Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts by Yi Wang, Guihua Chen, Deng Li

“…Abstract Clinically, phosphodiesterase type 5 inhibitors (PDE5-Is) remain the first-line therapy for erectile dysfunction (ED) patients; however, approximately 35% of these patients are still failing to respond to the therapeutic effects. …”
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The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches by Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner

“…Integrating epigenetic modulation with senolytic therapy offers a dual approach to improving healthspan and mitigating age-related pathologies. …”
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Functional morphology of digestive organs of newborn calves and pathogenesis of escherichiosis by S. M. Suleymanov

“…Digestive organ pathology plays the leading role in formation of the clinical and morphological picture at the initial stage of escherichiosis in calves. …”
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Double-Hit Primary Plasma Cell Leukemia with IGH/MYC and IGH/CCND1 Translocations by Masato Yasumi, Takaya Endo, Hiroshi Sata, Takahiro Karasuno

“…Although IGH/MYC translocation in association with dysregulation of antiapoptotic pathway leads to worse prognosis in lymphomas, the novel agent-based regimen showed good efficacy, suggesting that IGH/MYC plays a different role in the pathogenesis of MM. …”
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The Effect of P-Cymene on Glucose, Insulin, Antioxidant Power, and the Level of AKT Gene mRNA in Streptozotocin-Induced Diabetes Model in Male Wistar Rats by Maryam Arabloei Sani, Zahra Hajebrahimi, Parichehreh Yaghmaei, Nasim Hayati Roodbari

“…The AKT signaling pathways plays a critical role in regulating glucose homeostasis and proliferation of β cells. …”
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College Students’ Mental Health Education Consulting Management System Design Based on Big Data Algorithms by Xuezhen Song

“…Many people believe that the main purpose of student mental health education is to focus on counseling and therapy for some students with mental health problems. …”
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A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis by Jiwei Xue, Fanfan Xie, Junmei Xu, Yuan Liu, Yu Liang, Zhining Wen, Menglong Li

“…MicroRNA (miRNA) plays an important role in the degradation and inhibition of mRNAs and is a kind of essential drug targets for cancer therapy. …”
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A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis by Aleksandar R. Zivkovic, Sebastian O. Decker, Anne C. Zirnstein, Annette Sigl, Karsten Schmidt, Markus A. Weigand, Stefan Hofer, Thorsten Brenner

“…Early sepsis identification is of paramount importance for an effective therapy and the patient outcome; however, a suitable prognostic biomarker is lacking. …”
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Investigating the Existence of Ribosomal Protein L5 Gene in Syrian Strain of Leishmania tropica Genome: Sequencing It and Evaluating Its Immune Response as DNA Vaccine by Mohammad Maarouf, Alyaa A. Abdlwahab

“…Until now, there are no effective protective strategies, safe therapy, or efficacious vaccine to protect from this infection. …”
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Improving employee performance through compensation in savings and loans cooperatives by Sonny Hersona, Yamarthin Partogi Tarihoran, Sari Sekarini, Vicky Alvin Nugraha, Hilmy Muhammad Iqbal

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GnRH Peptide Antagonist: Comparative Analysis of Chemistry and Formulation with Implications for Clinical Safety and Efficacy by Shikha Patel, Bhagawati Saxena, Priti Mehta, Sarfaraz K. Niazi

“…Overexpression of the gonadotropin-releasing hormone receptor (GnRH-R) plays a vital role in the advancement of reproductive malignancies such as ovarian, endometrial, and prostate cancer. …”
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Relationship between Antibiotic Consumption and Resistance: A Systematic Review by Asrat Agalu Abejew, Gizachew Yismaw Wubetu, Teferi Gedif Fenta

“…Thus, advocating the implementation of stewardship programs plays a pivotal role in containing ABR.…”
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Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression by Elisa Carouge, Clémence Burnichon, Martin Figeac, Shéhérazade Sebda, Nathalie Vanpouille, Audrey Vinchent, Marie‐José Truong, Martine Duterque‐Coquillaud, David Tulasne, Anne Chotteau‐Lelièvre

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Evaluation of multidrug resistance in the Gram-negative microbiome of cancer patients and the adverse effects of their metabolites on albino rats and epithelial or fibroblasts cell... by Mervat Morsy Abbas Ahmed El-Gendy, Huda Ahmed Alghamdi, Khaled G. Abdel-Wahhab, Nabila S. Hassan, Aya A. M. El-Bondkly, Mohammed Abdel-Wahab, Ayman A. Farghaly, Ahmed Mohamed Ahmed El-Bondkly

“…All isolates derived from the cancer microbiome exhibited multidrug resistance to a large number of conventional therapies. Out of them Serratia sp. Esraa 1, Stenotrophomonas sp. …”
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Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation by Wenlong Shang, Guilin Chen, Yinxiu Li, Yujuan Zhuo, Yuhong Wang, Zhicai Fang, Ying Yu, Huiwen Ren

“…Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role in the healing process including the resolution phase. …”
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The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases by Huihui Xu, Meijie Liu, Jinfeng Cao, Xiaoya Li, Danping Fan, Ya Xia, Xiangchen Lu, Jingtao Li, Dahong Ju, Hongyan Zhao

“…Gut microbiota dysbiosis plays a crucial role in autoimmune disease pathogenesis as well as in bowel-related diseases. …”
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Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men by Madhu N. Rao, Morris Schambelan, Viva W. Tai, Donald I. Abrams, Hootan Khatami, Peter J. Havel, Giorgos Sakkas, Kathleen Mulligan

“…There is emerging evidence that leptin, a hormone secreted by adipocytes, plays an important role in bone metabolism. Several studies have assessed the relationship between leptin and bone density in healthy adults, but there are few such studies in HIV-infected individuals. …”
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RTEL1 is upregulated in gastric cancer and promotes tumor growth by Chunyu Yang, Suzeng Wang, Ge Gao, Peiwen Xu, Mengyuan Qian, Yuan Yin, Surui Yao, Zhaohui Huang, Zehua Bian

“…These findings suggest that RTEL1 plays a critical role in GC tumorigenesis and could be a promising target for the therapy and prognosis of GC.…”
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New Prospects of Cytoprotection in the Treatment and Prevention of Gastric and Intestinal Diseases (Resolution of an Expert Council and Literature Review) by A. I. Martynov, A. A. Sheptulin, I. V. Mayev, A. N. Kazyulin, A. Ye. Karateev, A. V. Melekhov, L. K. Pal’gova, K. L. Raikhel’son

“…In the treatment of gastroesophageal reflux disease, Rebamipide is recommended for patients refractory to therapy with proton pump inhibitors (PPIs) and for those with non-acid reflux. …”
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Endothelin Receptors Expressed by Immune Cells Are Involved in Modulation of Inflammation and in Fibrosis: Relevance to the Pathogenesis of Systemic Sclerosis by Tinazzi Elisa, Puccetti Antonio, Patuzzo Giuseppe, Barbieri Alessandro, Argentino Giuseppe, Confente Federico, Dolcino Marzia, Beri Ruggero, Marchi Giacomo, Ottria Andrea, Righetti Daniela, Rampudda Mariaelisa, Lunardi Claudio

“…Endothelin-1 (ET-1) plays a pivotal role in vasoconstriction, fibrosis, and inflammation, the key features of systemic sclerosis (SSc). …”
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