Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…Comparative analysis of rat blood samples and SHSY using UPLC-Q-TOF-MS identified 19 blood-entry components, the potential active components of SHSY acting on GD. …”
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Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy by Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, Ibrahim Akin

“…The immunofluorescence staining, flow cytometry, qPCR, single-cell contraction, intracellular calcium transients, patch-clamp, dual luciferase reporter assay and western blot were performed for the study. …”
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Preservation of cfRNA in cytological supernatants for cfDNA & cfRNA double detection in non‐small cell lung cancer patients by Yidan Ma, Yifei Wang, Lei He, Jun Du, Lin Li, Zhixin Bie, Yuanming Li, Xiaomao Xu, Wei Zhou, Xiaonan Wu, Li Yang, Jing Di, Chenyang Li, Xiaoguang Li, Dongge Liu, Zheng Wang

“…Methods A protective solution (PS) was applied for preserving cfRNA in cytological supernatant (CS), and the quality of protected cfRNA was assessed by cycle threshold (CT) values from reverse transcription quantitative polymerase chain reaction (RT‐qPCR). Furthermore, we collected an additional set of malignant cytological and matched tumor samples from 84 NSCLC patients, cfDNA & cfRNA extraction and double detection for driver gene mutations was validated using the multi‐gene mutations detection by RT‐qPCR. …”
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First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

“…Patients received escalating doses of livmoniplimab ranging from 3mg to 1500mg, once every 2 weeks (Q2W), as monotherapy or in combination with a 500mg fixed dose of budigalimab Q4W. …”
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Peroxisome Proliferator-Activated Receptor γ Regulates the Expression of Lipid Phosphate Phosphohydrolase 1 in Human Vascular Endothelial Cells by Yazi Huang, Beilei Zhao, Yahan Liu, Nanping Wang

“…In human umbilical vein endothelial cells (HUVECs), quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) demonstrated that activation of PPARγ increased the mRNA level of LPP1. …”
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Struggling with a Gastric Volvulus Secondary to a Type IV Hiatal Hernia by Dafnomilis George, Pappas V. Apostolos, Panoutsopoulos Athanasios, Lagoudianakis E. Emmanuel, Koronakis E. Nikolaos, Panagiotopoulos Nikolaos, Seretis Charalampos, Karanikas George, Manouras J. Andreas

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Human-Robot Interaction Learning Using Demonstration-Based Learning and -Learning in a Pervasive Sensing Environment by Yunsick Sung, Seoungjae Cho, Kyhyun Um, Young-Sik Jeong, Simon Fong, Kyungeun Cho

“…In addition, a robot can apply Q -learning to learn interactions with humans. …”
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Perinatal Outcome of Fetal Echogenic Bowel: A Single-Center Retrospective Cohort Study by Hidayet Sal, Erhan Huseyin Comert, Yasin Semih Ekici, Turhan Aran

“…Other chromosomal disorders were tetrasomy 12p (1%), 69XXX (1%) and 46 XX, t (2,22) (9q9) (1%). A fetal echogenic bowel was associated with major congenital malformations in 25 (%25) cases. …”
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La empresa moderna capitalista transnacional: entre el desarrollo y las crisis civilizatorias (dimension social) by Juan Manuel Arévalo-Viveros, Lina Maria Becerra-Valencia, Yasmin Puentes-Giraldo

“…El análisis de los datos fue orientado por la teoria fundamentada.CLASIFICACION JEL M14, Q01…”
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Transcriptome-Based Analysis of Dof Family Transcription Factors and Their Responses to Abiotic Stress in Tea Plant (Camellia sinensis) by Hui Li, Wei Huang, Zhi-Wei Liu, Yong-Xin Wang, Jing Zhuang

“…Gene expression was analyzed in “Yingshuang” and “Huangjinya” under four experimental stresses by qRT-PCR. CsDof genes were expressed differentially and related to different abiotic stress conditions. …”
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Hsa_circ_0000190 Promotes NSCLC Cell Resistance to Cisplatin via the Modulation of the miR-1253/IL-6 Axis by Hua He, Tian Li

“…Analyses of NSCLC expression of hsa_circ_0000190, miR-1253, and interleukin 6 (IL-6) were conducted via a quantitative real-time polymerase chain reaction (qPCR) approach, while the ability of these tumor cells to resist DDP treatment was evaluated with a CCK-8 assay. …”
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Thermal Changes in Guidewires Used During Endoscopic Retrograde Cholangiopancreatography During Electrical Conductance: An Ex-Vivo Safety Experiment by Rahul Karna, Nicholas Michael McDonald, Jacob Weiner, Théodon I. Netoff, Stuart K Amateau

“…We tested heat generation from eleven common guidewires used in endoscopic retrograde cholangiopancreatography using an electrosurgical generator in combination with thermocouple temperature probe in an ex vivo model.Thermal changes during electrical conductance were nominal except for minimally wrapped 0.018” wires where the maximum change in temperature were 4.9° C with ENDO CUT Q settings and 6.8° C with ENDO CUT I settings. …”
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Inhibition of Murine Pulmonary Microvascular Endothelial Cell Apoptosis Promotes Recovery of Barrier Function under Septic Conditions by Lefeng Wang, Sanjay Mehta, Michael Brock, Sean E. Gill

“…Pretreatment of PMVEC with the pan-caspase inhibitor Q-VD significantly decreased septic PMVEC apoptosis and was associated with reestablishment of PMVEC barrier function at 16 and 24 h after stimulation but had no effect on septic PMVEC barrier dysfunction over the first 8 h. …”
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Pharmacophore modeling and QSAR analysis of anti-HBV flavonols. by Basireh Baei, Parnia Askari, Fatemeh Sana Askari, Seyed Jalal Kiani, Alireza Mohebbi

“…Additionally, the QSAR model with two predictors, x4a and qed, exhibited predictive solid performance with an adjusted-R2 value of 0.85 and 0.90 of Q2. PCA showed essential patterns and relationships within the dataset, with the first two components explaining nearly 98% of the total variance. …”
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Phenotypic and Cytogenetic Characterization of Mesenchymal Stromal Cells in De Novo Myelodysplastic Syndromes by A. J. I. S. Rathnayake, H. W. W. Goonasekera, V. H. W. Dissanayake

“…No significant growth differences were observed between control MSCs and MDS-MSCs of all subtypes (p>0.05). 31% of MDS-MSCs had chromosomal aberrations (der(3),del(6q),del(7p), loss of chromosomes) whose BM karyotypes were normal. …”
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Cooperative Behaviors and Multienergy Coupling Through Distributed Energy Storage in the Peer-to-Peer Market Mechanism by Zeynep Tanis, Ali Durusu

“…The proposed model’s performance is benchmarked against conventional peer-to-peer energy trading and the Q-learning algorithm. Transactions are secured using blockchain-based payment systems. …”
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The Impact of Anglicisms on Ukrainian Undergraduates as Consumers of Social Media Content by Yasser Al Tamimi, Yanina Lisun

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The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response. by Tania Veuthey, Jeremy T Florman, Sebastián Giunti, Stefano Romussi, María José De Rosa, Mark J Alkema, Diego Rayes

“…Our data support a model in which tyramine negatively impacts environmental stress resistance by stimulating the release of INS-3 from the intestine via the activation of a TYRA-3-Gαq-IP3 pathway. The release of INS-3 systemically activates the DAF-2 pathway, resulting in the inhibition of cytoprotective mechanisms mediated by DAF-16/FOXO. …”
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Predicting Flash Point of Organosilicon Compounds Using Quantitative Structure Activity Relationship Approach by Chen-Peng Chen, Chan-Cheng Chen, Hsu-Fang Chen

“…This 6-descriptor model gave an R2 value of 0.9174, QLOO2 value of 0.9106, and Q2 value of 0.8989. The average fitting error and the average predictive error were found to be of 10.34 K and 11.22 K, respectively, and the average fitting error in percentage and the average predictive error in percentage were found to be of 3.30 and 3.60%, respectively. …”
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Plac8 regulates the fibrogenic ability of cardiac fibroblasts in mice with myocardial infarction by Ting Fu, Jianping Gong, Lei Xu, Ningning Ji

“…Hydroxyproline assay demonstrated enhanced collagen production in hypoxic CFs, and qRT-PCR revealed increased relative contents of type I and type III collagen (Col1a1 and Col3a1). …”
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