Age-Related Differences in the Association between Plasma High-Sensitivity C-Reactive Protein and Noncalcified or Mixed Coronary Atherosclerotic Plaques by Tiewei Li, Ning Chen, Zhengan Liu, Zhiming Shan, Geng Dong, Junmei Yang, Minglu Qi

“…Thus, the aim of this study was to investigate the role of hsCRP in predicting the presence of NCP/MP and evaluate whether age has any impact on this association. …”
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From Natural Hosts to Agricultural Threats: The Evolutionary Journey of Phytopathogenic Fungi by Asanka Madhushan, Dulan Bhanuka Weerasingha, Evgeny Ilyukhin, Paul W. J. Taylor, Amila Sandaruwan Ratnayake, Jian-Kui Liu, Sajeewa S. N. Maharachchikumbura

“…Understanding their evolutionary trends is crucial for predicting and designing control measures against future disease outbreaks. …”
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Protocol for the enhanced management of multimorbid patients with COPD and severe asthma: role of indoor air quality by Emili Vela, Isaac Cano, Josep Roca, Antoni Sisó-Almirall, Carme Hernandez, Ebymar Arismendi, Ramon Farré, Alba Gómez-López, María Figols, Antonio Montilla-Ibarra, Núria Sánchez-Ruano, Benigno Sánchez, Marta Sorribes, Jordi Piera-Jiménez, Jaume Benavent, Jose Fermoso, Rubèn González-Colom

“…Accordingly, the main objective is to implement a novel integrated care preventive service for enhanced management of these patients, as well as to evaluate its potential for value generation.Methods and analysis At the end of 2024, the specifics of the novel service will be defined through the articulation of its four main components: (1) enhanced lung function testing through oscillometry, (2) continuous monitoring of indoor air quality as a potential triggering factor, (3) digital support with an adaptive case management (ACM) approach and (4) predictive modelling for early identification and management of exacerbations. …”
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OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review by Cristian Metrangolo, Simone Donati, Marco Mazzola, Liviana Fontanel, Walter Messina, Giulia D’alterio, Marisa Rubino, Paolo Radice, Elias Premi, Claudio Azzolini

“…Optical coherence tomography (OCT) is the most widely used technology for the diagnosis and follow-up of nAMD patients, which is widely used to study and guide the clinical approach, as well as to predict and evaluate treatment response. The aim of this review is to describe and analyze various structural OCT-based biomarkers, which have practical value during both initial assessment and treatment follow-up of nAMD patients. …”
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Liver Transplantation without Perioperative Transfusions Single-Center Experience Showing Better Early Outcome and Shorter Hospital Stay by Nicolás Goldaracena, Patricio Méndez, Emilio Quiñonez, Gustavo Devetach, Lucio Koo, Carlos Jeanes, Margarita Anders, Federico Orozco, Pablo D. Comignani, Ricardo C. Mastai, Lucas McCormack

“…Recipient MELD score was not a predictive factor for P-RBC transfusion. Patients requiring P-RBC transfusions had worse postoperative outcome. …”
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Therapeutic effect and potential mechanism of Fufang Danshen dripping pills for stable coronary heart disease: a randomized controlled trial by Li-qin Meng, Li-qin Meng, Pei-ying Huang, Qing-min Li, Yu-chao Feng, Yu-chao Feng, Yu-chao Feng, Ding-jian Li, Guang-long Wu, Bo-wen Ao, Guo-chao Wu, Guo-xiong Zhang, Bo-jun Chen, Bo-jun Chen, Bo-jun Chen

“…Furthermore, we utilized mass spectrometry analysis, network pharmacology, and lipidomics to predict the potential mechanisms of FFDS in the treatment of SCHD.ResultsFollowing treatment, FFDS demonstrated significant improvements in serum triglyceride levels (P = 0.013) and a reduction in the frequency of angina episodes (P = 0.021). …”
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Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial by Guoshuang Shen, Zhilin Liu, Miaozhou Wang, Yi Zhao, Xinlan Liu, Yujin Hou, Wenbiao Ma, Jingqi Han, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Zitao Li, Shifen Huang, Yongzhi Chen, Yingjian He, Yan Liu, Zijun Zhu, Yongxin Li, Jinming Li, Mengting Da, Hongnan Mo, Feng Du, Liang Cui, Jing Bai, Zhen Liu, Fei Ma, Jiuda Zhao

“…Specimens collected pre-neoadjuvant therapy and post-surgery were retained for comprehensive analysis of predictive biomarkers and the impact on the tumor microenvironment. …”
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Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis by Xiaohui Meng, Xiaohui Meng, Li Sheng, Yongqing You, Yongqing You, Huibo Dai, Manshu Yu, Funing Wang, Funing Wang, Ziren Zhou, Ziren Zhou, Yun Shan, Meixiao Sheng

“…Targets underlying QXHZF-mediated improvement of PD-induced PF were predicted using network pharmacology analysis. Metabolites associated with QXHZF treatment of PD-related PF were analyzed by serum metabolomics. …”
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Waste ceramic powder for sustainable concrete production as supplementary cementitious material by Yasin Onuralp Özkılıç, Yasin Onuralp Özkılıç, Alireza Bahrami, Yusuf Güzel, Ali Sinan Soğancı, Memduh Karalar, Essam Althaqafi, Ali İhsan Çelik, Özer Zeybek, P. Jagadesh

“…Furthermore, taking into account our experimental research and previous studies on concrete produced utilizing WCP, straightforward equations were provided for practical use to predict CS, STS, and FS. In addition, scanning electron microscopy was done to validate the findings obtained from the experimental part of the study. …”
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NDVI Estimation Throughout the Whole Growth Period of Multi-Crops Using RGB Images and Deep Learning by Jianliang Wang, Chen Chen, Jiacheng Wang, Zhaosheng Yao, Ying Wang, Yuanyuan Zhao, Yi Sun, Fei Wu, Dongwei Han, Guanshuo Yang, Xinyu Liu, Chengming Sun, Tao Liu

“…The Normalized Difference Vegetation Index (NDVI) is an important remote sensing index that is widely used to assess vegetation coverage, monitor crop growth, and predict yields. Traditional NDVI calculation methods often rely on multispectral or hyperspectral imagery, which are costly and complex to operate, thus limiting their applicability in small-scale farms and developing countries. …”
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Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin by Ziwei Yang, Ziwei Yang, Tixin Han, Ruibin Yang, Ruibin Yang, Yinuo Zhang, Yinuo Zhang, Yifei Qin, Yifei Qin, Yifei Qin, Jialu Hou, Jialu Hou, Fei Huo, Fei Huo, Zhuan Feng, Zhuan Feng, Yaxin Ding, Yaxin Ding, Jiali Yang, Jiali Yang, Gang Zhou, Gang Zhou, Shijie Wang, Shijie Wang, Xiaohang Xie, Xiaohang Xie, Peng Lin, Peng Lin, Zhi-Nan Chen, Zhi-Nan Chen, Jiao Wu, Jiao Wu

“…Differentially expressed genes were identified and intersected with the ferroptosis-related genes (FRGs) listed in the FerrDb database, yielding the identification of 13 distinct FRGs.ResultsA ferroptosis signature index model (Risk Score) was developed to predict HCC prognosis. And SLC7A11 and NAD(P)H quinone dehydrogenase 1 (NQO1) were identified as candidate FRGs indicating poor prognosis of HCC. …”
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Changes in PD-1 expression on T lymphocyte subsets and related immune indicators before and after definitive chemoradiotherapy for esophageal squamous cell carcinoma by Xueling Shi, Hongyu Zhao, Jiaqi Yu, Peng Cai, Shixiang Zhou, Ning Yang, Duojie Li

“…PD-1 expression in T lymphocyte subsets can predict short-term outcomes in patients and provide a theoretical basis for the sequential application of PD-1 immunosuppressants after radiotherapy and chemotherapy.…”
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Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5 by You Ning, Jianhua Huang, Bill Kalionis, Qin Bian, Jingcheng Dong, Junzhen Wu, Xiantao Tai, Shijin Xia, Ziyin Shen

“…Through transcription factor binding site analyses of the upstream regulatory sequences of these genes, 87 genes were predicted to share a common motif for Nkx-2.5 binding. …”
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Evaluation of the recombinant protein Sh-TSP-2 for the serological diagnosis of imported urogenital schistosomiasis and comparison with commercially available tests by María Pilar Luzón-García, Laura Navarro, Esther Rodríguez, Manuel Jesús Soriano-Pérez, José Vázquez-Villegas, María Isabel Cabeza-Barrera, Alex Loukas, Nerea Castillo-Fernández, María Jesús Perteguer, Javier Sotillo, Joaquín Salas-Coronas

“…The sensitivity, specificity, positive and negative predictive values of an in-house enzyme-linked immunosorbent assay (ELISA) using the recombinant protein Sh-TSP-2 were analysed and compared with other commercial serological methods. …”
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Protocol for a nested case-control study: identifying neuroimaging biomarkers for the progression of subclinical depression and qi-stagnation constitution to major depressive disor... by Jing Wang, Chengfeng Zhang, Yueqi Zhang, Yuanyuan Liu, Jingli Zhang, Xingwei Fang, Wangyang Xia, Yanzhao Xie, Zhongli Lan, Jinhui Wang, Jinhui Wang, Jinhui Wang, Jinhui Wang, Min Lu, Jun Chen, Jun Chen

“…Finally, differences in these neuroimaging measures between the two groups at baseline will be analyzed to identify biomarkers that can predict the progression from adolescents with SD and QSC to those with MDD.Study registrationThis study protocol does not involve clinical interventions and is classified as an observational study, so it was not subject to prior registration.…”
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Differences in Characteristics of Peripartum Patients Who Did and Did Not Require an Upgrade to the Intensive Care Unit: A Propensity Score Matching Study by Jennifer A. Walker, Jerry M. Yang, Saad Pirzada, Manahel Zahid, Samantha Asuncion, Amanda Tuchler, Gillian Cooper, Allison Lankford, Emad Elsamadicy, Quincy K. Tran

“…The Sequential Organ Failure Assessment score at Maternal Fetal Ward admission was most predictive, followed by the Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and lactate dehydrogenase levels. …”
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Global, regional and national epidemiological trends of multiple myeloma from 1990 to 2021: a systematic analysis of the Global Burden of Disease study 2021 by Linmin Zhuge, Xiaowu Lin, Ziwei Fan, Mengxian Jia, Chaowei Lin, Minyu Zhu, Honglin Teng, Guoliang Chen

“…All Social-Demographic Index (SDI) regions showed increases in ASPR, ASIR, ASMR, and ASDR (all EAPCs >0), with the middle SDI regions exhibiting the most rapid growth. ARIMA model predictions suggest that the MM burden will continue rising over the next 15 years. …”
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Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review by Michael D Jenkinson, Ashwin Venkatesh, Colin Watts, Michael T C Poon, Victoria Wykes, Stephen John Price, Puneet Plaha, Georgios Solomou, Melissa Gough, Conor S Gillespie, Aref-Ali Gharooni, Waqqas Patel

“…Introduction 5-aminolevulinic acid (5-ALA) is a proagent developed for fluorescent-guided surgery for high-grade glioma patients associated with a significant increase in resection conferring survival. 5-ALA was shown to penetrate the blood–brain barrier accumulating in malignant glioma cells with high selectivity, sensitivity and positive predictive value. However, those have yet to be explored aiding diagnosis for tumours of the central nervous system (CNS) other than high-grade gliomas (HGG). …”
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Real-world enrollment for a prospective clinico-genomic database using a pragmatic technology-enabled platform by Alexia Exarchos, Ariel B. Bourla, Maneet Kaur, Katja Schulze, Sophia Maund, Yi Cao, Yihua Zhao, Elizabeth H. Williams, Sarah C. Gaffey, Richard Zuniga, Shaily Lakhanpal, Vladan Antic, Michelle Doral, Johanna Sy, Neal J. Meropol, Anne C. Chiang

“…Background: Discovery and incorporation of predictive and prognostic biomarkers enhance outcomes for patients with cancer. …”
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A comparative study of the performance of ten metaheuristic algorithms for parameter estimation of solar photovoltaic models by Adel Zga, Farouq Zitouni, Saad Harous, Karam Sallam, Abdulaziz S. Almazyad, Guojiang Xiong, Ali Wagdy Mohamed

“…This estimation is challenging due to computational complexity and the risk of optimization errors, which can hinder reliable performance predictions. The algorithms evaluated include the Crayfish Optimization Algorithm, the Golf Optimization Algorithm, the Coati Optimization Algorithm, the Crested Porcupine Optimizer, the Growth Optimizer, the Artificial Protozoa Optimizer, the Secretary Bird Optimization Algorithm, the Mother Optimization Algorithm, the Election Optimizer Algorithm, and the Technical and Vocational Education and Training-Based Optimizer. …”
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