A charge reversal nano-assembly prevents hepatic steatosis by resolving inflammation and improving lipid metabolism by Haoyu Wang, Sheng'e Su, Xin An, Yuan Xu, Jiacheng Sun, Mingming Zhen, Chunru Wang, Chunli Bai

“…Our nano-assembly (abbreviated as FPPD) is comprised of electropositive polyetherimide (PEI), charge-shielded dimethylmaleic anhydride (DMA), and poly(lactic-co-glycolic acid) (PLGA), which provides hydrophobic chains for self-assembly with anti-oxidative dicarboxy fullerene poly(ethylene glycol) molecule (FP). …”
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PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib by Xin‐Yuan Lei, Kai‐Yue He, Qiu‐Tong Li, Lei Zhang, Dan‐Hui Wu, Jing‐Yu Yang, Jin‐Rong Guo, Meng‐Jie Liu, Zi‐Long Zhao, Jun‐Qi Li, Huai Liu, Yuan Zhao, Yu‐Jia Li, Qian‐Hui Sun, Chen‐Guang Wu, Yun‐Fan Wang, Geng‐Sheng Cao, Gang Wang, Yong‐Ping Jian, Zhi‐Xiang Xu

“…In this study, we report the poly ADP‐ribosylation (PARylation) of HMGA1 during DNA damage, leading to desensitization of esophageal squamous cell carcinoma (ESCC) cells to the poly(ADP‐ribose) polymerase 1 (PARP1) inhibitor, olaparib. …”
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Morphological and Interfacial Engineering with a Surfactant Additive Toward High‐Performance Blade‐Coated Quantum Dot Light‐Emitting Diodes by Wei‐Zhi Liu, Hong‐Wei Duan, Shu‐Guang Meng, Dong‐Ying Zhou, Liang‐Sheng Liao

“…In this work, the blade‐coating process is explored for fabricating bottom‐emitting QLEDs using a poly(3,4‐ ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) layer modified with methanol (MeOH) and polyethylene glycol (PEG). …”
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Novel adaptive immune systems in pristine Antarctic soils by Marc W. Van Goethem, Oliver K. I. Bezuidt, Rian Pierneef, Surendra Vikram, David W. Hopkins, Thomas Aspray, Grant Hall, Stephan Woodborne, Ian D. Hogg, Trent R. Northen, Weidong Kong, Daniele Daffonchio, Don A. Cowan, Yves Van de Peer, Manuel Delgado-Baquerizo, Thulani P. Makhalanyane

“…Using genome-resolved metagenomics, we test the hypothesis that Antarctic poly-extreme high-latitude microbiomes harbour diverse adaptive immune systems. …”
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Palmprint recognition based on the line feature local tri‐directional patterns by Mengwen Li, Huabin Wang, Huaiyu Liu, Qianqian Meng

“…The matching scores of the two feature vectors are weighted differently in the matching stage to reduce intra‐class distance and increase inter‐class distance. Experiments on PolyU, PolyU Multi‐spectral, Tongji, CASIA and IITD palmprint databases show that LFLTriDP achieves promising recognition performance.…”
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Combinations of TLR Ligands: A Promising Approach in Cancer Immunotherapy by Saskia Stier, Claudia Maletzki, Ulrike Klier, Michael Linnebacher

“…To clarify TLRs’ role in colorectal cancer (CRC), we tested the impact of the TLR ligands LPS, Poly I:C, R848, and Taxol on primary human CRC cell lines (HROC40, HROC60, and HROC69) in vitro and in vivo (CT26). …”
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Whole Slide Imaging Based Digital Pathology Network between Pakistan and USA by Syeda Fatima Absar, Mohammad Tahir, Yukako Yagi, David Wilbur

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Management of Necrotising Fasciitis

“…Infection is usually of poly-microbial drug resistant organisms. Fasciotomy and surgical debridment was done in these cases under antibiotic cover but antibiotics failed to prove as effective mode of treatment …”
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Synthesis and Characterization of PPV Monomer for Subsequent Electropolymerization by Álvaro Fontana, Fábio Santana dos Santos, Flávia Aparecida Fonseca, Adonilson Dos Reis Freitas, Andersson Barison, Jarem Raul Garcia

“…Organic synthesis of the monomer of poly(p-phenylenevinylene) was performed starting by the 2,5-dimethylphenol compound. …”
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Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs by Siyuan Deng, Han Shao, Hongtao Shang, Lingjin Pang, Xiaomeng Chen, Jingyi Cao, Yi Wang, Zhao Zhao

“…<b>Methods:</b> We synthesized a cationic and ampholytic di-block copolymer, poly (poly (ethylene glycol)_4-5 methacrylate_a-<i>co</i>-hexyl methacrylate_b)_X-<i>b</i>-poly(butyl methacrylate_c-<i>co</i>-dimethylaminoethyl methacrylate_d-<i>co</i>-propyl acrylate_e)_Y (p(PEG_4-5MA_a-<i>co</i>-HMA_b)_X-<i>b</i>-p(BMA_c-<i>co</i>-DMAEMA_d-<i>co</i>-PAA_e)_Y), via reversible addition–fragmentation chain transfer polymerization. …”
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Determination of damaging SNP’s in SHANK3 gene with in silico methods by İrem Gülfem Albayrak, Şeyma Yektar, Süeda Kaya

“…Among these, 30 SNPs were confirmed damaging by both SIFT and PolyPhen-2, and 28 led to increased protein stability while two decreased it. …”
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The influence of concentration of Nd-Fe-B powder in composite coating of optical fiber to the sensibility to external magnetic field by Radojević Vesna J., Serbez T., Aleksić R., Nedeljković D., Brajović Lj.

“…Multi-mode optical fiber with magnetic composite coating was investigated as an optical fiber sensor element (OFMSE) for magnetic field sensing The composite coating was formed with dispersions of permanent magnet powder of Nd-Fe-B in poly (ethylene-co-vinyl acetate)-EVA solutions in toluene. …”
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Pleiotropic effects of mutant huntingtin on retinopathy in two mouse models of Huntington's disease by Hui Xu, Anakha Ajayan, Ralf Langen, Jeannie Chen

“…Huntington's disease (HD) is caused by the expansion of a CAG repeat, encoding a string of glutamines (polyQ) in the first exon of the huntingtin gene (HTTex1). …”
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Tadpole-Shaped POSS-Based Copolymers and the Aggregation Behavior at Air/Water Interface by Lin Zhu, Fang Chen, Xiaoyan Ma, Xiu Qiang, Zhiguang Li, Chen Dong, Duyang Zang

“…The aggregation behavior of three tadpole-shaped Polyhedral oligomeric silsesquioxane (POSS) based block copolymers using different blocks poly(methyl methacrylate) (PMMA) and poly(trifluoroethyl methacrylate) (PTFEMA) with different block sequence and ratio (POSS-PTFEMA161-b-PMMA236, POSS-PMMA277-b-PTFEMA130, and POSS-PMMA466-b-PTFEMA172) was investigated on the air-water interface. …”
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Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair by Yi Sun, Jingyun Liu, Kaijia Chen, Nannan Zhong, Chengpeng He, Xinming Luan, Xiaobei Zang, Jianbo Sun, Ning Cao, Wenbo Wang, Qiang Ren

“…A range of PEEK composite materials, including sulfonated polyether ether ketone (SPEEK), polydopamine-sulfonated polyether ether ketone (SPEEK-PDA), bone-forming peptide-poly-dopamine-sulfonated polyether ether ketone (SPEEK-PDA-BFP), and vascular endothelial growth factor-poly-dopamine-sulfonated polyether ether ketone (SPEEK-PDA-VEGF), were constructed by concentrated sulfuric acid sulfonation, polydopamine modification and grafting of bioactive factors. …”
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An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…In these devices, fabricated on flexible plastic substrates, the active material (reduced graphene oxide, rGO) is deposited by printing and then functionalized with Au nanoparticles decorated with polyU RNA reporter strands. In this system, the CRISPR/Cas13a complex acts as a catalyst: in the presence of a specific RNA target sequence, the enzymatic function is activated and the polyU RNA reporter strands are cleaved from the Au nanoparticles, inducing a loss of negative charges on the rGO layer. …”
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DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells by Maria Cristina Grimaldi, Sara Bozzer, Dick J. Sjöström, Dick J. Sjöström, Linnea I. Andersson, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Luca De Maso, Federico Riccardi, Michele Dal Bo, Daniele Sblattero, Paolo Macor

“…However, the nanoplatform must guarantee both the local production of the protein and the safety of the treatment to allow an effective therapy with reduced systemic toxicity.MethodsIn order to ensure a selective delivery of nucleic acids, we developed poly(lactic-co-glycolic acid) (PLGA)-poly(vinyl alcohol) (PVA) NPs loaded with an Enhanced Green Fluorescent Protein (EGFP)-coding plasmid and covalently coated with antiCD19 recombinant antibody as a targeting mechanism. …”
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Revealing enhanced dilution effect of conjugated polymers in partially miscible blends by Hongbo Chen, Ming Hu, Yuehua Zhao, Kaixuan Lyu, Yushuai Xu, Yuansheng Sun, Zhiyuan Xie, Jinying Huang, Dapeng Wang

“…In this work, we propose a cascade analysis by combining multiple fluorescence microscopic techniques and all‐atom molecular dynamics simulations to study the solid‐to‐solid dilution of poly[2‐methoxy‐5‐(2‐ethylhexyloxy)‐1,4‐phenylenevinylene] (MEH‐PPV) in MEH‐PPV/polystyrene (PS) blends and MEH‐PPV/poly(vinylcarbazole) (PVK) blends. …”
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Investigation of Gamma Radiation Shielding in NiMnGa-Doped Multifunctional Smart Polymer Composites Using Geant4 and WinXCOM by Mediha Kök, Mustafa Ersin Pekdemir, Seçil Niksarlıoğlu, Serpil Yalçın Kuzu, Mustafa Kaya

“…This study assesses the gamma radiation shielding efficiency of polymer composites doped with varying amounts of alloy, using software to demonstrate the potential application of innovative materials in radiation protection. Specifically, Poly Lactic Acid (PLA) and Poly Ethylene Glycol (PEG) composites doped with NiMnGa at concentrations of 2, 6, 10, and 15% were analyzed across an energy range of 0.0595 to 1.41 MeV using Geant4 and WinXCOM software. …”
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Effect of maturity status on lower-limb strength testing reliability in academy football players from an elite professional club by Maxime Violin, Abd-elbasset Abaïdia, Guillaume Rave, Sébastien Ratel

“…In addition, lower-limb strength testing reliability may also vary according to movements performed, whether these are mono- or poly-articular. In this sense, it is possible to suggest that pre-pubertal players exhibit lower scores of test-retest reliability during poly-articular movements than their older counterparts because of their poorer motor coordination due to immaturity of cerebellum. …”
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