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Multivariate Analyses with Two-Step Dimension Reduction for an Association Study Between <sup>11</sup>C-Pittsburgh Compound B and Magnetic Resonance Imaging in Alzheimer’s Disease
Published 2025-01-01“…To study the relationship between Aβ deposition and brain structure, as determined using <sup>11</sup>C-Pittsburgh compound B (PiB) and magnetic resonance imaging (MRI), respectively, we developed a regression model with PiB and MRI data as the predictor and response variables, respectively, and proposed a regression method for studying the association between them based on a supervised sparse multivariate analysis with dimension reduction based on a composite paired basis function. …”
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Amyloid Imaging in Aging and Dementia: Testing the Amyloid Hypothesis In Vivo
Published 2009-01-01“…In this review we survey current amyloid imaging techniques, focusing on positron emission tomography (PET) with ^{11}carbon-labelled Pittsburgh Compound-B (11C-PIB), the most extensively studied and best validated tracer. …”
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Perspectives in Molecular Imaging Using Staging Biomarkers and Immunotherapies in Alzheimer’s Disease
Published 2013-01-01“…The most promising diagnostic strategies in today’s world would consist in performing high diagnostic accuracy of combined modality imaging technologies using beta-amyloid 42 peptide-cerebrospinal fluid (CSF) positron emission tomography (PET), Pittsburgh compound B-PET, fluorodeoxyglucose-PET, total and phosphorylated tau-CSF, and volumetric magnetic resonance imaging hippocampus biomarkers for criteria evaluation and validation. …”
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Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease
Published 2012-01-01“…We explored associations between CSF BACE1 activity and fibrillar amyloid pathology as measured by carbon-11-labelled Pittsburgh Compound B positron emission tomography ([11C]PIB PET). [11C]PIB and CSF studies were performed in 31 patients with AD. …”
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