A new pathogen pattern of acute respiratory tract infections in primary care after COVID-19 pandemic: a multi-center study in southern China by Heng Zhang, Deqi Meng, Hao Huang, Longhao Feng, Yushao Li, Yong Jiang, Ling Wang, Ruoyu Deng, Yuchun Sun, Binqin Chen, Fuzhao Liao, Yumei Wu, Huancai Zheng, Junling Ding, Maokun Chen, Cui Zeng, Wanting Zhao, Meng Hou, Yinyan Li, Zhishen Li, Haibo Xia, Kai Yang, Lingwei Wang

“…Methods 1958 adult patients with ARTIs from 17 primary care clinics were recruited prospectively from January 2024 to March 2024. 17 and 62 pathogens in throat swab samples were tested using polymerase chain reaction (PCR) and targeted next-generation sequencing (tNGS), respectively. …”
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Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21 by Henry Chen, Henry Chen, Adam L. Numis, Adam L. Numis, Renée A. Shellhaas, John R. Mytinger, Debopam Samanta, Rani K. Singh, Rani K. Singh, Shaun A. Hussain, Danielle Takacs, Kelly G. Knupp, Li-Rong Shao, Carl E. Stafstrom

“…However, supporting data are largely from single-center, retrospective cohort studies.MethodsLeveraging the multi-center, prospective National Infantile Spasms Consortium (NISC) database, we evaluated the efficacy of first-line (standard) treatments for IESS in children with trisomy 21. …”
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Stratification system with dual human endogenous retroviruses for predicting immunotherapy efficacy in metastatic clear-cell renal cell carcinoma by Li Xu, Stephane Oudard, Catherine Sautes-Fridman, Xiaoping Su, Gabriel G. Malouf, Virginie Verkarre, Salma Kotti, Fangrong Yan, Yann-Alexandre Vano, Wolf Herve Fridman, Cheng-Ming Sun, Xiaofan Lu, Wenxuan Cheng

“…While the dysregulation of ERV transcription has been linked to immune cell infiltration in various cancers, its relationship with immune checkpoint inhibitor (ICI) response in solid tumors, particularly metastatic clear-cell renal cell carcinoma (ccRCC), remains inadequately explored.Methods This study analyzed patients with metastatic ccRCC from two prospective clinical trials, encompassing 181 patients receiving nivolumab in the CheckMate trials (−009 to –010 and −025) and 48 patients treated with the ipilimumab-nivolumab combination in the BIONIKK trial. …”
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MOMENT registry: Patients with advanced non-small-cell lung cancer harboring MET exon 14 skipping treated with systemic therapy by Michael Thomas, Petros Christopoulos, Wade T Iams, Julien Mazieres, Alexis B Cortot, Nir Peled, Gabriele Minuti, Egbert F Smit, Francois Audhuy, Karin Berghoff, S Peter Eggleton, Frank Fries, Maike Hildenbrand, Peter Liu, Seyed Hamidreza Mahmoudpour, Christoph Menzel, Dina Oksen

“…Given the rarity of this population and limitations of existing real-world data sources, the MOMENT registry aims to prospectively collect uniform, comprehensive, high-quality data from patients with METex14 skipping advanced NSCLC treated in routine clinical practice, which can support clinical and regulatory decision making. …”

Echo- and B-Type Natriuretic Peptide-Guided Follow-Up versus Symptom-Guided Follow-Up: Comparison of the Outcome in Ambulatory Heart Failure Patients by Gani Bajraktari, Nicola Riccardo Pugliese, Andreina D’Agostino, Gian Marco Rosa, Pranvera Ibrahimi, Luan Perçuku, Mario Miccoli, Gian Giacomo Galeotti, Iacopo Fabiani, Roberto Pedrinelli, Michael Henein, Frank L. Dini

“…Consecutive outpatients with LV ejection fraction (EF) ≤ 50% have been prospectively enrolled. In Group I (n=224), follow-up was guided by echo and BNP with the goal of achieving E-wave deceleration time (EDT) ≥ 150 ms, tissue Doppler index E/e′ < 13, B-line numbers < 15, and BNP ≤ 125 pg/ml or decrease >30%; in Group II (n=293), follow-up was clinically guided, while the remaining 277 patients (Group III) did not receive any dedicated follow-up. …”
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Increased serum soluble PD-l1 levels in patients with advanced stages of chronic kidney disease by Ayaka Hayashi, Ayaka Hayashi, Hiroto Ishihara, Mayuko Kawabe, Kazuhiko Kato, Kazuhiko Kato, Akio Nakashima, Akio Nakashima, Izumi Yamamoto, Teppei Sakano, Teppei Sakano, Hiroe Kobashi, Makoto Morita, Makoto Morita, Takashi Yokoo, Mitsuyoshi Urashima

“…The association of serum soluble programed death-ligand 1 (sPD-L1) levels and chronic kidney disease (CKD) progression is unknown.MethodsTo compare serum sPD-L1 levels among healthy individuals and patients with various CKD stages, including those undergoing dialysis, a secondary analysis was performed using clinical data and residual serum samples from four distinct cohorts, each prospectively collected for different research purposes: The Vaccine Cohort (2021–2022), the Cancer Cohort (2010–2018), the Dialysis Initiation Cohort (2023–2024), and the Dialysis Maintenance Cohort (2011–2015) included patients on stable maintenance dialysis.ResultsThe study analyzed serum sPD-L1 levels in 2,829 participants (mean age, 54.2 years; male, 54.2%) across the four cohorts. …”
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Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…The median onset time for AEs related to upadacitinib was 41.00 days (interquartile range [IQR] 10–141.5 days), with the majority occurring within 3 months of treatment initiation (n = 269, 66.09%), particularly in the first month (n = 171, 42.01%).ConclusionOur findings affirm clinical observations and reveal potential new AE signals for upadacitinib, underscoring the need for prospective clinical studies to verify these results and clarify their clinical relevance. …”
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Mixed reality infrastructure based on deep learning medical image segmentation and 3D visualization for bone tumors using DCU-Net by Kun Wang, Yong Han, Yuguang Ye, Yusi Chen, Daxin Zhu, Yifeng Huang, Ying Huang, Yijie Chen, Jianshe Shi, Bijiao Ding, Jianlong Huang

“…After realizing automatic segmentation and 3D reconstruction of osteosarcoma by optimizing feature extraction and improving target space clustering capabilities, we built a mixed reality (MR) infrastructure and explored the application prospects of the infrastructure combining deep learning-based medical image segmentation and mixed reality in the diagnosis and treatment of bone tumors. …”
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The burden and outcomes of firearm injuries at two district-level emergency centres in Cape Town, South Africa: A descriptive analysis by L Bush, C Hendrikse, C Van Koningsbruggen, K Evans

“…This study was a retrospective analysis of a prospectively collected database. All patients who presented to two district-level emergency centres with a firearm injury over a 12-month period (1 January 2019 - 31 December 2019) were eligible for inclusion. …”
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Oncological outcomes following extreme oncoplastic breast conserving surgery (eOPBCS) for locally advanced breast cancer (LABC): A systematic review and meta-analysis by Megan Chua Wern Ee, Ashley Lee Shi Hui, Wong Hung Chew, Emmeline Elaine Cua-Delos Santos, Sean Li Siwei, Sng Ming Xian, Qin Xiang Ng, Serene Goh Si Ning

“…However, slightly elevated local recurrence rates, though not statistically significant, highlight the importance of careful patient selection and further research. High-quality prospective studies are essential to validate these findings and refine criteria for incorporating eOPBCS into routine clinical practice.…”
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Insights from serial cardiovascular magnetic resonance imaging show early progress in diastolic dysfunction relates to impaired right ventricular deformation by Sören J. Backhaus, Alexander Schulz, Torben Lange, Simon F. Rösel, Lennart S. Schmidt-Schweda, Shelby Kutty, Johannes T. Kowallick, Julia Treiber, Andreas Rolf, Samuel Sossalla, Gerd Hasenuß, Andreas Schuster

“…Patients presenting with exertional dyspnoea and signs of diastolic dysfunction (E/e’>8, left ventricular (LV) ejection fraction > 50%) were prospectively enrolled in the HFpEF Stress Trial (NCT03260621). …”
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Protocolized approach saves the limb in peripheral arterial injury: A decade experience by Pratyusha Priyadarshini, Supreet Kaur, Komal Gupta, Abhinav Kumar, Junaid Alam, Dinesh Bagaria, Narender Choudhary, Amit Gupta, Sushma Sagar, Biplab Mishra, Subodh Kumar

“…Methods: This is a retrospective analysis of prospectively maintained database of trauma admissions at a level I trauma center from January 2008 to December 2019. …”
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Association between sleep duration and hypertension in southwest China: a population-based cross-sectional study by Yu Guo, Liming Li, Zhengming Chen, Qiang Sun, Pei Pei, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Guojin Luo, John S Ji, Xiaoyu Chang, Xiaofang Chen*

“…We examined the association between sleep duration and hypertension in southwest China.Design Population-based cross-sectional study.Setting This study was part of the baseline survey of a large ongoing prospective cohort study, the China Kadoorie Biobank. …”
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Behavior of SD-OCT Detectable Hyperreflective Foci in Diabetic Macular Edema Patients after Therapy with Anti-VEGF Agents and Dexamethasone Implants by Anne Rübsam, Laura Wernecke, Saskia Rau, Dominika Pohlmann, Bert Müller, Oliver Zeitz, Antonia M. Joussen

“…Our study was aimed to shed light on HF pathophysiology, by analyzing their number and location in DME patients at baseline and after therapy. Methods. A prospective, observational study on 59 eyes of 51 DME patients who were treated with antivascular endothelial growth factor (VEGF) therapy (VEGF group, n=40 eyes) or dexamethasone implant (DEX group, n=19). …”
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Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi a... by Mami Ishikuro, Shinichi Kuriyama, Shigeo Kure, Junichi Sugawara, Taku Obara, Nobuo Yaegashi, Tatsui Otsuka, Aoi Noda, Keiko Murakami, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Zen Watanabe, Naomi Shiga, Noriyuki Iwama, Hamada Hirotaka, Masahito Tachibana, Hiroaki Tomita, Masatoshi Saito

“…Objectives This study aimed to examine the association between infertility treatment and neurodevelopment in children at 2 and 3.5 years of age.Design Prospective cohort study.Setting and participants The study population consisted of mother–child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. …”
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Computational identification of promising genetic markers associated with molecular mechanisms of reduced rice resistance to <i>Rhizoctonia solani</i> under excess nitrogen fertili... by E. A. Antropova, A. R. Volyanskaya, A. V. Adamovskaya, P. S. Demenkov, I. V. Yatsyk, T. V. Ivanisenko, Y. L. Orlov, Ch. Haoyu, M. Chen, V. A. Ivanisenko

“…The results provide a theoretical basis for experimental work on creating new rice varieties with increased pathogen resistance under excessive nitrogen nutrition. This study opens prospects for developing innovative strategies in rice breeding aimed at optimizing the balance between yield and disease resistance in modern agrotechnical conditions.…”
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Preconception diet quality and modified natural cycle in vitro fertilisation outcomes by Janine P.M. Faessen, Irene Homminga, Marion E.C. Buso, Ruxandra A. Nagy, Jannie van Echten-Arends, Edith J.M. Feskens, Uwe J.F. Tietge, Annemieke Hoek, Elske M. Brouwer-Brolsma

“…We studied associations between adherence to the Dutch guidelines for a Healthy diet 2015 and pregnancy chances among women receiving modified natural cycle in vitro fertilisation (MNC-IVF). This prospective cohort study utilised data from 109 women undergoing MNC-IVF between 2014 and 2018 at University Medical Centre Groningen enrolled in a study examining associations between metabolic profile of follicular fluid and oocyte quality. …”
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Association between Comorbidities and Progression of Transvalvular Pressure Gradients in Patients with Moderate and Severe Aortic Valve Stenosis by Tim Salinger, Kai Hu, Dan Liu, Scharoch Taleh, Sebastian Herrmann, Daniel Oder, Daniel Gensler, Jonas Müntze, Georg Ertl, Kristina Lorenz, Stefan Frantz, Frank Weidemann, Peter Nordbeck

“…These findings suggest that disease progression of aortic valve stenosis is faster in patients with fewer cardiac comorbidities and risk factors, especially if they do not have coronary heart disease. Further prospective studies are warranted to investigate the outcome of patients with slow versus fast progression of transvalvular gradient with regards to comorbidities and risk factors.…”
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The effects of mother-infant bonding on children's strengths and difficulties by Tomoko Kawasaki, Yoshikazu Noda, Yoshiyuki Hirano, Akiko Kawanami, Kenichi Sakurai, Chisato Mori, Eiji Shimizu

“…We analyzed factors including maternal mental health and mother-infant bonding to predict subtype classes as a prospective cohort study. Methods: Data from Japan's Chiba Study of Mother and Child Health (C-MACH) were used. …”
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The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA by Manuel C. Olma, Lena Steindorf‐Sabath, Serdar Tütüncü, Claudia Kunze, Cornelia Fiessler, Paulus Kirchhof, Joanna Dietzel, Johannes Schurig, Patrick Oschmann, Ludwig Niehaus, Christian Urbanek, Götz Thomalla, Darius G. Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U. Heuschmann, Karl Georg Haeusler, Matthias Endres, for the MonDAFIS Investigators

“…Methods Post hoc analysis of the prospective, investigator‐initiated, multicenter MonDAFIS study (NCT02204267) to analyze whether AF‐related oral anticoagulation (OAC), and/or AF‐symptom severity are associated with HRQOL after ischemic stroke or transient ischemic attack (TIA). …”
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