Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome by Sara E.L. Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B. Calixto

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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

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Revealing novel protein interaction partners of glyphosate in Escherichia coli by Alix Sarah Aldehoff, Dominique Türkowsky, Patrick Lohmann, Masun Nabhan Homsi, Ulrike Rolle–Kampczyk, Elke Ueberham, Jörg Lehmann, Martin von Bergen, Nico Jehmlich, Sven–Bastiaan Haange

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Benefits from Long-Term Treatment in Irritable Bowel Syndrome by Stefano Evangelista

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Glutamate Receptors in Neuroinflammatory Demyelinating Disease

“…The search for new MS treatments invariably employs EAE to determine drug activity and provide a rationale for exploring clinical efficacy. The preclinical development of compounds for MS has generally followed a conventional, immunotherapeutic route. …”
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On QSPR analysis of pulmonary cancer drugs using python-driven topological modeling by Huiling Qin, Mazhar Hussain, Muhammad Farhan Hanif, Muhammad Kamran Siddiqui, Zahid Hussain, Mohamed Abubakar Fiidow

“…The integration of computational and mathematical chemistry will make it easier to evaluate drugs because it can assure consistent data for preclinical development. The paper also reveals specific indices that are superior to others regarding predictive accuracy, thus giving a basis for refining the models to suit the individual compound. …”
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Unwanted disorders and xenogeneic graft‐versus‐host disease in experimental immunodeficient mice: How to evaluate and how to report by Seyed Mostafa Monzavi, Samad Muhammadnejad, Vahid Mansouri, Hami Ashraf, Naser Ahmadbeigi

“…Abstract Human‐derived tumor models are essential for preclinical development of new anticancer drug entities. Generating animal models bearing tumors of human origin, such as patient‐derived or cell line–derived xenograft tumors, is dependent on immunodeficient strains. …”
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Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells by Christian Sávio-Silva, Stephany Beyerstedt, Poliana E. Soinski-Sousa, Expedito B. Casaro, Maria Theresa A. Balby-Rocha, Antônio Simplício-Filho, Jamille Alves-Silva, Érika B. Rangel

“…Laboratory research set the basis for establishing further translation research including preclinical development and proof of concept in model systems. …”
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A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells by Zhao Zhang, Lianfeng Zhao, Tinghui Huang, Zhengliang Chen, Zhengliang Chen, Yaoyao Zhao, Yaoyao Zhao, Junqing Liang, Xudong Ao, Xiaoqiong Jia, Lei Kang, Linghui Kong, Qi Jing, Jianhua Hu, Lili Gu, Feiyan Pan, Zhigang Hu, Lingfeng He, Muya Zhou, Jiannan Chen, Zhigang Guo

“…Furthermore, SAP UCAR-T cells maintained process stability during scale-up production, indicating the potential for large-scale manufacturing.DiscussionOur findings highlight the SAP module as a promising strategy for the preclinical development of anti-CD70 UCAR-T, paving the way for an 'off-the-shelf' cell therapy product.…”
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A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response by Emilie Crouchet, Nuno Almeida, Sarah C. Durand, Marie Parnot, Marine A. Oudot, Fabio Giannone, Cloé Gadenne, Natascha Roehlen, Antonio Saviano, Emanuele Felli, Patrick Pessaux, Hong Tuan Duong, Hideki Ohdan, Hiroshi Aikata, Kazuaki Chayama, Thomas F. Baumert, Catherine Schuster

“…The discovery and preclinical development of compounds targeting HCC are hampered by the absence of authentic tractable systems recapitulating the heterogeneity of HCC tumors in patients and the tumor microenvironment (TME). …”
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