The Exposure to Osteoarthritic Synovial Fluid Enhances the Immunomodulatory Profile of Adipose Mesenchymal Stem Cell Secretome by Adriana Cifù, Rossana Domenis, Massimo Pozzi-Mucelli, Paolo Di Benedetto, Araldo Causero, Massimo Moretti, Marta Stevanato, Cinzia Pistis, Pier Camillo Parodi, Martina Fabris, Francesco Curcio

“…Several clinical studies have proposed the infusion of adipose mesenchymal stem cells (AMSCs) as an alternative therapy for joint diseases with inflammatory components, such as osteoarthritis. …”
Get full text

Bell’s Palsy: Symptoms Preceding and Accompanying the Facial Paresis by Daniele De Seta, Patrizia Mancini, Antonio Minni, Luca Prosperini, Elio De Seta, Giuseppe Attanasio, Edoardo Covelli, Andrea De Carlo, Roberto Filipo

“…Our findings could be of important interest to early address a BP patient to further examinations and subsequent therapy.…”
Get full text

Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions by Kyle D. Gromer, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Colin Shearn, Swati Antala, Swati Antala, Joshua B. Wechsler, Carla M. Cuda, Cara L. Mack, Ronald J. Sokol, William J. Janssen, Richard M. Green, Harris Perlman, Deborah R. Winter, Sarah A. Taylor, Sarah A. Taylor

“…IntroductionMacrophages play an important role in disease progression of pediatric cholestatic liver disease, particularly biliary atresia (BA); however, the restorative versus pathogenic role for precise macrophage subsets remains poorly defined. …”
Get full text

Prevention of Cyclophosphamide-Induced Immunosuppression in Mice with the Antimicrobial Peptide Sublancin by Shuai Wang, Shuo Huang, Qianhong Ye, Xiangfang Zeng, Haitao Yu, Desheng Qi, Shiyan Qiao

“…Taken together, these findings suggest that sublancin plays a crucial role in the protection against immunosuppression in cyclophosphamide-treated mice and could be a potential candidate for use in immune therapy regimens.…”
Get full text

LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation by Litao Liang, Wenbo Jia, Jinyi Wang, Yanzhi Feng, Deming Zhu, Wenhu Zhao, Chao Xu, Xiangyu Ling, Qingpeng Lv, Xiaoming Ai, Lianbao Kong, Wenzhou Ding

“…Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and a major public health challenge. Lipid metabolism plays a crucial role in the metabolic reprogramming observed in HCC, although the underlying mechanisms are still being elucidated. …”
Get full text

Epigenetic Mechanisms in Type-2 Diabetes Mellitus: A Narrative Review by Deenadhayalan Ashok, Monisha Prasad, Mohammad Fareed, Anis Ahmad Chaudhary

“…With an emphasise on the part that epigenetics plays in the pathophysiology of T2DM, the present study attempts to give a thorough overview of the mechanisms behind disease initiation, possible biomarkers, and the consequences for T2DM. …”
Get full text

The role of interleukin-17 in inflammation-related cancers by Xingru Zhang, Xingru Zhang, Bangjie Li, Tian Lan, Tian Lan, Conner Chiari, Xiaoyang Ye, Kepeng Wang, Ju Chen

“…IL-17 is a highly versatile pro-inflammatory cytokine that plays a pivotal role in host defense, tissue repair, the pathogenesis of inflammatory diseases, and cancer progression. …”
Get full text

FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury by Chonghui Tang, Yudong Shan, Yilan Hu, Zhanjian Fang, Yun Tong, Mengdan Chen, Xiaojie Wei, Xiaojun Fu, Xinlong Xu

“…This study extended our understanding of FGF2’s neuroprotective effects and shed lights on the pharmacological therapy after TBI.…”
Get full text

Correlation between Intraoperative Fluid Administration and Outcomes of Pancreatoduodenectomy by Xuefeng Cao, Xixiu Wang, Baolei Zhao, Lingqun Kong, Lei Zhou, Wentao Zhu, Xutao Lin, Qiangpu Chen, Xingyuan Zhang

“…Intraoperative fluid (IOF) administration plays an important role during major abdominal surgery although increased fluid intake can adversely influence postoperative outcomes. …”
Get full text

Prognostic Relevance and Function of MSX2 in Colorectal Cancer by Jiancheng Liu, Huaying An, Wei Yuan, Qiang Feng, Lianzhen Chen, Jie Ma

“…In vitro experiments demonstrated that knockdown of MSX2 expression attenuated cell proliferation and invasion, promoted cell cycle arrest and apoptosis, and inactivated Akt phosphorylation. In conclusion, MSX2 played a crucial role in the progression of CRC and may be a potential novel prognostic factor and therapeutic target for CRC therapy. …”
Get full text

Effect of Compression Loading on Human Nucleus Pulposus-Derived Mesenchymal Stem Cells by Hang Liang, Sheng Chen, Donghua Huang, Xiangyu Deng, Kaige Ma, Zengwu Shao

“…Purpose. Mechanical loading plays a vital role in the progression of intervertebral disc (IVD) degeneration, but little is known about the effect of compression loading on human nucleus pulposus-derived mesenchymal stem cells (NP-MSCs). …”
Get full text

Knockdown of Fibromodulin Inhibits Proliferation and Migration of RPE Cell via the VEGFR2-AKT Pathway by He Hu, Shanshan Li, Jianqiao Li, Chao Huang, Fang Zhou, Li Zhao, Wenzhen Yu, Xiao Qin

Get full text

Polydatin-Induced Shift of Redox Balance and Its Anti-Cancer Impact on Human Osteosarcoma Cells by Alessio Cimmino, Magda Gioia, Maria Elisabetta Clementi, Isabella Faraoni, Stefano Marini, Chiara Ciaccio

“…Overall, our findings underscore that PD-induced redox imbalance plays a crucial role in its anti-OS effects, warranting further exploration into the molecular mechanisms behind its pro-oxidant activity.…”
Get full text

The Transcription Factor SOX18 Inhibitor Small Molecule 4 Is a Potential Treatment of Cancer‐Induced Lymphatic Metastasis and Lymphangiosarcoma by Katja K. Koll, Martin M. Zimmermann, Patrick A. Will, Ulrich Kneser, Christoph Hirche

“…The transcription factor SOX18 plays a crucial role in both lymphatic endothelial cell differentiation and cancer‐induced lymphangiogenesis. …”
Get full text

SALIVARY SPECIFIC IgE TO D1 AND G6 IN PATIENTS WITH RHINITIS WITH OR WITHOUT S. AUREUS COLONIZATION by Diana Hristova, Antoaneta Decheva, Deyan Donchev, Damyan Vangelov, Vancho Donev, Georgi Nikolov, Maria Nikolova

“…Immunoglobulin E (IgE) plays a crucial part in allergic inflammation, with two sources: spontaneously produced IgE, and IgE stemming from reactions to environmental allergens. …”
Get full text

Acupuncture for Chronic Prostatitis or Chronic Pelvic Pain Syndrome: An Updated Systematic Review and Meta-Analysis by Juanhong Pan, Song Jin, Quan Xie, Ying Wang, Zhipeng Wu, Jianfeng Sun, Tai Pin Guo, Di Zhang

“…Meta-analysis showed that compared to sham acupuncture (SAT) and western medicine (WM), acupuncture (AT) played superior roles for CP/CPPS patients in pain score, NIH-CPSI score, quality of life score, urinary symptom, and efficacy rate. …”
Get full text

Feasibility and accuracy of CARLO© guided optic canal unroofing by Schicker Martina, Tu Ha Thanh, Luder Yann, Morawska Marta, Röthlisberger Michel

“…The surgical procedure known as optic nerve unroofing plays a vital role in skull base surgery. This critical intervention focuses on relieving pressure and decompressing the optic nerve to safeguard vision, restore optimal nerve function, and enhance the surgical view during aneurysm therapy. …”
Get full text

Relationship between dietary intake and atherogenic index of plasma in cardiometabolic phenotypes: a cross-sectional study from the Azar cohort population by Shirin Soheilifard, Elnaz Faramarzi, Reza Mahdavi

Get full text

Contribution of vitamin B 6 deficiency to anemia in children on regular hemodialysis by Fatma Atia, Hafez Bazaraa, Yara Abdelatty, Sarah Lotfy, Eman Eryan

“…However, a significant proportion of patients remain anemic. Vitamin B6 plays a vital role in the biosynthesis of heme and may be deficient in children with chronic kidney disease (CKD), particularly those on regular hemodialysis (HD). …”
Get full text

EVALUATION OF ANTIBACTERIAL ACTIVITY OF TRICHILIA DREGEANA SOND (MELIACEAE) CRUDE EXTRACTS AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA by Tesfa Mossie, Temesgen Kasa, Bekesis Urge, Hilena Yifred

“… Medicinal plants have been playing a crucial role in drug discovery and development against infectious diseases. …”
Get full text