Methods to address functional unblinding of raters in CNS trials by Steven D. Targum, William P. Horan, Vicki G. Davis, Alan Breier, Stephen K. Brannan

“…Two different methods were used to examine possible functional unblinding in pooled data from three recent five-week, double-blind, placebo-controlled trials of xanomeline and trospium chloride (formerly known as KarXT) in participants with schizophrenia experiencing acute psychosis. …”
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Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia by Lukui Chen, Guilong Zhang, Ahsan Ali Khan, Xiaoyuan Guo, Yuchun Gu

“…The results based upon the pooled mean difference from baseline to follow-up points showed that the stem cell transplantation group was superior to the control group with statistical significance in the neurologic deficits score (NIHSS, MD = 1.57; 95% CI, 0.64–2.51; I2=57%; p=0.001), motor function (FMA, MD = 4.23; 95% CI, 3.08–5.38; I2=0%; p<0.00001), daily life ability (Barthel, MD = 8.37; 95% CI, 4.83–11.91; I2=63%; p<0.00001), and functional independence (FIM, MD = 8.89; 95% CI, 4.70–13.08; I2=79%; p<0.0001). …”
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Evaluating Producer Welfare Benefits of Whole-Farm Revenue Insurance by Moharram Ainollahi Ahmadabadi, Mohammad Ghahremanzadeh, Ghader Dashti, Seyed-Ali Hosseini-Yekani

“…The basic principle of whole-farm insurance consists of pooling all the insurable risks of a farm into a single policy and overcoming most of the major impediments to existing policies. …”
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Respiratory symptoms and pulmonary function in paint industry workers exposed to volatile organic compounds: A systematic review and meta-analysis. by Lavanya Sekhar, Akila Govindarajan Venguidesvarane, Gayathri Thiruvengadam, Yogita Sharma, Vidhya Venugopal, Santhanam Rengarajan, Priscilla Johnson

“…The meta-analysis included 12 studies on respiratory symptoms and 18 on PFT. Pooled meta-analysis was done using random effect model, and the crude odds of respiratory symptoms such as cough (OR: 2.72, 95% confidence interval [CI]: 1.74 to 4.25), dyspnoea (OR: 3.59, 95% CI: 2.13 to 6.05), nasal/throat irritation (OR: 4.5, 95% CI: 1.7 to 12.1), and wheezing (OR: 2.28, 95% CI: 1.37 to 3.82) were significantly higher among paint industry workers exposed to VOC compared to unexposed population. …”
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Caesarean sections and private insurance: systematic review and meta-analysis by Ilir Hoxha, Medina Braha, Lamprini Syrogiannouli, David C Goodman, Peter Jüni, Bruno R da Costa

“…The meta-analysis of crude estimates from 12 studies revealed a somewhat more pronounced association (pooled OR 1.35, 95% CI 1.27 to 1.44) with no relevant heterogeneity between studies (τ2=0.011).Conclusions Caesarean sections are more likely to be performed in privately insured women as compared with women using public health insurance coverage. …”
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The international trial of nasal oxygen therapy after cardiac surgery (NOTACS) in patients at high risk of postoperative pulmonary complications: Economic evaluation protocol and a... by Siddesh Shetty, Melissa Duckworth, Richard Norman, Jacquita Affandi, Sarah Dawson, Julia Fox-Rushby, NOTACS investigators, NOTACS Trial Steering Committee, NOTACS DMEC Committee

“…<h4>Methods and analysis</h4>The economic evaluation will identify, measure and value resources and health outcomes in both trial arms and compare changes in costs with 'days alive and at home' and EQ-5D-5L quality adjusted life years (QALYs) from the perspective most relevant to the decision-making country. Results from pooling data across the trial will use health and social care sector perspective. …”
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The impact of caesarean scar niche on fertility - a systematic review by M. M van den Tweel, S. van der Struijs, S. Le Cessie, K. E Boers

“…The overall direction of effect shows a negative impact of a niche on the live birth rate (pooled aOR 0.58, 95% CI 0.48-0.69) with low-grade evidence. …”
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Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy by Yiji Tu, Zenggan Chen, Feng Zhang, Zhenglin Di, Junhui Zhang, Li Cai

“…The present study identified a pool of candidate biomarkers such as Cdk1, C3, Mapk12, Agt, Adipoq, Cxcl2, and Mmp9 and molecular mechanisms which may be involved in the early phase of experimental DPN. …”
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Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study by Kaiwen Wang, Yu Lou, Shunjie Tian, Zhihui Tao, Zhihui Tao

“…ObjectiveThe aim of this study was to investigate the bidirectional causal relationship between sex hormones and IBD through a two-sample bidirectional Mendelian randomization (MR) study.MethodsBased on Genome-Wide Association Study (GWAS) pooled data on SHBG, total testosterone, bioavailable testosterone, estradiol, and IBD in a European population, we performed two-sample bidirectional MR analyses using single nucleotide polymorphisms (SNPs) as instrumental variables. …”
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Role of biosimilar introduction on insulin glargine prices: a retrospective analysis in 28 European countries by David Beran, Margaret Ewen, Mario Raviglione, Tido von Schoen-Angerer, Davide Morolla

“…Segmented regression analysis using a dual-model approach: pooled and country-specific.Setting 28 European countries using data from the European Medicine Price Database for the period 2013–2023.Main outcome measures Price variations between countries were analysed to assess trends and correlations before and after biosimilar market entry.Results In the 28 countries studied, cost of insulin glargine underwent a median 21.6% decrease overall in the last decade (p&lt;0.001). …”
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Mineral composition of bread wheat lines with introgressions of alien genetic material by O. A. Orlovskaya, S. I. Vakula, L. V. Khotyleva, A. V. Kilchevsky

“…Wild and primitive wheats demonstrate rich genetic diversity, including the content of minerals in the grain, and can be used to improve the wheat gene pool for this trait. The aim of this work was to study the mineral composition in the grain of bread wheat lines with introgressions of the genetic material from Triticum L. spp.Materials and methods. …”
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Stress, anxiety, depression and sleep disturbance among healthcare professional during the COVID-19 pandemic: An umbrella review of 72 meta-analyses. by Mohammed Al Maqbali, Ahmad Alsayed, Ciara Hughes, Eileen Hacker, Geoffrey L Dickens

“…The umbrella review revealed that the pooled prevalence of stress, anxiety, depression, and sleep disturbance among HCPs during the COVID-19 pandemic was 37% (95% CI 32.87-41.22), 31.8% (95% CI 29.2-34.61) 29.4% (95% CI 27.13-31.84) 36.9% (95% CI 33.78-40.05) respectively. …”
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DNA-marker based identification of the RPV3 gene determining downy mildew resistance in grapevines by E. T. Ilnitskaya, M. V. Makarkina, S. V. Tokmakov, L. G. Naumova

“…To determine the Rpv3 gene in the grape gene pool we, using these markers, studied 35 different genotypes of grapevines, most of which are interspecies cultivars. …”
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<i>Triticum durum</i> Desf. is a valuable source for spring bread wheat genetic diversity enhancement by A. E. Druzhin, S. N. Sibikeev, E. I. Gultyaeva, L. B. Andreeva

“…Introgression of chromatin from durum wheat cultivars into the spring bread wheat gene pool made it possible to produce lines resistant to the local P. triticina population, as well as to some test clones of this pathogen. …”
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Towards the Measurement of Sea-Ice Thickness Using a Time-Domain Inductive Measurement System by Danny Hills, Becan Lawless, Rauan Khangerey, Jeremy Wilkinson, Liam A. Marsh

“…The sensor was tested at a tidal pool containing seawater and measured to have a conductivity of 57.3 mS/cm. …”
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Does Asthma Affect the Risk of Developing Breast Cancer? by Karin B. Michels, Orianne Dumas, Raphaelle Varraso, Carlos A. Camargo Jr

“…In NHS, women with asthma had a covariate‐adjusted hazard ratio of 0.92 (95% CI: 0.86–0.99) to develop breast cancer compared to women without asthma; the respective HR in NHS II was 0.93 (0.84–1.03), and 0.92 (0.87–0.98) in the pooled analysis. Among never‐smokers, the HR for breast cancer was 0.91 (0.81–1.02) in NHS, 0.81 (0.70–0.93) in NHS II, and 0.86 (0.77–0.97) combined. …”
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Oxidative stress and DNA lesions: the role of 8-oxoguanine lesions in Trypanosoma cruzi cell viability. by Pedro H N Aguiar, Carolina Furtado, Bruno M Repolês, Grazielle A Ribeiro, Isabela C Mendes, Eduardo F Peloso, Fernanda R Gadelha, Andrea M Macedo, Glória R Franco, Sérgio D J Pena, Santuza M R Teixeira, Leda Q Vieira, Alessandra A Guarneri, Luciana O Andrade, Carlos R Machado

“…We focused on the MutT enzyme, which is responsible for removing 8-oxoG from the nucleotide pool. To investigate the importance of 8-oxoG during parasite infection of mammalian cells, we characterized the MutT gene in T. cruzi (TcMTH) and generated T. cruzi parasites heterologously expressing Escherichia coli MutT or overexpressing the TcMTH enzyme. …”
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Distinguishing glioblastoma from brain metastasis; a systematic review and meta-analysis on the performance of machine learning by Mohammad Amin Habibi, Reza Omid, Shafaq Asgarzade, Sadaf Derakhshandeh, Ali Soltani Farsani, Zohreh Tajabadi

“…The meta-analysis model results revealed a pooled sensitivity and specificity estimate of 0.83 [0.80–0.86] and 0.87 [0.83–0.90], respectively, indicating a commendable overall diagnostic accuracy across all the studies. …”
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Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case Series by Ana Rita Mira, João Pedro Pereira, Catrine Dahlstedt-Ferreira, Margarida Enes, Hélder Oliveira Coelho, Ana Beatriz Godinho

“…The aim of our study is to report a perinatal outcome of SARS-CoV-2 infection in pregnancy adding information to the pool of data on COVID-19 pregnancy outcomes. Case Presentation. …”
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Vision-Based Underwater Docking Guidance and Positioning: Enhancing Detection with YOLO-D by Tian Ni, Can Sima, Wenzhong Zhang, Junlin Wang, Jia Guo, Lindan Zhang

“…Tests on an underwater docking markers dataset demonstrated that YOLO-D achieved a detection accuracy of mAP@0.5 to 94.5%, surpassing the baseline YOLOv11n with improvements of 1.5% in precision, 5% in recall, and 4.2% in mAP@0.5. Pool experiments verified the feasibility of the method, achieving a 90% success rate for single-attempt docking and recovery. …”
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