Monitoring of Circulating Tumor DNA and Indication of De-Escalation Adjuvant Targeted Therapy for EGFR-Mutated NSCLC After Complete Resection by Song Dong, PhD, Bingfa Yan, PhD, Si-Yang Liu, PhD, Xuan Gao, PhD, Hui-Zhao Hong, MD, Hong-Ji Li, MD, Wei Gao, PhD, Hong-Hong Yan, PhD, Si-Yang Maggie Liu, PhD, Hai-Yan Tu, PhD, Yi Pan, PhD, Qing Zhou, PhD, Xue-Ning Yang, PhD, Xue-Feng Xia, PhD, Xin Yi, PhD, Wen-Zhao Zhong, PhD, Yi-Long Wu, MD, Jia-Tao Zhang, PhD

“…Only four patients (11.8%) recurred with longitudinal undetectable MRD, indicating a negative predictive value of 88.2%. Of the patients who had detectable MRD after surgery, nine subsequently received EGFR TKI treatment, with only one (11.1%) achieving persistent circulating tumor DNA clearance post–EGFR TKI. …”
Get full text

ICRF resonance cones in the low-density scrape-off-layer of ASDEX Upgrade by Felix Paulus, Volodymyr Bobkov, Helmut Faugel, Helmut Fünfgelder, Oleksii Girka, Gustavo Grenfell, Roman Ochoukov, Wouter Tierens, Hartmut Zohm, the ASDEX Upgrade Team

“…In agreement with simulations and with predicted characteristics which depend on operation parameters, the RCs are excited by an RF antenna and propagate through the relatively homogeneous plasma in ISHTAR. …”
Get full text

Effect of thermomechanical processing defects on fatigue and fracture behaviour of forged magnesium by Andrew Gryguc, S.B. Behravesh, H. Jahed, M. Wells, B. Williams, R. Gruber, A. Duquett, T. Sparrow, M. Lambrou, X. Su

“…A novel in-situ non-contact approach (utilizing Digital-Image Correlation) was used as a screening test to establish the presence of these intrinsic defects and reliably predict their effect on the final fracture behaviour in an accelerated manner compared to conventional methods.…”
Get full text

Hydraulic conductivity over a wide suction range of loess with different dry densities by Xiaokun Hou, Shengwen Qi, Yan Li, Fangcui Liu, Tonglu Li, Hua Li

“…Meanwhile, the mercury intrusion porosity (MIP) technique is employed to obtain the pore characteristic (i.e. pore size distribution (PSD)) and a method of predicting the HCC using the PSD data is proposed, emphasizing the dominant role of the pore structure in shaping the HCC. …”
Get full text

Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model by Frankangel Servin, Jarrod A. Collins, Jon S. Heiselman, Katherine C. Frederick-Dyer, Virginia B. Planz, Sunil K. Geevarghese, Daniel B. Brown, William R. Jarnagin, Michael I. Miga

“…This study establishes an MR imaging framework to construct three-dimensional biophysical digital twins to predict ablation delivery in livers with 5 levels of fat content in the presence of a tumor. …”
Get full text

Serological insights from SARS-CoV-2 heterologous prime and boost responses in Thailand by Daniel Ward, Lapasrada Pattarapreeyakul, Rujiraporn Pitaksalee, Naphatcha Thawong, Waritta Sawaengdee, Suthida Tuntigumthon, Catriona Patterson, Kevin Tetteh, Susana Campino, Panadda Dhepakson, Surakameth Mahasirimongkol, Taane G. Clark

“…The development of statistical models to predict breakthrough infections can improve serological surveillance. …”
Get full text

Characterization of heart failure patients with reverse left ventricular remodelling post‐angiotensin receptor blockers/neprilysin inhibitors therapy by Leonid Maizels, Yishay Wasserstrum, Boris Fishman, Amitai Segev, David Ben‐Nun, Anan Younis, Dov Freimark, Israel Mazin, Avishay Grupper

“…Abstract Aims To assess the effect of angiotensin receptor blockers/neprilysin inhibitors (ARNI) on left ventricular (LV) ejection fraction (LVEF) and LV dimensions in a real‐life cohort of heart failure and reduced ejection fraction (HFrEF) patients, while analysing patient characteristics that may predict reverse LV remodelling. Methods and results The ARNI‐treated HFrEF patients followed at a single tertiary medical centre HF‐outpatient clinic were included in the study. …”
Get full text

Mutation in the COL2A1 gene is associated with acetabular dysplasia by Miaomiao Xin, Xin Guan, Xin Guan, Jiangfei Yang, Yi Li, Zhentao Man, Hongsheng Sun, Min Fu

“…Bioinformatics analysis was performed to assess the pathogenicity of the identified variant, and 3D protein modeling was conducted to predict its impact on protein structure.ResultsThe proband presented with pain in bilateral hips, and based on clinical symptoms, laboratory findings and imaging studies, the final diagnosis was considered to be acetabular dysplasia with overlapping secondary synovial chondromatosis. …”
Get full text

Computational and experimental exploration of morpholine pendent 2-hydrazineyl thiazole: Insights from DFT, ADME profiling, antifungal efficacy and molecular docking analyses by Vishnu A. Adole, I.Antony Danish, J.Jebasingh Kores, J.Winfred Jebaraj, S. Janani, Suresh K. Ghotekar, Rakesh D. Amrutkar

“…Furthermore, the ADME analysis predicted favorable pharmacokinetic properties. With a zone of inhibition of 10.87 mm, the thiazole derivative demonstrated substantial antifungal effectiveness against Aspergillus flavus. …”
Get full text

Serum metalloproteinase-7 as a biomarker of progressive pulmonary fibrosis by Márcia Araújo, Marília Beltrão, Oksana Sokhatska, Natália Melo, Patrícia Caetano Mota, Helder Novais Bastos, André Terras, David Coelho, Luís Delgado, António Morais

“…A cut-off value of 3.53 ng·mL−1 for serum MMP-7 levels had a sensitivity of 61% and a specificity of 74% for predicting PPF in non-IPF ILDs. Conclusions In patients with fibrotic non-IPF ILDs, serum MMP-7 levels were significantly greater in the subgroup of patients meeting the PPF criteria at follow-up. …”
Get full text

Evaluation of low cryptococcal antigen titer as determined by the lateral flow assay in serum and cerebrospinal fluid among HIV-negative patients: a retrospective diagnostic accura... by Xuan Wang, Jia-Hui Cheng, Ling-Hong Zhou, Jun-Hao Zhu, Rui-Ying Wang, Hua-Zhen Zhao, Ying-Kui Jiang, Li-Ping Huang, Ching-Wan Yip, Chun-Xing Que, Min Zhu, Li-Ping Zhu

“…No false-positive cases were identified in patients with low CrAg titers in CSF and all positive predictive values (PPVs) were 100%. Among the cases with low serum CrAg titers, lumbar puncture was performed in 97 patients and positive CSF CrAg titers were reported in 6 patients. …”
Get full text

Attributing heatwave-related mortality to climate change: a case study of the 2009 Victorian heatwave in Australia by Sarah E Perkins-Kirkpatrick, Linda Selvey, Philipp Aglas-Leitner, Nina Lansbury, Samuel Hundessa, Dáithí Stone, Kristie L Ebi, Nicholas John Osborne

“…Despite the small total number of attributable deaths as per the epidemiological model, six out of eight climate models predicted a statistically significant anthropogenic influence, indicating that climate change increased the heatwave-related mortality impact of this event. …”
Get full text

Developing a ceRNA-based lncRNA-miRNA-mRNA regulatory network to uncover roles in skeletal muscle development by Wang Wenlun, Wang Wenlun, Yu Chaohang, Huang Yan, Li Wenbin, Zhou Nanqing, Hu Qianmin, Wu Shengcai, Yuan Qing, Yu Shirui, Zhang Feng, Zhu Lingyun

“…LncRNA-miRNA relationships were predicted using miRcode and lncBaseV2, with miRNA-mRNA pairs identified via miRcode, miRDB, and Targetscan7. …”
Get full text

The features of Tat protein of human immunodeficiency virus type 1 (Retroviridae: <i>Lentivirus: Lentivirus humimdef1</i>) non-A6 variants, characteristic for the Russian Federatio... by Anna I. Kuznetsova, Anastasiia A. Antonova, Aleksey V. Lebedev, Ekaterina N. Ozhmegova, Anastasia V. Shlykova, Ilya A. Lapovok, Oxana V. Galzitskaya

“…CRF63_02A6 consensus sequence contained the highest number of amino acid substitutions, 31, and had no helix at positions 30‒33 in the secondary structure; however, this did not change its predicted tertiary structure. CRF03_A6B consensus sequence contained a stop codon at position 87. …”
Get full text

Modeling of peatland fire risk early warning based on water dynamics by B. Kartiwa, . Maswar, A. Dariah, . Suratman, N.L. Nurida, N. Heryani, P. Rejekiningrum, H. Sosiawan, S.H. Adi, I. Lenin, S. Nurzakiah, Ch. Tafakresnanto

“…Consequently, this study found that soil moisture was the suitable parameter to estimate peat fire risk owing to its predictability. Furthermore, this study has identified a threshold of low and high peat fire risk in the area with less than 104 percent and 129 percent dry weight of soil moisture content, respectively. …”
Get full text

Study protocol on risk factors for the diagnosis of gestational diabetes mellitus in different trimesters and their relation to maternal and neonatal outcomes (GDM-RIDMAN) by Khalida Ismail, Boon How Chew, Iliatha Papachristou Nadal, Angus Forbes, Nurul Iftida Basri, Rozita Zakaria, Pamela Phui Har Yap, Veronika Rysinova, Intan Nureslyna Samsudin, Nurain Mohd Noor, Ziti Akthar Supian, Haslinda Hassan, Fuziah Paimin, Siti Rohani Mohamed Alias, Norizzati Bukhary Ismail Bukhary, Madeleine Benton

“…The comparative incidences of maternal and neonatal health outcomes, the comparative prevalence of the psychosocial outcomes between women with GDM and without GDM, specificity, sensitivity, positive and negative predictive values of the risk factors, separately and combined, will be reported. …”
Get full text

Exploring the impact of genetic factors and fatty acid quality on visceral and overall Fat levels in overweight and obese women: a genetic risk score study by Niloufar Rasaei, Atefeh Tavakoli, Saba Mohammadpour, Mehdi Karimi, Alireza Khadem, Azam Mohamadi, Seyedeh Fatemeh Fatemi, Fatemeh Gholami, Khadijeh Mirzaei

“…Genetic risk scores (GRS) can predict obesity risk based on genetic factors. This study investigates how GRS and fatty acid quality affect visceral adiposity index (VAI) and body adiposity index (BAI) in overweight and obese women. …”
Get full text

Multi-observatory Study of Young Stellar Energetic Flares (MORYSEF): No Evidence for Abnormally Strong Stellar Magnetic Fields after Powerful X-Ray Flares by Konstantin V. Getman, Oleg Kochukhov, Joe P. Ninan, Eric D. Feigelson, Vladimir S. Airapetian, Abygail R. Waggoner, L. Ilsedore Cleeves, Jan Forbrich, Sergio A. Dzib, Charles J. Law, Christian Rab, Daniel M. Krolikowski

“…This requirement for giant dipolar loops aligns with MHD predictions of strong dipoles supported by polar magnetic surface active regions in fast-rotating, fully convective stars.…”
Get full text

Simulating the ENSO impact on the distribution and fate of floating litter particles in the Northern South China Sea by Ke Pang, Ke Pang, Ke Pang, Yang Feng, Yang Feng, Yang Feng, Youchang Zheng, Youchang Zheng, Youchang Zheng, Chao Fang, Xiangrong Xu, Xiangrong Xu

“…However, the transport of floating litter after release is difficult to predict due to the complex hydrodynamic conditions caused by the climate variability. …”
Get full text

Downsystem grain-size trends and mass balance of an ancient wave-influenced sediment routing system: Middle Jurassic Brent Delta, northern North Sea, offshore UK and Norway by Ikenna C. Okwara, Gary J. Hampson, Alexander C. Whittaker, Gareth G. Roberts

“…Few of the Brent Group sediment routing systems exhibit the downsystem-fining grain-size trend predicted by sediment mass balance theory. Deviations from this reference trend reflect: (1) sparse sampling of channelised fluvial and fluvio-tidal sand bodies in upsystem locations; (2) preferential trapping of sand in underfilled antecedent and syn-depositional, half-graben depocentres in genetic sequences J22 and J32; and (3) nearshore retention of sand by shoaling waves in wave-dominated shoreface and barrier-strandplain systems. …”
Get full text