Impact of early initiation of renal replacement therapy in patients on venoarterial ECMO using target trial emulation with Japanese nationwide data by Toshihiro Kubo, Tomonori Takeuchi, Norihiko Inoue, Augusto Cama-Olivares, Deepak Chandramohan, Ashita J. Tolwani, Keith M. Wille, Kiyohide Fushimi, Javier A. Neyra, Kenji Wakabayashi

“…The primary outcomes were 28-day and 90-day hospital mortality analyzed by Cox proportional hazards models and the secondary outcome was 90-day RRT dependence by pooled logistic regression models. Inverse probability censoring weights were applied to adjust the models. …”
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Comparative analysis of the profile of circulating microRNAs in the blood plasma of patients with gliomas by D. Yu. Gvaldin, N. A. Petrusenko, E. E. Rostorguev, S. N. Dimitriadi, S. E. Kavitskiy, N. N. Timoshkina

“…During the primary analysis, a pool of 71 differentially expressed microRNAs was identified, the expression of which was tumor-specific: 20 microRNAs for glioblastoma, 4 microRNAs for astrocytoma, 23 microRNAs for oligodendroglioma, 24 microRNAs for meningioma. …”
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Clinical Research Network: JHCRN Infrastructure and Lessons Learned by Rahul Kashyap, Gayane Yenokyan, Robert Joyner, Melissa Gerstenhaber, Mary Alderfer, Erika Siegrist, Joan Moore, Channing J. Paller, Hanan Aboumatar, James J. Potter, Stanley Watkins Jr, John E. Niederhuber, Daniel E. Ford, Adrian Dobs

“…With one IRB of record, a centralized contracting office, and a pool of dedicated network coordinators, it facilitates research partnerships to expand research collaborations among the differing sizes and types of hospitals/health systems in a region. …”
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A comparative template-switching cDNA approach for HTS-based multiplex detection of three viruses and one viroid commonly found in apple trees by Francisco Mosquera-Yuqui, Daniel Ramos-Lopez, Xiaojun Hu, Yu Yang, Joshua L. Mendoza, Emmanuel Asare, Joshua Habiger, Oscar P. Hurtado-Gonzales, Andres S. Espindola

“…Treatments with oligo d(T)23-VN or its combination with random hexamers yielded the highest relative reads for viruses, while treatments containing the reverse primer pool produced more relative reads for AHVd. These treatments and random hexamers also generated the highest genome coverages, which were typically similar in both HTS workflows. …”
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Comparative efficacy and acceptability of psychotherapies for post-traumatic stress disorder in children and adolescents: a systematic review and network meta-analysis by Andrea Cipriani, Pim Cuijpers, Yuqing Zhang, David Cohen, Jürgen Barth, Peng Xie, Cinzia Del Giovane, Xinyu Zhou, Donna Gillies, Teng Teng, Xuemei Li, Li Fan, Yajie Xiang, John R. Weisz, Xueer Liu, Yuanliang Jiang, Kang Du, Arun V. Ravindran

“…The pairwise meta-analyses and frequentist network meta-analyses estimated pooled standardised mean differences (SMDs) and ORs with random-effects model. …”
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Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis by Yu Zhang, Cheng-Ming Xiao, Yan Zhang, Qiong Chen, Xiao-Qin Zhang, Xue-Feng Li, Ru-Yue Shao, Yi-Meng Gao

“…Databases were searched for observational studies until August 20, 2020. Pooled odds ratios (ORs) were calculated using fixed- or random-effects models. 103 studies involving 1,826,454 pregnant women were identified. …”
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ABO-Incompatible Adult Living Donor Liver Transplantation in the Era of Rituximab: A Systematic Review and Meta-Analysis by Dipesh Kumar Yadav, Yong Fei Hua, Xueli Bai, Jianying Lou, Risheng Que, Shunling Gao, Yun Zhang, Ji Wang, Qinfen Xie, Muhammad Ibrahim Alhadi Edoo, Vikram Kumar Chutturghoon, Tingbo Liang

“…The strategy of ABOi liver transplantation (LT) was originated initially to increase the donor pool and to enable liver transplantation in emergency conditions. …”
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Optimal Timing and Treatment Modalities of Arytenoid Dislocation and Subluxation: A Meta-Analysis by Andrea Frosolini, Valeria Caragli, Giulio Badin, Leonardo Franz, Patrizia Bartolotta, Andrea Lovato, Luca Vedovelli, Elisabetta Genovese, Cosimo de Filippis, Gino Marioni

“…Data on treatment success were pooled, and the impact of TT on recovery outcomes was analyzed. …”
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Experimental and theoretical study on ceiling temperature distributions in mountain tunnel with a lateral open shaft by Yuchun Zhang, Xinyu Liu, Rui Tan, Wei Hou, Longfei Chen, Shaoshuai Xing, Zhisheng Li, Yunhai Guo, Xiaoqing Han

“…Analysis was performed to explore the maximum excess temperature and longitudinal temperature decay under the influence of a mechanical exhaust system with a lateral open shaft. Three different pool sizes and numerous extraction rates were considered. …”
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Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes by Mehdi Maanaoui, Florence Debillon, Rémi Lenain, Frédérique Defrance, Marie-Christine Vantyghem, Marine Van Triempont, François Provôt, Mikael Chetboun, Julie Kerr-Conte, Aghiles Hamroun, Marie Frimat, Violeta Raverdy, François Pattou, Marc Hazzan, François Glowacki

“…Abstract Type 2 diabetes (T2D) is a common comorbidity in kidney transplant recipients, representing a significant proportion of the candidate pool. Post-kidney transplantation management of T2D remains challenging, leading to inferior long-term outcomes compared to non-diabetic recipients. …”
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Influence of welding sequences on residual stress and deformation of U-rib components fabricated by laser-arc hybrid welding by Shaoning Geng, Yuantai Li, Ping Jiang, Yilin Wang, Jun Jin, Chu Han

“…The results show that the experimental and numerical results are in general agreement in terms of temperature field, melt pool morphology, residual stress, and deformation. …”
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Noggin Combined With Human Dental Pulp Stem Cells to Promote Skeletal Muscle Regeneration by Meng-Han Zhang, Li-Ming Yu, Wei-Hua Zhang, Jia-Jia Deng, Bing-Jing Sun, Mei-Hua Chen, Wei Huang, Jiao Li, Hua He, Xin-Xin Han, Yue-Hua Liu

“…Noggin-treated DPSCs can benefit the Pax7+ SC pool and promote muscle regeneration. This work reveals that Noggin can enhance the production of satellite-like cells from the MyoD of DPSCs by regulating BMP/Smad signaling, and these satellite-like cell bioconstructs might possess a relatively fast capacity for muscle regeneration.…”
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Downregulation of MerTK in circulating T cells of patients with non-proliferative diabetic retinopathy by Shimiao Bu, Shimiao Bu, Jiang-Yue Ling, Jiang-Yue Ling, Xiaojun Wu, Xiaojun Wu, Liting Zhang, Liting Zhang, Xiangyu Shi, Lang Huang, Zheng Zhao, Ying Yang, Zongqin Xiang, Yong U. Liu, Yong U. Liu, Yufeng Liu, Yuehong Zhang, Yuehong Zhang

“…ObjectiveTo explore the differential gene expression in peripheral blood immune cells of individuals with type 2 diabetes mellitus (DM), comparing those with and without non-proliferative diabetic retinopathy (NPDR).MethodsFrom a pool of 126 potential participants, 60 were selected for detailed analysis. …”
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Mitochondrial ROS modulate presynaptic plasticity in the drosophila neuromuscular junction by Irina Stavrovskaya, Bethany Kristi Morin, Stephen Madamba, Cliyahnelle Alexander, Alexis Romano, Samia Alam, Lucas Pavlov, Erna Mitaishvili, Pablo M. Peixoto

“…However, in existing boutons we observed an increase in the active zone (AZ) marker Brp/Erc1, which serves as docking site for the neurotransmitter vesicle release pool. We propose the involvement of putative redox switches in AZ components as the molecular target of mitochondrial H2O2. …”
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Transient Elastography in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis by Changzhou Cai, Xin Song, Xueyang Chen, Weihua Zhou, Qi Jin, Shenghui Chen, Feng Ji

“…In patients with ALD/NAFLD, the pooled results revealed that the sensitivity and specificity of CAP were 0.84, 0.83, and 0.78 and 0.83, 0.71, and 0.62 for steatosis grades ≥S1, ≥S2, and =S3, respectively. …”
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First evidence of immunomodulation of the renin-angiotensin system through substance P/neurokinin 1 receptor: a case and control study in hypertension and cardiac patients by Ibrahim M. Alanazi, Riffat Mehboob, Ayesha Tariq, Sajid Hameed, Uzma Malik, Noreen Sarwar, Imran Shahid, Khurram Mehboob

“…Participants were chosen from a pool of hypertensive (n=30) and cardiac patients (n=35) in addition to a control group (n=12). …”
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Pediatric Intracochlear Schwannoma: Case Series and Review of the Literature by Enrico Liaci, Maurizio Negri, Francesco Maccarrone, Silvia Piccinini, Enrico Pasanisi, Andrea Bacciu, Filippo Di Lella

“…Data analysis resumes the pooled data of the latter case and the authors’ patients. …”
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Differential gene expression profile in Porphyromonas gingivalis treated human gingival keratinocytes and their role in the development of HNSCC by Dakshinya M, Anitha P, A.S. Smiline Girija, Paramasivam A, Vijayashree Priyadharsini J

“…Results: The study revealed 29 genes from a pool of transcripts acquired after comparing the Pg-HIGK and Sham-HIGK. …”
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Culture-independent detection of Mycobacterium tuberculosis complex DNA using targeted next generation sequencing in African buffalo (Syncerus caffer) oronasal swabs in South Afric... by Sinegugu Kholeka Mhlophe, Charlene Clarke, Giovanni Ghielmetti, Giovanni Ghielmetti, Megan Matthews, Tanya Jane Kerr, Michele Ann Miller, Wynand Johan Goosen, Wynand Johan Goosen

“…The DNA was extracted directly from the oronasal swabs, amplified using Mycobacterium genus-specific PCRs, then amplicons were pooled and sequenced using Oxford Nanopore Technologies (ONT) long-read platform. …”
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Efficient biosynthesis of β-caryophyllene by engineered Yarrowia lipolytica by Young-Kyoung Park, Lucie Studena, Piotr Hapeta, Ramdane Haddouche, David J. Bell, Pablo Torres-Montero, Jose Luis Martinez, Jean-Marc Nicaud, Adriana Botes, Rodrigo Ledesma-Amaro

“…Results Two genes, tHMG1 from S. cerevisiae to boost the mevalonate pool and QHS1 from Artemisia annua, were expressed under different promoters and copy numbers in Y. lipolytica. …”
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