Impacts of intestinal microbiota metabolite trimethylamine N-oxide on cardiovascular disease: a bibliometric analysis by Xiaohui Leng, Xiaohui Leng, Xiunan Wei, Jun Wang, Xiaodong Yao, Miaomiao Zhang, Dajuan Sun, Junwei Liang, Lili Chi, Yan Cheng

“…Keyword analysis shows that gut microbiota, metabolism, phosphatidylcholine and atherosclerosis (AS) are the hotspots in this field.ConclusionThis study summarizes the research situation of TMAO and CVD in the past 20 years, focusing on the effect of TMAO on pathogenesis of AS, predictive value of TMAO on CVD risk, and dietary and drug intervention for TMAO. …”
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Drought Adaptation and Responses of Stipa krylovii Vary Among Different Regions: Evidence From Growth, Physiology, and RNA‐Seq Transcriptome Analysis by Ziqing Gong, Zehang Qu, Yulin Liu, Tao Wang, Baijie Fan, Anzhi Ren, Yubao Gao, Nianxi Zhao

“…ABSTRACT In the context of global climate change, exploring how plant adaptation and responses to drought vary among different regions are crucial to understanding and predicting its geographic distribution. In this study, to explore the drought adaptation and responses of the dominant species in the semi‐arid Eurasian Steppes and their differences among the different regions in terms of growth, physiology, and RNA‐seq transcriptome, Stipa krylovii was chosen as the study material, and a seed source (three regions: eastern, middle, and western regions) × soil moisture treatment (three treatments: control, light drought, and heavy drought) two‐factor experiment was conducted. (1) Four growth traits for individuals from the western region were significantly lower than those from the other two regions. …”
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Network pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease by Yuyan Li, Yueming Luo, Yilan Hu, Siting Li, Guandong Li, Wanyangchuan Zhang, Xiufen Gu, Jianting Wang, Shunmin Li, Hong Cheng

“…Specifically, the study focused on macrophage polarization and metabolic changes that may slow down the progression of CKD.ResultsA total of 14,946 CKD-related targets were identified from the GeneCards and Online Mendelian Inheritance in Man (OMIM) databases through network pharmacology analyses. 227 potential targets of the JPYS formula were predicted using the TCMSP database. Additionally, network diagram demonstrated that 11 targets were associated with macrophage activity. …”
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IGF2BP2 Shapes the Tumor Microenvironment by Regulating Monocyte and Macrophage Recruitment in Bladder Cancer by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Lizhao Wang, Quanpeng Qiu, Rundong Song, Yuanchun Pu, Yuanquan Zhang, Nan Mei, Mengzhao Zhang, Jinhai Fan

“…NicheNet and SCENIC analyses were used to predict cell–cell interactions and transcriptional regulators, respectively. …”
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The relation of radiological tumor volume response to histological response and outcome in patients with localized Ewing Sarcoma by Lianne M. Haveman, Andreas Ranft, Henk vd Berg, Anne Smets, Jarmila Kruseova, Ruth Ladenstein, Benedicte Brichard, Michael Paulussen, Thomas Kuehne, Heribert Juergens, Stephanie Klco‐Brosius, Uta Dirksen, Johannes H.M. Merks

“…Conclusions Early inadequate TVR does not predict adverse outcome; therefore, changing the treatment to second line chemotherapy is not indicated in case of inadequate early TVR. …”
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Unburned habitat essential for amphibian breeding persistence following wildfire by Larissa L. Bailey, Richard Henderson, Wendy A. Estes-Zumpf, Charles C. Rhoades, Ellie Miller, Dominique Lujan, Erin Muths

“…Importantly, we found that remotely sensed data typically produced to predict flooding and erosion at broad (catchment) scales is a poor representation of the amount and variation in soil burn severity surrounding small habitat features, suggesting that additional field sampling is necessary to understand wildfire responses for species that rely on these small habitat features. …”
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Differences in the Quality Components of Wuyi Rock Tea and Huizhou Rock Tea by Zhaobao Wu, Weiwen Liao, Hongbo Zhao, Zihao Qiu, Peng Zheng, Yuxuan Liu, Xinyuan Lin, Jiyuan Yao, Ansheng Li, Xindong Tan, Binmei Sun, Hui Meng, Shaoqun Liu

“…High-performance liquid chromatography showed that the theanine contents of WS and WR were 0.183% and 0.103%, respectively, which were much higher than those of other varieties. The OPLS-DA model predicted the factors that caused their different tastes, in order of contribution: CG > ECG > caffeine > EGCG > theanine. …”
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Effects of replacing fishmeal with soybean meal on growth performance, liver antioxidant capacity and intestinal health in juvenile Asian red-tailed catfish (Hemibagrus wyckioides) by Weijia Cai, Xinping Li, Minglang Cai, Zhe Tang, Bo Zhu, Mengxi Yang, Yi Hu, Jihong Dai

“…In the SBM60 group, the relative abundances of Cetobacterium and Lawsonia significantly increased, and the intestinal microbiota function was predicted to undergo upregulation of complex carbohydrate metabolism and fermentation. …”
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Right ventricular strain impairment due to hypoxia in patients with COPD: a post hoc analysis of two randomised controlled trials by Konrad E Bloch, Mona Lichtblau, Silvia Ulrich, Felix C Tanner, Talant Sooronbaev, Maamed Mademilov, Michael Furian, Helga Preiss, Laura Mayer, Simon Rafael Schneider, Julian Müller, Stephanie Saxer, Anna Titz, Anwer Shehab, Lena Reimann

“…An RVFWS over −20% was considered as an indicator of RV dysfunction.Results A total of 54 patients (57% men, mean±SD age 58±9 years, forced expiratory volume in 1 s (FEV1 % predicted 77.3±22.5)) with echocardiographs of sufficient quality were included. …”
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Black Carbon Exposure Characteristics in Diesel Engine Vehicle-related Jobs by Sangjun Choi, Ju-Hyun Park, Won Kim, Seung Won Kim, Kyong-Hui Lee, Taejin Chung, Jihoon Park, Seung-Hun Ryu, Jungah Shin, Dong-Hee Koh, Dong-Uk Park

“…Our findings potentially contribute to the development of a model that predicts the level of exposure for various types of jobs.…”
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Genome-wide identification and functional roles relating to anthocyanin biosynthesis analysis in maize by Xiaofang Wang, Huangai Li, Shuai Wang, Meiqi Ruan, Yiping Li, Lei Zhu, Zhenying Dong, Yan Long

“…In this study, gene numbers, distribution, structure, cis-elements of the anthocyanin synthetic gene family were identified, and then the potential transcriptional factors were predicted by two analyzed methods. Finally, genes involved in maize silk pigment were screened by un-targeted metabolism analysis. …”
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Ursodeoxycholic Acid at 18–22 mg/kg/d Showed a Promising Capacity for Treating Refractory Primary Biliary Cholangitis by Xinyu Xiang, Xiaoli Yang, Mengyi Shen, Chen Huang, Yifeng Liu, Xiaoli Fan, Li Yang

“…Additionally, the risk score predicted by the UK-PBC model was lower in high-dosage UDCA-treated patients than in the standard dosage group (all P<0.05). …”
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Resident action in smart waste management during landfill disclosure transition: Insights from Yogyakarta's smart city initiatives by Sapta Suhardono, Chun-Hung Lee, Thi Thanh Thuy Phan, I Wayan Koko Suryawan

“…Key elements of the methodological framework include sensing, learning, understanding, and acting, enabling a comprehensive exploration of the technological and human dimensions of waste management. Advanced predictive models analyze patterns in waste generation, optimizing system responsiveness and efficiency, while qualitative data reveal the critical role of education and tailored communication strategies in fostering resident participation. …”
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Heat-related mortality in Mexico: A multi-scale spatial analysis of extreme heat effects and municipality-level vulnerability by Lara Schwarz, Chen Chen, Javier Emmanuel Castillo Quiñones, L.C. Aguilar-Dodier, Kristen Hansen, Jaime Reyes Sanchez, David J.X. González, Gordon McCord, Tarik Benmarhnia

“…A random-effects meta-regression was applied to understand which municipality-level socio-demographic characteristics such as education, age and housing predicted observed spatial heterogeneity. Extreme heat increased the odds of mortality overall, and this was consistent across extreme heat thresholds. …”
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Neoadjuvant adebrelimab combined with chemotherapy (cisplatin/carboplatin and etoposide) for limited-stage small-cell lung cancer: a study protocol of phase 2 trial (NIUS) by Yan Zhang, Qian Huang, Mengxia Li, Xi Zheng, Yanyang Liu, Long Tian, Guizhi Chen, Hongyu Xu, Daxing Zhu

“…The secondary endpoints will be a major pathological response, objective response rate, event-free survival, OS, R0 resection rate, safety and potential predictive biomarker parameters related to efficacy in peripheral blood samples, including minimal residual disease, circulating tumour cells and cluster of differentiation (CD) 4/CD8. …”
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CAVIN-2 positively correlates with diabetic PAD and promotes LDL transcytosis by inhibiting eNOS activation by Li Wang, Yi Song, Yan Shu, Baorui Xue, Fangyang Yu, Yao Yin, Ziyun Feng, Xiang Ma, Yulin Yao, Yangze Pan, Si Jin

“…The correlation between CAV1, CAVIN-1, CAVIN-2, and diabetic PAD was examined using Spearman correlation analysis. The predictive effect of CAV1 and CAVIN-2 were analyzed by receiver operating characteristic (ROC) curves. …”
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Impacts of Chemical Initial Conditions in the WRF-CMAQ Model on the Ozone Forecasts in Eastern China by Tangyan Hou, Shaocai Yu, Yaping Jiang, Xue Chen, Yibo Zhang, Mengying Li, Zhen Li, Zhe Song, Pengfei Li, Jianmin Chen, Xiaoye Zhang

“…In this study, we applied the Weather Research and Forecasting/Community Multiscale Air Quality (WRF/CMAQ) model to predict the air quality, and evaluated the influences of different chemical initial conditions on the O3 forecasts with observations in Tai’an and other 13 cities in eastern China in June 2021. …”
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Organ-specific immune-related adverse events and prognosis in cancer patients receiving immune checkpoint inhibitors by Xinyue Han, Yingcui Chen, Hong Xie, Yuekai Zhang, Yu Cui, Yaping Guan, Weiwei Nie, Qi Xie, Jisheng Li, Baocheng Wang, Bicheng Zhang, Jun Wang

“…On the basis of the results from organ-specific irAEs, the first development of skin or endocrine toxicities as protective irAEs rather than other irAEs was an independent indicator for predicting OS (P < 0.001) and PFS (P < 0.001). A protective irAE burden score based on organ-specific irAEs was further developed to show the significant protective effect of total irAEs on patient outcomes. …”
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Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility by Rosalyn W Sayaman, Masaru Miyano, Eric G Carlson, Parijat Senapati, Arrianna Zirbes, Sundus F Shalabi, Michael E Todhunter, Victoria E Seewaldt, Susan L Neuhausen, Martha R Stampfer, Dustin E Schones, Mark A LaBarge

“…A machine learning classifier based on luminal-specific aging distinguished normal from cancer tissue and was highly predictive of breast cancer subtype. We speculate that luminal epithelia are the ultimate site of integration of the variant responses to aging in their surrounding tissue, and that their emergent phenotype both endows cells with the ability to become cancer-cells-of-origin and represents a biosensor that presages cancer susceptibility.…”
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The neural correlates of guilt highlight preclinical manifestations between bipolar and major depressive disorders by Yu-Chi Lo, Chenyi Chen, Yawei Cheng

“…Results: A significant interaction between group and sense of agency in predicting guilt ratings for ambiguous, rather than painful, scenarios. …”
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