The Long Last Mile of Polio Eradication by Sanjay Chaturvedi

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The evolution, facilitators, barriers, and additional activities of acute flaccid paralysis surveillance platform in polio eradication programme Bangladesh: a mixed-method study by Humayra Binte Anwar, Yameen Mazumder, Sanjana Nujhat, Bushra Zarin Islam, Anna Kalbarczyk, Olakunle Alonge, Malabika Sarker

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Post-vaccination campaign evaluation of systemic and mucosal immunity of trivalent oral poliovirus vaccine in Karachi, Pakistan (2020–2021): a cross-sectional studyResearch in cont... by Ali Faisal Saleem, Visalakshi Jeyaseelan, Zaubina Kazi, Mahjabeen Zehra, Muhammad Masroor Alam, Grace Macklin, Rocio Lopez Cavestany, Sajid Muhammad, Najeeb Rehman, Ondrej Mach

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Tracking acute flaccid paralysis in Niger: a half-decade epidemiological portrait (2016–2021) by El Khalef Ishagh, Marc Talatou Ouédraogo, Batouré Oumarou, Mutenda Sheria Kaya, Gbaguidi Aichatou Diawara, Abdoulaye Macire Camara, Seyni Moussa, Kuyangisa Bienvenu, Joseph Toko, Hamidou Harouna, Haladou Moussa, N.’Zue Kofi, Jacques L. Tamuzi, Patrick D. M. C. Katoto, Charles S. Wiysonge, Blanche-Philomene Melanga Anya, Manengu Casimir Tshikolasoni

“…Enhancing these aspects can improve public health efforts in conflict-affected areas and contribute to polio eradication in the region.…”
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Characterization of environmental and clinical surveillance inputs to support prospective integrated modeling of the polio endgame. by Kamran Badizadegan, Kimberly M Thompson

“…Relatively recently, the GPLN expanded to include environmental surveillance to obtain additional information about poliovirus transmission in some geographies and to increase confidence about the absence of poliovirus transmission after successful eradication and/or the cessation of use of live-attenuated oral poliovirus vaccines (OPVs). Historical polio eradication strategic plans anticipated that successful global poliovirus eradication would lead to reduced requirements for financial investments for a poliovirus-specific surveillance system, and consequent transition of capacity and resources into integrated national disease surveillance systems. …”
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Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination by Darja Kanduc, Candida Fasano, Giovanni Capone, Antonella Pesce Delfino, Michele Calabrò, Lorenzo Polimeno

“…Although rare, adverse events may associate with anti-poliovirus vaccination thus possibly hampering global polio eradication worldwide. Objective. To design peptide-based anti-polio vaccines exempt from potential cross-reactivity risks and possibly able to reduce rare potential adverse events such as the postvaccine paralytic poliomyelitis due to the tendency of the poliovirus genome to mutate. …”
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Documenting and Reporting Implementation Strategies of Vaccination Efforts (DRIVE) framework for fostering systems learning to enhance cross-context replication in immunization pro... by Abdu A. Adamu, Amos Petu, Balcha G. Masresha, Blaise Bathondoli, Rabiu Ibrahim Jalo, Duduzile Ndwandwe, Charles S. Wiysonge

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Advancing poliovirus eradication: lessons learned from piloting direct molecular detection of polioviruses in high-risk and priority geographies by Paula L. Marcet, Brandon Short, Ashley Deas, Hong Sun, Chelsea Harrington, Shahzad Shaukat, Muhammad Masroor Alam, Marycelin Baba, Adedayo Faneye, Prossy Namuwulya, Lea Necitas Apostol, Tamer Elshaarawy, John Kofi Odoom, Peter Borus, Shelina Moonsamy, Yogolelo Riziki, Marie Claire Endegue Zanga, Mesfin Tefera, Anfumbom K. W. Kfutwah, Salmaan Sharif, Varja Grabovac, Cara C. Burns, Nancy Gerloff

“…DD-ITD implementation would entail building proficiency in advanced molecular laboratory techniques and data analysis, and increased demand for confirmatory sequencing.IMPORTANCESurveillance of acute flaccid paralysis (AFP) and sensitive poliovirus detection are key components of the WHO Global Polio Eradication Strategy. This work summarizes the results of a multi-laboratory evaluation designed to field-test the performance and applicability of a molecular Direct Detection strategy (DD-ITD) that does not require amplification of live poliovirus. …”
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