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Mitochondrial Complex I Deficiency among Egyptian Pediatric Patients with Steroid-Resistant Nephrotic Syndrome
Published 2021-01-01“…Mitochondrial complex I deficiency in patients who have a nephrotic syndrome complaint may play a role in their responsiveness to steroid therapy and the development of SRNS and even the prognosis of their illness.…”
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563
Duodenal Eosinophilia in Functional Dyspepsia
Published 2023-08-01“…Histamine-neutralizing drugs may play a role in the treatment of FD with duodenal eosinophilia in the future.…”
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564
Access to employee assistance programs and employee wellbeing: a cross-sectional study of employees in Southeast Asia
Published 2025-01-01“…The COVID-19 pandemic has spearheaded the importance of employee mental health, highlighting the role that employers can play in preserving employee wellbeing. Although Employee Assistance Programs (EAPs) are slowly becoming an established practice, it is still a relatively new phenomenon in most of Asia. …”
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565
The Clock Drawing Task reveals executive dysfunction in the dialysis population – an underrecognized and underestimated problem
Published 2024-12-01“…There appear to be a deficit in the spatial domain as well. Better education may play a protective role.…”
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566
THE EFFECTIVENESS OF THE DECOCTION OF RED BETEL LEAVES (PIPER CROCANTUM) AGAINST THE REDUCED SYMPTOMS OF FLUOR ALBUS IN ADOLESCENT GIRLS
Published 2022-03-01“…These red betel leaves (Piper crocantum) contain alkaloids that the green betel leaves do not have, and the alkaloids play a role as an antimicrobial agent. Besides, the red betel leaves have antiseptic power that is twice higher than the green betel leaves. …”
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567
Possible Roles of Micro RNA‑142‑5p and Claudin-1 in Development of Hashimoto’s Thyroiditis in Iraqi Patients
Published 2022-06-01“… Background: Micro RNA 142-5p may one day be employed as diagnostic or therapeutic targets in the therapy of autoimmune diseases. The expression of microRNA142-5p in serum from newly diagnosed patients with Hashimoto's thyroiditis has only been studied in a few tissue cases. …”
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568
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569
GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway
Published 2025-01-01“…Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential therapeutic targets for gene therapy are crucial for improving patient outcomes. …”
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570
Toll-like receptors in atopic dermatitis: pathogenesis and therapeutic implications
Published 2025-02-01“…Toll-like receptors (TLR), the key players of the innate immune system, contribute to the pathogenesis of atopic dermatitis (AD) through multiple pathways. TLRs play a crucial role in delaying barrier repair, promoting Th2-mediated dermatitis, shifting the response toward Th1 in the chronic phase, and contributing to the establishment of the itch-scratch cycle, as well as mediating the effects of UV radiation. …”
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571
Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances
Published 2025-02-01“…Conclusions: This study provides a thorough comprehension of the molecular basis of AD and proposes that Quercetin and Berberine have the potential as efficacious therapy options. This research provides a promising viewpoint on treatments for AD by focusing on proteins that are increased in certain parts of the brain, such as the EC and PC, which play a crucial role in the pathways leading to neurodegeneration.…”
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572
Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats
Published 2025-01-01“…Cocaine and HIV neurotoxins play roles in neuronal damage during neuroHIV progression by disrupting glutamate homeostasis in the brain. …”
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573
Fungal Infections in Kidney Transplant Recipients: A Comprehensive Narrative Review
Published 2025-01-01“…The use of novel tools (such as PCR-based molecular assays and NGS) for rapid and accurate diagnosis may play an important role. Conclusions: Early recognition, the appropriate use of antifungal therapy, and preventive strategies are essential for improving graft loss and fatal outcomes in this vulnerable population. …”
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574
Characterization of tumor prognosis and sensitive chemotherapy drugs based on cuproptosis-related gene signature in ovarian cancer
Published 2025-01-01“…Other cancer cell death processes, such as necroptosis, pyroptosis, and ferroptosis, have been shown to play crucial roles in the therapy and prognosis of ovarian cancer. …”
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575
The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook
Published 2020-01-01“…Dendritic cells (DC) are key phagocytic cells that play crucial roles in both the innate and adaptive immune responses against the human immunodeficiency virus type 1 (HIV-1). …”
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576
Determining the Potential Roles of Branched-Chain Amino Acids in the Regulation of Muscle Growth in Common Carp (Cyprinus carpio) Based on Transcriptome and MicroRNA Sequencing
Published 2023-01-01“…Furthermore, miR-135c, miR-192, miR-194, and miR-203a may play key roles in maintaining the normal activities of the organism by regulating genes related to muscle growth, protein synthesis, and catabolism. …”
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577
Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer
Published 2015-01-01“…Fibroblast growth factor receptors (FGFR) play key roles in tumor growth via activated signaling pathways in GC. …”
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578
Evaluation of Antimicrobial Activity and Cytotoxicity of an Epoxy Resin-Based Endodontic Sealer Containing Nanoparticles Amorphous Calcium Phosphate
Published 2023-01-01“…These sealers play a vital role in eradicating any remaining microorganisms and preventing recontamination, especially in situations where there might be microleakage. …”
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579
The Role of EGFR/PI3K/Akt/cyclinD1 Signaling Pathway in Acquired Middle Ear Cholesteatoma
Published 2013-01-01“…This study will facilitate the development of potential therapeutic targets for intratympanic drug therapy for cholesteatoma.…”
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580
The Effects of Statin Dose, Lipophilicity, and Combination of Statins plus Ezetimibe on Circulating Oxidized Low-Density Lipoprotein Levels: A Systematic Review and Meta-Analysis o...
Published 2021-01-01“…Oxidative modification of LDL (ox-LDL) is considered to be the most important atherogenic modification of LDL and is supposed to play a crucial role in atherogenesis and ASCVD outcomes. …”
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