Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy by Trond Lamark, Terje Johansen

“…Protein aggregation is a continuous process in our cells. …”
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Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery by Celien Bollen, Sofie Louwagie, Femke Deroover, Wouter Duverger, Ladan Khodaparast, Laleh Khodaparast, Dieter Hofkens, Joost Schymkowitz, Frederic Rousseau, Liselot Dewachter, Jan Michiels

“…Furthermore, we demonstrate that structural features of protein aggregates determine the cell’s ability to exit dormancy and resume growth. …”
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Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma by Deanna Tiek, Xiao Song, Xiaozhou Yu, Runxin Wu, Rebeca Iglesia, Alicia Catezone, Katy McCortney, Jordain Walshon, Craig Horbinski, Pouya Jamshidi, Rudolph Castellani, Robert Vassar, Jason Miska, Bo Hu, Shi-Yuan Cheng

“…These findings suggest a new pathway for protein aggregation within drug resistant brain cancer that should be further studied in other brain disorders.…”
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Enhancing the texture of fat-free yogurt with Panax ginseng leaf-stem extract and casein: Focusing on their softening effect by Dong Hyun Keum, Hyun Ju Lee, Ji Hwan Ryoo, Sung Gu Han

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Pleiotropic effects of mutant huntingtin on retinopathy in two mouse models of Huntington's disease by Hui Xu, Anakha Ajayan, Ralf Langen, Jeannie Chen

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The question of strains in AA amyloidosis by Gunilla T. Westermark, Ebba Nyström, Sofie Nyström, K. Peter R. Nilsson, Per Hammarström, Per Westermark

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Design of a thermal stress microfluidic platform to screen stability of therapeutic proteins in pharmaceutical formulations by O. Bortone, S. Fiorenza, M. Baldassarre, N. Falco, M. Amidi, T. Markkula, P.A. Netti, E. Torino

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In-situ biophysical characterization of high-concentration protein formulations using wNMR by Jing Song, Marc Taraban, Y. Bruce Yu, Lynn Lu, Pallavi Guha Biswas, Wei Xu, Hanmi Xi, Akhilesh Bhambhani, Guangli Hu, Yongchao Su

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Optimization of Conditions for Expression of Dengue Serotype 2 EDIII Protein in <i>Escherichia coli</i> and Immune Responses of Adjuvant-Free EDIII Ferritin Nanoparticles Against D... by M.S.B.W.T.M. Nipuna Sudaraka Tennakoon, Kyoung-Ho Lee, Hye-Mi Lee, Jae-Yeon Park, Hyun-Jin Shin

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Anthracyclines disaggregate and restore mutant p63 function: a potential therapeutic approach for AEC syndrome by Fabiana Boncimino, Ludovica D’Auria, Kristina Todorova, Sabina Y. van der Zanden, Jacques Neefjes, Anna Mandinova, Caterina Missero, Stefano Sol

“…By performing a high-throughput screening of epigenetic and FDA-approved compounds in a co-transfection model of wild-type and mutant p63, we found that two compounds, Doxorubicin and Epirubicin, alleviate protein aggregation and restore p63 transactivation function. …”
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Glutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation by Rasangi Tennakoon, Teija M.I. Bily, Farah Hasan, Sunidhi Syal, Aaron Voigt, Tugce B. Balci, Kyle S. Hoffman, Patrick O’Donoghue

“…HD-causative polyQ alleles lead to protein aggregation, which is a prerequisite for disease. …”
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Interaction between 𝛼-Synuclein and Other Proteins in Neurodegenerative Disorders by Kurt A. Jellinger

“…Protein aggregation is a common characteristic of many neurodegenerative disorders, and the interaction between pathological/toxic proteins to cause neurodegeneration is a hot topic of current neuroscience research. …”
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Estrogen-related receptor gamma is a regulator of mitochondrial, autophagy, and immediate-early gene programs in spiny projection neurons: Relevance for transcriptional changes in... by Stephanie N. Fox, Cody H. Savage, Narcy R. Amireddy, Laura J. McMeekin, David K. Crossman, Peter J. Detloff, Michelle Gray, Rita M. Cowell

“…Mitochondrial dysfunction, transcriptional dysregulation, and protein aggregation are hallmarks of multiple neurodegenerative disorders, including Huntington's disease (HD). …”
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Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies by Verónica Muñoz-Soriano, Nuria Paricio

“…Analyses of their function have provided important insights into the disease process, demonstrating that three types of cellular defects are mainly involved in the formation and/or progression of PD: abnormal protein aggregation, oxidative damage, and mitochondrial dysfunction. …”
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Collective Deformation Modes Promote Fibrous Self-Assembly in Deformable Particles by Hugo Le Roy, M. Mert Terzi, Martin Lenz

“…This indicates that generic proteinlike characteristics such as allostery and incompressibility could favor the formation of fibers in protein aggregation, and suggests design principles for artificial self-assembling structures.…”
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Association of p53 with Neurodegeneration in Parkinson’s Disease by Qiang Luo, Wei Sun, Yi-Fan Wang, Ji Li, Da-Wei Li

“…Recent studies have revealed that p53 levels and activity are substantially increased in affected neurons in cellular and animal models of Parkinson’s disease (PD) as well as in the brains of PD patients. p53 activation in response to neurodegenerative stress is closely associated with the degeneration of dopaminergic neurons accompanied by mitochondrial dysfunction, reactive oxygen species (ROS) production, abnormal protein aggregation, and impairment of autophagy, and these pathogenic events have been implicated in the pathogenesis of PD. …”
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Effects of Various Flavonoids on the α-Synuclein Fibrillation Process by Xiaoyun Meng, Larissa A. Munishkina, Anthony L. Fink, Vladimir N. Uversky

“…Currently, there is no approved therapeutic agent directed toward preventing the protein aggregation, which has been recently shown to have a key role in the cytotoxic nature of amyloidogenic proteins. …”
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Effects of Momordica cochinchinensis Aril Extract on Sterilized Low-Fat Milk, Antioxidant and Antiproliferative Activities by Thitiporn Anunthawan, Santi Phosri, Jirayus Woraratphoka, Rasapirose Somwatcharajit, Panee Terdsaksri, Prangruethai Prangphet

“…At an accelerated rate (50°C, 28 days), there was no effect of the extract addition on protein aggregation in low-fat milk. Moreover, the TBA values indicate the ability of the extract to inhibit lipid oxidation. …”
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Effect of Ultrasonic-Assisted Thermal Treatment on the Structure and Solubility of Rapeseed Protein by ZHAO Kangyu, YANG Ping, MA Junkun, SHU Wenjing, YANG Feng, XIE Yisha, LIU Qingqing

“…For the individual thermal treatment groups, as the heating temperature increased, protein aggregation occurred. The particle size increased from 1 188.18 to 5 630.00 nm. …”
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Optimization of amino acid-stabilized erythropoietin parenteral formulation: In vitro and in vivo assessment by Fayed Bahgat E., Tawfik Abdulkader F., Yassin Alaa Eldeen B.

“…The results showed that the presence of surfactant was very useful in preventing the initial adsorption of EPO on the walls of vials and in minimizing protein aggregation. Amino acid combinations, glycine with glutamic acid, provided maximum stability. …”
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