Geopolitical (non) opportunities vs. "late" response of the foreign political service of North Macedonia in the process of European integration by Jelisavac-Trošić Sanja, Arnaudov Mitko

“…First of all, North Macedonia needs a strong internal institutional infrastructure, which simultaneously ensures political, social and economic stability and predictability. In this way, it would be possible to realize the established goals of the foreign policy of North Macedonia.…”
Get full text

GPR87 promotes invasion and migration through the RHO/ROCK pathway in non-small cell lung cancer by LIU Chenxi, HAN Lin, YANG Yi, ZHOU Han, LIU Yayun, SHENG Deqiao

“…Objective·To explore the role and molecular mechanism of GPR87 in regulating the invasion and migration of non-small cell lung cancer (NSCLC).Methods·Bioinformatics methods, including GEO, UALCAN, KM Plotter and other public database analysis platforms, were used to screen candidate genes related to NSCLC invasion and predict their clinical relevance to NSCLC. Eighty NSCLC clinical patient samples and corresponding clinical pathological data were collected from Yichang Central People's Hospital from January 2018 to August 2020. …”
Get full text

Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI by Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel

“…Multiple DL methods were developed with NAQ or HAQ using either SPACE or MRPAGE images and evaluated on their detection performance using positive predictive value (PPV), sensitivity, and F1 score and on their delineation performance using volumetric Dice similarity coefficient, PPV, and sensitivity on one internal and four additional test datasets (660 patients). …”
Get full text

Transition to competent oral feeding in preterm infants: Analyzing timing and determinants by Gabriela Bolea Muguruza, Cristina de Frutos Martínez, M. Teresa Tamayo Martínez, Judith Martín Corral

“…We analyzed the number of days needed to achieve OFC and which variables predicted greater delay in achieving OFC. Results: We included 145 VLBW infants with a median gestational age (GA) of 29 weeks with a weight of 1247 g. …”
Get full text

The natural immune molecules urinary Tamm–Horsfall protein and pentraxin 3 as predictors for recurrent urinary tract infection severity: a single-center self-control study by Zongping Li, Yingru Xu, Qian Wang, Gang Yuan, Jing Shu, Shiwei Liu, Xuezhong Gong

“…Dysregulation of the innate immune system can result in recurrent urinary tract infections (RUTI) due to heightened susceptibility to uropathogens. Despite this, predicting the risk of recurrence and the degree of immune compromise in patients who have had one urinary tract infection remains challenging. …”
Get full text

Safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcino... by Lei Yu, Lan Zhang, Xin Xu, Zheng Wang, Jian Zhou, Jia Fan, Wentao Wang, Zhenggang Ren, Lixing Li, Peiran Huang

“…We employed the Elastic Net regression model to analyze radiomic features from tumor and peritumoral areas to predict the efficacy of this treatment strategy.Conclusion TACE plus PD-1 inhibitors demonstrated promising efficacy and an acceptable safety profile, suggesting it as a potential treatment option for patients with intermediate-stage HCC beyond up-to-seven criteria. …”
Get full text

A FAIR and open geographic data collection for the Massaciuccoli Lake basin wetland in ItalyZenodoZenodo by Gian Luca Vannini, Pasquale Bove, Gianpaolo Coro

“…It can easily be integrated with ecological models and predictive studies to analyse the effects of climate change and anthropogenic pressures on wetlands. …”
Get full text

Regulatory Role of rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro by Yuanyuan Sun, Dadong Guo, Bin Liu, Xuewei Yin, Huixia Wei, Kai Tang, Hongsheng Bi

“…MicroRNAs (miRNAs) are a class of small noncoding RNAs which regulate messenger RNA (mRNA) expression. It is predicted that rno-miR-30b-5p can regulate the expressions of interleukin-10 (IL-10) and Toll-like receptor 4 (TLR4). …”
Get full text

Preoperative ultrasound risk factors for peripartum hysterectomy among PAS suspected pregnancies by Lulu Wang, Tianjiao Liu, Yang Yang, Yalan Li, Li Xiao, Xin Li, Sumei Wei

“…Cesarean deliveries, placental positioning on the anterior uterine wall, GHD, types of PAS, and ultrasound PAS score higher than 10 predicts peripartum hysterectomy, highlighting the importance of early, timely, and consistent monitoring of the placenta using obstetric ultrasound in pregnancies with suspected PAS. …”
Get full text

Deep Neck Infections: The Effectiveness of Therapeutic Management and Bacteriological Profile by Geanina Bandol, Mihail Dan Cobzeanu, Mihaela Moscalu, Octavian Dragos Palade, Liliana Moisii, Florentina Severin, Emilia Patrascanu, Florin Mocanu, Andrei Ionut Roman, Bogdan Mihail Cobzeanu

“…However, there are insufficient data to predict the evolution of this pathology. This study aims to review the microbiology of DNIs and to identify the factors that influence prolonged hospitalization. …”
Get full text

Disturbances of visual perception in non-demented patients with Parkinson’s disease by R. Timofejavaitė, V. Vilda, A. Liveikienė, R. Kaladytė-Lokominienė

“…Disturbances of visual perception are usually considered to be a complication of PD progression predicting a probability of psychosis or coexisting dementia. …”
Get full text

Association of systemic immune-inflammatory index with in-stent restenosis in patients with and without diabetes mellitus by Xunwei Deng, Xunwei Deng, Xunwei Deng, Qiaoting Deng, Qiaoting Deng, Qiaoting Deng, Qunji Zhang, Qunji Zhang, Qunji Zhang, Jingyuan Hou, Jingyuan Hou, Jingyuan Hou

“…Spearman's rank correlation analysis demonstrated that elevated SII levels are related to earlier ISR onset in diabetics (r = −0.272, P = 0.049).ConclusionOur study suggests that SII may be an affordable and convenient marker that could be applied to predict the risk of ISR among ACS patients. Moreover, the study emphasized that high SII is an independent predictor of more severe and earlier ISR and may be helpful for patients' risk stratification, especially those with comorbid DM.…”
Get full text

Risk of All-Cause Mortality in Mild Chronic Obstructive Pulmonary Disease: Evidence From the NHANES III and 2007–2012 by Zou W, Ou J, Wu F, Xiao S, Deng Z, Li H, Wang Z, Tang G, Liu S, Ye D, Zhu D, Hu J, Ran P

“…Mild COPD was defined as prebronchodilator forced expiratory volume in 1 second /forced vital capacity < 0.70 and FEV1 ≥ 80% of the predicted value. All-cause mortality risk is the total risk of death from all causes over a given period of time. …”
Get full text

Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence in the community: findings from surveys in Zambia and South Africa by Richard Hayes, Sarah Fidler, Sian Floyd, María Rupérez, Helen Ayles, Redwaan Vermaak, Kwame Shanaube, Albertus Schaap, Eveline Klinkenberg, Petra de Haas, Barry Kosloff, Thomas Gachie, Pete J Dodd, Chali Wapamesa, Michael J Burnett, Nico Kalisvaart, Tila Mainga, Linda Mureithi

“…Among individuals with both Xpert-Ultra results grade low or above, the positive-predictive-value was 90% (27/30); 3/30 were plausibly false-negative culture results.Conclusion Using Xpert-Ultra as the primary diagnostic test in TBPS, with culture only for confirmatory testing, would identify a high proportion of TB cases while massively reducing survey culture requirements.Trial registration number NCT03739736.…”
Get full text

Analysis and comparison of the trends in burden of spinal cord injury in China and worldwide from 1990 to 2021: an analysis of the global burden of disease study 2021 by Hao Qin, Yuhang Diao, Mingyu Hao, Zhitan Wang, Minghao Xie, Xiaojun Hu, Tao Zhu

“…Although the ASPR and ASIR for SCI are predicted to show a downward trend over the next 15 years, policy makers should continue to consider interventions to minimize the risk.…”
Get full text

Exploring socio-economic inequalities in mental healthcare utilization in adults with self-reported psychological distress: a survey-registry linked cohort design by J. J. Muwonge, C. Dalman, B. Burström, B. Jablonska, A-C. Hollander

“…Comparable results were found for secondary care but not primary care i.e., lower education predicted reduced access to primary care in moderate-to-severe distress groups (e.g., OR = 0.63 [0.45–0.90]), and for physical but not digital services. …”
Get full text

Association between relative telomere length and a genetic variant of SIRT1 gene and age-related macular degeneration by L.K. Moshetova, O.P. Dmitrenko, O.I. Abramova, N.S. Karpova, K.I. Turkina, I.N. Saburina

“…In the future, these molecular markers can be applied to predict the individual course of AMD and to implement preventive measures.…”
Get full text

Desnutrición y obesidad en mayores autónomos y determinantes de salud relacionados con ambos trastornos nutricionales by Claudia Haitzell Bonilla-Barrera, Laura Bea Berges, Jesús Seco-Calvo

“…Binary logistic regression was performed to predict dichotomous dependent variables. Results: The prevalence of malnutrition and its risk (DR) were 18.7% and obesity and its risk were 66,5%. …”
Get full text

Borrelia burgdorferi radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology by Andrés F. Londoño, Ajay Sharma, Jared Sealy, Vipin S. Rana, Shelby D. Foor, Vera Y. Matrosova, Elena K. Gaidamakova, Robert P. Volpe, Michael J. Daly, Brian M. Hoffman, Utpal Pal, J. Stephen Dumler

“…However, B. burgdorferi cells are significantly more sensitive than predicted by EPR, implicating their linear genome architecture as an additional explanation for radiosensitivity. …”
Get full text

Efficacy and safety of combined Kahook Dual Blade goniotomy with phacoemulsification in Chinese patients with primary open angle glaucoma by Lin Fu, Jiang-Tao Lou, Yue Guo, Pei-Juan Wang, Rong-Rong Le, Shu-Xia Xu, Guo-Xing Li, Yuan-Bo Liang

“…Preoperative VA and mean deviation may predict the surgical success.…”
Get full text