Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong by Reena Rajasuriar, Syaza Hisham, John Son Lim, Jean Yi Cheong, Wen Ying Ho, Siew Hwei Yap, Nurul Syuhada Zulhaimi, Malinee Neelamegam, Catherine Cheung, Vivian Wong, Ruhana Che Yusof, Kejal Hasmukharay, Shahrul Bahyah Kamaruzzaman, Sharifah Faridah Syed Omar, Meng Li Chong, Pui Li Wong, Grace Chung‐Yan Lui

“…Area under the receiver operator characteristic (AUC‐ROC) was calculated to predict frailty and IADL deficits in the current cohort and an independent cohort of 275 PWH from Hong Kong (HK). …”
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Clinical validation of an artificial intelligence-based decision support system for diagnosis and risk stratification of heart failure (STRATIFYHF): a protocol for a prospective, m... by Prithwish Banerjee, Guy A MacGowan, Frans H Rutten, Iacopo Olivotto, Petar M Seferović, Jonathan Mant, Djordje G Jakovljevic, Oscar Fernandez, Josep Darbà, Nduka C Okwose, Jose Zamorano, Duncan Edwards, David Sinclair, Lazar Velicki, Amy Groenewegen, Lars S Maier, Dimitris Fotiadis, Sarah Jane Charman, Annamaria Del Franco, Maria Tafelmeier, Andrej Preveden, Cristina Garcia Sebastian, Amy S Fuller, Anne Pauline Nelissen, Petros Malitas, Aikaterini Zisaki, Zoran Bosnic, Petar Vracar, Fausto Barlocco, Marta Jiménez-Blanco Bravo, Nenad Filipovic, Bano Fatima, Williams Kate, Fornaro Alessandra, Milovancev Aleksandra, Ascanio Meritxell, Aguera Ainoa, Pičulin Matej, Flis Borut, Boucharas Dimitrios, Manousos Dimitris, Tsiknakis Manolis, Kassiotis Thomas, Sustersic Tijana, Milicevic Bogdan, Hobbs FD Richard, Kaagman Onno

“…The primary aim of the present study is to collect prospective clinical data to validate the STRATIFYHF DSS (in terms of diagnostic accuracy, sensitivity and specificity) as a tool to predict the risk, diagnosis and progression of HF. …”
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Characteristics, controlling factors of development and exploration areas of deep coal-rock reservoirs in rift basins: a case study of the second member of Cretaceous Nantun Format... by Geng GAO, Yingyi XIE, Beibei HOU, Wenjuan MA, Hui XU, Yujie WANG, Yingdong HUO, Jingyuan ZHANG, Shichao LIU, Wei ZHAO, Yuan LIANG

“…The southern depression zones and steep slope zones are more likely to form multiple favorable source and reservoir configurations, with superior reservoir formation conditions. The predicted resource volume exceeds one trillion cubic meters, making it a favorable breakthrough area for deep coal-rock gas exploration in the Huhehu Sag. …”
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High Ki67 expression, HER2 overexpression, and low progesterone receptor levels in high-grade DCIS: significant associations with clinical practice implications by Hossein Schandiz, Hossein Schandiz, Lorant Farkas, Lorant Farkas, Daehoon Park, Yan Liu, Yan Liu, Solveig N. Andersen, Torill Sauer, Jürgen Geisler, Jürgen Geisler

“…This elucidation underscores the translational significance of Ki67 as a prognostic and predictive biomarker in DCIS, with implications for personalized treatment paradigms and patient outcomes.BackgroundThe Ki67 proliferation index is widely used in various tumors, including invasive breast carcinoma (IBC). …”
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Ventilatory variables and computed tomography features in COVID-19 ARDS and non–COVID-19-related ARDS: a prospective observational cohort study by Li-Chung Chiu, Hsin-Hsien Li, Yu-Hsiang Juan, How-Wen Ko, Scott Chih-Hsi Kuo, Chung-Shu Lee, Tien-Ming Chan, Yu-Jr Lin, Li-Pang Chuang, Han-Chung Hu, Kuo-Chin Kao, Ping-Chih Hsu

“…Pulmonary non–COVID-19 patients presented higher values for mechanical power (MP), MP normalized to predicted body weight (MP/PBW), MP normalized to compliance (MP/compliance), ventilatory ratio (VR), peak inspiratory pressure (Ppeak), and dynamic driving pressure (∆P) as well as lower dynamic compliance from day 1 to day 7 after ARDS onset. …”
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Impact of gender on self-assessment accuracy among fourth-year French medical students on faculty’s online Objective Structured Clinical Examinations by Sylvain Bodard, Donia Bouzid, Valentine Marie Ferré, Claire Carette, Joelle Kivits, Yann Nguyen, Michael Thy, Ugo Marchèse, Bénédicte Oulès, Lina Khider, Christian de Tymowski, Nelly Burnichon, Tristan Mirault, Albert Faye, Laura I. Levi

“…Additionally, students predicted their grade out of twenty. The assessment covered three independent stations. …”
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Molecular-level characterization of supraglacial dissolved and water-extractable organic matter along a hydrological flow path in a Greenland Ice Sheet micro-catchment by E. L. Doting, E. L. Doting, I. T. Stevens, A. M. Kellerman, P. E. Rossel, R. Antony, R. Antony, A. M. McKenna, A. M. McKenna, M. Tranter, L. G. Benning, L. G. Benning, R. G. M. Spencer, J. R. Hawkings, J. R. Hawkings, A. M. Anesio

“…An understanding of weathering crust biogeochemical cycling is especially critical as climatic warming is predicted to lead to an increase in Arctic rainfall, consequently increasing the frequency of weathering crust degradation events, with unknown impacts on the export of supraglacial DOM to downstream ecosystems.…”
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Association study of the JAK/STAT signaling pathway with susceptibility to COVID-19 in moroccan patient and in-silico analysis of rare variants by Meriem El Houdi, Hanaa Skhoun, Meriem El Fessikh, Reda Benmansour, Fatima-Zahra El Yousfi, Chaimae Nebhani, Mohamed Rida Tagajdid, Idriss Lahlou Amine, Hicham El Annaz, Rabii Ameziane El Hassani, Zohra Ouzzif, Redouane Abouqal, Khalid Ennibi, Ahmed Bouhouche, Jamila El Baghdadi

“…Notably, IFNAR1 p.Val168Leu mutated C allele was significantly associated with reduced susceptibility to COVID-19 severity (p=0.028, OR=0.5936 [0.3725 – 0.9461]), under the additive model (p=0.045, OR=0.626 [0.3958 – 0.9899]).Rare variants IFNAR1 p.Trp318Cys, p.Ser476Phe, and IFNAR2 p.Cys271Tyr were predicted deleterious, impacting protein structure via hydrogen bond and hydrophobic interaction alterations. …”
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Interactions between NAD+ metabolism and immune cell infiltration in ulcerative colitis: subtype identification and development of novel diagnostic models by Linglin Tian, Huiyang Gao, Tian Yao, Tian Yao, Yuhao Chen, Linna Gao, Jingxiang Han, Lanqi Zhu, He Huang, He Huang, He Huang

“…Nomograms developed for subtyping and diagnosis demonstrated high predictive accuracy, achieving area under curve (AUC) values up to 0.989 and 0.997 in the training set and up to 0.998 and 0.988 in validation sets. …”
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Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia With the Circadian Rhythm of Myocardial Infarction by Xiaochen Liu, Bin Wang, Wen Hao, Yuyao Qiu, Qian Guo, Yingying Guo, Qingjie Xin, Jingyao Fan, Bin Que, Wei Gong, Wen Zheng, Xiao Wang, Shaoping Nie

“…Moderate/severe OSA (adjusted odds ratio 1.66 [95% CI, 1.13–2.43]; P=0.01) and nocturnal hypoxemia (oxygen desaturation index ≥15 model, adjusted odds ratio 1.80, [95% CI, 1.21–2.66]; minimum oxygen saturation ≤86% model, adjusted odds ratio 1.70 [95% CI, 1.16–2.47]; P=0.006; total sleep time with saturation <90% ≥2% model, adjusted odds ratio 1.54 [95% CI, 1.04–2.27]; P=0.03) significantly predicted MI occurrence from midnight to 6:00 am. Conclusions A peak of incident MI onset between midnight to 5:59 am was observed in patients with moderate/severe OSA, especially in those presenting with nocturnal hypoxemia.…”
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QuickStroop for screening for minimal hepatic encephalopathy in patients with cirrhosis by Christian Labenz, Simon J. Gairing, Leonard Kaps, Alena F. Ehrenbauer, Eva M. Schleicher, Sophie Mengel, Julius F.M. Egge, Maria M. Gabriel, Peter R. Galle, Heiner Wedemeyer, Alexander Zipprich, Cristina Ripoll, Robin Greinert, Benjamin Maasoumy

“…The discriminative ability of QuickStroop (total cohort: AUC 0.88) was superior to ANT (AUC 0.70). QuickStroop predicted PHES-MHE with a sensitivity of 74% and a specificity of 89%, and took a median of only 34.5 s to complete. …”
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The performance of upper arm circumference for age in diagnosing severe acute malnutrition in children aged 6 to 59 months in South Kivu, Eastern Democratic Republic of Congo: Lwir... by Gaylord Ngaboyeka, Armand Mulume, Emmanuel Lurhangire, Anouk Neven, Lydia Zigabe, Serge Balolebwami, Pacifique Mwene-Batu, Michelle Dramaix, Philippe Donnen, Ghislain Bisimwa

“…To evaluate the performance of MUACZ using the combination of weight-for-height (WHZ) and Mid-Upper Arm Circumference (MUAC) as the reference, we calculated sensitivity, specificity, positive and negative predictive values (PPV and NPV) overall. Subsequently, we stratified the results by age category, presence or absence of stunting, and presence or absence of edema. …”
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Identification of biomarkers for the diagnosis of type 2 diabetes mellitus with metabolic associated fatty liver disease by bioinformatics analysis and experimental validation by Guiling Wu, Guiling Wu, Sihui Wu, Sihui Wu, Tian Xiong, Tian Xiong, Tian Xiong, You Yao, You Yao, Yu Qiu, Yu Qiu, Yu Qiu, Liheng Meng, Cuihong Chen, Xi Yang, Xi Yang, Xi Yang, Xinghuan Liang, Yingfen Qin

“…Immune dysregulation was observed in MAFLD, with TNFRSF1A and SERPINB2 strongly linked to immune regulation.ConclusionThe sensitivity and accuracy in diagnosing and predicting T2DM-associated MAFLD can be greatly improved using SERPINB2 and TNFRSF1A. …”
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High-throughput methylation sequencing reveals novel biomarkers for the early detection of renal cell carcinoma by Wenhao Guo, Weiwu Chen, Jie Zhang, Mingzhe Li, Hongyuan Huang, Qian Wang, Xiaoyi Fei, Jian Huang, Tongning Zheng, Haobo Fan, Yunfei Wang, Hongcang Gu, Guoqing Ding, Yicheng Chen

“…Further analysis using Cox regression identified 7 of the 23 DMCGIs as prognostic markers for RCC, allowing the development of a prognostic model with strong predictive power for 1-, 3-, and 5-year survival (AUC-ROC > 0.7). …”
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The First 24 h Hemodynamic Management in NICU after Revascularization Surgery in Moyamoya Disease by Jie Song, Yu Lei, Long Chen, Chao Gao, Wei Ni, Xing Wu, Gang Wu, Ying Mao, Jin Hu, Yuxiang Gu

“…What is more, a higher early postoperative Hb level also seemed to predict a worse long-term clinical outcome (favorable group 116.9±17.1 g/L vs. unfavorable group 123.7±13.0 g/L, p=0.03), but the difference disappeared after adjusting sex and age. …”
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Plasmodium falciparum transcription factor AP2-06B is mutated at high frequency in Southeast Asia but does not associate with drug resistance by Qiyang Shi, Changhong Wang, Wenluan Yang, Xiaoqin Ma, Jianxia Tang, Jiayao Zhang, Guoding Zhu, Yinlong Wang, Yaobao Liu, Xiaoqin He

“…Contrary to expectation, Pf3D7 Plasmodium lines modified by either K3124R mutation of AP2-06B or conditional knockdown of AP2-06B did not have altered sensitivity to artemisinin or quinolines by modulating pfk13 or pfcrt expression.DiscussionAP2-06B was predicted to be associated with artemisinin and quinoline resistance, but no change in resistance was observed after mutation or conditional knockdown. …”
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Incidence of severe maternal outcomes following armed conflict in East Gojjam zone, Amhara region, Ethiopia: using the sub-Saharan Africa maternal near-miss criteria by Tirusew Nigussie Kebede, Kidist Ayalew Abebe, Ambachew Getahun Malede, Abinet Sisay, Ayenew Yirdie, Worku Taye, Tebabere Moltot Kitaw, Bezawit Melak Fente, Mesfin Tadese, Tesfanesh Lemma Demisse, Mulualem Silesh, Solomon Hailemeskel Beshah, Getaneh Dejen Tiche, Michael Amera Tizazu, Moges Sisay Chekole, Birhan Tsegaw Taye

“…This concept assumes that severe maternal morbidity predicts mortality risk, enabling the analysis of risk factors for life-threatening outcomes and improving our understanding on the causes of maternal death. …”
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Rationale and design of a multicentre randomised controlled trial on circulating tumour DNA-guided neoadjuvant treatment strategy for locally advanced rectal cancer (CINTS-R) by Bin Wu, Yi Xiao, Xiao Zhang, Tao Xu, Qian Liu, Wei Fu, Yang An, Yongheng Li, Guole Lin, Huadan Xue, Guoju Wu, Jiaolin Zhou, Hongwei Yao, Zhenjun Wang, Weijie Chen, Junyang Lu, Guannan Zhang, Xiaoyuan Qiu

“…Our previous study has shown that circulating tumour DNA (ctDNA) effectively reflects tumour burden and genetic characteristics and has significant predictive value for tumour recurrence, demonstrating great potential in guiding the choice of neoadjuvant strategies.Methods and analysis The CINTS-R trial is a multicentre, open-label, randomised controlled trial designed to evaluate the efficacy and safety of a ctDNA-guided neoadjuvant treatment strategy compared with conventional neoadjuvant therapy regime in patients with LARC. …”
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Secular trend and projection of overweight and obesity among Chinese children and adolescents aged 7–18 years from 1985 to 2019: Rural areas are becoming the focus of investment by Jiajia Dang, Yunfei Liu, Shan Cai, Panliang Zhong, Di Shi, Ziyue Chen, Yihang Zhang, Yanhui Dong, Jun Ma, Yi Song, Jing Ni, Xuehong Zhang

“…Polynomial regression models were used to predict the prevalence of overweight and obesity among children and adolescents in 2025 and 2030, considering urban/rural areas, sex, and age groups. …”
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Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer by Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia, Huanxin Lin

“…This model combined with various clinical features and critical breast cancer facets, demonstrated remarkable efficacy in predicting patient outcomes. AIFM1 appeared to enhance the proliferation, migration, and invasiveness of breast cancer cell lines MDA-MB-231 and HCC1806. …”
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