after Oral Administration by UPLC/ESI-Q-TOF MS and Their Protective Effects on PC12 Cells by Erwei Hao, Jianfeng Qin, Wei Wei, Jianhua Miao, Yan Xie, Xianglong Pan, Hangxuan Wu, Jinling Xie, Xiaosu Fan, Zhengcai Du, Xiaotao Hou, Jiagang Deng

“…The results showed that 9 compounds protect PC12 cells from Aβ25–35 with cell viability (%) of 111.00 ± 8.12 (G-Rb1), 102.20 ± 4.22 (G-Rb2), 100.34 ± 6.47 (G-Rd), 102.83 ± 2.10 (G-Re), 101.68 ± 7.64 (NG-Fa), 101.19 ± 7.83 (NG-R1), 102.53 ± 0.55 (NG-R2), 106.88 ± 4.95 (gypenoside A), and 103.95 ± 4.11 (gypenoside XLIX), respectively, versus the control group (87.51 ± 6.59). …”
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Diseño e implementación de mejoras aplicando la norma ISO/IEC 25000 para la calidad de software en un sistema de gestión bibliotecario by Pedro Damián González Villalba, Hugo David Ortega Domínguez

“…El lenguaje de programación utilizado fue Ruby On Rails (RoR), la metodología de desarrollo fue SCRUM por la adaptabilidad a RoR para el desarrollo ágil del proyecto en etapas y fases. …”
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Repeatability and reproducibility of a new spectral-domain optical coherence tomography biometer and agreement with swept-source optical coherence tomography based biometer by Xin Li, Chak Seng Lei, Rui Ning, Luze Liu, Aodong Chen, Xinning Yang, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Jinhai Huang

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Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point Test by Yi-Chou Hou, Wen-Chih Liu, Min-Tser Liao, Kuo-Cheng Lu, Lan Lo, Heng-Chih Pan, Chia-Chao Wu, Oliver Yoa-Pu Hu, Hung-Shang Tang

“…Among the 74 HD patient, only the post-HD Cr levels and years on dialysis were significantly correlated with GSP values (r=0.280, P<0.05 and r=-0.240, P<0.05, resp.). 14 of 74 patients were selected for GSP evaluation before and after a single HD session, and the hepatic clearance of galactose was similar (pre-HD 410 ± 254 g/mL, post-HD 439 ± 298 g/mL, P=0.49). …”
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Instantaneous self-recovery and ultra-low detection limit hydrogel electronic sensor for temporomandibular disorders intelligent diagnosis by Yujie Yan, Lixia Yu, Xuefeng Zhang, Qi Han, Zhixin Yang, Xingyuan Lu, Jiongke Wang, Hao Xu, Qianming Chen, Hang Zhao

“…It could efficiently diagnose disc displacement with reduction (DDwR) with satisfactory accuracy of 90.00%, and also had a clear indication of the typical clinical manifestations of DDwR and the timing of temporomandibular joint (TMJ) clicking, with a sensitivity of up to 100% in human compared to the diagnostic criteria for TMD (DC/TMD). …”
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Comparative Analysis of Multiple Hydrological Models in Assessing Climate Change Impacts on the Mille Watershed, Awash Basin, Ethiopia by Asmare Belay Nigussie, Mihiretie Ayana, Dessalegn Worku Ayalew, Gerawork Feleke, Asnake Enawgaw Amognehegn, Anteneh Yayeh Adamu, Andualem Endalew, Tewodrose Desale Meselaw, Shankar Karuppannan

“…Similarly, the HBV model shows NSE values of 0.683 for calibration and 0.706 for validation, R2 values of 0.705 for calibration and 0.71 for validation, and PBIAS values of −4.25 for calibration and −6.669 for validation. …”
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PENGEMBANGAN MODUL ELEKTRONIK BERBANTUAN SIMULASI PhET PADA POKOK BAHASAN GERAK HARMONIK SEDERHANA DI SMA by Melva Oktaviana, Desy Hanisa Putri, Eko Risdianto

“…ABSTRAK   Penelitian ini merupakan R&D level 1 yang dilaksanakan dalam lima tahap yaitu potensi masalah, studi literatur dan pengumpulan informasi, desain produk, validasi desain dan desain teruji. …”
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