Identification of novel autoantibodies in Sjögren’s disease by Fiona Engelke, Petra Budde, Salvatore De Vita, Thomas Dörner, Diana Ernst, Jan Gras, Harald Heidecke, Annika Loredana Kilian, Katja Kniesch, Ann-Sophie Lindemann, Luca Quartuccio, Jacob Ritter, Kai Schulze-Forster, Benjamin Seeliger, Hans-Dieter Zucht, Torsten Witte

“…Both panels discriminate these patients from HC, whereas the three-marker more effectively differentiates between Ro/SSA negative patients and NSS.DiscussionNovel autoantibodies will facilitate the diagnosis of Ro/SSA negative patients with SjD, in particular our predictive panel will be useful in the diagnosis and differentiation of these patients from healthy and NSS individuals in a clinical context. …”
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Gut microbiota interacting with vitamin D but not anandamide might contribute to the pathogenesis of preeclampsia: a preliminary study by Xiao-Qiang Han, Xiao-Qiang Han, Hui-Hui Jiang, Meng-Ling Chen, Meng-Ling Chen, De-Yang Han, De-Yang Han, Su-Fen Zhou, Su-Fen Zhou, Jin-Wen Wang, Shu-Shen Ji, Ling-Yun Wang, Jing-Wei Lou, Ming-Qun Li, Ming-Qun Li

“…Despite numerous studies highlighting the potential roles of gut microbiota, anandamide (AEA), and Vitamin D (VitD) in PE, none have established them as reliable biomarkers for predicting disease onset. Moreover, their interactions in late-stage pregnancy women remain poorly understood.MethodsThirty-four preeclamptic patients (called PE group) and thirty-nine matched healthy late-pregnant women (called LP group) were involved in this case-control study. …”
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Microgeographical Variation in <i>Dirofilaria immitis</i> Prevalence in Dogs in Suburban and Urban Areas of Rio De Janeiro, Brazil by Marianna Laura Elis Chocobar, Elizabeth Moreira dos Santos Schmidt, Ângelo Joel Ferreira Mendes, Paul Christopher Duncan Johnson, William Weir, Rossella Panarese

“…Dogs aged over two years had a higher risk of being infected (<i>p</i> < 0.001), while features such as breed, sex, size, coat type, use of macrocyclic lactones or access to outdoor spaces were not found to be predictive factors. This study reinforces the evidence that the prevalence of <i>D. immitis</i> is increasing in areas previously considered to have low prevalence or to be non-endemic. …”
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Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patients by Dominika Klimczak‐Tomaniak, Elke Bouwens, Anne‐Sophie Schuurman, K. Martijn Akkerhuis, Alina Constantinescu, Jasper Brugts, B. Daan Westenbrink, Jan vanRamshorst, Tjeerd Germans, Leszek Pączek, Victor Umans, Eric Boersma, Isabella Kardys

“…Serially measured biomarkers predicted the PE in a multivariable model adjusted for baseline clinical characteristics [hazard ratio (95% confidence interval) per 1‐standard deviation change in biomarker]: CD163 [2.07(1.47–2.98), P < 0.001], TRAP [0.62 (0.43–0.90), P = 0.009], GRN [2.46 (1.64–3.84), P < 0.001], SPON1 [3.94 (2.50–6.50), P < 0.001], and PGLYRP1 [1.62 (1.14–2.31), P = 0.006]. …”
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Case report: Novel ACTN4 variant of uncertain significance in a pediatric case of steroid-resistant nephrotic syndrome requesting kidney transplantation by Ignacio Alarcón, Carolina Peralta, Francisco Cammarata-Scalisi, Maykol Araya Castillo, Francisco Cano, Francisco Cano, Angélica Rojo, María Luisa Ceballos, María Luisa Ceballos, Paola Krall, Paola Krall

“…Exome sequencing identified a novel variant of uncertain significance (VUS), ACTN4 c.625_633del that predicted the in-frame deletion p.L209_E211del in a highly conserved functional domain. …”
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Weight-based enoxaparin thromboprophylaxis in young trauma patients: analysis of the CLOTT-1 registry by Sarah Lombardo, Ram Nirula, Elliott R Haut, Scott Brakenridge, Brandon Bruns, Charles E Wade, M Margaret Knudson, Thomas Scalea, Todd W Costantini, Lisa Marie Knowlton, David Spain, Ernest E Moore, Michelle K McNutt, Matthew J Martin, Andrew J Kerwin, George C Velmahos, Bruce Crookes, Marta McCrum, Lucy Kornblith, Mark D Cipolle, Laszlo N Kiraly, David J Milia, Alicia Mohr, Frederick Rogers, Sherry Sixta, Jade Nunez

“…Multivariate logistic regression was used to generate a predicted probability of VTE for WB and SFD patients.Results Of 4360 patients analyzed, 1065 (24.4%) were WB and 3295 (75.6%) were SFD. …”
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S100A13-driven interaction between pancreatic adenocarcinoma cells and cancer-associated fibroblasts promotes tumor progression through calcium signaling by Liuyuan Xia, Xin Guo, Dong Lu, Yixin Jiang, Xiaohui Liang, Yiwen Shen, Jiayi Lin, Lijun Zhang, Hongzhuan Chen, Jinmei Jin, Xin Luan, Weidong Zhang

“…Methods Bioinformatic analysis was employed to predict the pathogenic potential of CAFs and S100A13. …”
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Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome by Natalya B. Zakharzhevskaya, Olga Yu Shagaleeva, Daria A. Kashatnikova, Daria A. Kashatnikova, Anton O. Goncharov, Anton O. Goncharov, Daria V. Evsyutina, Dmitry A. Kardonsky, Elizaveta A. Vorobeva, Artemiy S. Silantiev, Viktoria D. Kazakova, Irina V. Kolesnikova, Ivan O. Butenko, Anna A. Vanyushkina, Svetlana V. Smirnova, Andrei V. Chaplin, Andrei V. Chaplin, Boris A. Efimov, Boris A. Efimov

“…The following components of the T6SS were identified in culture media and cells: ClpV (TssH), TssK, TssC, TssB, Hcp (TssD), and TetR. The predicted effector protein AKA51715.1 (VU15_08315) was also detected in media. …”
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A dextrorotatory residues-incorporated bioactive dodecapeptide against enterohemorrhagic Escherichia coli by Ping Zeng, Xuemei Yang, Kwok-Yin Wong, Sheng Chen, Kin-Fai Chan, Sharon Shui Yee Leung, Lanhua Yi

“…Methods: Spatial conformation of synthetic peptide zp39 (GIIAGIIiKIKk-NH2, lowercase letters indicate dextrorotatory amino acids) was predicted by PEPstrMOD and its secondary structure was further determined by circular dichroism (CD) spectroscopy. …”
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Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma by Chun-Nan Yeh, Yu-Chan Chang, Yi-Chen Yeh, Yu-Chao Wang, Dennis Shin-Shian Hsu, Meng-Lun Lu, Michael Hsiao, Ming-Huang Chen, Nai-Jung Chiang, Shin-Yi Chung, Chien-Jung Huang, Ming-Hsien Chan, Tzu-Sheng Hsu, Yi-Ping Hung

“…Clinical data corroborated these findings, with higher PD-L1 and LAG-3 expression in TLS-positive tumors.Conclusion Our findings revealed that TILs in TLS-positive tumors have more exhausted T cell signature and PD-1 and LAG-3 protein expression in CCA which support our clinical finding. TLSs can predict favorable immunotherapy responses in patients with cholangiocarcinoma, highlighting their potential as a biomarker and therapeutic target to enhance treatment efficacy.…”
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UBE2T/CDC42/CD276 signaling axis mediates brain metastasis of triple-negative breast cancer via lysosomal autophagy by Lin Li, Rong Fu, Yan Chen, Jin Yao, Xiaobing Jiang, Tao Liang, Jun jun Li, Qian zhi Chen, Liang Liang Shi, Ming Xing Xie, Xin Wei Qiao, Qi Hong Cheng, Min Jie Wang

“…Here, we used public databases and bioinformatics analysis as well as clinical samples from different cohorts to investigate the interrelationship between UBE2T/CDC42/CD276. This predicted relationship was then repeatedly validated using different in vivo and in vitro experimental methods. …”
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Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) by Parisa Riahi, Amir Hossein Saeidian, Albert Tenesa, Carolyn T. Hogan, Michael March, Kamran Guity, Mahmoud Amiri Roudbar, Asieh Zahedi, Maryam Zarkesh, Farideh Neshati, Mehdi Hedayati, Fereidoun Azizi, Hakon Hakonarson, Maryam S. Daneshpour, Mahdi Akbarzadeh

“…Besides, we provide data showing that AM is predicted to result in a10 % increase in the heritability of height, which is related to the assortative nature of alleles in the population and not to the segregation of genetic variations. …”
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ANN-based two hidden layers computational procedure for analysis of heat transport dynamics in polymer-based trihybrid Carreau nanofluid flow over needle geometry by Adil Darvesh, Fethi Mohamed Maiz, Basma Souayeh, Luis Jaime Collantes Santisteban, Hakim AL. Garalleh, Afnan Al Agha, Lucerito Katherine Ortiz García, Nicole Anarella Sánchez-Miranda

“…Numerical computation of ODEs is made by a well-known bvp4c scheme and then an advanced artificial neural network (ANN) computational framework is integrated to train the resulting dataset, which is based on scaled conjugate gradient neural network (SCG-NN) to facilitate predictions regarding advanced solutions. Findings: The velocity profile of a trihybrid nanofluid decreases with an increasing values of Weissenberg number and magnetic parameter but in case of numeric growth in Carreau index parameter, the magnitude of velocity is increasing due to shear-thinning behavior. …”
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Turning the Surface Electronic Effect Over Core‐Shell CoS2─FexCo1‐xS2 Nanooctahedra Toward Electrochemical Water Splitting in the Alkaline Medium by Lian‐Ming Lyu, Yu‐Chung Chang, Han‐Jung Li, Pei‐En Wang, Ruei‐Hung Juang, Ming‐Yen Lu, Cheng‐Shiuan Li, Chun‐Hong Kuo

“…Catalyzed by the CoS2, Fe0.25Co0.75S2, and Fe0.9Co1.0S2 {111} surfaces, the results of alkaline OER and HER indicated the Fe0.9Co1.0S2 the most superior activities by virtue of the optimized Fe─Co electronic effect. From the predictions by density functional theory (DFT) calculations in reaction thermodynamics, the energy barriers in OER and HER both follow the order of Fe0.9Co0.1S2(111) < Fe0.25Co0.75S2(111) < CoS2(111). …”
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Two-dimensional semantic morphological feature extraction and atlas construction of maize ear leaves by Hongli Song, Hongli Song, Weiliang Wen, Weiliang Wen, Ying Zhang, Ying Zhang, Yanxin Zhao, Xinyu Guo, Xinyu Guo, Chunjiang Zhao, Chunjiang Zhao, Chunjiang Zhao

“…The results of maize leaf inbred line identification can determine the probability that the corresponding true inbred line ranked within the top 10 of the predicted results is 0.706, within the top 20 is 0.810, and within the top 45 is 0.900. …”
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Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort st... by Charles Agyemang, Ellis Owusu-Dabo, Erik Beune, Karlijn Meeks, Bert-Jan H van den Born, Liffert Vogt, Felix P Chilunga, Charles F Hayfron-Benjamin, Sampson Twumasi-Ankrah, Muhulo Muhau Mungamba, Eva L van der Linden, Engwa A Godwill, Samuel N Darko, Benedicta N Chungag

“…Age, female sex, alcohol use, uric acid levels and hypertension were predictive factors. CKD progression to ESKD was minimal. …”
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Improper lung volume-dose parameters are risk factors for acute fatal radiation pneumonitis among esophageal cancer patients receiving chemoradiotherapy: a case-control study by Ruinuo Jia, Liuyan Li, Xiaoyi Liu, Junqian Zhang, Shuoguo Li, Ziqi Wang, Jingxia Li, Bingyi Xu, Manxi Sheng, Lei Ni, Danni Yang, Shegan Gao, Shegan Gao, Shegan Gao

“…V5 &gt; 80% significantly increased the susceptibility to AFRP and predicted worse overall survival.ConclusionV5 &gt; 60%, V20 &gt; 25% and MLD &gt; 15 Gy are key risk factors for AFRP in EC patients undergoing DCRT. …”
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Correlation between immune signature and high‐density lipoprotein cholesterol level in stage II/III colorectal cancer by Yun Wang, Xiao‐qiang Sun, Hao‐cheng Lin, De‐shen Wang, Zhi‐qiang Wang, Qiong Shao, Feng‐hua Wang, Shu‐mei Yan, Jie‐ying Liang, Zhao‐lei Zeng, Huai‐qiang Ju, Rui‐hua Xu, Yu‐hong Li

“…This study reveals that a low HDL‐C level in stage II/III CRC patients predicts poor prognosis. The correlation between the HDL‐C level and immune signature in tissue specimens suggested that HDL‐C is likely to play an inhibitory role in tumor development via affecting immune responses.…”
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Unambiguous identification of fungi: where do we stand and how accurate and precise is fungal DNA barcoding? by Robert Lücking, M. Catherine Aime, Barbara Robbertse, Andrew N. Miller, Hiran A. Ariyawansa, Takayuki Aoki, Gianluigi Cardinali, Pedro W. Crous, Irina S. Druzhinina, David M. Geiser, David L. Hawksworth, Kevin D. Hyde, Laszlo Irinyi, Rajesh Jeewon, Peter R. Johnston, Paul M. Kirk, Elaine Malosso, Tom W. May, Wieland Meyer, Maarja Öpik, Vincent Robert, Marc Stadler, Marco Thines, Duong Vu, Andrey M. Yurkov, Ning Zhang, Conrad L. Schoch

“…Mycetozoa, Oomycota) constitute the second largest group of organisms based on global richness estimates, with around 3 million predicted species. Compared to plants and animals, fungi have simple body plans with often morphologically and ecologically obscure structures. …”
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Impacts of free-roaming dogs on spatiotemporal niches of native carnivores in Taiwan by Hsin-Cheng Ho, Tzung-Su Ding, Hsiao-Wei Yuan, Jo-Szu Tsai, Guo-Jing Weng, Yu-Hsiu Lin, Hsiang Ling Chen, Yu-Bo Huang, Shih-Ching Yen

“…We hypothesize that free-roaming dogs dominate spatial and temporal resources, which forces native mesocarnivores to adjust their realized niches to avoid dogs. We predict that threats from free-roaming dogs result in (1) the activity levels of native carnivores being correlated negatively with those of dogs, (2) native carnivores undergoing spatial or temporal avoidance in response to the presence of dogs, and (3) increased spatial or temporal niche overlap among native carnivores. …”
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