Exploring the influence of pre-analytical variables on gene expression measurements and relative expression orderings in cancer research by Tian Tian, Guie Lai, Ming He, Xiaofang Liu, Yun Luo, You Guo, Guini Hong, Hongdong Li, Kai Song, Hao Cai

“…Abstract Gene expression profiling is an effective method for identifying predictive and prognostic biomarkers. However, measurements are prone to uncertainty and errors due to various pre-analytical variables. …”
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Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway by Zihan Song, Zijun Zhao, Xuehua Liu, Yiran Song, Siyu Zhu, Ziyang Jia, Yijie Li, Zairan Wang, Boyu Sun, Qianxu Jin, Shiyang Zhang, Zongmao Zhao, Liqiang Liu

“…Previous studies have revealed important roles of SPHK1 in inflammatory, anti-apoptotic, immune processes, and cancer. Although the predictive significance and possible roles of SPHK1 in gliomas have recently been examined, the precise molecular mechanisms remain unclear. …”
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Development and Optimization of Nano-Hydroxyapatite Encapsulating Tocotrienol-Rich Fraction Formulation Using Response Surface Methodology by Anis Syauqina Mohd Zaffarin, Shiow-Fern Ng, Min Hwei Ng, Haniza Hassan, Ekram Alias

“…The outcomes for the optimized formulation are not significantly different from the predicted RSM outcomes. The optimized nHA/TRF formulation is freeze-dried and results in an average particle size of ~270 nm, a negative zeta potential value of ~−20 mV, a polydispersity index of <0.4, and an encapsulation efficiency of ~18.1%. …”
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The GWAS-MAP platform for aggregation of results of genome-wide association studies and the GWAS-MAP|homo database of 70 billion genetic associations of human traits by T. I. Shashkova, D. D. Gorev, E. D. Pakhomov, A. S. Shadrina, S. Zh. Sharapov, Y. A. Tsepilov, L. C. Karssen, Y. S. Aulchenko

“…The GWAS-MAP platform and database can be used for studying the etiology of human diseases, building predictive risk models and finding potential biomarkers and therapeutic interventions. …”
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Ultrasonographic Assessment of Intima-Media Thickness (IMT), as a Surrogate of Future Atherosclerosis and Cardiac Diseases in Patients with Hashimoto’s Thyroiditis and Concomitant... by Maryam Alaei, Mohamad Ghazanfari Hashemi, Seyedeh Nooshin Miratashi Yazdi, Mohammad Ali Kaviani, Ali Asadifar, Sahand Adib Moradi, Khazar Adibmoradi Langaroudi, Helia Helali, Mina Mahboudi, Aynaz Gerami

“…This can indicate the potential importance and predictive value of ultrasonic IMT evaluation in Celiac disease and Hashimoto’s thyroiditis as a marker of atherosclerosis progression as well as future risk of cardiovascular insults. …”
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Antimicrobial susceptibility and epidemiological types of Legionella pneumophila human isolates from Italy (1987–2020) by Maria Scaturro, Alessio Lanni, Fabiola Mancini, Antonietta Girolamo, Silvia Fillo, Andrea Ciammaruconi, Florigio Lista, Clementina Elvezia Cocuzza, Rosario Musumeci, Christophe Ginevra, Ghislaine Descours, Sophie Jarraud, Jessica Iera, Paolo Visca, Maria Luisa Ricci

“…Conclusions: The presence of L. pneumophila strains with reduced susceptibility or resistance to azithromycin should be monitored to predict future trends and suggest to physicians a combined therapy with fluoroquinolones when a poor response to azithromycin is observed. © 2025 The Author(s). …”
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Ecotoxicity of lanthanides to Daphnia magna: insights from elemental behavior and speciation in a standardized test medium by Vignati, Davide A.L., Martin, Loïc A., Poirier, Laurence, Zalouk-Vergnoux, Aurore, Fouque, Chantal, Bojic, Clément, Hissler, Christophe, Cossu-Leguille, Carole

“…In particular, only limited information is available on i) the actual relationships between LN speciation vs. ecotoxicological responses in standardized laboratory tests and ii) the existence of regular and predictable patterns in LN ecotoxicity (expressed as e.g., EC50) along the LN series. …”
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Cold sprayed Cu/Invar alloy composite by D.L. Ouyang, Z.R. Wang, T. Yang, L.W. Zhang, D. Wu, W.F. Chen, Q. Hu, S. Guo

“…Both α and the thermal conductivity λ increased slightly due to the release of internal stress and recrystallization of Cu. α of the annealed composites basically agreed with the theoretical predication, but λ was far below the values predicted by the Hasselman–Johnson model, mostly because the Invar alloy had an extraordinarily large surface area caused by impact deformation. …”
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Exploring how attachment insecurities mediate the link between sexual and partnership satisfaction in adolescents and young adults with cancer by Svenja Heyne, Hannah Brock, Diana Richter, Annekathrin Sender, Jenny Rosendahl, Michael Friedrich, Kristina Geue, Anja Mehnert-Theuerkauf

“…Sexual satisfaction partially predicted partnership satisfaction of AYA cancer survivors through attachment-related anxiety and attachment-related avoidance while the mediating effect accounted for 75% of the total effect. …”
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EMA/CO Combination Chemotheraphy in Gestational Trophoblastic Neoplasia: Update of Our Results by Tolga Taşçı, Işın Üreyen, Günsu Kimyon, Alper Karalök, Sevgi Koç, M. Faruk Köse, Gökhan Tulunay, Taner Turan

“…Because of the differences in many studies, risk factors for predicting the success of the treatment are not clear. …”
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CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite by Juliana Costa Ferreira Neves, Hiochelson Najibe Santos Ibiapina, Fábio Magalhães-Gama, Jacqueline Almeida Gonçalves Sachett, Iran Mendonça Silva, Kerolaine Fonseca Coelho, Eliane Campos Alves, Andréa Monteiro Tarragô, Luiz Carlos de Lima Ferreira, Adriana Malheiro, Wuelton Marcelo Monteiro, Allyson Guimarães Costa

“…Here, we characterize the profile of these soluble immunological molecules as possible predictive biomarkers of the development of AKI. The study involved 34 patients who had been victims of snakebites by Bothrops sp. …”
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Does Differential Habitat Selection Facilitate Coexistence Between Badgers and Hedgehogs? by Katie A. Lee, Antonio Uzal, Louise K. Gentle, Philip J. Baker, Richard J. Delahay, Anthony Sévêque, Robert S. Davis, Richard W. Yarnell

“…ABSTRACT Predicting the spatial and temporal responses of species exhibiting intraguild predation (IGP) relationships is difficult due to variation in potential interactions and environmental context. …”
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Assessment of depression in patients admitted with acute coronary syndrome: a double-blind study by Ela Giladi, Sapir Tzadok, Tamar Shitrit, Ilya Losin, Ziad Arow, Ranin Hilu, Sharon Reisfeld, Yoav Arnson, Abid Assali, David Pereg

“…Negative and positive predictive values were 82.6% and 35.8%, respectively. …”
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Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs by Khushboo Agrawal, Viswanath Das, Natálie Táborská, Ján Gurský, Petr Džubák, Marián Hajdúch

“…The data show an increased activity of DAC in high stromal cell cocultures and suggest the potential of the tumor-stroma ratio in predicting the outcome of DNA-demethylating epigenetic cancer therapy.…”
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Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases by Xing Li, Mingyu Liao, Rufei Shen, Linlin Zhang, Hua Hu, Jun Wu, Xiuli Wang, Hua Qu, Shaodong Guo, Min Long, Hongting Zheng

“…These findings suggest the correlation of plasma asprosin level with glucose metabolism, lipid metabolism, sex-related hormones, and inflammation in females, supporting asprosin as a potential predictive factor for females with metabolic-related diseases. …”
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Virtual biopsy for non-invasive identification of follicular lymphoma histologic transformation using radiomics-based imaging biomarker from PET/CT by Chong Jiang, Chunjun Qian, Qiuhui Jiang, Hang Zhou, Zekun Jiang, Yue Teng, Bing Xu, Xin Li, Chongyang Ding, Rong Tian

“…The R-signature was then tested for its predictive ability in the t-FL test cohort. Subsequently, this R-signature was combined with clinical parameters and SUVmax to develop a t-FL scoring system. …”
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The Effectiveness of Cancer Pain Management in a Tertiary Hospital Outpatient Pain Clinic in Thailand: A Prospective Observational Study by Suratsawadee Wangnamthip, Skaorat Panchoowong, Carolina Donado, Kimberly Lobo, Pimporn Phankhongsap, Pinyo Sriveerachai, Pramote Euasobhon, Pranee Rushatamukayanunt, Sahatsa Mandee, Nantthasorn Zinboonyahgoon, Charles B. Berde

“…Radiation therapy during pain care can be used to predict pain outcomes. Ongoing improvement domains were identified and considered in the context of cultural, economic, and geographic factors.…”
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Lymphopenia Is Associated with Gross Target Volumes and Fractions in Hepatocellular Carcinoma Patients Treated with External Beam Radiation Therapy and Also Indicates Worse Overall... by Hai-Ge Zhang, Ping Yang, Tao Jiang, Jian-Ying Zhang, Xue-Juan Jin, Yong Hu, Jing Sun, Shi-Suo Du, Zhao-Chong Zeng

“…Lymphocyte nadir and Barcelona Clinic Liver Cancer (BCLC) stage were independent prognostic factors predicting OS of HCC patients (all p<0.001). Patients in the GTV ≤55.0 cc and fractions ≤16 groups were stratified by lymphocyte nadir, and the group with the higher lymphocyte counts (LCs) showed longer survival than the group with lower LCs (p<0.001 and p=0.006, respectively). …”
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Prognostic Impact of the Postoperative Carcinoembryonic Antigen Level after Curative Resection of Locally Advanced Rectal Cancer by Ryoichi Tsukamoto, Kiichi Sugimoto, Yuki Ii, Takahiro Irie, Megumi Kawaguchi, Aya Kobari, Yuki Tsuchiya, Kumpei Honjo, Masaya Kawai, Shun Ishiyama, Makoto Takahashi, Kazuhiro Sakamoto

“…Objectives: This study was conducted to investigate whether preoperative or postoperative carcinoembryonic antigen (CEA) with a new cut-off value is more optimal for predicting long-term outcomes in patients with Stage II/III rectal cancer, and to investigate the effectiveness of postoperative adjuvant chemotherapy (POAC) based on the CEA values. …”
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The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19 by Xuan Niu, Wenrui Bao, Zhaoyao Luo, Pang Du, Heping Zhou, Haiyang Liu, Baoqi Wang, Huawen Zhang, Bo Wang, Baoqin Guo, Hui Ma, Tao Lu, Yuchen Zhang, Junya Mu, Shaohui Ma, Jixin Liu, Ming Zhang

“…Crucially, the initial GMV in the right DLPFC can predict fatigue symptoms 3 months after infection. …”
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