Outcomes of Idecabtagene Vicleucel Therapy in Patients with Relapsed/Refractory Multiple Myeloma: A Single-Institution Experience by Aaron Trando, Farid Ghamsari, Philip Yeung, Caitlin Costello, Ila Saunders, Ah-Reum Jeong

“…Nevertheless, given its limitations, including the risk of adverse effects and unclear durability of efficacy, there remains a need to report the real-world clinical outcomes of ide-cel therapy in patients with R/R MM, as well as explore host predictive factors for therapy. <b>Methods:</b> We performed a single-center retrospective analysis of 25 adult patients with R/R MM who received ide-cel between 2021 and 2023 at the University of California San Diego Health. …”
Get full text

LE COLLOCAZIONI N-ADJ DELL’ITALIANO ACCADEMICO PARLATO. UN’INDAGINE CORPUS-BASED by Diana Peppoloni

“…In fact, knowledge of collocations and the correct use of such phraseological units are predictive of an advanced level of linguistic-communicative competence of the speaker and of his/her belonging to a certain social or professional group, as in the case of academic communication. …”
Get full text

Thermodynamic Assessment of Different Feedstocks Gasification Using Supercritical Water and CO₂ for Hydrogen and Methane Production by Luis David García Caraballo, Julles Mitoura dos Santos Junior, Icaro Augusto Maccari Zelioli, York Castillo Santiago, Juan F. Perez Bayer, Adriano Pinto Mariano

“…The supercritical water gasification (SCWG) and carbon dioxide gasification of agro-industrial and urban waste residues—Coffee Husk, Eucalyptus Biochar, Energy Sugarcane, and Refuse-Derived Fuel (RDF)—were studied using TeS^® v.2 software, which employs a non-stoichiometric thermodynamic model to minimize Gibbs free energy and predict equilibrium compositions. The effects of temperature (873.15–1273.15 K), pressure (220–260 bar), biomass feed (18–69%), and gasifying agents on hydrogen and methane formation were analyzed. …”
Get full text

A novel synthetic synovial fluid model for investigating biofilm formation and antibiotic susceptibility in prosthetic joint infections by Amber De Bleeckere, Frits van Charante, Thibault Debord, Stien Vandendriessche, Michiel De Cock, Marte Verstraete, Fabien Lamret, Bram Lories, Jerina Boelens, Fany Reffuveille, Hans P. Steenackers, Tom Coenye

“…In addition, we believe that inclusion of in vivo-like media in antimicrobial susceptibility testing might be able to more accurately predict the in vivo susceptibility, which could ultimately result in a better clinical outcome after antimicrobial treatment.…”
Get full text

Clinical benefits of modifying the evening light environment in an acute psychiatric unit: A single-centre, two-arm, parallel-group, pragmatic effectiveness randomised controlled t... by Håvard Kallestad, Knut Langsrud, Melanie Rae Simpson, Cecilie Lund Vestergaard, Daniel Vethe, Kaia Kjørstad, Patrick Faaland, Stian Lydersen, Gunnar Morken, Ingvild Ulsaker-Janke, Simen Berg Saksvik, Jan Scott

“…Inpatients exposed to the blue-depleted evening light showed higher improvement during admission (CGI-I difference 0.28 (95% CI [0.02, 0.54]; p = 0.035), Number Needed to Treat for clinically meaningful improvement (NNT): 12); lower illness severity at discharge (CGI-S difference -0.18 (95% CI [-0.34, -0.02]; p = 0.029), NNT for mild severity at discharge: 7); and lower levels of aggressive behaviour (difference in BVC predicted serious events per 100 days: -2.98 (95% CI [-4.98, -0.99]; p = 0.003), NNT: 9). …”
Get full text

Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism by Handan Tan, Zhenyu Zhong, Xiaojie Feng, Xiang Luo, Qingfeng Cao, Peizeng Yang

“…Results: Among 125 single nucleotide polymorphisms (SNPs) with P < 1 × 10-5 identified in our previous GWAS study on BD, rs4936415 (G/C) was predicted with the highest conserved score as an expression quantitative-trait-locus SNP for IL10RA in whole blood. …”
Get full text

The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity by Cong Han, Ran-ran Gao, Le Zhou, Wei Li

“…Five target genes of AS-IV, Ugt1a2, Ugt1a9, Ugt1a5, Pck1, and Slc7a11, were also identified and predicted by NONMMUT144584.1, MSTRG.30357.1 and ENSMUST00000174821. …”
Get full text

The mediating role of social support in self-management and quality of life in patients with liver cirrhosis by Ying Zhang, LeYao Xiao, Qian Liu, XinYi Zhang, MingDan Li, YaLi Xu, Mei Dai, Fei Zhao, YouShu Shen, Jordan Tovera Salvador, Ping Yang

“…Data were analyzed using SPSS and PROCESS software. (1) Patients in the decompensated stage of liver cirrhosis and those classified in Child–Pugh class B/C had lower scores in self-management, quality of life, and social support compared to patients in the compensated stage of liver cirrhosis and those classified in Child–Pugh Class A. (2) Quality of life was positively correlated with both social support and self-management (r = 0.668, r = 0.665, both P < 0.001). (3) Mediation analysis showed that self-management had a direct predictive effect on quality of life. Social support had a mediating effect between self-management and quality of life, with an indirect effect of 0.489 (95% CI: 0.362, 0.629), accounting for 40.58% of the total effect. (4) Exercise frequency and malnutrition risk assessment were independent influencing factors for social support, self-management, and quality of life. (5) In the regression model, after excluding confounding factors, Model I explained 14% of the variance in quality of life due to control variables, Model II explained 49.5%, and when social support was added, Model III explained 56.9% of the variance in quality of life. …”
Get full text

Hydrogen and hydrogen sulphide in volcanic gases: abundance, processes, and atmospheric fluxes by Aiuppa, Alessandro, Moussallam, Yves

“…The high H$_{2}$ concentrations (and low H$_{2}$S/SO$_{2}$ compositions, of ${\sim }$0.1 on average) in high-temperature (${>}$1000 °C) magmatic gases are overall consistent with those predicted thermodynamically assuming external redox buffering operated by the coexisting silicate melt, at oxygen fugacities ranging from ${\Delta }$FMQ $-$1 to 0 (non-arc volcanoes) to ${\Delta }$FMQ 0 to ${+}$2 (arc volcanoes) (where ${\Delta }$FMQ is oxygen fugacity expresses as a log unit difference relative to the Fayalite–Magnetite–Quartz oxygen fugacity buffer). …”
Get full text

Exploring the assessment of post-cardiac valve surgery pulmonary complication risks through the integration of wearable continuous physiological and clinical data by Lixuan Li, Yuekong Hu, Zhicheng Yang, Zeruxin Luo, Jiachen Wang, Wenqing Wang, Xiaoli Liu, Yuqiang Wang, Yong Fan, Pengming Yu, Zhengbo Zhang

“…We systematically evaluated three different input types (physiological, clinical, and both) and five classifiers (XGB, LR, RF, SVM, KNN) to identify the combination with strong predictive performance for PPCs. Feature selection was conducted using Recursive Feature Elimination with Cross-Validated (RFECV) for each model, yielding an optimal feature subset for each, followed by a grid search to tune hyperparameters. …”
Get full text

Utility of Pulse Oximetry Oxygen Saturation (SpO2) with Incorporation of Positive End-Expiratory Pressure (SpO2∗10/FiO2∗PEEP) for Classification and Prognostication of Patients wit... by Pratibha Todur, Anitha Nileshwar, Souvik Chaudhuri, Nitin Gupta, Srikant Natarajan, Shwethapriya Rao

“…The secondary objective was to determine the cut-off value of S/FP∗10 ratio to predict severe ARDS and survival. Methods. Patients aged 18–80 years on invasive mechanical ventilation (MV) diagnosed with ARDS as defined by the Berlin definition were included. …”
Get full text

Spatial-Temporal Variation and Driving Forces of Carbon Storage at the County Scale in China Based on a Gray Multi-Objective Optimization-Patch-Level Land Use Simulation-Integrated... by Gui Chen, Qingxia Peng, Qiaohong Fan, Wenxiong Lin, Kai Su

“…Exploring and predicting the spatiotemporal evolution characteristics and driving forces of carbon storage in typical mountain forest ecosystems under land-use changes is crucial for curbing the effects of climate change and fostering sustainable, eco-friendly growth. …”
Get full text

Gene content of seawater microbes is a strong predictor of water chemistry across the Great Barrier Reef by Marko Terzin, Steven J. Robbins, Sara C. Bell, Kim-Anh Lê Cao, Renee K. Gruber, Pedro R. Frade, Nicole S. Webster, Yun Kit Yeoh, David G. Bourne, Patrick W. Laffy

“…Microbial indicator analysis has centered around measuring the taxonomic composition of seawater microbial communities, but this can obscure heterogeneity of gene content between taxonomically similar microbes, and thus, microbial functional genes have been hypothesized to have more scope for predictive potential, though empirical validation for this hypothesis is still pending. …”
Get full text

Role of Cardiac Magnetic Resonance Imaging in Detecting Myocardial Viability in Patients with Chronic Ischaemic Heart Disease: A Prospective Observational Study by Subhosree Dey, Parul Dutta, Bornali Dutta, Baloy Jyoti Talukdar, Sushant Agarwal, Dhiraj Baruah

“…Conclusion: Delayed Enhanced-Cardiac Magnetic Resonance (DE-CMR) imaging assesses severity of the infarcted myocardium and helps in predicting recovery following intervention.…”
Get full text

Inflammatory Indices and MAFLD Prevalence in Hypertensive Patients: A Large-Scale Cross-Sectional Analysis from China by Shen D, Cai X, Hu J, Song S, Zhu Q, Ma H, Zhang Y, Ma R, Zhou P, Yang W, Hong J, Zhang D, Li N

“…This study investigates the relationship between inflammatory indices and MAFLD in hypertensive patients and assesses the predictive accuracy of these indices for MAFLD.Methods: We performed a cross-sectional analysis involving 34,303 hypertensive patients from a Chinese hospital-based registry. …”
Get full text

Mechanical properties and damage mechanism of steel fiber reinforced cemented tailings backfill by Yanbi XIONG, Xiaohui LIU, Haiyong CHENG, Shunchuan WU, Jing ZHANG, Weihua LIU, Rujun TUO, Zemin LIU

“…This model exhibits high accuracy in predicting the strength of steel fiber-reinforced backfill.…”
Get full text

Association between the hemoglobin A1c/High-density lipoprotein cholesterol ratio and stroke incidence: a prospective nationwide cohort study in China by Chaojuan Huang, Hongtao You, Yuyang Zhang, Ligang Fan, Xingliang Feng, Naiyuan Shao

“…Using the T1 of cumulative mean HbA1c/HDL-C as a reference, the fully adjusted OR for stroke was 1.65 (95% CI: 1.21–2.24) in T2 and 1.54 (95% CI: 1.08–2.19) in T3. The predictive value of the HbA1c/HDL-C in stroke risk assessment have been significantly improved compared to the traditional HDL-C and HbA1c. …”
Get full text

Impact of a positive end-expiratory pressure on oxygenation, respiratory compliance, and hemodynamics in obese patients undergoing laparoscopic surgery in reverse Trendelenburg pos... by Gulfairus A. Yessenbayeva, Aizhan M. Meyerbekova, Sergey I. Kim, Murat B. Zhumabayev, Gulbanu S. Berdiyarova, Sanzhar B. Shalekenov, Dinara S. Zharlyganova, Irina Y. Mukatova, Yekaterina A. Yukhnevich, Dmitriy A. Klyuyev, Andrey I. Yaroshetskiy

“…We calculated mean differences (MD) with 95% confidence intervals (CI), and predictive intervals (PI) using random-effects models. …”
Get full text

Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway by Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie

“…Network pharmacology and molecular docking analyses were used to predict the anti-arthritic targets of SBR. The effect of SBR on the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway was evaluated. …”
Get full text

Penerapan Text Augmentation untuk Mengatasi Data yang Tidak Seimbang pada Klasifikasi Teks Berbahasa Indonesia by Iftitah Athiyyah Rahma, Lya Hulliyyatus Suadaa

“…Meanwhile, the minority label data tends to be classified incorrectly by the model, even though, in some cases, the model's ability to predict data with minority labels is more important. …”
Get full text