Prognostic Impact of the Postoperative Carcinoembryonic Antigen Level after Curative Resection of Locally Advanced Rectal Cancer by Ryoichi Tsukamoto, Kiichi Sugimoto, Yuki Ii, Takahiro Irie, Megumi Kawaguchi, Aya Kobari, Yuki Tsuchiya, Kumpei Honjo, Masaya Kawai, Shun Ishiyama, Makoto Takahashi, Kazuhiro Sakamoto

“…Objectives: This study was conducted to investigate whether preoperative or postoperative carcinoembryonic antigen (CEA) with a new cut-off value is more optimal for predicting long-term outcomes in patients with Stage II/III rectal cancer, and to investigate the effectiveness of postoperative adjuvant chemotherapy (POAC) based on the CEA values. …”
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The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19 by Xuan Niu, Wenrui Bao, Zhaoyao Luo, Pang Du, Heping Zhou, Haiyang Liu, Baoqi Wang, Huawen Zhang, Bo Wang, Baoqin Guo, Hui Ma, Tao Lu, Yuchen Zhang, Junya Mu, Shaohui Ma, Jixin Liu, Ming Zhang

“…Crucially, the initial GMV in the right DLPFC can predict fatigue symptoms 3 months after infection. …”
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Process Optimization and Antioxidant Activity of Pine Needle Essential Oil Extracted by Microwave-assisted Extraction by Suyuan LÜ, Bingqing SHANG, Luyan SUN, Guolong LIU, Fa ZHAO, Xiuqing LIANG, Qiu WU, Yue GENG

“…Results: The optimal extraction processes were as follows: extraction time 55 min, microwave power 550 W, liquid-to-solid ratio 10:1 mL/g, the predicted yield was 0.245%, and the validation result of the optimized process was 0.238%. …”
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Applications of MR Finger printing derived T1 and T2 values in Adult brain: A Systematic review [version 1; peer review: 2 approved] by Rajagopal Kadavigere, Obhuli Chandran M, Kaushik Nayak, Abhijith S, Saikiran Pendem, Varsha Raghu, Shailesh Nayak S, Riyan Mohamed Sajer, Tancia Pires, Priyanka -

“…MRF effectively differentiated meningioma subtypes, glioma grades, and IDH mutation status, with T2 values providing particularly predictive for glioma classification. In brain metastases, significant relaxometry differences were noted between normal and lesional tissues. …”
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Acute and chronic effects of physical exercise on atherosclerosis, kynurenine pathway, endothelial function and inflammation in patients with coronary artery disease: a clinical tr... by Eliete Bouskela, Gabriela Andrade Paz, Marcus VDS Rangel, Caio Luan Farias, André Luiz Conveniente Soares, Erica Langner, Tatiana Teixeira, Patrícia M L Dutra, Paulo Farinatti, Maria das Graças C Souza, Juliana P Borges

“…Patients with CAD exhibit increased levels of kynurenine (KYN) pathway (KP) metabolites, which are key products of tryptophan (TRP) catabolism and have been identified as predictive markers for cardiovascular events and atherosclerosis progression. …”
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Serological markers of exocrine pancreatic function are differentially informative for distinguishing individuals progressing to type 1 diabetes by Desmond Schatz, Laura Jacobsen, Todd M Brusko, Michael J Haller, Mark Atkinson, MacKenzie D Williams, Catherine Ramsey Grace, Amanda L Posgai, Kieran M McGrail, Maigan A Brusko, Rhonda Bacher, Clive H Wasserfall

“…We collectively evaluated seven such biomarkers, combined with islet autoantibodies (AAb) and genetic risk score (GRS2), for their utility in predicting AAb/T1D status.Research design and methods Cross-sectional serum samples (n=154 T1D, n=56 1AAb+, n=77 ≥2AAb+, n=256 AAb−) were assessed for IGF1, IGF2, adiponectin, leptin, amylase, lipase, and trypsinogen (n=543, age range 2.7–30.0 years) using random forest modeling.Results GRS2, age, lipase, trypsinogen, and AAb against ZnT8, GAD65, and insulin were the most informative markers. …”
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Neuroprotective Potential of <i>Origanum majorana</i> L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model by Ion Brinza, Razvan Stefan Boiangiu, Iasmina Honceriu, Ahmed M. Abd-Alkhalek, Samir M. Osman, Omayma A. Eldahshan, Elena Todirascu-Ciornea, Gabriela Dumitru, Lucian Hritcu

“…In parallel, we performed in silico predictions (research conducted using computational models) of the pharmacokinetic properties of the main compounds identified in OmEO, using platforms such as SwissADME, pKCSM, ADMETlab 2.0, and ProTox-II. …”
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The clinical frailty scale is associated with an increased risk of postoperative complications and the development of post-traumatic osteoarthritis in elderly patients with trimall... by Qingsong Zhou, Wei Deng, Ming Zhao, Wei Zhou, Duo Chen, Heng Wang, Shengtao Wang, Hongsheng Yang, Yong Yin

“…The objective of this study was to determine the predictive power of the CFS for adverse clinical and radiographic outcomes after surgery in elderly patients with trimalleolar fractures. …”
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Disparities in surgical treatments for stress, urge and mixed urinary incontinence: Evidence from the 2019 National Ambulatory Surgery Sample (NASS) by Christabel Egemba, Edie Duncan, Katherine Amin, Alan Wein, Alberto J. Caban-Martinez, Raveen Syan

“…Conclusion:: Among female patients with UI, certain factors predict whether a patient will receive surgical treatment, including race, insurance status, and income level. …”
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A cross-tissue transcriptome-wide association study identifies new susceptibility genes for benign prostatic hyperplasia by Li Wang, Si-yu Chen, Jian-wei Yang, Kang-yu Wang, Kun-peng Li, Shun Wan, Xiao-ran Li, Li Yang

“…Our research identified the INO80B gene, whose predicted expression is associated with BPH risk and hence provided a new insight into the genetic basis of this disease. …”
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Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study by Zhang-Yang Xu, Hong Zheng, Zi-Jun Pan, Shou-Yi Hu, Yun-Xia Wang, Wen-Jun Su

“…This study aimed to clarify the connection between TyG levels and depression risk, as well as explore its predictive potential. A total of 3,021 participants without a prior history of depression were recruited from the China Health and Retirement Longitudinal Study (CHARLS) and followed for seven years. …”
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Exploring the clinical significance of anti-acetylcholine receptor antibody titers, changes, and change rates in Myasthenia Gravis by Lijun Luo, Xinyi Zhu, Chunbei Wen, Yifan Guo, Jie Yang, Dongsheng Wei, Ping Yu, Mei Wan

“…However, using AChR-Ab titers to predict MG severity and improvement remains controversial. …”
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RAS/BRAF Circulating Tumor DNA Mutations as a Predictor of Response to First-Line Chemotherapy in Metastatic Colorectal Cancer Patients by Jiannan Yao, Wanchun Zang, Yang Ge, Nathaniel Weygant, Pan Yu, Lei Li, Guanhua Rao, Zhi Jiang, Rui Yan, Linjia He, Yang Yu, Mulan Jin, Gang Cheng, Guangyu An

“…RAS/BRAF mutations detected in ctDNA predict a worse PFS in mCRC patients with first-line chemotherapy. …”
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Serum calprotectin and renal function decline in ANCA-associated vasculitides: a post hoc analysis of MAINRITSAN trial by Xavier Romand, Benjamin Terrier, Athan Baillet, Philippe Gaudin, Loic Guillevin, Christian Pagnoux, Minh Vu Chuong, Marie Hélène Paclet

“…The aim of this study was to assess whether serum calprotectin levels can predict decline in renal function in AAV patients receiving maintenance therapy.Methods Serum calprotectin levels were assessed at inclusion and month 6 in AAV patients, in complete remission after induction therapy, randomly assigned to rituximab or azathioprine. …”
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Dynamics of retinal changes in early-stage Parkinson’s disease by Ane Murueta-Goyena, Sara Teijeira-Portas, Elisa Blanco Martín, Raquel Vázquez-Picón, Blanca Ruiz Bajo, Jone Bocos, Jorge Sánchez-Molina, Patricia Alves Dias, Ioana Croitoru, Iñaki Rodríguez Agirretxe, Rocío Del Pino, Marian Acera, Beatriz Tijero, Oihane Sáez-Atxukarro, David Romero-Bascones, Juan Carlos Gómez-Esteban, Javier Aritz Urcola, Javier Ruiz Martínez, Iñigo Gabilondo

“…In PD patients, greater central GCIPL thickness was associated with poorer contrast sensitivity and reduced performance on the Farnsworth D15 color vision test. It also predicted subsequent thinning in both the GCIPL (2- to 3-mm ring) and the inner nuclear layer (2- to 5-mm rings). …”
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School-based mindfulness training in early adolescence: what works, for whom and how in the MYRIAD trial? by Susan Ball, Obioha C Ukoumunne, Tamsin Ford, Sarah Byford, Tim Dalgleish, Willem Kuyken, Jesus Montero-Marin, Kate Tudor, Alice Tickell, Catherine Crane, Ariane Petit, Elise Sellars, Laura Taylor, Maris Vainre, Benjamin Jones, Kirsty Griffiths, Elizabeth Nuthall, J Mark G Williams, Sarah-Jayne Blakemore, Katie Fletcher, Emma Medlicott, Anam Raja, Matthew Allwood, Louise Aukland, Tríona Casey, Nicola Dalrymple, Katherine De Wilde, Eleanor-Rose Farley, Jennifer Harper, Nils Kappelmann, Maria Kempnich, Liz Lord, Lucy Palmer, Alice Philips, Isobel Pryor-Nitsch, Lucy Radley, Anna Sonley, Jem Shackleford, Mark T Greenberg, Verena Hinze, Saz Ahmed, Marc Bennett, Lucy Foulkes, Cait Griffin, Konstantina Komninidou, Rachel Knight, Suzannah Laws, Jovita Leung, Jenna Parker, Blanca Piera Pi-Sunyer, Ashok Sakhardande, Lucy Warriner, Brian Wainman

“…Pregains−postgains in mindfulness skills and executive function predicted better outcomes at 1-year follow-up, but the SBMT was unsuccessful to teach these skills with clinical relevance.SBMT as delivered in this trial is not indicated as a universal intervention. …”
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Attitudes of nurses toward telenursing and influencing factors in resource-limited settings: Northwest Ethiopia 2022 by Fikadu Wake Butta, Biniyam Chaklu Tilahun, Berhanu Fikadie Endehabtu, Adamu Ambachew Shibabaw, Alex Ayenew Chereka, Ayenew Sisay Gebeyew, Mekides Molla Reda, Gemeda Wakgari Kitil, Teshome Demis Nimani

“…BackgroundThe worldwide scarcity of nurses is a pressing concern, with the World Health Organization predicting a deficit of 5.9 million nurses globally by 2025. …”
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Mapping Susceptibility and Risk of Land Subsidence by Integrating InSAR and Hybrid Machine Learning Models: A Case Study in Xi&#x0027;an, China by Chen Chen, Mimi Peng, Mahdi Motagh, Xinxin Guo, Mengdao Xing, Yinghui Quan

“…In this study, four machine learning models are compared to determine the optimal model, and found that the Random Forest (RF) performs the best in predicting InSAR-derived spatial deformation (Root Mean Square Error = 3.53 mm) and susceptibility (Area Under the Curve = 0.97). …”
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Runs of homozygosity in spontaneous abortions from families with recurrent pregnancy loss by N. A. Skryabin, S. A. Vasilyev, T. V. Nikitina, D. I. Zhigalina, R. R. Savchenko, N. P. Babushkina, M. E. Lopatkina, A. A. Kashevarova, I. N. Lebedev

“…Homozygous regions may also occur due to uniparental disomy, and abnormalities of genomic imprinting may be another mechanism responsible for the pathological manifestation of ROHs in embryogenesis. Indeed, five predicted imprinted genes were identified within ROHs according to the Geneimprint database: OBSCN, HIST3H2BB, LMX1B, CELF4, and FAM59A. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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