Identification of blood plasma protein ratios for distinguishing Alzheimer's disease from healthy controls using machine learning by Ali Safi, Elisa Giunti, Omar Melikechi, Weiming Xia, Noureddine Melikechi

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Editorial: Immunomics of the immune regulatory networks in the one health perspective by Lucia Santorelli, Laxmikanth Kollipara, Marianna Caterino, Marianna Caterino, Michele Costanzo, Michele Costanzo

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Elucidating the degradation mechanism of beef myofibrillar proteins under hydroxyl radical oxidation through the lens of cysteine oxidation modifications by Jiale Li, Jun Liu, Hui Yue, Yuanyuan Ma, He Li, Yuanliang Hu, Xiang Yu, Weiwei Dong, Yanli Feng

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Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigationResearch... by Karl Michaëlsson, Rui Zheng, John A. Baron, Tove Fall, Alicja Wolk, Lars Lind, Jonas Höijer, Carl Brunius, Eva Warensjö Lemming, Olga E. Titova, Bodil Svennblad, Susanna C. Larsson, Shuai Yuan, Håkan Melhus, Liisa Byberg, Hannah L. Brooke

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Protocol for a multicentre, prospective cohort study of clinical, proteomic and genomic patterns associated with osteoporosis to develop a multidimensional fracture assessment tool: the PoCOsteo Study by Noushin Fahimfar, Bagher Larijani, Afshin Ostovar, Iraj Nabipour, Patricia Khashayar, Hans Peter Dimai, Nahid Moradi, Safoora Gharibzadeh

“…The fracture risk model is intended to be developed in two different populations, namely a European and a Middle Eastern one; (2) to develop a medical device, which would measure and/or quantify proteomic as well as genomic factors as present in whole blood samples collected through finger prick; (3) to test the clinical applicability and the validity of prototypes of the to be developed point of care device at both clinical centres.Methods and analysis This article presents the protocol of this prospective cohort that will be carried out independently at two different centres (Division of Endocrinology and Diabetology at the Medical University of Graz (MUG) as a clinic-based cohort, and Endocrinology and Metabolism Research Institute (EMRI) at the Tehran University of Medical Sciences (TUMS) as a population-based cohort). …”
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Discovery and Verification of Gelsolin as a Potential Biomarker of Colorectal Adenocarcinoma in a Chinese Population: Examining Differential Protein Expression using an Itraq Labelling-Based Proteomics Approach by Nai-Jun Fan, Chun-Fang Gao, Chang-Song Wang, Jing-Jing Lv, Guang Zhao, Xin-Hua Sheng, Xiu-Li Wang, Dong-Hui Li, Qing-Yin Liu, Jian Yin

“…However, the identification of differentially expressed proteins or novel protein biomarkers in CRC may have some utility and, ultimately, improve patient care and survival. Proteomics combined with mass spectroscopy and liquid chromatography are emerging as powerful tools that have led to the discovery of potential markers in cancer biomarker discovery in several types of cancers. …”
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A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of Primary Cultured Cells and Subcultured Cells Using Mouse Adipose-Derived Mesenchymal Stem Cells by Yoshiki Nakashima, Saifun Nahar, Chika Miyagi-Shiohira, Takao Kinjo, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Jiro Fujita, Hirofumi Noguchi

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Global proteomics and affinity mass spectrometry analysis of human Schwann cells indicates that variation in and loss of neurofibromin (NF1) alters protein expression and cellular and mitochondrial metabolism by Christian X Fay, Elizabeth R.M. Zunica, Elias Awad, William Bradley, Cameron Church, Jian Liu, Hui Liu, David K. Crossman, James A. Mobley, John P. Kirwan, Christopher L. Axelrod, Erik Westin, Robert A. Kesterson, Deeann Wallis

“…Next, we evaluated global proteomes. We identified over 1900 proteins in immortalized human Schwann cells both with and without NF1 expression. …”
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Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma by Angélica Luna-Nophal, Fernando Díaz-Castillo, Vanessa Izquierdo-Sánchez, Jesús B. Velázquez-Fernández, Mario Orozco-Morales, Luis Lara-Mejía, Johana Bernáldez-Sarabia, Noemí Sánchez-Campos, Oscar Arrieta, José Díaz-Chávez, Jorge-Ismael Castañeda-Sánchez, Alexei-Fedorovish Licea-Navarro, Saé Muñiz-Hernández

“…The effects of s-cal14.1b and s-cal14.2b on cell proliferation, apoptosis, and cytotoxicity were evaluated in 2D and 3D cultures of MPM-derived cells. Proteomics analysis of 3D cultures treated with conotoxins was performed to examine changes in expression or abundance. …”
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Characteristics and bioinformatics of peptides from natural and cultured sandfish (Holothuria scabra) by Pawitporn Daopa, Chakkapat Aenglong, Sittiruk Roytrakul, Teerasak E-kobon, Xue Zhao, Wanwimol Klaypradit

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Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone by Yue Ge, Maliha S. Nash, Aimen K. Farraj

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Identification of novel pQTL‐SNPs associated with lung adenocarcinoma risk: A multi‐stage study by Yutong Wu, Huiwen Xu, Liping Mao, Rongrong Zhao, Junfeng Chu, Lili Huang, Wendi Zhang, Yiran Liu, Qiong Chen, Xiaobo Tao, Siqi Li, Shenxuan Zhou, Anhui Ning, Zhenyu Li, Tian Tian, Lei Zhang, Jiahua Cui, Guangyu Tian, Minjie Chu

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Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion by Lu Wang, Jia-Qi Ma, Li-Jia Song, Xiao-Peng Qu, Yue Zhang, Hai-Ming Fan, Chao Wang, Long-Long Zheng, Guo-Dong Gao, Yan Qu, Liang-Liang Shen, Bei Liu

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Structure-Based Approaches for Protein–Protein Interaction Prediction Using Machine Learning and Deep Learning by Despoina P. Kiouri, Georgios C. Batsis, Christos T. Chasapis

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Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy by Julia Uffenorde, Mehran Hariri, Eleftherios Papalanis, Annika Staffas, Josefine Berg, Bo Stenerlöw, Hanna Berglund, Christer Malmberg, Diana Spiegelberg, Diana Spiegelberg

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The epididymal microenvironment in Akodon cursor (Muridae, Sigmodontinae, Akodontini): The lifetime of spermatozoa from production to maturation by Tatiana Prata Menezes, Fernanda Carolina Ribeiro Dias, Nara Clara Lazaroni e Merchid, Camila Folly Batista, Camilo Jose Ramirez-Lopez, Arabela Guedes de Azevedo Viana, Renner Philipe Rodrigues Carvalho, Adrielli Ribeiro Araújo, José Lino-Neto, Gisele Lessa, Arlindo A. Moura, Mariana Machado-Neves

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Mechanistic insight into human milk extracellular vesicle‐intestinal barrier interactions by Xiang Luo, Yunyue Zhang, Ning Ding, Jana Javorovic, Bahijja Tolulope Raimi‐Abraham, Steven Lynham, Xiaoping Yang, Natalie Shenker, Driton Vllasaliu

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Insights of cellular and molecular changes in sugarcane response to oxidative signaling by Lucas Felipe Silva, Kellya F. M. Barreto, Helaine Cristiane Silva, Iara Dantas de Souza, Carlos H. S. G. Meneses, Adriana F. Uchôa, Katia C. Scortecci

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Proteotranscriptomic Profiling of the Toxic Mucus of <i>Kulikovia alborostrata</i> (Pilidiophora, Nemertea) by Vasiliy G. Kuznetsov, Daria I. Melnikova, Sergey V. Shabelnikov, Timur Yu. Magarlamov

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WWTR1-AS1 LncRNA as a Novel Potential Diagnostic and Prognostic Biomarker in Breast Cancer by Mohadese Safabakhsh, Sohrab Boozarpour, Kamran Ghaedi, Mina Lashkarboloki, Shaaban Ghalandarayeshi

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