Comparative safety of the sodium glucose co-transporter 2 (SGLT2) inhibitors: a systematic review and meta-analysis by Kris Aubrey-Bassler, John-Michael Gamble, Jennifer R Donnan, Catherine A Grandy, Eugene Chibrikov, Carlo A Marra, Karissa Johnston, Michelle Swab, Jenna Hache, Daniel Curnew, Hai Nguyen

“…Random effects models were used to estimate pooled relative risks (RRs).Intervention SGLT2 inhibitors, compared with placebo or active comparators.Primary outcomes Acute kidney injury (AKI), diabetic ketoacidosis (DKA), urinary tract infections (UTI), bone fractures and lower limb amputations.Results We screened 2418 citations of which 109 were included. …”
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Comprehensive analysis of antimicrobial resistance dynamics among broiler and duck intensive production systems by Zsombor Szoke, Peter Fauszt, Maja Mikolas, Peter David, Emese Szilagyi-Tolnai, Georgina Pesti-Asboth, Judit Rita Homoki, Ildiko Kovacs-Forgacs, Ferenc Gal, Laszlo Stundl, Levente Czegledi, Aniko Stagel, Sandor Biro, Judit Remenyik, Melinda Paholcsek

“…This study examines AMR dynamics in Ross 308 broilers and Cherry Valley ducks over 15 months and 15 stocking periods under consistent rearing conditions. A total of 96 pooled samples were collected: 50 from broiler farms (26 biological, 24 environmental) and 46 from duck farms (24 biological, 22 environmental). …”
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Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study by Dongsheng Liu, Dongsheng Liu, Dongsheng Liu, Nan Wang, Nan Wang, Nan Wang, Ming Song, Ming Song, Ming Song, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Dawei Kong, Zhuhuan Song, Guangming Zhang, Lei Liu, Xiaosong Wang, Guoqiang Chen, Shaoya Yin, Shaoya Yin, Shaoya Yin, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

“…Using the above diagnostic criterion, the diagnostic accuracy yielded an area under the curve (AUC) of 0.89 across the pooled cohort (95%CI 0.79–0.99). There was an 85% correct classification between MCS and UWS, with 88% sensitivity and 81% specificity for MCS. …”
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Safety of influenza vaccination during pregnancy: a systematic review by Brian Hutton, David Moher, Danielle B Rice, Claire Butler, Andrea C Tricco, Becky Skidmore, Candyce Hamel, Chantelle Garritty, Paul A Khan, Marco Ghassemi, Charlene Soobiah, Leila Esmaeilisaraji, Dianna M Wolfe, Deshayne Fell, Mona Hersi, Nadera Ahmadzai, Alan Michaud, Angela Sinilaite

“…Control for confounding and temporal biases was inconsistent across studies, limiting pooling of data. Meta-analyses for preterm birth, spontaneous abortion and small-for-gestational-age birth demonstrated no significant associations with seasonal influenza vaccination. …”
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Prevalence of pulmonary tuberculosis and associated factors among adults living with HIV/AIDS in Ethiopia, systematic review and meta-analysis by Amlaku Nigusie Yirsaw, Berihun Agegn Mengistie, Eyob Getachew, Gebrehiwot Berie Mekonnen, Adamu Ambachew Shibabaw, Alex Ayenew Chereka, Gemeda Wakgari Kitil, Wubet Tazeb Wondie, Gebeyehu Lakew

“…Conclusion This systematic review and meta-analysis found a significant 15% pooled prevalence of pulmonary tuberculosis (PTB) among adults living with HIV/AIDS in Ethiopia. …”
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Ovarian Reserve: A Critical Indicator of Female Reproductive Health by Julia Ufnal, Anna Wolff, Maria Morawska, Dominika Lewandowska, Dominika Rosińska-Lewandoska, Marcelina Szewczyk, Klaudia Kożuchowska, Dawid Pilarz, Kinga Jarosz, Szymon Gruszka

“… Introduction: Ovarian reserve, defined as the quantity and quality of a woman’s remaining oocytes, is a critical determinant of fertility potential. The finite pool of oocytes established in utero declines progressively throughout life, which is a natural process but may result in diminished ovarian reserve (DOR) in some women. …”
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Effects of Environmental Factors on Carbon Stocks of Dry Evergreen Afromontane Forests of the Choke Mountain Ecosystem, Northwestern Ethiopia by Fikirte Asrat, Teshome Soromessa, Tesefaye Bekele, Rama Mohan Kurakalva, Sravya Sai Guddeti, David Russel Smart, Kristine Steger

“…As a result, the research reveals that environmental factors have a significant impact on carbon stock value of Choke Mountain forest ecosystem, but the impact is not consistent among carbon pools.…”
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Impacts of stem cells from different sources on wound healing rate in diabetic foot ulcers: a systematic review and meta-analysis by Le Tong, Le Tong, Le Tong, Lin Tang, Lin Tang, Lin Tang, Bangli Tang, Jianna Zhang, Jianna Zhang, Jianna Zhang

“…Asymmetrical funnel plots pointed to publication bias, but the trim-and-fill method to correct for this brought the effect estimates even lower: based on the pooled OR, corrected OR was 3.40 (95% CI 2.39–4.84). …”
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The impact of weight loss interventions on disordered eating symptoms in people with overweight and obesity: a systematic review & meta-analysisResearch in context by Elena Tsompanaki, Dimitrios A. Koutoukidis, Gina Wren, Heather Tong, Annika Theodoulou, Danni Wang, Rebecca J. Park, Susan A. Jebb, Paul Aveyard

“…Interventions included behavioural weight loss programmes (BWL) and pharmacotherapy licenced for weight loss, with or without concurrent psychological support, provided for at least 4 weeks. Pooled standardised mean differences (SMD) in scores of disordered eating were calculated using random effects meta-analyses. …”
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Association of preoperative blood biomarkers with postoperative major adverse cardiac events and mortality in major orthopaedic surgery: a systematic review and meta-analysis by Lin Lu, Yi Ren, Zhen Hua, Yanxia Sun, Zhenghao Wen, Suzhen Zhou

“…This study aimed to assess the association between preoperative blood biomarkers and postoperative MACEs as well as all-cause mortality in patients undergoing major orthopaedic surgery.Design A systematic review and meta-analysis.Data sources PubMed, EMBASE, the Cochrane Controlled Trials Register and Cochrane Database of Systematic Reviews from inception to 20 October 2024 were searched.Eligibility criteria Observational or experimental studies reporting the correlation between preoperative blood biomarkers and postoperative MACEs—categorised as short-term (within 3 months) or long-term (beyond 3 months)—and all-cause mortality in patients undergoing major orthopaedic surgery.Data extraction and synthesis Data from studies reporting OR or HR and its 95% CI were pooled for analysis using random-effects model.Results 21 preoperative blood-based biomarkers from 80 studies with 226 468 patients were analysed. …”
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Prognostic value of body adipose tissue parameters in cancer patients treated with immune checkpoint inhibitors by Yan Li, Yean Yu, Kun Lv, Rongjuan Ge, Xie Xie

“…The primary outcomes analyzed were hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS), as well as odds ratios (ORs) for disease control rate (DCR). Pooled estimates and 95% confidence intervals (CIs) were calculated.ResultsA total of 23 studies were included, encompassing 2741 cancer patients. …”
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Enhancement of convolutional neural network for urban environment parking space classification by S. Rahman, M. Ramli, F. Arnia, R. Muharar, M. Ikhwan, S. Munzir

“…The fourth layer is composed in the same way as the third layer, but with the addition of maximum pooling. The software used in the test is Python with a Python framework.FINDINGS: The proposed architecture is the Efficient Parking Network or EfficientParkingNet. …”
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Finding RB/Rpi-blb1/Rpi-sto1-like sequences in conventionally bred potato varieties by O. Y. Antonova, N. S. Klimenko, Z. Z. Evdokimova, L. I. Kostina, T. A. Gavrilenko

“…Recently these genes have been transferred into cultivated potato gene pool using the cisgene  approach. At the same time there is a high probability of finding geno types with the Rpi-sto1 gene (functional homologues of  Rpi-blb1) among conventionally bred varieties because for about 40 years S. stoloniferum has been used in breeding as a source of the Rysto and Ry-fsto genes of the extreme resistance to the most important viral pathogen PVY. …”
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Internalizing and externalizing symptoms in individuals with neurofibromatosis type 1: a systematic review and meta-analysis by Dan Liu, Liyan Yu, Xian Wu, Julia Moreira, Benjamin Felipe Mujica, Elora Shelly Mukhopadhyay, Angelena Novotney, André B. Rietman, Yang Hou

“…Study effect sizes were pooled using robust variance estimation and random-effects models. …”
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Tofacitinib Efficacy/Safety in Patients with Ankylosing Spondylitis by Baseline Body Mass Index: A Post Hoc Analysis of Phase 2/3 Trials by Hillary Norton, Paula Sliwinska-Stanczyk, Tomas Hala, Bassel El-Zorkany, Lori Stockert, Rajiv Mundayat, Lisy Wang, Christopher T. Ritchlin

“…Abstract Introduction We assessed tofacitinib efficacy and safety in ankylosing spondylitis (AS) by body mass index (BMI) category. Methods Data were pooled from phase 2/3 trials; analyses included patients with active AS randomized (1:1) to tofacitinib 5 mg twice daily or placebo, who were stratified by baseline BMI into < 25, ≥ 25 to < 30, and ≥ 30 kg/m2 categories. …”
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Therapeutic effect of proprioceptive dolphin assisted activities on health-related quality of life and muscle tension, biomechanical and viscoelastic properties in major depressive... by Brigita Kreivinienė, Laura Šaltytė-Vaisiauskė, Sonata Mačiulskytė

“…Proprioceptive dolphin assisted activities varied from heavy muscle work to muscles and joints pressure which was held in a special therapeutic pool, where adults wore wetsuits. The SF—36 scale was used, with levels of QoL compared among: (a) before dolphin assisted activities, (b) after two-week proprioceptive dolphin assisted activities, (c) in a year after two-week proprioceptive dolphin assisted activities. …”
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Deep-learning prediction of cardiovascular outcomes from routine retinal images in individuals with type 2 diabetes by Mohammad Ghouse Syed, Emanuele Trucco, Muthu R. K. Mookiah, Chim C. Lang, Rory J. McCrimmon, Colin N. A. Palmer, Ewan R. Pearson, Alex S. F. Doney, Ify R. Mordi

“…Clinical 10-year CVD risk was calculated using the pooled cohort equation (PCE) risk score. A polygenic risk score (PRS) for coronary heart disease was also obtained. …”
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The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysis by Qingling Zeng, Yuhui Yang, Limin Zhang, Jiangyu Yan, Jian Wang, Jingmin Nie, Qingmei Wang, Yu Luo, Gaoming Li

“…The prevalence of syphilis was significantly higher in men living with HIV than in women living with HIV (pooled odds ratio 1.67, 95% CI 1.29–2.15), with the highest prevalence in the eastern region (2.55, 95% CI 1.80–3.59). …”
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Comparison of biodegradable and durable polymer drug-eluting stents in acute coronary syndrome: a meta-analysis by Tingting Wei, Can Huang, Yifan Zeng, Haoyong Yuan, Zhongshi Wu, Ting Lu, Yalin Liu

“…Safety endpoints included all-cause death, cardiac death, target vessel myocardial infarction and stent thrombosis (ST).Methods We searched PubMed, Medline, Embase and the Cochrane Controlled Register of Trials for comparative studies of BP-DES and DP-DES in patients with ACS from January 2000 to July 2021. Statistical pooling was performed to estimate incidence using a random-effects model with generic inverse-variance weighting. …”
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Use of artificial intelligence for gestational age estimation: a systematic review and meta-analysis by Sabahat Naz, Sahir Noorani, Syed Ali Jaffar Zaidi, Abdu R. Rahman, Saima Sattar, Jai K. Das, Jai K. Das, Zahra Hoodbhoy

“…Five (29%) studies were from high-income countries (HICs), four (24%) from upper-middle-income countries (UMICs), one (6%) from low-and middle-income countries (LMIC), and the remaining seven studies (41%) used data across different income regions. The pooled mean error in GA estimation based on 2D images (n = 6) and blind sweep videos (n = 4) was 4.32 days (95% CI: 2.82, 5.83; l2: 97.95%) and 2.55 days (95% CI: −0.13, 5.23; l2: 100%), respectively. …”
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