Malnutrition among the Elderly in Malaysia and Its Associated Factors: Findings from the National Health and Morbidity Survey 2018 by Mohamad Hasnan Ahmad, Ruhaya Salleh, Cheong Siew Man, Munawara Pardi, Norsyamlina Che Abdul Rahim, Norhafizah Shahril, Mohd Hatta Abdul Mutalib, Suzana Shahar, Noor Ani Ahmad

“…Background. Malaysia is predicted to become an ageing population by 2035. Malnutrition among the elderly is one of growing concern. …”
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Septuple XBi2Te4 (X=Ge, Sn, Pb) intercalated MnBi2Te4 for realizing interlayer ferromagnetism and quantum anomalous hall effect by Ruixia Yang, Xiaoxiao Man, Jiahui Peng, Jingjing Zhang, Fei Wang, Fang Wang, Huisheng Zhang, Xiaohong Xu

“…Monte Carlo simulations predict a magnetic transition temperature of 38 K for the MnBi2Te4/PbBi2Te4/MnBi2Te4 heterostructure. …”
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The scoping, design, and plasma physics optimization of the Eos neutron source stellarator by C.P.S. Swanson, D.A. Gates, S.T.A. Kumar, M.F. Martin, T.G. Kruger, D.W. Dudt, P.J. Bonofiglo, the Thea Energy team

“…In this paper, a set of 1D plasma physics models are coupled and used to design the operating point of the facility and predict performance. At this foundational stage of the design, analytic and approximate models are sufficient to capture the leading-order effects, and fast enough to run in the inner loop of an optimizer. …”
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Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia by Dong-Qing Yuan, Wei-Wei Zhang, Liu-Wei Gu, Qing-Huai Liu

“…Integrating mfERG into initial assessments or treatment follow-ups can aid in identifying potential hidden retinal defects and predicting the prognosis of the amblyopic eye.…”
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Mutation in CDC42 Gene Set as a Response Biomarker for Immune Checkpoint Inhibitor Therapy by Kun Wang, Yingying Zhang, Zhaoming Su, Bei Wang, Yuanyang Zhou, Xiaochu Tong, Chengying Xie, Xiaomin Luo, Sulin Zhang, Mingyue Zheng

“…Consequently, there is a critical need for reliable predictive biomarkers. Our focus is on CDC42, which stimulates multiple signaling pathways promoting tumor growth. …”
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Abnormal glymphatic system in patients with autoimmune encephalitis: Relationship with cognitive performance by Yingchi Zhang, Dianwei Wu, Zhirong Fan, Xiuxiu Leng, Ting Wan, Xiaodan Shi, Xiaomu Wang, Xuan Wang, Changgeng Song, Fang Du, Wen Jiang

“…Additionally, a low baseline ALPS index may predict an increased risk of long-term cognitive impairment in AE patients.…”
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Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients by Yongjie Xie, Xiaoran Feng, Youqun Gao, Xiaojiang Zhan, Fenfen Peng, Qian Zhou, Xianfeng Wu, Xiaoyang Wang, Na Tian, Qingdong Xu, Ning Su, Xingming Tang, Jianbo Liang, Jiao Li, Yueqiang Wen

“…Cox regression analysis was applied to assess the independent predictive value while adjusting for confounding factors. …”
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Integrated Lung, Diaphragm and Lower Limb Muscular Ultrasound: Clinical Correlations in Geriatric Patients with Acute Respiratory Illness by Nicoletta Cerundolo, Carmine Siniscalchi, Chukwuma Okoye, Simone Scarlata, Alberto Parise, Martina Rendo, Angela Guerra, Tiziana Meschi, Antonio Nouvenne, Andrea Ticinesi

“…The LUS score on T0 predicted 3-month rehospitalization. Frail patients exhibited higher LUS scores on T1. …”
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Five-year carry-over effects in dune slack vegetation response to hydrology by Lisanne van Willegen, Hilary Wallace, Angela Curreli, Ciara Dwyer, John Ratcliffe, Davey L. Jones, Graham Williams, Martin Hollingham, Laurence Jones

“…Dune slacks are biodiverse seasonal wetlands within sand dune systems, strongly influenced by the dynamics of the local groundwater regime. Future climate predictions indicate strong adverse impact on the hydrology and therefore ecology of these wetland ecosystems. …”
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Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…In solution phase, ISB 1442 forms a 2:2 complex with CD38 as determined by size-exclusion chromatography with multi-angle light scattering and electron microscopy. The predicted antibody-antigen stoichiometries at different CD38 surface densities were experimentally validated by surface plasmon resonance and cell binding assays. …”
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Designing multi-epitope vaccines against Echinococcus granulosus: an in-silico study using immuno-informatics by Jadoon Khan, Asma Sadiq, May M. Alrashed, Nosheen Basharat, Syed Nadeem Ul Hassan Mohani, Tawaf Ali Shah, Kotb A. Attia, Aamer Ali Shah, Hayat Khan, Ijaz Ali, Arif Ahmed Mohammed

“…The five Echinococcus granulosus antigen B (EgAgB) subunits were examined for eminent antigenic epitopes, and then the best B-cell and Major Histocompatibility Complex MHC-binding epitopes were predicted. Most significant epitopes were combined to create an effective multi-epitope vaccine, which was then validated by testing its secondary and tertiary structures, physicochemical properties, and molecular dynamics (MD) modelling. …”
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LincRNA Cox-2 Regulates Lipopolysaccharide-Induced Inflammatory Response of Human Peritoneal Mesothelial Cells via Modulating miR-21/NF-κB Axis by Yaoyao Bian, Lili Yang, Bin Zhang, Wen Li, Sen Wang, Shuling Jiang, Xi Chen, Wenlin Li, Li Zeng

“…And suppression of Cox-2 reversed the LPS induced HPMCs injury by regulation of miR-21 negatively. miR-21 was negatively correlated with TLR4, and TLR4 was predicted as target gene of miR-21. Furthermore, the suppression of miR-21 on LPS induced HPMCs injury was reversed by knockdown of TLR4, which could inhibited the activation of NF-κB pathway axis. …”
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Risk Factor Analysis in Vascular Access Complications for Hemodialysis Patients by Cristian Dan Roşu, Sorin Lucian Bolintineanu, Bogdan Florin Căpăstraru, Roxana Iacob, Emil Robert Stoicescu, Claudia Elena Petrea

“…Logistic regression modeling for thrombosis demonstrated moderate predictive accuracy (AUC: 0.64). <b>Conclusions</b>: These findings suggest that clinical interventions, such as stricter perioperative glycemic and blood pressure control, and personalized surgical strategies for patients with high BMI or comorbidities, could significantly reduce the incidence of vascular access complications and improve outcomes in this high-risk population.…”
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Desmoglein-2 was a novel cancer-associated fibroblasts-related biomarker for oral squamous cell carcinoma by Jin Liu, Zhonghao Sun, Shihui Cao, Hao Dai, Ze Zhang, Jingtao Luo, Xudong Wang

“…The Area Under Curve values of DSG2 in predicting prognosis exceeded 0.6 in both training-set and validation-set. …”
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RNA editing-based biomarker blood test for the diagnosis of bipolar disorder: protocol of the EDIT-B study by Andrea Miranda-Mendizabal, Diana Vetter, Juan Zambrano, Jeff Zarp, Victor Chavarría, Anna Giménez-Palomo, Meritxell Gonzalez-Campos, Marc Valenti, Lara Walczer Baldinazzo, Sara Siddi, Maurizio Ferrari, Dinah Weissmann, Chantal Henry, Josep Maria Haro, Lars Vedel Kessing, Eduard Vieta

“…The clinical validation performance of the EDIT-B will be evaluated using the area under the curve, sensitivity, specificity, positive and negative predictive values, and likelihood ratios. Ethics and dissemination The principles of the Declaration of Helsinki 2013, precision psychiatry research and good clinical practice will be followed. …”
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Radiochemistry and Preclinical PET Imaging of Ga-Desferrioxamine Radiotracers Targeting Prostate-Specific Membrane Antigen by Eleni Gourni PhD, Luigi Del Pozzo BSc, Mark Bartholomä PhD, Yvonne Kiefer BSc, Philipp T. Meyer MD, PhD, Helmut R. Maecke PhD, Jason P. Holland D.Phil

“…Protein dissociation constants ( K d values) were found to be predictive of pharmacokinetics in vivo. Compared to 68 Ga-1, 68 Ga-4 and 68 Ga-7 resulted in decreased tumor uptake but enhanced blood pool clearance and reduced residence time in the kidney. …”
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A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma by Yingkun Xu, Xiunan Li, Yuqing Han, Zilong Wang, Chenglin Han, Ningke Ruan, Jianyi Li, Xiao Yu, Qinghua Xia, Guangzhen Wu

“…Most importantly, we used 13 of these genes successfully to establish a risk model that could accurately predict patients’ prognosis. There is a clear correlation between this model and metastasis, tumor, stage, grade, and fustat. …”
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Exploring the influence of pre-analytical variables on gene expression measurements and relative expression orderings in cancer research by Tian Tian, Guie Lai, Ming He, Xiaofang Liu, Yun Luo, You Guo, Guini Hong, Hongdong Li, Kai Song, Hao Cai

“…Abstract Gene expression profiling is an effective method for identifying predictive and prognostic biomarkers. However, measurements are prone to uncertainty and errors due to various pre-analytical variables. …”
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Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway by Zihan Song, Zijun Zhao, Xuehua Liu, Yiran Song, Siyu Zhu, Ziyang Jia, Yijie Li, Zairan Wang, Boyu Sun, Qianxu Jin, Shiyang Zhang, Zongmao Zhao, Liqiang Liu

“…Previous studies have revealed important roles of SPHK1 in inflammatory, anti-apoptotic, immune processes, and cancer. Although the predictive significance and possible roles of SPHK1 in gliomas have recently been examined, the precise molecular mechanisms remain unclear. …”
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Development and Optimization of Nano-Hydroxyapatite Encapsulating Tocotrienol-Rich Fraction Formulation Using Response Surface Methodology by Anis Syauqina Mohd Zaffarin, Shiow-Fern Ng, Min Hwei Ng, Haniza Hassan, Ekram Alias

“…The outcomes for the optimized formulation are not significantly different from the predicted RSM outcomes. The optimized nHA/TRF formulation is freeze-dried and results in an average particle size of ~270 nm, a negative zeta potential value of ~−20 mV, a polydispersity index of <0.4, and an encapsulation efficiency of ~18.1%. …”
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