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Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization
Published 2025-01-01“…Zhenxuan Sun,1– 3,* Jie Liu,1– 3,* Peng Ge,1– 3,* Yinan Cao,4 Jin Liu,1– 3 Haiyun Wen,1– 3 Xinyu Luo,1– 3 Boliang Pei,1– 3 Zuocang Jin,1,3 Huijuan Li,3 Lu Xun,1– 3 Yalan Luo,5 Qi Yang,6 Hailong Chen1– 3 1Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 2Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 3Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 4Day Surgery Center, Dalian Municipal Central Hospital, Dalian, Liaoning, 116033, People’s Republic of China; 5Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 6Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116023, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hailong Chen, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Zhongshan Road 222, Dalian, Liaoning, 116011, People’s Republic of China, Tel +86 411 83635963, Fax +86 411 83622844, Email chenhailong@dmu.edu.cnPurpose: Explore the therapeutic effect and molecular mechanism of rhein on severe acute pancreatitis associated acute lung injury (SAP-ALI).Methods: The SAP-ALI rat model was constructed by retrograde injection of 5% sodium taurocholate into the pancreaticobiliary duct, and pulmonary microvascular endothelial cell (PMVEC) injury model was induced by LPS. …”
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Exosomes Derived from Apelin-Pretreated Mesenchymal Stem Cells Ameliorate Sepsis-Induced Myocardial Dysfunction by Alleviating Cardiomyocyte Pyroptosis via Delivery of miR-34a-5p
Published 2025-01-01“…Ting Li,1,2,* Yuechu Zhao,3,* Zhi Cao,2,* Ying Shen,2 Jiaqi Chen,2 Xinran Huang,2 Zhuang Shao,2 Yi Zeng,2 Qi Chen,2 Xiaofei Yan,3 Xin Li,1,2 Yuelin Zhang,1,2 Bei Hu1,2 1School of Medicine, South China University of Technology, Guangzhou, Guangdong, People’s Republic of China; 2Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 3Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuelin Zhang; Bei Hu, Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510080, People’s Republic of China, Tel +86-20-83827812-20974, Email zhangyuelin1999@163.com; qhubei@hotmail.comBackground: Exosomes sourced from mesenchymal stem cells (MSC-EXOs) have become a promising therapeutic tool for sepsis-induced myocardial dysfunction (SMD). …”
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Soil phosphorus mobilization as affected by long-term organic fertilization in a tropical Regosol
Published 2024-03-01Get full text
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Beyond identification of familial hypercholesterolemia: Improving downstream visits and treatments in a large health care system
Published 2025-03-01“…Methods: Individuals at UT Southwestern Medical Center with an LDL-C ≥ 190mg/dL (n = 8368) ever recorded in the EHR were included in an FH registry. As part of a QI program, random individuals from the registry deemed to possibly have FH were contacted via (1) MyChart message, (2) phone call, (3) letter, and/or (4) InBasket message to their PCP to notify them of the potential FH diagnosis, higher risk of ASCVD events, and offering referral to an FH specialist. …”
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Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide
Published 2025-01-01“…Yizhuo Xie,1 Ming Zhu,1 Han Bao,1 Kejia Chen,1 Shanshan Wang,1 Jingwen Dai,1 Hongzhu Chen,1 He Li,1 Qi Song,2 Xinlu Wang,2 Liangping Yu,2 Jin Pei1 1Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, Changchun, People’s Republic of China; 2Department of Clinical Pharmacy, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Jin Pei, Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, No. 1163 Xinmin Street, Changchun, 130021, People’s Republic of China, Tel +86-431-85619725, Email peijin@jlu.edu.cn Liangping Yu, Department of Clinical Pharmacy, the First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130061, People’s Republic of China, Tel +86 431 81879802, Email liangpingyu@jlu.edu.cnPurpose: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. …”
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Remarkable Phytochemical Characteristics of Chi-Nan Agarwood Induced from New-Found Chi-Nan Germplasm of Aquilaria sinensis Compared with Ordinary Agarwood
Published 2021-01-01“…An integrated strategy using SHS-GC-MS and UPLC-Q/Tof-MS was applied to explore the phytochemical characteristics of a kind of agarwood induced from a newly identified germplasm of Chi-Nan A. sinensis. Progenesis QI and MS-Dial were used to preprocess the UPLC-Q/Tof-MS and GC-MS raw data, respectively. …”
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Effect of Muladhara moxibustion on perineal injury during childbirth and physical rehabilitation of parturients (新型底轮灸治疗对产后会阴伤口及体质康复的影响)
Published 2024-06-01“…Conclusion Muladhara moxibustion treatment can effectively reduce pain, swelling and other accompanying symptoms, to a certain extent improve the postpartum Qi and blood weakness, with high treatment safety and effectiveness. …”
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TRACE Model: Predicting Treatment Response to Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma
Published 2025-01-01“…Weilang Wang,1,* Qi Zhang,2,* Ying Cui,1,* Shuhang Zhang,1 Binrong Li,1 Tianyi Xia,1 Yang Song,3 Shuwei Zhou,1 Feng Ye,4 Wenbo Xiao,5 Kun Cao,6 Yuan Chi,7 Jinrong Qu,8 Guofeng Zhou,9,10 Zhao Chen,11 Teng Zhang,12 Xunjun Chen,13 Shenghong Ju,1 Yuan-Cheng Wang1 1Department of Radiology, Zhongda Hospital, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 2Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, People’s Republic of China; 3MR Scientific Marketing, Siemens Healthineers Ltd, Shanghai, People’s Republic of China; 4Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 5Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 6Department of Radiology, Peking University Cancer Hospital and Institute, Beijing, People’s Republic of China; 7Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China; 8Department of Radiology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, People’s Republic of China; 9Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 10Shanghai Institute of Medical Imaging, Shanghai, People’s Republic of China; 11Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 12Institute for Artificial Intelligence in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, People’s Republic of China; 13Department of Radiology, The People’s Hospital of Xuyi County, Huaian, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuan-Cheng Wang, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, Jiangsu, 210009, People’s Republic of China, Tel +086 25 83272121, Fax +086 25 83311083, Email yuancheng_wang@seu.edu.cnPurpose: To develop and validate a predictive model for predicting six-month outcome by integrating pretreatment MRI features and one-month treatment response after TACE.Methods: A total of 108 patients with 160 hCCs from a single-arm, multicenter clinical trial (NCT03113955) were analyzed and served as the training cohort. …”
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Population of Merging Compact Binaries Inferred Using Gravitational Waves through GWTC-3
Published 2023-03-01Get full text
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