STAT3 inhibition ameliorates renal interstitial inflammation in MRL/lpr mice with diffuse proliferative lupus nephritis by Jianfen Zhu, Yijing Chen, Yulan Chen, Yinqiu Lv, Tianxin Chen

“…FLLL32 combined with methylprednisolone therapy significantly inhibited the STAT3 activation, improved acute kidney damage, reduced the interstitial infiltration of inflammatory cells and decreased the AKI incidence in MRL/lpr mice.Conclusion STAT3 activation may play an important role in the pathogenesis of DPLN and the development of AKI. …”
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Combination of Anti-VEGF and Laser Photocoagulation for Diabetic Macular Edema: A Review by Laura N. Distefano, Jose Garcia-Arumi, Vicente Martinez-Castillo, Anna Boixadera

“…However, with the development of anti-VEGF drugs (bevacizumab, ranibizumab, and aflibercept), better outcomes were obtained in terms of visual acuity gain and decrease in macular thickness in some studies when antiangiogenic drugs were administered in monotherapy. Macular laser therapy may still play an important role as an adjuvant treatment because it is able to improve macular thickness outcomes and reduce the number of injections needed. …”
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The success of the tumor immunotherapy: neutrophils from bench to beside by Meng Zhu, Ru Jia, Xiaojie Zhang, Pingwei Xu

“…The present immune therapy was focused on the immune checkpoint blockade or Chimeric Antigen Receptor T-Cell Immunotherapy (CART) transfer, but how to activate the innate immune system to antitumor still lags out. …”
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Bilateral Renal Colic as an Initial Presentation of Erdheim-Chester Disease by Julien Sarkis, Fady Haddad, Sarah Nasr, Elie Hanna, Ahmad Mroueh, Elie Nemr

“…Kidney CT-guided biopsy and 18-fluorodeoxyglucose (FDG) positron emission tomography whole body scan as well as the history of hypopituitarism and vasculitis confirmed the diagnosis of Erdheim-Chester disease. Proper therapy with interferon-α was started. This case describes the multifaced manifestation of this disease and the difficulty to establish the diagnosis, as well as the pivotal role that a urologist can play in its management.…”
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The Role of Lipid Rafts in Cancer Cell Adhesion and Migration by Toshiyuki Murai

“…Recently, it was demonstrated that lipid rafts play critical roles in cancer cell adhesion and migration. …”
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Permasalahan Anak Asuh dan Aplikasi Pelayanan Konseling Terhadap Mereka by Yusida Imran

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Smoking and Health: A Physician Responsibility—A Statement of the Joint Committee on Smoking and Health by Joint Committee on Smoking and Health

“…Although the addicting properties of nicotine can make cessation difficult, both medical interventions aimed at helping smokers quit and social policies aimed at control of cigarette smoking can have significant benefits. Physicians should play an active role in control of smoking by ensuring that counselling and pharmacological therapy be available for the individual smoker. …”
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Online game addiction in adolescent: What should school counselor do? by Eryzal Novrialdy, Rozi Atyarizal

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Prevalence of behavioral risk factors among Ukrainians during war amid existing stress factors by Olena Kolesnikova, Olena Vysotska, Anastasiia Radchenko, Olga Zaprovalna, Nataliya Emelyanova

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Platelet Rich Plasma in the Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw: Personal Experience and Review of the Literature by F. Longo, A. Guida, C. Aversa, E. Pavone, G. Di Costanzo, L. Ramaglia, F. Ionna

“…The most debated topic about ARONJ/BRONJ is therapy. The most adequate procedure is far from being standardized and prevention seems to play a pivotal role. …”
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Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal. by William J Cisneros, Shimaa H A Soliman, Miriam Walter, Lacy M Simons, Daphne Cornish, Simone De Fabritiis, Ariel W Halle, Eun-Young Kim, Steven M Wolinsky, Ramon Lorenzo-Redondo, Ali Shilatifard, Judd F Hultquist

“…The persistence of HIV-1 in long-lived latent reservoirs during suppressive antiretroviral therapy (ART) remains one of the principal barriers to a functional cure. …”
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Dysregulated Expression and Methylation Analysis Identified TLX1NB as a Novel Recurrence Marker in Low-Grade Gliomas by Hongzhou Duan, Zuozhen Yang, Chen Li, Jiayong Zhang, Shengli Shen, Changwei Yuan, Yingjin Wang

“…However, LGG recurrence occurs frequently. Biomarkers play a crucial role in evaluating the recurrence and prognosis of LGGs. …”
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Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats by Merhan Ragy, Fatma Ali, Maggie M. Ramzy

“…In the brain, the heme oxygenase (HO) system has been reported to be very active and its modulation seems to play a crucial role in the pathophysiology of neurodegenerative disorders. …”
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Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015 by Hadi Darvishi Khezri, Ebrahim Salehifar, Mehrnoush Kosaryan, Aily Aliasgharian, Hossein Jalali, Arash Hadian Amree

“…Antioxidant components play an important role in the treatment of the disease. …”
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The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth by Tamilselvan Subramani, Vidhya Rathnavelu, Noorjahan Banu Alitheen

“…Since inflammation is the prerequisite for gingival overgrowth, mast cells and its protease enzymes also play a vital role in the pathogenesis of gingival fibrosis. …”
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Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma by Jing Jing Han, De Rong Xie, Li Li Wang, Ye Qing Liu, Gong Fa Wu, Qing Sun, Yan Xian Chen, Ying Wei, Zhi Quan Huang, Hai Gang Li

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Phenotypic Characterization of Circulating CD4+ T Cells in ANCA-Associated Vasculitis by Sandra Lilliebladh, Åsa Johansson, Åsa Pettersson, Sophie Ohlsson, Thomas Hellmark

“…T cell-mediated immune responses are thought to play an important role in the pathogenesis of anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitides (AAV). …”
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Comparative Analysis of the Influence of Selected Physical Factors on the Level of Pain in the Course of Temporomandibular Joint Disorders by Łukasz Kopacz, Żaneta Ciosek, Helena Gronwald, Piotr Skomro, Roman Ardan, Danuta Lietz-Kijak

“…Temporomandibular joints (TMJs) play a very significant function in the activity of the locomotor system of the masticatory system. …”
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Gene Expression Profiling in Lungs of Chronic Asthmatic Mice Treated with Galectin-3: Downregulation of Inflammatory and Regulatory Genes by Esther López, M. Paz Zafra, Beatriz Sastre, Cristina Gámez, Carlos Lahoz, Victoria del Pozo

“…In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 and Th2 cells. …”
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Therapeutic applications of artemisinin in ophthalmic diseases by Hao Sun, Ping Zhao, Lianghui Zhao, Zhizhong Zhao, Haoyu Chen, Cong Ren, Bin Guo

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