PDZRN3 regulates adipogenesis of mesenchymal progenitors in muscle by Hiroki Iida, Minako Kawai-Takaishi, Yoshihiro Miyagawa, Yasuhiko Takegami, Akiyoshi Uezumi, Takeshi Honda, Shiro Imagama, Tohru Hosoyama

“…Introduction: Intramuscular adipose tissue (IMAT) is frequently formed in certain pathological conditions, such as biological aging, and ectopic fat accumulation leads to muscle weakness and a subsequent decline in physical function. Although mesenchymal progenitors (MPs) are present in postnatal skeletal muscle and are the cells from which IMAT originates, the molecular mechanism by which MPs contribute to IMAT formation has not been completely elucidated. …”
Get full text

A Comparative Analysis of Morphological Characteristics between Endangered Local Prickly Pear and the Newly Introduced Dactylopius opuntiae-Resistant Species in Eastern Morocco by Ahmed Marhri, Mehdi Boumediene, Aziz Tikent, Reda Melhaoui, Kawtar Jdaini, Aatika Mihamou, Hana Serghini-Caid, Ahmed Elamrani, Christophe Hano, Malika Abid, Mohamed Addi

“…However, O. robusta is distinguished by its short stalk, which poses a challenge for fruit harvesting and leaves it susceptible to physical damage and quality loss. Conversely, O. dillenii displays a low pulp content, which serves as a critical indicator of fruit quality. …”
Get full text

The role of light and vision in farmed ungulates and implications for their welfare by Julia Stuhlträger, Eberhard von Borell, Jan Langbein, Christian Nawroth, Maria Vilain Rørvang, Camille M. C. Raoult, Camille M. C. Raoult

“…This poses the risk of not appropriately assessing the importance of these abilities when the animals interact with their physical environment. Here, we provide an overview of the current state of research on the impact of light parameters on farmed ungulates and their preferences for light settings in the most common farmed ungulate species: pigs, sheep, goats, cattle and horses. …”
Get full text

Experiences of gender-based violence among women in sub-Saharan Africa: identifying evidence for intervention and public health priorities by Lucky Norah Katende-Kyenda, Judith I. Ani

“…Women in Comoros had the lowest reported prevalence (10.76%), while Sierra Leone women had the highest (60.27%), followed by Uganda (56.92%). Emotional and physical violence were most prevalent in Sierra Leone, while sexual violence was most common in Burundi and the Democratic Republic of Congo.DiscussionThis study highlights the urgent need for targeted interventions for younger women in rural areas and those with limited education. …”
Get full text

A patient choice‐driven lifestyle intervention lowers HbA1c in type 2 diabetes: A feasibility study by Nathan R. Weeldreyer, Mindy L. McEntee, Matthew P. Martin, Chong D. Lee, Farshad Fani Marvasti, Glenn A. Gaesser, Rodger Kessler, Siddhartha S. Angadi

“…Twenty patients with non‐insulin‐dependent T2D completed a 90‐day intervention driven by patient choices of nutrition and physical activity. Medical assistants were trained by members of the study team and administered the intervention under nurse practitioner supervision. …”
Get full text

Effect of propofol and ciprofol in patients undergoing bronchoscopy: protocol for a double-blind, randomised controlled trial by Fang Chen, Cheng Li, Dongliang Li, Jinxuan Tang, Jiayu Huang

“…Introduction Propofol is a fast-acting intravenous anaesthetic widely used for sedation and anaesthesia in gastrointestinal endoscopy, bronchoscopy, and the induction/maintenance of general anaesthesia in outpatients and inpatients; however, propofol has several undesirable effects, including injection pain, which affects the physical and mental health of patients, and cardiopulmonary depression, characterised by hypotension, bradycardia and apnea, which commonly occur in clinical practice. …”
Get full text

Effect of HTST Thermal Treatments on End-Use Quality Characteristics of Goat Milk by B. D. Rohitha Prasantha, K. M. S. Wimalasiri

“…Goat milk samples were pasteurized at high-temperature (72°C, 75°C, and 81°C) and in short-time (15 s and 25 s) combinations. Physical, chemical and microbial qualities of the pasteurized milk samples were evaluated 0, 2, 3, and 4 weeks of storage at 4°C. …”
Get full text

Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle by Mutsumi Katayama, Kazuhiro Nomura, Jonathan M. Mudry, Alexander V. Chibalin, Anna Krook, Juleen R. Zierath

“…Objectives: Environmental factors such as physical activity induce epigenetic modifications, with exercise-responsive DNA methylation changes occurring in skeletal muscle. …”
Get full text

Contributions of a Child's Built, Natural, and Social Environments to Their General Cognitive Ability: A Systematic Scoping Review. by Jazmin Del Carmen Ruiz, James J Quackenboss, Nicolle S Tulve

“…We found that recent literature mainly assessed the hypothesized negative effects of either inherent factors or chemical exposures present in the physical environment. Prenatal growth, sleep health, lead and water pollutants showed consistent negative effects. …”
Get full text

Case report: A severe myositis mimicking bulbar palsy after administration of immune checkpoint inhibitors by Philippe Rochigneux, Philippe Rochigneux, Alexandre Bertucci, Elika Loir, Alexia Mattei, Danielle Robert, Michael Dassa, Brice Chanez, Mikael Ebbo, Lea Gaigne, Anne Sophie Chretien, Giovanni Corazza, Giovanni Corazza, Nicolas Schleinitz

“…In a multidisciplinary setting, she was treated with IV corticosteroids (methylprednisolone 1 mg/kg started at day 10, with a progressive decrease until 1 mg of prednisone in March 2024), IV immunoglobulins started at day 18 (1.5 g/kg in 2 days, administered monthly, with a progressive decrease and a cessation in June 2022), enteral nutrition, speech therapy and physical therapy, with noticeable improvement. After 4 years of follow-up, and only one infusion of Ipi/Nivo, the melanoma is still in complete response.ConclusionWe report an ICI-induced severe myositis mimicking bulbar palsy after the administration of Ipi/Nivo. …”
Get full text

AOZORA: long-term safety and joint health in paediatric persons with haemophilia A without factor VIII inhibitors receiving emicizumab – protocol for a multicentre, open-label, pha... by Seitaro Yoshida, Masashi Taki, Hideyuki Takedani, Midori Shima, Keiji Nogami, Azusa Nagao, Haruko Yamaguchi-Suita, Yui Kyogoku, Akira Ishiguro, Kaoru Kitsukawa

“…Exploratory endpoints include characterising participants’ physical activities and the number of activity-related bleeds requiring coagulation factor treatment. …”
Get full text

High prevalence of overweight/obesity and central obesity among women in a rural district of Nepal in 2012–2013: a population-based study by Chandra Yogal, Chandra Yogal, Astrid Kamilla Stunes, Astrid Kamilla Stunes, Sunila Shakya, Biraj Karmarcharya, Rajendra Koju, Mats P. Mosti, Mats P. Mosti, Miriam K. Gustafsson, Miriam K. Gustafsson, Bjørn Olav Åsvold, Bjørn Olav Åsvold, Berit Schei, Unni Syversen, Unni Syversen

“…Our findings underscore the need for public health programs addressing nutritional patterns and physical activity to prevent obesity.…”
Get full text

Previous Intestinal Resection Is Associated with Postoperative Complications in Crohn’s Disease: A Cohort Study by Yantao Duan, Yifan Liu, Yousheng Li

“…These patients were more likely to be older (P=0.031), have longer disease duration (P=0.025), use less 5-aminosalicylic acid/sulfasalazine preoperatively (P=0.013), have lower body mass index (P=0.003), and have a higher American Society of Anesthesiologists (ASA) Physical Status Classification System score (P=0.043). …”
Get full text

Joint association of sleep patterns and oxidative balance score with all-cause and cardiovascular mortality among the general population by Chen Chen, Hanzhang Wu, Hanzhang Wu, Hongyu Jin, Zhiping Jiang, Wei Wang, Xiao Tan, Xiao Tan, Wen-Yang Li

“…BackgroundThis study investigates the joint effect of sleep patterns and oxidative balance score (OBS) on all-cause and CVD mortality in the general population.MethodsWe examined 21,427 individuals aged 18–85 from NHANES 2005–2014, connecting them to mortality data until December 31, 2019, using interview and physical examination dates. Surveys collected data on sleep duration, self-reported sleep disturbance, and doctor-told sleep disorders, classified into healthy, intermediate, and unhealthy sleep patterns. …”
Get full text

The role of natural exosomes from SHED-MSC in immunoregulation of M0/M1 polarized macrophage cells by Ali Fallah, Abasalt Hosseinzadeh Colagar, Ayyoob Khosravi, Ayyoob Khosravi, Azadeh Mohammad-Hasani, Azadeh Mohammad-Hasani, Mohsen Saeidi, Mohsen Saeidi

“…These nanovesicles, with their distinct physical properties and ability to penetrate target cells, may prove beneficial in conditions involving the depletion of M2 macrophages and M1 macrophage-induced diseases, potentially aiding in the reduction of inflammation and tissue injury.…”
Get full text

The Effect of Continuity of Midwifery Care (CoMC) Based on EDUGARLIN Application and Booklet on Postpartum Fitness Quality by Junengsih Junengsih, Rosita Syarifah, Ani Kusumastuti, Herlyssa Herlyssa, Elly Dwi Wahyuni, Yulia Ulfah Fatimah, Lia Nurcahyani, Fahmi Hafid

“…During this recovery period, mothers often experience several physiological and physical changes that cause discomfort. Several studies have shown that the discomfort experienced can lead to pathological development and complications when not treated properly. …”
Get full text

Evaluation of laboratory findings indicating pancreatitis in healthy lean, obese, and diabetic cats by Freja K. Jørgensen, Charlotte R. Bjornvad, Birgit Krabbe, Stinna Nybroe, Ida N. Kieler

“…Methods Cross‐sectional study. The cats underwent physical examination, and blood tests. Linear regression models compared differences in fPLI, fTLI, cobalamin, and folate concentrations. …”
Get full text

What are the lived healthcare experiences of patients with primary sclerosing cholangitis? A community-based qualitative interview study by Sheila Greenfield, Gideon Hirschfield, Jayne Parry, Katherine Arndtz, Madeline Cameron

“…Patients with a history of liver transplantation were excluded.Results Participants confirmed the ongoing physical and psychological burden of PSC and its related healthcare. …”
Get full text

Mathematical Modeling of Cyberattack Defense Mechanism Using Hybrid Transfer Learning With Snow Ablation Optimization Algorithm in Critical Infrastructures by Mohamad Khairi Ishak

“…It is possible to entirely stop these physically located devices’ operations and do substantial destruction with a cyberattack. …”
Get full text

Influence of Acidic Substances on Compression Deformation Characteristics of Loess by Hao Tang, Chiyang Liu, Nianqin Wang, Huahua Li, Guannan Wu, Jinzhi Luo, Mengli Zeng

“…Current research theories on acid-contaminated soils indicate that acids can alter the physical properties of soils, which in turn can affect their engineering mechanical properties. …”
Get full text