Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation by Lenka Dzurová, Edita Holásková, Hana Pospíšilová, Gabriela Schneider Rauber, Jitka Frébortová

“…Cathelicidins are a group of cationic, amphipathic peptides that play a vital role in the innate immune response of many vertebrates, including humans. …”
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Glyoxylate, a New Marker Metabolite of Type 2 Diabetes by Victoria J. Nikiforova, Pieter Giesbertz, Jan Wiemer, Bianca Bethan, Ralf Looser, Volker Liebenberg, Patricia Ruiz Noppinger, Hannelore Daniel, Dietrich Rein

“…Reactive aldehydes derived from sugars play an important role in the generation of AGEs. …”
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A Biopsychosocial Overview of Speech Disorders: Neuroanatomical, Genetic, and Environmental Insights by Diya Jaishankar, Tanvi Raghuram, Bhuvanesh Kumar Raju, Divyanka Swarna, Shriya Parekh, Narendra Chirmule, Vikramsingh Gujar

“…Neuroanatomical structures, such as Broca’s area, Wernicke’s area, the arcuate fasciculus, and basal ganglia, along with their connectivity, play critical roles in speech production, comprehension, and motor coordination. …”
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Aberrant Expression of JAM2 Inhibits Invasion and Migration in Lung Adenocarcinoma by Jun Chen, Yuan Cui, Zhimeng Chen, Hao Ding, Chang Li, Sheng Ju, Cheng Ding, Chun Xu, Jun Zhao, Xin Tong

“…JAM2, a member of the Junctional adhesion molecule (JAM) family, plays diverse roles in cell–cell contacts and tumor development. …”
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Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells by Roberta Santarelli, Paola Currà, Michele Di Crosta, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone

“…Epigenetic abnormalities play a critical role in colon carcinogenesis, making them a promising target for therapeutic interventions. …”
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Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid by Leah A. Marquez-Curtis, Yuanyuan Qiu, April Xu, Anna Janowska-Wieczorek

“…The interactions between stromal cell-derived factor (SDF)-1 and its receptors CXCR4 and CXCR7 play pivotal roles in the migration of MSC to injured tissues. …”
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Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents by null Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani

“…By fine-tuning drug release profiles and enhancing drug uptake at specific sites, LBDDS can potentially target renin-angiotensin-aldosterone system components, sympathetic nervous system pathways, and endothelial dysfunction, all of which play crucial roles in hypertension pathophysiology. …”
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Transcriptome sequencing reveals regulatory genes associated with neurogenic hearing loss by Fengfeng Jia, Fang Wang, Song Li, Yunhua Cui, Yongmei Yu

“…Through differential gene expression analysis, we identified key genes, including ICAM1, SLC1A1, and CD24, which have already been shown to play important roles in neurogenic hearing loss. …”
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Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer? by Raisa Nauli, Sri Widia A Jusman

“…Protoporphyrin combines with a protein-forming hemoprotein compound that plays an essential role in oxygen-binding and transport as well as in the process of energy production in the mitochondria. …”
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Epidemiology of Kidney Cancer by D. Pascual, A. Borque

“…Viral infections and radiation therapy have also been described as risk factors. …”
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Interleukin 2-Based Fusion Proteins for the Treatment of Cancer by Alana MacDonald, T.-C. Wu, Chien-Fu Hung

“…Interleukin 2 (IL-2) plays a fundamental role in both immune activation and tolerance and has revolutionized the field of cancer immunotherapy since its discovery. …”
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Role of Endoscopy in the Investigation of Upper Gastrointestinal Symptoms in HIV-Infected Patients by C Mel Wilcox

“…Endoscopy plays a pivotal role in the management of patients with the acquired immunodeficiency syndrome (AIDS), because tissue documentation of opportunistic processes is often necessary to establish a definitive diagnosis. …”
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Exploring cardiovascular implications in systemic lupus erythematosus: A holistic analysis of complications, diagnostic criteria, and therapeutic modalities, encompassing pharmacol... by Dawi John, Affa Scarlet, Misakyan Yura, Fardeheb Sabrina, Kades Samuel, Kiriaki Anthony, Mohan Aishvaryaa Shree, Norris Brandon, Yoon Sonyeol, Venketaraman Vishwanath

“…Anti-malarial therapy, particularly hydroxychloroquine, shows promise in mitigating cardiovascular risk factors. …”
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Endoscopic Management of Portal Hypertension by Said A. Al-Busafi, Peter Ghali, Philip Wong, Marc Deschenes

“…Cirrhosis is the leading cause of portal hypertension worldwide, with the development of bleeding gastroesophageal varices being one of the most life-threatening consequences. Endoscopy plays an indispensible role in the diagnosis, staging, and prophylactic or active management of varices. …”
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Patients’ preferences on atopic dermatitis skincare and social media use: a qualitative study by Roxana Mazilu, Stefanie Ziehfreund, Stephan Traidl, Alexander Zink

“…Over-the-counter products play a crucial role in AD treatment. The emergence of social media (SM) as a vast information source for skincare and healthy lifestyle has transformed its role from mere entertainment. …”
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Angiogenesis and Its Therapeutic Opportunities by So Young Yoo, Sang Mo Kwon

“…Angiogenesis plays critical roles in human physiology that range from reproduction and fetal growth to wound healing and tissue repair. …”
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Role of Microbiota and Innate Immunity in Recurrent Clostridium difficile Infection by Stefano Bibbò, Loris Riccardo Lopetuso, Gianluca Ianiro, Teresa Di Rienzo, Antonio Gasbarrini, Giovanni Cammarota

“…Recent observations suggest that the alteration of the intestinal microbiota and impaired innate immunity may play a leading role in the development of recurrent infection. …”
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Is There a Role for Probiotics in Liver Disease? by Robert S. Lo, Andrew S. Austin, Jan G. Freeman

“…Intestinal microbiota plays an important role in health and disease. Alteration in its healthy homeostasis may result in the development of numerous liver disorders including complications of liver cirrhosis. …”
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Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction by Yue Liu, Yiqing Yin

“…Postoperative cognitive dysfunction (POCD), a long-lasting cognitive decline after surgery, is currently a major clinical problem with no clear pathophysiological mechanism or effective therapy. Accumulating evidence suggests that neuroinflammation plays a critical role in POCD. …”
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Algorithm of management of patients with acute cholestatic hepatitis (Clinical case presentation) by T. A. Deyeva, Ye. N. German, M. V. Mayevskaya, V. T. Ivashkin

“…In the submitted case a main role in recognition of an etiology of liver disease have played by careful taking of past history and analysis of all possible causes of disease, that can be the key point in diagnostic search and choice of patient management tactics.…”
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