Baseline Triglyceride Level Affected the Efficacy of Vildagliptin in Treating Type 2 Diabetes: A Post Hoc Analysis of the VISION Study by Lingli Zhou, Xiaoling Cai, Yingying Luo, Fang Zhang, Linong Ji

“…Collectively, baseline TG was an independent predictive factor for the efficacy of a dipeptidyl peptidase-IV in treating type 2 diabetes during its initial use.…”
Get full text

CADD based designing and biological evaluation of novel triazole based thiazolidinedione coumarin hybrids as antidiabetic agent by Anchal Sharma, Anmol Narang, Nitish Kumar, Rupali Rana, Megha, Pooja, Muskan Dhir, Harmandeep Kaur Gulati, Jyoti, Aanchal Khanna, Jatinder Vir Singh, Sukhraj Kaur, Preet Mohinder Singh Bedi

“…Compound I-1 was synthesized based on the insights gained from molecular docking and simulations, which helped predict interactions and identify critical structural features. …”
Get full text

Approximation-Aware Training for Efficient Neural Network Inference on MRAM Based CiM Architecture by Hemkant Nehete, Sandeep Soni, Tharun Kumar Reddy Bollu, Balasubramanian Raman, Brajesh Kumar Kaushik

“…This architecture includes a mapping algorithm that modulates inputs and map AFC to crossbar arrays directly, eliminating the need to predict approximated weights for evaluating output. …”
Get full text

DyCeModel: a tool for 1D simulation for distribution of plant hormones controlling tissue patterning by D. S. Azarova, N. A. Omelyanchuk, V. V. Mironova, E. V. Zemlyanskaya, V. V. Lavrekha

“…Importantly, the tool is capable of automatically adjusting the parameters by fitting the distribution of the substance concentrations predicted in the model to experimental data taken from the microscopic images. …”
Get full text

Synthesis and Characterization of Hydroxyapatite- (HAP-) Clay Composites and Adsorption Studies on Methylene Blue for Water Treatment by Ebenezer Annan, Grace Karikari Arkorful, David Sasu Konadu, Bernard Asimeng, David Dodoo-Arhin, Martin Egblewogbe

“…The thermodynamical modeling predicts that based on the value of the change in enthalpy and Gibbs free energy the process was exothermic and spontaneous. …”
Get full text

Optimization of Polyphenol Extraction from Purple Corn Pericarp Using Glycerol/Lactic Acid-Based Deep Eutectic Solvent in Combination with Ultrasound-Assisted Extraction by Ravinder Kumar, Sherry Flint-Garcia, Miriam Nancy Salazar Vidal, Lakshmikantha Channaiah, Bongkosh Vardhanabhuti, Stephan Sommer, Caixia Wan, Pavel Somavat

“…The relative standard error among the predicted and experimental yields was <10%, validating the robustness of the model. …”
Get full text

Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1) by Umashankar Vetrivel, Shalini Muralikumar, B Mahalakshmi, K Lily Therese, HN Madhavan, Mohamed Alameen, Indhuja Thirumudi

“…Machine learning approaches also predicted these two compounds to possess more relevant activities. …”
Get full text

Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer by Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan Mo

“…In particular, analysis of a tamoxifen-treated patient cohort indicates that Lnc-DC expression can predict the response to tamoxifen. Together, this study demonstrates a previously uncharacterized function of Lnc-DC/STAT3/cytokine axis in estrogen independent growth and tamoxifen resistance, and Lnc-DC may serve as a potential predictor for tamoxifen response.…”
Get full text

Determining sensory drivers of complex metadescriptors through regression modelling by Emily Fisher, Charles Diako, Rebecca Shingleton, Sidsel Jensen, Joanne Hort

“…LASSO and PLSR were compared for their predictive ability and attributes retained using sensory attributes (trained panel) as predictors and creaminess ratings (consumers) as the response variable.LASSO identified four key sensory attributes with a good model fit (R2 = 0.951), while PLSR suggested thirteen (R2 = 0.933). …”
Get full text

Analysis and Characterization of the Immunogenicity of Rhoptry Protein 18 by Masoud Foroutan, Amir Karimipour-Saryazdi, Ali Dalir Ghaffari, Hamidreza Majidiani, Arezo Arzani Birgani, Elaheh Karimzadeh-Soureshjani, Shahrzad Soltani, Hany M Elsheikha

“…Allergenicity and antigenicity assessments indicated that TgROP18 is a nonallergenic, immunogenic protein. Predictions using the C-ImmSim server suggest that TgROP18 can stimulate humoral and cell-mediated immune responses, based on antibody titers and cytokine profiles following antigen administration. …”
Get full text

Mendelian Randomisation Study of Childhood BMI and Early Menarche by Hannah S. Mumby, Cathy E. Elks, Shengxu Li, Stephen J. Sharp, Kay-Tee Khaw, Robert N. Luben, Nicholas J. Wareham, Ruth J. F. Loos, Ken K. Ong

“…Using this BMI-increasing-allele-score as an instrumental variable for BMI, each 1 kg/m2 increase in childhood BMI was predicted to result in a 6.5% (95% CI: 4.6–8.5%) higher absolute risk of early menarche (before age 12 years). …”
Get full text

Blood Pressure Variability during Angiography in Patients with Ischemic Stroke and Intracranial Artery Stenosis by Hui Pan, Rong Zhao, Feng-Di Liu, Yi-Lan Wu, Ge-Fei Li, Yan-Hui Shi, Yi-Sheng Liu, Ying Zhao, Mei-Ting Zhuang, Tian-Yu Hou, Qi-Ting Zhang, Qian Yao, Yuan Qiao, Rui-Jue Huang, Li-Na Chen, Yi-Min Zhu, Liang Shu, Jing-Jing Su, Jie Fang, Xue-Mei Tang, Shuo Wang, Guo-Hong Cui, David Z. Wang, Jian-Ren Liu

“…Our aim was to investigate factors predicting blood pressure (BP) variability during diagnostic cerebral angiography and associations between BP variability and clinical outcomes in patients with acute and subacute ischemic stroke and intracranial artery stenosis. 114 patients with ischemic stroke and intracranial artery stenosis (stenosis rate >50%) were recruited. …”
Get full text

Numerical Method of Flexible Pavement considering Moisture and Stress Sensitivity of Subgrade Soils by Jue Li, Jianlong Zheng, Yongsheng Yao, Junhui Zhang, Junhui Peng

“…This study aimed to establish a numerical approach to predict the dynamic behavior of flexible pavements considering the stress sensitivity and moisture variation of subgrade soils. …”
Get full text

Preservation of the Photoreceptor Inner/Outer Segment Junction in Dry Age-Related Macular Degeneration Treated by Rheohemapheresis by Eva Rencová, Milan Bláha, Jan Studnička, Vladimír Bláha, Miriam Lánská, Ondřej Renc, Alexander Stepanov, Věra Kratochvílová, Hana Langrová

“…RHF contributed to sparing of photoreceptor IS/OS junction integrity in the fovea, which is assumed to be a predictive factor for preservation of visual acuity.…”
Get full text

Solid-Pseudopapillary Tumor of the Pancreas: A Single Center Experience by Valentina Beltrame, Gioia Pozza, Enrico Dalla Bona, Alberto Fantin, Michele Valmasoni, Cosimo Sperti

“…We lack sufficient information regarding clinicopathologic features predicting prognosis. Caution is needed when performing limited resection, and long and careful follow-up is required for all patients after surgery.…”
Get full text

Understanding and Modeling the Dynamics of Storm‐Time Atmospheric Neutral Density Using Random Forests by K. Murphy, A. J. Halford, V. Liu, J. Klenzing, J. Smith, K. Garcia‐Sage, J. Pettit, I. J. Rae

“…Abstract Atmospheric neutral density is a crucial component to accurately predict and track the motion of satellites. During periods of elevated solar and geomagnetic activity atmospheric neutral density becomes highly variable and dynamic. …”
Get full text

The modulating effect of circulating carbohydrate antigen 125 on ST2 and long-term recurrent morbidity burden by Elena Revuelta-López, Rafael de la Espriella, Gema Miñana, Enrique Santas, Sandra Villar, Juan Sanchis, Antoni Bayés-Genís, Julio Núñez

“…This sub-study of the IMPROVE-HF trial shows that sST2 predicted the composite of cardiovascular or renal rehospitalizations when CA125 was elevated (> 35 U/ml) but not when CA125 ≤ 35 U/ml. …”
Get full text

Prognostic Value of Combination of Pretreatment Red Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio in Patients with Gastric Cancer by Danyang Zhou, Ying Wu, Zhenyu Lin, Liangliang Shi, Lei Zhao, Tao Liu, Dandan Yu, Tao Zhang

“…Pretreatment RDW + NLR is a simple, inexpensive, and valid prognostic system to predict the survival in patients with GC, especially AGC.…”
Get full text

Assessment of the Personal Dose Received by School Children due to PM10 Air Pollution in Lisbon by Eleftheria Chalvatzaki, Sofia Eirini Chatoutsidou, Vânia Martins, Tiago Faria, Evangelia Diapouli, Manousos Manousakas, Susana Marta Almeida, Konstantinos Eleftheriadis, Mihalis Lazaridis

“…Hence, this study applied a dosimetry model (ExDoM2) to predict the personal dose received by students in five primary schools in Lisbon, Portugal. …”
Get full text

Identification of HNF4A Mutation p.T130I and HNF1A Mutations p.I27L and p.S487N in a Han Chinese Family with Early-Onset Maternally Inherited Type 2 Diabetes by Ying Yang, Tai-Cheng Zhou, Yong-Ying Liu, Xiao Li, Wen-Xue Wang, David M. Irwin, Ya-Ping Zhang

“…We demonstrated that mutation p.T130I in HNF4A was pathogenic as were the predicted polymorphisms p.I27L and p.S487N in HNF1A by genetic and functional analysis. …”
Get full text