The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency by Ryan C. Tsou, Kendra K. Bence

“…The PTP1B protein is encoded by the PTPN1 gene on human chromosome 20q13, a region that shows linkage with insulin resistance, type 2 diabetes, and obesity in human populations. …”
Get full text

On Curvilinear Regression Analysis via Newly Proposed Entropies for Some Benzene Models by Guangwu Liu, Muhammad Kamran Siddiqui, Shazia Manzoor, Muhammad Naeem, Douhadji Abalo

“…Other remaining physical characteristics include Gibb’s energy qℰ, logP, molar refractivity ℳℛ, and Henry’s law ℋℒ that can be predicted by using sixth ND entropy.…”
Get full text

A plantwide control proposal for ethylbenzene production by Victor Dias Veloso, Anamaria de Oliveira Cardoso

“…The structural decisions adopted and the results obtained through computational simulation indicated that although there are interactions between the control loops, the possible pairs, T1-FR2 and T4-Q4, minimize the system interactions. The adjusted parameters of the controller were effective in controlling the disturbance, presenting little or no overshoot with satisfactory ascent and response times. …”
Get full text

Analysis of Eccentricity-Based Topological Invariants with Zero-Divisor Graphs by Zhi-hao Hui, Abdul Rauf, Muhammad Mohsin Abbas, Adnan Aslam

“…Let R=Z♭1♭2♭3×Zq2 be a commutative ring, where ♭1,♭2,♭3 are distinct primes, and q is any prime integer. A zero divisor graph JR of ring R is a graph with vertex set consist of zero divisors elements of R and any two vertices a,b are adjacent if and only if ab=0. …”
Get full text

Dynamic Modeling and Simulation of a Super-High-Speed Circumferential-Flux Hysteresis Motor by A. Halvaei Niasar, M. Zare, H. Moghbelli

“…A nonlinear mathematical model based on a d-q axis theory in the rotor reference frame is applied to study the starting and synchronization processes of a hysteresis machine with a circumferential-flux-type rotor. …”
Get full text

First discoveries of colonies of the rare ant species Camponotus tergestinus Müller, 1921 (Hymenoptera: Formicidae) in situ by Gregor Bračko

“…In 2016 and 2017, two colonies were found at Lipica (SW Slovenia), the first nesting on Quercus pubescens at the height of 3.2 m, the second on Q. cerris at the height of 2.2 m. Both nests had two entrances each. …”
Get full text

University of Florida Potato Variety Trials Spotlight: Marcy by Mario H. M. L. Andrade, Rodrick Z. Mwatuwa, Christian T. Christensen, Lincoln Zotarelli

“…The cultivar was selected from a cross between ‘Atlantic’ and Q155-3 (De Jong et al. 2006). In trials conducted at the University of Florida, ‘Marcy’ demonstrated high yield and good tuber characteristics compared to its matched commercial standards, ‘Atlantic’ and ‘La Chipper’. …”
Get full text

Constraints on the Origin of the Martian Dichotomy From Southern Highlands Marsquakes by Weijia Sun, Hrvoje Tkalčić

“…Using the spectral ratio method, we estimate the quality factor Q in the range 481–543 for Terra Cimmeria versus 800–2,000 determined for Cerberus Fossae. …”
Get full text

Perioperative Management of a Patient Taking Suboxone® at the Time of Ambulatory Surgery by Shawn H. Malan, Christopher H. Bailey, Narjeet Khurmi

“…Buprenorphine is a unique opioid which acts as a partial μ agonist and ĸ antagonist. These properties make it an effective tool in treating OUD and abuse. …”
Get full text

αAsarone alleviates neuronal injury by facilitating autophagy via miR-499-5p/PDCD4/ATG5 signaling pathway in ischemia stroke by Yonghuan Yan, Linfang Wu, Lu Wang, Dandan Wang, Mengting Huang, Jinyong Peng, Jinyong Peng, Yingying Huang, Yingying Huang, Yingying Huang

“…However, its mechanism of action remains poorly understood.MethodsThe effects of αAsarone on autophagy were examined by WB, RT-qPCR, immunofluorescence colocalization, transmission electron microscope, and autophagic flux activity was measured by infecting HT22 cells with mRFP-GFP-LC3 adenovirus. …”
Get full text

To construct and validate a risk score model of angiogenesis-related genes to predict the prognosis of hepatocellular carcinoma by Duangui Gao, Yuan Lu, Tianpeng Jiang, Qinghong Duan, Zhi Huang

“…Finally, in the three pairs of HCC tissues and tissue adjacent to carcinoma by real-time fluorescent quantitative PCR (qRT_PCR) and western blotting (WB) to evaluate angiogenesis-related genes (ATP2A3 AEBP1 PNMA1, PLAT) expression level in HCC, and AEBP1 was knocked out in HCCLM3 cells, which is to study AEBP1 biological function in HCC. …”
Get full text

The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network by Yi Wang, Yi Wang, Moran Xu, Xiaoli Zuo, Sheng Wang, Yong Yu, Zhaobing Gao, Zhaobing Gao, Jingbo Qie, Ye Jiang, Fang Huang, Bingqing Xia, Bingqing Xia

“…However, the mechanisms by which MLKL functions in the process of intracerebral hemorrhage (ICH)-induced damage remain unclear.MethodsHere, we explored the correlation between MLKL and pathological damage in ICH patients through histopathological staining and RT-qPCR. Furthermore, we established an intracerebral hemorrhage model by collagenase IV injection in WT and Mlkl-/- mice. …”
Get full text

Comparación de métodos térmicos para remediar suelos contaminados con hidrocarburos: Una revisión sistemática by Cristian Aguilar, Kiara Zárate, Katherine Chira, Giacomo Velasco, Joaquin Larrea, Yaneth Vasquez Olivera

“…Para llevar a cabo este análisis, se seleccionaron 98 artículos científicos de cuartiles Q1 y Q2 de bases de datos como Web of Science, Scopus, ScienceDirect, Wiley y MDPI, utilizando los operadores booleanos «Techniques» AND «Remediation» AND «Hydrocarbons». …”
Get full text

Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis by Xiaohui Meng, Xiaohui Meng, Li Sheng, Yongqing You, Yongqing You, Huibo Dai, Manshu Yu, Funing Wang, Funing Wang, Ziren Zhou, Ziren Zhou, Yun Shan, Meixiao Sheng

“…Western blotting (WB), quantitative real-time PCR (qRT-PCR), TdT-mediated dUTP Nick-End Labeling (TUNEL) staining, and flow cytometry were conducted.ResultsQXHZF had potent therapeutic efficacy against PF according to WB, qRT-PCR, and pathological section examination. …”
Get full text

Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation by Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han

“…Quantitative real-time PCR (qRT‒PCR), Western blot (WB), immunofluorescence staining and collagen gel contraction assays were performed to evaluate the collagen production and activation capacity of HSFs. …”
Get full text

Regulation of LPS-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells via TLR4-Mediated NF-κB and MAPK Signaling Pathways by Lactoferrin by Kai Zhang, Ruizhen Zhang, Yuanyuan Zhang, Min Zhang, Hong Su, Feifei Zhao, Daqing Wang, Guifang Cao, Yong Zhang

“…The expression of inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α at both the gene and protein levels was detected using RT-qPCR and ELISA. Western blotting was employed to evaluate the phosphorylation levels in the inflammatory signaling pathways MAPK/P38/ERK and NF-κB/P65, while RT-qPCR was used to examine the impact on TLR4 receptor gene expression. …”
Get full text

Genome-wide identification of the bHLH gene family in Scutellaria baicalensis and their relationship with baicalin biosynthesis under drought stress by Yingxin Sun, Beier Wang, Lichao Zhang, Xiaohan Zheng, Peng Xu, Meng Zhang, Meiguang Han, Peng Di, Mei Han, Lin Cheng, Limin Yang

“…Transcriptomic data and qRT-PCR results demonstrated tissue-specific expression patterns for the 142 SbbHLH genes. …”
Get full text

Melting curve analyses in the quantitative real-time polymerase chain reaction of methylated/non-methylated DNA toward the detection of oral cancer using gargle fluid by Yusaku Noma, Hayate Sawayama, Kouta Yamashiro, Keitaro Nishi, Haruka Yoshinaga, Ryota Takaoka, Tsuyoshi Sugiura, Tomonori Sasahira, Tomofumi Hamada, Yasuo Suda, Tatsuo Okui

“…We therefore sought to develop a simple screening method for the diagnosis of oral cancer by conducting a melting curve analysis in a quantitative real-time polymerase chain reaction (qPCR). The assay was performed by a qPCR of DNA from the gargle fluid of 20 patients with oral cancer and 20 healthy control subjects in the training set. …”
Get full text

Molecular characterization of EBV-associated primary pulmonary lymphoepithelial carcinoma by multiomics analysis by Meiling Yang, Guixian Zheng, Fukun Chen, Haijuan Tang, Yaoyao Liu, Xuan Gao, Yu Huang, Zili Lv, Benhua Li, Maolin Yang, Qing Bu, Lixia Zhu, Pengli Yu, Zengyu Huo, Xinyan Wei, Xiaoli Chen, Yanbing Huang, Zhiyi He, Xuefeng Xia, Jing Bai

“…Results Compared with other types of NSCLC and EBV+-NPC, pLEC patients exhibited a lower somatic mutation burden and extensive copy number deletions, including 1p36.23, 3p21.1, 7q11.23, and 11q23.3. Integration of EBV associated dysregulation of gene expression, with CNV-altered regions coinciding with EBV integration sites. …”
Get full text

Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China by Liu A, Li X, Zhang X, Chen K, Zou Z, Sun Y, Zhou J, Li Z, Wu X, Lv X, Li H, Guo Z, Li Y

“…This association persisted even after adjusting for other variables, indicating a heightened risk of hyperuricemia among prediabetic individuals with elevated LFC [Q4 vs Q1: odds ratio (OR 2.70), 95% confidence interval (CI) 1.93– 3.79, P < 0.001; P for trend < 0.001]. …”
Get full text