Preventable hospitalizations through ED: does the number of hospital beds matter under the global budget in a single-payer system in Taiwan? by Hsueh-Fen Chen, Hsueh-Fen Chen, Hsueh-Fen Chen, Hui-Min Hsieh, Hui-Min Hsieh, Hui-Min Hsieh, Wei-Shan Chang

“…The present study aimed to examine the relationship between the supply of hospital beds and hospitalizations following an emergency department (ED) visit (called ED hospitalizations) by using diabetes-related ambulatory care sensitive conditions (ACSCs) that are preventable and discretionary as an example.MethodsThe study was a pooled cross-sectional design analyzing 2011–2015 population-based claims data in Taiwan. …”
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Strategies to Improve Health Care Provider Prescription of and Patient Adherence to Guideline-Recommended Cardiovascular Medications for Atherosclerotic Occlusive Disease: Protocol... by Aidan M Kirkham, Dean A Fergusson, Justin Presseau, Daniel I McIsaac, Risa Shorr, Derek J Roberts

“…Where limited clinical heterogeneity exists between RCTs, estimates describing the effectiveness of implementation or adherence-supporting strategies within different refined EPOC taxonomy levels and BCW interventions and policies will be pooled using random-effects models. Stratified meta-analyses and meta-regressions will assess if strategy effectiveness varies by recruited patient populations, prescriber types, clinical practice settings, and study design characteristics. …”
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Validation of biomarkers and clinical scores for the detection of uterine leiomyosarcoma: a case-control study with an update of pLMS by Marcus Vollmer, Günter Köhler, Julia Caroline Radosa, Marek Zygmunt, Julia Zimmermann, Martina Köller, Christine Seitz, Helena Bralo, Marc Philipp Radosa, Askin Cangül Kaya, Johann Krichbaum, Erich-Franz Solomayer, Lars Kaderali, Zaher Alwafai

“…Missing values were imputed by random forest imputation to create the updated scoring system ‘pLMS2’ using penalized logistic regression based on the pooled data sets of 384 uLMS and 1485 LM. Results pLMS achieved an AUC of 0.97 on the validation data, but sensitivity and specificity varied at the proposed thresholds due to a shift in the score distributions. 43 uLMS and 578 LM were included in the comparison of pLMS with Zhang’s scoring system, with pLMS being superior (AUC 0.960 vs 0.845). …”
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Risk of Symptomatic Intracranial Hemorrhage After Mechanical Thrombectomy in Randomized Clinical Trials: A Systematic Review and Meta-Analysis by Abdullah Reda, Alireza Hasanzadeh, Sherief Ghozy, Hossein Sanjari Moghaddam, Tanin Adl Parvar, Mohsen Motevaselian, Ramanathan Kadirvel, David F. Kallmes, Alejandro Rabinstein

“…Random-effect models in a meta-analysis were employed to obtain the pooled risk ratios (RRs) and their corresponding 95% confidence intervals (95% CI) for sICH with MT, and were then compared to other reperfusion treatment regimens, including best medical treatment and intravenous thrombolysis (IVT). …”
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Resistance exercise training improves disuse-induced skeletal muscle atrophy in humans: a meta-analysis of randomized controlled trials by Xian Guo, Yanbing Zhou, Xinxin Li, Jinhao Mu

“…Studies reporting outcomes related to muscle volume, MVC, peak power, concentric peak force, eccentric peak force, isometric MVC torque of knee extension, isometric MVC torque of knee flexion were included. Data were pooled using random-effects models. Results Eleven randomized controlled trials were finally included. …”
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Establishing a new human pneumococcal standard reference serum, MPRSS-01 by Joseph M. Antonello, Rocio D. Murphy, Chitrananda Abeygunawardana, Juliana C. Malinverni, Rajam Gowrisankar, Tina Green, Rebecca Greway, Jenna Schmauch, Adrienne Howlett, Cyrille J. Bonhomme, Katrina M. Nolan

“…MPRSS-01 was generated by pooling high-titer serum samples from adults immunized with either 23-valent pneumococcal polysaccharide vaccine (PPSV23) or V116. …”
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A first study on sperm sexing in water buffalo through magnetic nanoparticles by Syed Murtaza Hassan Andrabi, Muhammad Hammad Fayyaz, Muhammad Shafiq Haider, Ghulam Muhammad Ali

“…Qualified semen samples from five buffalo bulls were pooled and divided into four aliquots. Each aliquot of 50 million sperm was diluted in 1 mL of modified human tubal fluid (mHTF). …”
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Estimating Trends in Cardiovascular Disease Risk for the EXPOSE (Explaining Population Trends in Cardiovascular Risk: A Comparative Analysis of Health Transitions in South Africa a... by Shaun Scholes, Jennifer S Mindell, Mari Toomse-Smith, Annibale Cois, Kafui Adjaye-Gbewonyo

“…Creating a harmonized dataset by pooling repeated cross-sectional surveys to model trends in CVD risk is challenging due to changes in aspects such as survey content, question wording, inclusion of boost samples, weighting, measuring equipment, and guidelines for data protection. …”
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The association between physician sex and patient outcomes: a systematic review and meta-analysis by Kiyan Heybati, Ashton Chang, Hodan Mohamud, Raj Satkunasivam, Natalie Coburn, Arghavan Salles, Yusuke Tsugawa, Ryo Ikesu, Natsumi Saka, Allan S. Detsky, Dennis T. Ko, Heather Ross, Mamas A. Mamas, Angela Jerath, Christopher J. D. Wallis

“…There is a paucity of pooled evidence examining the association of physician sex with clinical outcomes. …”
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Efficacy of brain stimulation therapies across psychiatric, movement, and cognitive disorders: an umbrella review synthesizing meta-analyses of randomized controlled trialsResearch... by Zhenyue Zu, Fenglan Chen, Linxi Yang, Wenzhuo Wei, Mi Zhang, Limin Huang, Ni Li, Zihan Lv, He Du, Xinrong Xue, Lijun Ma, Huixue Wang, Kai Wang, Xiaoming Li

“…We evaluated quality using 11 criteria. We calculated pooled effect estimates for core symptoms based on the largest meta-analyses, then conducted sensitivity and subgroup analyses, and assessed heterogeneity, publication bias, and small-study effects. …”
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Beta-hydroxy-beta-methylbutyrate (HMB) improves daily activity and whole-body protein metabolism in Duchenne muscular dystrophy dogs: a pilot study by Peter P. Nghiem, Alexis M. Rutledge, Kyle Tehas, Corine Kaderli, Meredith Poling, Sidney Arnim, Vitaliy Dernov, Celine van Sas, Macie L. Mackey, Gabriella A. M. ten Have, Mariëlle P. K. J. Engelen, Nicolaas E. P. Deutz

“…The intra- and extracellular pool sizes and flux between the two compartments of hydroxyproline was reduced in HMB treated dogs. …”
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Comprehensive coronary CT angiography in people living with HIV: a systematic review and meta-analysis by Binh T Nguyen, Edward Hulten, Venkatesh L Murthy, Tarin Phillips, Gregory M Blake, Jonathan A Aun, Lisa M Conte, Ritika Gadodia, Aakash Tuli, Sara L Robinson, Travis E Harrell

“…This systematic review and meta-analysis summarise and estimate pooled effect sizes for observational studies among PLWH using comprehensive coronary CT angiography (CTA).Design Preferred Reporting Items for Systematic Review and Meta-analysis reporting guidelines were used.Data sources PubMed, Embase, Web of Science, CINAHL, Cochrane Clinical Trials and EBM were searched from inception to 23 February 2024.Eligibility criteria We included studies evaluating coronary atherosclerosis in adult PLWH with controls and CTA results for plaque prevalence, extent, severity and high-degree stenosis.Data extraction and synthesis Two independent reviewers used standardised methods to screen for relevance by title, abstract and full-text review. …”
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Spotted fever group rickettsiae in black rats, pets, and humans in Zungarococha community, A rural area in the surroundings of Iquitos, Peru by Cusi Ferradas, Guillermo Salvatierra, David Payahuanca, Winnie Contreras, Andrés M. López-Pérez, Therangika A. Hangawatte, Diana León, Bruno M. Ghersi, Ricardo Gamboa, Katia Manzanares Villanueva, Viviana Pinedo-Cancino, Risa Pesapane, Gabriela Salmón-Mulanovich, Andrés G. Lescano, Janet Foley

“…Rhipicephalus sanguineus s.l. (2/91 ticks) and Ct. felis (53/56 fleas and 55/55 flea pools) were qPCR-positive for Rickettsia spp. Recovered genetic material from 53 Ct. felis was sequenced and all were identified as Rickettsia asembonensis. …”
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Identification of Genetic Markers of <i>APOM</i> and <i>CYP7A1</i> Genes Affecting Milk Production Traits in Chinese Holstein by Yanan Liu, Zijiao Guo, Junqing Ni, Chendong Yang, Bo Han, Yabin Ma, Jianming Li, Guie Jiang, Weijie Zheng, Dongxiao Sun

“…By dual-direction sequencing of the polymerase chain reaction (PCR) products of the complete coding sequences and 2000 bp of the 5′ and 3′ flanking regions on pooled DNA sample, seven and three single nucleotide polymorphisms (SNPs) were identified in <i>APOM</i> and <i>CYP7A1</i>, respectively. …”
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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…Rechallenge with ICI resulted in 57.3% DCR and 28.6% pooled CR rates (n=22, CR rate 28.6%, 95%CI 17.1 – 40.2, I2 68%). …”
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Causal role of plasma liposome in diabetic retinopathy: mendelian randomization (MR) study by Kai Yin, Lu Ding, Xueyan Li, Yuqi Zhang, Siyu Song, Liyuan Cao, Ruixue Deng, Min Li, Zirui Li, Qinjing Xia, Daqing Zhao, Xiangyan Li, Zeyu Wang

“…Results Analysis of the pooled MR results and after correction for the false discovery rate (FDR) revealed that five lipid levels were associated with DR risk. …”
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Total neoadjuvant therapy based on short-course radiotherapy versus standard long-course chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis... by Wenji Pu, Wenji Pu, Wenji Pu, Wenqi Chen, Haiman Jing, Jishi Li, Yong Jiang, Shasha Li, Weijie Wen, Zhiyuan Xu, Jing Jin

“…Finally, RevMan 5.4 software was utilized to conduct the meta-analysis for determining the 95% confidence interval (CI) and pooled risk ratio (RR). There were 9 study indicators, including the pathologic complete remission (pCR) rate, tumor downstaging rate, R0 resection rate, sphincter preservation rate, disease-free survival (DFS), overall survival (OS), acute ≥3 grade toxicity rate, surgery complication rate, and distant recurrence rate. …”
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Noninvasive respiratory support following extubation in critically ill adults with obesity: a systematic review and network meta-analysisResearch in context by Joris Pensier, Arthur Naudet-Lasserre, Clément Monet, Mathieu Capdevila, Yassir Aarab, Inès Lakbar, Gérald Chanques, Nicolas Molinari, Audrey De Jong, Samir Jaber

“…Secondary outcome was 28-day mortality. We generated pooled risk ratios (RR) and numbers needed to treat (NNT). …”
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Accelerating CO₂ Outgassing in the Equatorial Pacific from Satellite Remote Sensing by Yiwu Shang, Jingyuan Xi, Yi Yu, Wentao Ma, Shuangling Chen

“…., upwelling) and western (i.e., warm pool) regions makes it difficult to fully characterize its CO₂ dynamics with limited in situ observations. …”
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Impact of pediatric tracheostomy on family caregivers’ burden and quality of life: a systematic review and meta-analysis by Win Thu Aung, Natasha Yixuan Ong, Shina Qing Chun Yeo, Nur Syahindah Binti Juhari, Gwyneth Kong, Nicole-Ann Lim, Zubair Amin, Zubair Amin, Yvonne Peng Mei Ng, Yvonne Peng Mei Ng

“…Seven studies (469 caregivers) using Pediatric Quality of Life Family Integrated Module underwent meta-analysis. The pooled mean total family impact score, parental health-related QOL, family functioning score were 70.29 [95% CI, 61.20–79.37], 69.27 [95% CI, 60.88–77.67], and 72.96 [95% CI, 65.92–80.00] respectively. …”
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