Effects of Long-Term Testosterone Therapy on Patients with “Diabesity”: Results of Observational Studies of Pooled Analyses in Obese Hypogonadal Men with Type 2 Diabetes by Ahmad Haider, Aksam Yassin, Gheorghe Doros, Farid Saad

“…Systolic and diastolic blood pressure, lipid profiles including total cholesterol: HDL ratio, CRP, and liver enzymes all improved (P<0.0001). Long-term T therapy for up to 6 years resulted in significant and sustained improvements in weight, T2DM, and other cardiometabolic risk factors in obese, diabetic men with TD and this therapy may play an important role in the management of obesity and diabetes (diabesity) in men with T deficiency.…”
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Tubulocystic renal cell carcinoma: Case report and literature review by Yun-Shen Ding, Yi-Han Wang, Feng Liu

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Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat by Jasińska-Stroschein Magdalena, Owczarek Jacek, Wesołowska Anna, Orszulak-Michalak Daria

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Therapeutic potential of SOX family transcription factors in osteoarthritis by Yue Huang, Zhuo Wang

“…The regulation of the WNT signalling pathway, Nrf2/ARE signalling pathway, NF-κB signalling pathway and SOX9 is implicated in the emergence of osteoarthritis. Non-coding RNA may play a role in the onset and progression of osteoarthritis by modulating various SOX family members, including SOX2, SOX4, SOX5, SOX6, SOX8, SOX9 and SOX11.Conclusion SOX9 has the capability of mitigating the onset and progression of osteoarthritis through means such as medication therapy, stem cell therapy, recombinant adeno-associated virus (rAAV) vector therapy, physical therapy and other approaches.…”
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Immunomodulatory Effect of Bisphosphonate Risedronate Sodium on CD163+ Arginase 1+ M2 Macrophages: The Development of a Possible Supportive Therapy for Angiosarcoma by Taku Fujimura, Yumi Kambayashi, Sadanori Furudate, Aya Kakizaki, Setsuya Aiba

“…An imbalance of immunosuppressive cells and cytotoxic cells plays an important role in inhibiting the antitumor immune response of the tumor-bearing host. …”
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High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions by Victor Davi R. S. Oliveira, Ana Paula M. G. Reis, Claiton V. Brenol, Ivânio A. Pereira, Karina R. Bonfiglioli, Letícia R. Pereira, Manoel B. Bértolo, Maria de Fátima L. C. Sauma, Maria Fernanda B. R. Guimarães, Paulo Louzada-Júnior, Rina D. N. Giorgi, Sebastião C. Radominski, Licia Maria H. Mota, Cleandro P. Albuquerque, Geraldo R. Castelar-Pinheiro

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Biomolecular condensates: Formation mechanisms, biological functions, and therapeutic targets by Xin Niu, Lei Zhang, Yuchen Wu, Zhi Zong, Bin Wang, Jisheng Liu, Long Zhang, Fangfang Zhou

“…Over the past decade, it has become widely appreciated that biomolecular condensates are ubiquitous in eukaryotic cells and play a vital role in physiological and pathological processes. …”
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Circulating MicroRNAs in Patients with Psoriasis Treated with Anti-IL-23: A Cohort Study by Federico Diotallevi, Giulia Matacchione, Anna Campanati, Elena Marinelli Busilacchi, Nadia Viola, Ilaria Pace, Beatrice Fontana, Roberta Roncarati, Massimiliano Bonafè, Manuela Ferracin, Jacopo Sabbatinelli, Fabiola Olivieri

“…Abstract Introduction Psoriasis is characterized by aberrant keratinocyte activity and immune cell infiltration, driven by immune-mediated pathways. MicroRNAs (miRNAs) play crucial roles in regulating these processes, offering insights into disease mechanisms and therapeutic targets. …”
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S’étonner pour se professionnaliser : une expérience d’immersion sur le terrain en première année de formation d’ergothérapeutes by Dominique Broussal, Jean-Michel Caire, Sabrina Techene, Evelyne Castel-Lacanal, Xavier De Boissezon

“…This research studies the experimentation led from September 2016 to January 2017 in the Occupational therapy training Institute in Toulouse. It consisted in sending first-year students in immersion in physical therapy and rehabilitation services. …”
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Silent enemy of the hand: The Viking disease by Stoiljković Vera

“…It is more common in Caucasian men, and heredity, which shows variable expression, plays a vital role in its aetiology. The etiopathogenesis of DK is still unclear and includes the formation of collagen nodules, which progress into fibrous bands between the dermis and fascia at pressure points. …”
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Characterization and genomic analysis of a Herelleviridae bacteriophage UHP46 infecting mastitis-causing Staphylococcus aureus by Sara Najeeb, Imran Khan, Javed Muhammad, Muhammad Jahangir, Iqbal Ahmad Alvi, Anza Abbas, Aman Ullah, Arif Ullah, Wajiha Sajjad, Hashir Khan, Amjad Khan, Amjad Khan

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Caregivers' Barriers to Disclosing the HIV Diagnosis to Infected Children on Antiretroviral Therapy in a Resource-Limited District in South Africa: A Grounded Theory Study by Sphiwe Madiba, Kebogile Mokwena

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Effectiveness of app-based cognitive behavioral therapy for insomnia on preventing major depressive disorder in youth with insomnia and subclinical depression: A randomized clinica... by Si-Jing Chen, Jian-Yu Que, Ngan Yin Chan, Le Shi, Shirley Xin Li, Joey Wing Yan Chan, Weizhen Huang, Chris Xie Chen, Chi Ching Tsang, Yuen Lam Ho, Charles M Morin, Ji-Hui Zhang, Lin Lu, Yun Kwok Wing

“…<h4>Background</h4>Increasing evidence suggests that insomnia plays an important role in the development of depression, supporting insomnia intervention as a promising approach to prevent depression in youth. …”
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Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions by Sibani Sarkar, Subhajit Karmakar, Malini Basu, Pratyasha Ghosh, Mrinal K Ghosh

“…Suppression of immunological machinery and inhibition of ROS play an important role in neurological disturbances. …”
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Efficacy and safety of various drug combinations in treating plaque Psoriasis: A meta-analysis [version 2; peer review: 2 approved] by Nayak Snehasis, Karshe Haji Ali, Pendyala Siri, Ngabo Herve, Sayed Zafar

“…Genetic and environmental factors also play key roles. Topical corticosteroids, calcineurin inhibitors, and oral corticosteroids help to manage plaque psoriasis symptoms, but combination therapies might offer greater effectiveness and improved safety profiles. …”
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Perceptions and experiences of directly observed treatment in tuberculosis: insights from a mixed-methods cross-sectional study by Diana Amorim, João Pedro Ramos, Pedro Barbosa, Mariana Vieira, Raquel Duarte

“…ABSTRACT Objective: The demanding nature and psychosocial burdens of directly observed treatment (DOT) have opened a path to alternative strategies such as video-observed therapy (VOT), which offers comparable treatment outcomes and patient satisfaction while potentially saving time and reducing costs. …”
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First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood by A. Jensen, E. Hamelmann

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Nonsurgical Management of Adductor-related groin pain with Ultrasound-Guided Platelet-Rich Plasma Injection and Physical Therapy in a Competitive Soccer Player: A Case Report by Giorgio Zeppieri, Micheal S Smith, Ryan P. Roach

“…The patient completed 12 physical therapy sessions over six weeks post PRP injection…”
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Calcific Uremic Arteriolopathy: A Case Series and Review from an Inner-City Tertiary University Center in End-Stage Renal Disease Patients on Renal Replacement Therapy by Mohamed Omer, Zeenat Yousuf Bhat, Nanette Fonte, Nashat Imran, James Sondheimer, Yahya Osman‐Malik

“…A multifaceted approach may play a role in treating CUA. Referral to a nephrologist may aid in the early diagnosis and prompt management of CUA.…”
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Cognitive behavioural therapy plus Kiesler Circle Training (CBT+) versus CBT only for patients with interpersonal problems: study protocol for a randomised controlled feasibility t... by Stephan Köhler, Philipp Sterzer, Eva-Lotta Brakemeier, Karen Ollrogge, Daniel Schulze, Eva Friedel, Nina Romanczuk-Seiferth, Anna-Lena Siegerist, Anne Guhn

“…All patients will receive individual, state-of-the-art cognitive behavioural therapy (CBT) during the study. They will be randomly assigned to one of two conditions: the experimental group will receive the KCT in group sessions, in addition to individual CBT, while the control group will receive only individual CBT. …”
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