Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans by Yifan Xiang, Vineeta Tanwar, Parminder Singh, Lizellen La Follette, Vikram Pratap Narayan, Pankaj Kapahi

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Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness by Christopher R Bauer, Shuang Li, Mark L Siegal

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Inheritance of Indehiscent Capsule Character, Heritability and Genetic Advance Analyses in the Segregation Generations of Dehiscent x Indehiscent Capsules in Sesame by Engin Yol, Bulent Uzun

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A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics by Richard Head, Saiful Islam, Jennifer H. Martin

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Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices by BaHammam AS, Jahrami H

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A Trade‐Off Between Antimicrobial Peptide Resistance and Sensitivity to Host Immune Effectors in Staphylococcus aureus In Vivo by Baydaa El Shazely, Jens Rolff

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Exploring the Pleiotropy of PCSK9: A Wide Range of Influences from Lipid Regulation to Extrahepatic Function by Wang H, Tang G, Wu J, Qin X

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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

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Clinical Aspects of a Rare Disease: Bardet Biedl Syndrome by Ina Ofelia FOCSA, Magdalena BUDISTEANU, Cristina STOICA, Florina NEDELEA, Claudia JURCA, Lavinia CABA, Lacramioara BUTNARIU, Monica PANZARU, Cristina RUSU, Mihaela BALGRADEAN

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The potential of inversions to accumulate balanced sexual antagonism is supported by simulations and Drosophila experiments by Christopher S McAllester, John E Pool

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Bidirectional two-sample Mendelian randomization analysis unveils causal association between inflammatory cytokines and the risk of diabetic nephropathy by Siyuan Song, Qianhua Yan, Jiangyi Yu

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Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation by Wei-Yun Lai, Sheng-Kai Hsu, Andreas Futschik, Christian Schlötterer

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The genetic overlap and causal relationship between attention deficit hyperactivity disorder and obstructive sleep apnea: a large-scale genomewide cross-trait analysis by Yao Tong, Yan-Jing Chen, Guang-Bin Cui

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Tradeoffs between proliferation and transmission in virus evolution– insights from evolutionary and functional analyses of SARS-CoV-2 by Jui-Hung Tai, Ding-Chin Lee, Hsin-Fu Lin, Tai-Ling Chao, Yongsen Ruan, Ya-Wen Cheng, Yu-Chi Chou, You-Yu Lin, Sui-Yuan Chang, Pei-Jer Chen, Shiou-Hwei Yeh, Hurng-Yi Wang

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Pleiotropic expression quantitative trait loci are enriched in enhancers and transcription factor binding sites and impact more genes by Aitor González, Pascale Paul

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Shared genetic architecture between stroke and blood lipids: a large-scale genome-wide cross-trait analysis by Wenya Bai, Guilin Zhou, Huan Jiang, Xuelian Li, Jianlin Shao

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Investigating the shared genetic architecture between Parkinson's disease and magnetic susceptibility of the substantia nigra by Jilian Fu

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Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk by Nicolas P. Ciochetti, Victor F. de Oliveira, Iago Junger-Santos, Cibele E. Bandeira, Maria E. Tavares, Eduardo S. Vitola, Luis A. Rohde, Gustavo Melo de Andrade, Bruna S. da Silva, Eugenio H. Grevet, Claiton H. Dotto Bau, Diego L. Rovaris

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Cortical and Striatal Functional Connectivity in Juvenile-Onset Huntington’s Disease by Amy Barry, Peg C. Nopoulos

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Shared Genetic Links Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease by Hua Di, Shouhao Wang, Chengan Xu, Qiaoqiao Yin, Keyang Xu, Wei Zheng

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