Significant Depletion of CD4+ T Cells Occurs in the Oral Mucosa during Simian Immunodeficiency Virus Infection with the Infected CD4+ T Cell Reservoir Continuing to Persist in the... by Jeffy George, Wendeline Wagner, Mark G. Lewis, Joseph J. Mattapallil

“…The loss of CD4+ T cells that play a critical role in maintaining mucosal immunity likely contributes to this process. …”
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Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…Normalization is a type of therapy targeted at abnormal tumor blood vessels. …”
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Elevated LIF and JAK-STAT activation drive severe COVID-19 in myeloma patients receiving the BCMA-CD3 bispecific antibody Elranatamab by Ziping Li, Fujing Zhang, Xianghong Jin, Junling Zhuang

“…Conclusions BiTe therapy is linked to a higher risk of severe COVID-19 due to an inflammatory cytokine storm, with LIF and the JAK-STAT pathway playing key roles. …”
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Biopsychosocial Model Analysis of a Recurrent Guillain–Barré Syndrome Patient’s Recovery by Prashant P. Naik, Rutuja A. Phadke, Amogh R. Kulkarni, Vishagh K. Nair

“…The patient’s excellent socioeconomic status, social activity, and strong family support along with vigorous physical therapy played a crucial role in their remarkable recovery.…”
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Dynamical properties and tumor clearance conditions for a nine-dimensional model of bladder cancer immunotherapy by K. E. Starkov, Svetlana Bunimovich-Mendrazitsky

“…Understanding the global interaction dynamics between tumor and the immunesystem plays a key role in the advancement of cancer therapy.Bunimovich-Mendrazitsky et al. (2015) developed a mathematical model for thestudy of the immune system response to combined therapy for bladder cancerwith Bacillus Calmette-Guérin (BCG) and interleukin-2 (IL-2) . …”
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Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE−/− mice by Xiaocui Chen, Minghui Sun, Xiang Ma, Yitong Ma, Bangdang Chen

“…Adeno-associated virus (AAV) is the most widely utilized vector for gene therapy. Proprotein convertase subtilisin/kexin type 9 (PCSK9), predominantly expressed in the liver, plays a crucial role in lipid regulation and atherosclerosis progression. …”
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Prominent Naturally Derived Oxidative-Stress-Targeting Drugs and Their Applications in Cancer Treatment by Eunsun Lee, Dongki Yang, Jeong Hee Hong

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Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…Cytokine-mediated inflammation is increasingly recognized for playing a vital role in the pathophysiology of a wide range of brain disorders, including neurodegenerative, psychiatric, and neurodevelopmental problems. …”
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HIF-1α and VEGF Immunophenotypes as Potential Biomarkers in the Prognosis and Evaluation of Treatment Efficacy of Atherosclerosis: A Systematic Review of the Literature by Dimitra P. Vageli, Panagiotis G. Doukas, Dimitrios Georgiou, Michailangelos P. Prokopiou, Nefeli E. Ladaki, Androniki Papadopoulou, Sotirios G. Doukas, Konstantina Zacharouli, Konstantinos P. Makaritsis, Maria Ioannou

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Molecular mechanisms of autism as a form of synaptic dysfunction by E. A. Trifonova, T. M. Khlebodarova, N. E. Gruntenko

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Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy by Xiaopeng Li, Yang Zhong, Pengyuan Qi, Daoming Zhu, Chenglong Sun, Nan Wei, Yang Zhang, Zhanggui Wang

“…However, intracellular glutathione (GSH) plays a key role in protecting cancer from radiation damage. …”
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Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer by Anita Thyagarajan, Zaid Sirhan, Ravi P. Sahu

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Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment by Shaoyan Shi, Xuehai Ou, Chao Liu, Hao Wen, Jiang Ke

“…The hypoxia-inducible factor-1α (HIF-1α) plays a key role in facilitating the adaptation of cells to hypoxia, profoundly influencing the immune vascular microenvironment (IVM) and immunotherapy outcomes. …”
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Basic provisions that ensure effectiveness of adaptive physical education classes with students with health disorders by Tarasov, Pavel V., Kozenko, Elena Yu., Miroshnik, Denis Yu.

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Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and... by Ramashish Kumar, Ashok Chauhan, Sovan Sarang Dhar, Nitish Kumar

“…Prevention and treatment of these reactions play an important role in the completion of the prescribed course of EBRT within stipulated time period while maintaining the quality of life. …”
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A study on the current status of home-based pulmonary rehabilitation in stable chronic obstructive pulmonary disease patients and its impact on quality of life (稳定期慢性阻塞性肺疾病患者居家肺康复现... by WANG Tao (王涛), YAN Qiaoyuan (颜巧元), WU Hongyan (吴红艳), YANG Hualu (杨华露), ZHOU Juan (周娟), MO Beirong (莫蓓蓉), LIU Xianliang (刘贤亮)

“…Conclusion Home-based pulmonary rehabilitation helps improve self-management abilities among patients with COPD, encourages the adoption of healthy lifestyle habits, and promotes adherence to scientifically guided home oxygen therapy. Adequate respiratory and exercise training, as well as maintaining a positive mood, play a crucial role in enhancing patients' quality of life. …”
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Influence of Cosmetic Skincare Products with pH < 5 on the Skin Microbiome: A Randomized Clinical Evaluation by Ciska Janssens-Böcker, Claudia Doberenz, Marta Monteiro, Marta de Oliveira Ferreira

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Clinical Study of Limosilactobacillus reuteri for the Treatment of Children with Chronic Tic Disorders/Tourette Syndrome: A Mid-Term Efficacy Evaluation by Yan Liang, Lin Wan, Guanglei Wang, Huimin Yan, Jing Zhang, Xinting Liu, Ziyan Zhang, Gang Zhu, Guang Yang

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Everyday Activities for Children with Mitochondrial Disorder: A Retrospective Chart Review by Marieke Lindenschot, Imelda J. M. de Groot, Saskia Koene, Ton Satink, Esther M. J. Steultjens, Maria W. G. Nijhuis-van der Sanden

“…Seventeen patient records, presenting notes on capacities and performed activities, showed an overview of everyday activities that covered the categories: self-care, house chores, therapy, school, computing, hobby, play, sports, and mobility/transport. …”
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Adolescent Psychological Assistance Treatment Strategy Integrating Home-School Coordination and Network Information by Yaling Li

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