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20161
Prognostic significance of pathological response and lymph node status in neoadjuvant immunotherapy for potentially resectable non-small cell lung cancer
Published 2025-12-01“…Objective To evaluate the predictive value of pathological response and lymph node status on progression-free survival (PFS) in patients with potentially resectable non-small cell lung cancer (NSCLC) receiving neoadjuvant immunotherapy.Methods A retrospective analysis was conducted on 143 patients with potentially resectable NSCLC who underwent neoadjuvant immunotherapy followed by surgical resection. …”
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20162
Modelling Seismically Induced Mesothermal Goldfields along the Deep-Rooted Cadillac-Larder Lake Fault, Abitibi, Canada
Published 2018-01-01“…Two-dimensional SSM permits the predictive mapping of these high-potential zones. These modelled zones correlate positively with the actual observed gold distribution. …”
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20163
Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle
Published 2025-02-01“…The co-expression of these genes occurs in breast cancer patients highlighting their clinical significance as predictive biomarkers for CDK2-targeted therapies. In cancer models that are genetically independent of CDK2, pharmacological inhibitors suppress cell proliferation by inducing 4N cell cycle arrest and increasing the expressions of phospho-CDK1 (Y15) and cyclin B1. …”
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20164
Neoadjuvant or concurrent atezolizumab with chemoradiation for locally advanced cervical cancer: a randomized phase I trial
Published 2025-01-01“…Secondary objectives were safety and feasibility, 2-year disease-free survival (DFS), and predictive value of PD-L1 expression. Forty patients were randomized, 36 received treatment, and 25 were evaluable for the primary endpoint. …”
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20165
Leveraging Next-Generation Sequencing Application from Identity to Purity Profiling of Nucleic Acid-Based Products
Published 2024-12-01“…<b>Results</b>: Our workflow predicted most of the critical quality controls of mRNA vaccine and plasmid DNA samples, especially focusing on the identity and the nucleotide-based impurities. …”
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20166
High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models
Published 2025-01-01“…The observed phenotypes were diverse, but mutations of genes predicted to have related functions led to similar behavioural differences in worms. …”
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20167
Large-deformation finite-element modeling of seismic landslide runout: 3D probabilistic analysis with cross-correlated random field
Published 2025-01-01“…The study highlights that 2D random analyses substantially underestimate the mean value and overestimate the variability of runout distance, underscoring the importance of 3D modeling in accurately predicting landslide behavior. Overall, this work emphasizes the essential role of understanding 3D cross-correlation in soil strength for landslide hazard assessment and mitigation strategies.…”
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20168
Exploiting venom toxins in paratransgenesis to prevent mosquito-borne disease
Published 2025-01-01“…Mosquito populations are geographically expanding into temperate regions and their distribution is predicted to continue increasing. Mosquito symbionts, including fungi, bacteria and viruses, have desirable traits for mosquito disease control including spreading horizontally and vertically through mosquito populations and potentially colonising multiple important vector species. …”
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20169
Interactive effects of temperature, cadmium, and hypoxia on rainbow trout (Oncorhynchus mykiss) liver mitochondrial bioenergetics
Published 2025-01-01“…Overall, our findings suggest a complex in vivo interaction of multiple stressors on mitochondrial function that are not adequately predicted by their individual effects.…”
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20170
Optimization of Breeding Tools in Quinoa (<i>Chenopodium quinoa</i>) and Identification of Suitable Breeding Material for NW Europe
Published 2024-12-01“…NIRS could accurately predict seed crude protein content with a determination coefficient of 0.94. …”
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20171
Genetic coupling of enhancer activity and connectivity in gene expression control
Published 2025-01-01“…Many detected QTLs overlap disease susceptibility loci and influence the predicted binding of myeloid transcription factors, including SPI1, GABPB and STAT3. …”
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20172
Estimation of soil erosion and risk assessment in Somalia
Published 2024-12-01“…Cutting-edge modeling techniques, supported by historical erosion trends, help to develop accurate predictions about future soil loss, offering a robust basis for creating effective intervention strategies. …”
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20173
Accelerating computational fluid dynamics simulation of post-combustion carbon capture modeling with MeshGraphNets
Published 2025-01-01“…Our models can adapt to a wide range of these parameters and accurately predict the complex interactions within the system at rates over 1700 times faster than CFD, affirming its practicality in downstream design optimization tasks. …”
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20174
On the Lunar Origin of Near-Earth Asteroid 2024 PT5
Published 2025-01-01“…While one object might be an outlier, two suggest that there is an underlying population to be characterized. Long-term predictions of the position of 2024 PT5 are challenging due to the slow Earth encounters characteristic of objects in these orbits. …”
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20175
Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach
Published 2014-12-01“…Mutations in the KCNJ11 gene, encoding the kir6.2 channel, are reported to be associated with congenital hyperinsulinism, having a major impact in causing type 1 diabetes, and due to the lack of its 3D structure, an attempt has been made to predict the structure of kir6.2, applying fold recognition methods. …”
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20176
Linkage of Equatorial Ionization Anomaly With the Day‐To‐Day Occurrence of Postsunset Irregularities and Scintillation in Low‐Latitude Region Around 110°E
Published 2022-10-01“…These results can help us understand and predict the day‐to‐day variability of irregularities and scintillation in equatorial and low‐latitude regions.…”
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20177
Comparative analysis of HKTs in six poplar species and functional characterization of PyHKTs in stress-affected tissues
Published 2025-01-01“…Furthermore, cis-element analysis and protein interaction predictions provide insights into the functions of HKTs under salt stress through the activation of ion transporters, proline content, and ATPases regulated by hormonal signals and MYB transcription factors. …”
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20178
Personality organization and anxiety symptoms: Investigating the mediation of perfectionism
Published 2025-04-01“…Higher levels of GPD predicted higher rates of self-oriented and socially prescribed perfectionism, which contributed to more severe symptoms of anxiety. …”
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20179
Girth and groomed radius of jets recoiling against isolated photons in lead-lead and proton-proton collisions at sNN=5.02 TeV
Published 2025-02-01“…The measured Rg and g distributions are unfolded to the particle level, which facilitates the comparison between the PbPb and pp results and with theoretical predictions. It is found that jets with pTjet/pTγ>0.8, i.e., those that closely balance the photon pTγ, are narrower in PbPb than in pp collisions. …”
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20180
The Bullseye: HST, Keck/KCWI, and Dragonfly Characterization of a Giant Nine-ringed Galaxy
Published 2025-01-01“…We find that the locations of the detected rings are an excellent match to predictions from analytic theory if the galaxy was a 10-ring system whose outermost ring has faded away. …”
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