Therapies for Mitochondrial Disorders by Kayli Sousa Smyth, Anne Mulvihill

“…Future therapies comprise of personalised and precision medicine approaches which include gene, mitochondrial, cell, and in utero-based therapies. …”
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Epidemiological trends and healthcare disparities in onychomycosis: An analysis of the All of Us research program. by Aditya K Gupta, Vasiliki Economopoulos, Tong Wang, Vincent Piguet

“…The AoU program gathers survey, and electronic health records from participants in the United States with the aim of increasing the representation of minorities groups in health research under the framework of precision medicine. We identified 18,763 onychomycosis patients (2017-2022) and compared the rates of diagnostic testing, prescription medications and surgical procedures. …”
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Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases by Jie Zheng, George Davey Smith, Tom R Gaunt, Maria K Sobczyk

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HisCoM-PCA: software for hierarchical structural component analysis for pathway analysis based using principal component analysis by Nan Jiang, Sungyoung Lee, Taesung Park

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The Skin-Lightening Power of Tirbanibulin 1% Ointment by Federica Li Pomi, Andrea d’Aloja, Michelangelo Rottura, Mario Vaccaro, Francesco Borgia

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Digital Representation of Patients as Medical Digital Twins: Data-Centric Viewpoint by Stanislas Demuth, Jérôme De Sèze, Gilles Edan, Tjalf Ziemssen, Françoise Simon, Pierre-Antoine Gourraud

“… AbstractPrecision medicine involves a paradigm shift toward personalized data-driven clinical decisions. …”
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Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster by Ren-Di Jiang, Yun-Zhe Luo, Hao-Feng Lin, Xiao-Shuang Zheng, Wen-Tao Zeng, Mei-Qin Liu, Hao-Hao Deng, Qi Wang, Ya-Na Lai, Ying Chen, Zi-Shuo Guo, Ya Zeng, Qian-Chun Gong, Chen Qiu, Mei Dong, Xi Wang, Zi-Yi Wang, Li-Na Ji, Pan-Pan Hou, Qian Li, Xu-Rui Shen, Bei Li, Yun Gao, Ai-Hua Zhang, Ting-Ting Jiang, Ai-Min Shi, Peng Zhou, Xin-Hua Lin, Zi-Qing Deng, Jian-Min Li, Zheng-Li Shi

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Naxos Disease and Related Cardio-Cutaneous Syndromes by Alexandros Protonotarios, MD, Angeliki Asimaki, Ph.D, Cristina Basso, MD, Zafeirenia Xylouri, MD, Emanuele Monda, MD, Ioannis Protonotarios, MD, Giulia Crisci, MD, Dominic JR. Abrahms, MMBS, MD, MBA, Aris Anastasakis, MD, Loizos Antoniades, MD, Athanasios Bakalakos, MD, Andreina Carbone, MD, Aman S. Coonar, MD, Juan Ramon Gimeno, MD, George Lazaros, MD, Stamatis Lerakis, MD, Luisa Mestroni, MD, George Papadopoulos, MD, Leandro Pecchia, MD, Francesca Romana Prandi, MD, Petros Syrris, MD, Julia Cadrin-Turigny, MD, Anargyros Vasilakis, MSc, Jeffrey E. Saffitz, MD, PhD, Stamatios Gaetano Thiene, MD, Perry M. Elliott, MD, Juan Pablo Kaski, MD, William J. McKenna, MD, Eduardo Bossone, MD, Giuseppe Limongelli, MD, Adalena Tsatsopoulou, MD

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PANoptosis in Bacterial Infections: A Double-Edged Sword Balancing Host Immunity and Pathogenesis by Xiaoe He, Xiangyan Jiang, Jiayin Guo, Hui Sun, Jing Yang

“…These insights provide a foundation for designing targeted antibacterial strategies, modulating inflammation, and advancing precision medicine to improve clinical outcomes.…”
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Structural Analysis of Recombinant Human Preproinsulins by Structure Prediction, Molecular Dynamics, and Protein-Protein Docking by Sung Hun Jung, Chang-Kyu Kim, Gunhee Lee, Jonghwan Yoon, Minho Lee

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Stem cell status and prognostic applications of cuproptosis-associated lncRNAs in acute myeloid leukemia by Zhuodong Chai, Zhongyue Yuan, Yifei Chen

“…High-risk patients demonstrated lower sensitivity to chemotherapeutic agents such as Axitinib, GSK429286A, Navitoclax, and ZM-447439, underscoring the need for alternative therapeutic strategies.DiscussionCRLPM offers a promising framework for integrating stem cell-focused approaches into personalized treatment regimens, paving the way for precision medicine in AML management.…”
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Microbiome immune system interactions in selected neurological disorder by P. Omosigho, G. Sulaiman, O. Okesanya

“…Researchers should collaborate, conduct longitudinal studies tracking gut microbiota changes in at-risk populations, use precision medicine approaches tailored to individual microbiota composition, and promote gut health from birth.…”
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Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases by Nargish Parvin, Sang Woo Joo, Tapas K. Mandal

“…This review highlights the transformative potential of biodegradable and stimuli-responsive nanomaterials, presenting them as a promising strategy to advance precision medicine and improve patient outcomes in autoimmune disease management.…”
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Comparing subsampling strategies for metagenomic analysis in microbial studies using amplicon sequence variants versus operational taxonomic units. by Daniel Segura, Divya Sharma, Osvaldo Espin-Garcia

“…The microbiome is increasingly regarded as a key component of human health, and analysis of microbiome data can aid in the development of precision medicine. Due to the high cost of shotgun metagenomic sequencing (SM-seq), microbiome analyses can be done cost-effectively in two phases: Phase 1-sequencing of 16S ribosomal RNA, and Phase 2-SM-seq of an informative subsample. …”
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Transcriptomics profiling of Parkinson’s disease progression subtypes reveals distinctive patterns of gene expression by Carlo Fabrizio, Andrea Termine, Carlo Caltagirone

“…Conclusion This study provides novel information regarding the transcriptomics profiles of PD progression subtypes, which may foster precision medicine with relevant indications for a finer-grained diagnosis and prognosis.…”
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STADIUM: Species-Specific tRNA Adaptive Index Compendium by Jonghwan Yoon, Yeun-Jun Chung, Minho Lee

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Association between exposure to particulate matter and heart rate variability in vulnerable and susceptible individuals by Yong Whi Jeong, Hayon Michelle Choi, Youhyun Park, Yongjin Lee, Ji Ye Jung, Dae Ryong Kang

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Natural products against resistant bacterial infections: A systematic literature review by Harshit Kaushik, Ruchika Sharma, Anoop Kumar

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Quantifying the regulatory potential of genetic variants via a hybrid sequence-oriented model with SVEN by Yu Wang, Nan Liang, Ge Gao

“…Understanding the transcription effects of noncoding genetic variants are still major unsolved problems, which is critical for downstream applications in human genetics and precision medicine. Here, we integrate regulatory-specific neural networks and tissue-specific gradient-boosting trees to build SVEN: a hybrid sequence-oriented architecture that can accurately predict tissue-specific gene expression level and quantify the tissue-specific transcriptomic impacts of structural variants across more than 350 tissues and cell lines. …”
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Hormonal Contraceptive Use and Affective Disorders: An Updated Review by Mengelkoch S, Afshar K, Slavich GM

“…Looking forward, research, and funding for this research, is needed to elucidate the mechanistic pathways through which the use of different contraceptives impacts mood in different women to allow for a precision medicine approach to contraceptive treatment. …”
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