Characterization of visual cognition in pre-manifest, manifest and reduced penetrance Huntington’s disease by Rocio Del Pino, Maria Ángeles Acera, Amaia Ortiz de Echevarrría, Beatriz Tijero, Marta Ruiz-Lopez, Johanne Somme, Javier Ruiz-Martínez, Andrea Gabilondo, Ioana M. Croitoru, Lara Pardina, Naia Ayo-Mentxakatorre, Ane Murueta-Goyena, Iñigo Gabilondo, Rosario Sanchez-Pernaute, Tamara Fernández-Valle, Juan Carlos Gómez Esteban

“…Abstract Cognitive and visual impairment are common in Huntington’s Disease (HD) and may precede motor diagnosis. We investigate the early presence of visual cognitive deficits in 181 participants, including HD carriers (40 pre-manifest, 30 early manifest, 27 manifest, and 6 reduced penetrance) and 78 healthy controls (HC). …”
Get full text

Fast because it’s just: fostering acceptance to accelerate sustainability transitions in coal-dependent regions by Cristian Pons-Seres de Brauwer, Paola Andrea Yanguas Parra

“…To substantiate this argument, we conduct a narrative review cutting across the literature on JTs and SA of renewables’ innovations, and reinterpret them using a socio-technical (sustainability) transition perspective to outline three core propositions: (i) justice perceptions underlie acceptance; (ii) acceptance precedes reorientation; (iii) reorientation as a transition acceleration strategy. …”
Get full text

A Multimethod Approach towards Assessing Urban Flood Patterns and Its Associated Vulnerabilities in Singapore by Winston T. L. Chow, Brendan D. Cheong, Beatrice H. Ho

“…We find that, despite effective flood management, (i) significant increases in reported flash flood frequency occurred in contemporary (post-2000) relative to preceding (1984–1999) periods, (ii) these flash floods coincide with more localised, “patchy” storm events, (iii) storms in recent years are also more intense and frequent, and (iv) floods result in low human casualties but have high economic costs via insurance damage claims. …”
Get full text

Early Diagnosis of Alzheimer’s Disease Using Adaptive Neuro K-Means Clustering Technique by Karan Kumar, Shweta Agrawal, Isha Suwalka, Celestine Iwendi, Cresantus N. Biamba

“…Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, behavioral changes, and impaired self-care, often preceded by Mild Cognitive Impairment (MCI). Not all MCI cases progress to AD, creating a diagnostic challenge. …”
Get full text

Preclinical Cognitive Markers of Alzheimer Disease and Early Diagnosis Using Virtual Reality and Artificial Intelligence: Literature Review by María de la Paz Scribano Parada, Fátima González Palau, Sonia Valladares Rodríguez, Mariano Rincon, Maria José Rico Barroeta, Marta García Rodriguez, Yolanda Bueno Aguado, Ana Herrero Blanco, Estela Díaz-López, Margarita Bachiller Mayoral, Raquel Losada Durán

“…ResultsFollowing an analysis of 38 selected articles, we highlight verbal episodic memory as a sensitive preclinical AD marker, with supporting evidence from neuroimaging and genetic profiling. Executive functions precede memory decline, while processing speed is a significant correlate. …”
Get full text

Autonomous sortie scheduling for carrier aircraft fleet under towing mode by Zhilong Deng, Xuanbo Liu, Yuqi Dou, Xichao Su, Haixu Li, Lei Wang, Xinwei Wang

“…In this paper, the problem is investigated in the perspective of hybrid flow-shop scheduling problem by synthesizing the precedence, space and resource constraints. Specifically, eight processing procedures are abstracted, where tractors, preparing spots, catapults, and launching are virtualized as machines. …”
Get full text

Standardization for 5G technology and beyond: impact on military communications by Zoran M. Miličević, Zoran S. Bojković, Nataša Z. Bojković, Tanja M. Živojinović

“…It analyzes the areas of major enhancements for the existing features and expansion to new use cases and industries as well as to military usage through the 3GPP Releases, starting from Release 15 as 5G Basic, over 16 and 17 as 5G Evolution, up to 18 and 19 as 5G Advanced which precede the upcoming Release 20 and the initial 6G network whose launch is expected by the end of this decade.…”
Get full text

The spectrum of giant cell arteritis and polymyalgia rheumatica: a longitudinal prospective study to assess for subclinical giant cell arteritis in new onset polymyalgia rheumatica by Yasser El Miedany, Maha El Gaafary, Mathias Toth, Sami Bahlas, Waleed Hassan, Safaa Mahran, Mohammed Hassan Abu-Zaid, Ali El Miedany, Walaa Elwakil

“…Conclusion The key finding of this study is the incorporation of the concept that vascular inflammation mainly precedes the classical clinical manifestations. Routine screening for subclinical GCA in PMR patients should be considered as part of standard care for PMR patients. …”
Get full text

‘Just because something works doesn’t mean it can’t be improved’: an ethnographic analysis of the health system in Black Panther’s Wakanda by Jennifer Jackson, Carla Ferreira, Samantha Perry, Carla Ginn, Melissa Scott, Elke Jaibeeh Barah, Zahra Upal, Krista Phelps, Carol Mei, Haneul Woo, Megan Tung, Farida Gadimova, Alexandra Ewanyshyn, Twyla Ens

“…We propose four healthcare system themes within the context of Wakandan identity: (1) technology as an instrument (blending bodies and technology, blending technology with tradition); (2) reimagining medication; (3) warfare and rehabilitation; and (4) preventative approaches to health (prioritising collective health, deprofessionalisation of healthcare services). The preceding themes represent core elements of Wakandan health systems that allow the people of Wakanda to thrive. …”
Get full text

Application of targeted 2D planar chromatography in the control of ginkgolic acids in some herbal drugs and dietary supplements by Migas Piotr, Romańczuk Anna, Szumacher Marta, Krauze-Baranowska Mirosława

“…Separation of ginkgolic acids C15:1 and C17:1 on HPTLC RP18 WF254s was preceded by its separation from the sample matrix on TLC Si60 F254s. …”
Get full text

Refined construction of semi-provincial hydrogeological models using hierarchical modeling: A case study in Western Shandong Province, China by Guangjun Ji, Zizhao Cai, Xiaobo Tan, Tao Wang, Chuanqi Wang, Qiuxiao Xu, Bo Zhou, Yang Cui

“…In this framework, each preceding model constrains the subsequent one. Additionally, a systematic design for structural and attribute models was conducted before modeling, based on hydrogeological conditions and data distribution. …”
Get full text

Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the Literature by Gaurang Modi, Irappa Madabhavi, Harsha Panchal, Apurva Patel, Asha Anand, Sonia Parikh, Pritam Jain, Swaroop Revannasiddaiah, Malay Sarkar

“…It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukemia. Here, we are presenting a rare case of primary vaginal myeloid sarcoma in a geriatric female patient without initial presentation of acute myeloid leukemia (AML). …”
Get full text

Striatal Injury with 6-OHDA Transiently Increases Cerebrospinal GFAP and S100B by Cristiane Batassini, Núbia Broetto, Lucas Silva Tortorelli, Milene Borsoi, Caroline Zanotto, Fabiana Galland, Tadeu Mello Souza, Marina Concli Leite, Carlos-Alberto Gonçalves

“…Current data reinforce the idea that glial changes precede neuronal damage in PD; however, these findings also indicate that caution is necessary regarding the interpretation of data in this PD model.…”
Get full text

Identification of Two Types of Metallogenic Fluids in the Ultra-Large Huize Pb–Zn Deposit, SW China by Yan Zhang, Runsheng Han, Pingtang Wei, Lei Wang

“…This work investigates the ultra-large Huize Pb–Zn deposit, based on the results of preceding studies and detailed field geological surveys. …”
Get full text

The effect of auditory rhythm on the temporal allocation of visual attention in aging by Zhihan Xu, Juan Huang, Yuxuan Shen, Yanna Ren, Yulin Gao, Ting Guo

“…Moreover, whether the cross-modal temporal expectation effect in aging is influenced by tempo has not yet been explored.MethodsTo address these issues, both younger and older participants performed a rhythmic temporal expectation task in which auditory isochronous rhythms, presented at either 600 ms (faster) or 1,400 ms (slower) tempo, were used to trigger temporal expectation for a visual target.ResultsThe results demonstrated a cross-modal temporal expectation effect, with participants exhibiting significantly faster responses when the visual target appeared in synchrony with the preceding auditory rhythm compared to out-of-synchrony trials. …”
Get full text

Temporal Characteristics of High-Frequency Lower-Limb Oscillation during Freezing of Gait in Parkinson’s Disease by Don A. Yungher, Tiffany R. Morris, Valentina Dilda, James M. Shine, Sharon L. Naismith, Simon J. G. Lewis, Steven T. Moore

“…A total of 23 isolated FOG events, defined as occurring at least 5 s after gait initiation and with no preceding FOG, were identified from the clinical ratings. …”
Get full text

Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling by Chalystha Yie Qin Lee, Yee Teng Chan, Yi Ying Cheok, Grace Min Yi Tan, Ting Fang Tang, Heng Choon Cheong, Jamuna Vadivelu, Suhailah Abdullah, Chung Yeng Looi, Won Fen Wong

“…Helicobacter pylori colonization and persistence could precede gastric adenocarcinoma. Elucidating immune recognition strategies of H. pylori is therefore imperative to curb chronic persistence in the human host. …”
Get full text

IL-1 and its role in rat carrageenan pleurisy by R. Goodman, L. R. Mantegna, C. L. McAIlister, E. Bruin, R. L. Dowling, H. George, W. Feeser, B. Freimark, M. Lischwe, S. Pick, R. R. Harris, J. S. Kerr

“…Significant increases in IL-1β levels precede cell influx suggesting IL-1β plays a role in the maintenance of cell accumulation in the pleural cavity. …”
Get full text

The gut microbiota predicts and time-restricted feeding delays experimental colitis by Hannah K. Ruple, Eva Haasis, Anna Bettenburg, Carina Maier, Carolin Fritz, Laura Schüle, Sarah Löcker, Yvonne Soltow, Lynn Schintgen, Nina S. Schmidt, Celine Schneider, Axel Lorentz, W. Florian Fricke

“…Compositional changes and reduced rhythmicity of the fecal microbiota preceded colitis and could predict colitis symptoms for individual IL-10-/- mice across different experiments. …”
Get full text

Abrogation of mercuric chloride-induced nephritis in the Brown Norway rat by treatment with antibodies against TNFα by A. Molina, F. Sánchez-Madrid, T. Bricio, A. Martín, E. Escudero, V. Alvarez, F. Mampaso

“…In addition, whole isolated glomeruli from HgCl2-induced nephritis secreted TNF-α commencing on day 8, being maximally detected on day 11 and preceding, between 2 to 3 days, the development of proteinuria. …”
Get full text