Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis by Michał Korostyński, Natalia Małek, Marcin Piechota, Katarzyna Starowicz

Get full text

Whole Blood Metabolomic Profiling of Mice with Tacrolimus-Induced Chronic Nephrotoxicity: NAD⁺ Depletion with Salvage Pathway Impairment by Sho Nishida, Tamaki Ishima, Daiki Iwami, Ryozo Nagai, Kenichi Aizawa

Get full text

The “e-Generation”: The Technological Usage and Experiences of Medical Students from a Developing Country by Priyasdarshani Galappatthy, Wasundara S. Wathurapatha, Priyanga Ranasinghe, Maheshi D. M. S. Wijayabandara, Dinuka S. Warapitiya, Krishantha Weerasuriya

Get full text

Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism by L. Di Cesare Mannelli, G. D'Agostino, A. Pacini, R. Russo, M. Zanardelli, C. Ghelardini, A. Calignano

Get full text

Bio-primed machine learning to enhance discovery of relevant biomarkers by David M. Henke, Alexander Renwick, Joseph R. Zoeller, Jitendra K. Meena, Nicholas J. Neill, Elizabeth A. Bowling, Kristen L. Meerbrey, Thomas F. Westbrook, Lukas M. Simon

Get full text

Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies by Donatus Wewura Adongo, Priscilla Kolibea Mante, Kennedy Kwami Edem Kukuia, Charles Kwaku Benneh, Robert Peter Biney, Eric Boakye-Gyasi, Nicholas Akinwale Titiloye, Eric Woode

Get full text

Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study by Jon Trærup Andersen, Morten Petersen, Espen Jimenez-Solem, Jeppe Nørgaard Rasmussen, Nadia Lyhne Andersen, Shoaib Afzal, Kasper Broedbaek, Brian Rafn Hjelvang, Lars Køber, Christian Torp-Pedersen, Henrik Enghusen Poulsen

Get full text

Evaluating knowledge gains from structured sexual and reproductive health education among in-school adolescents in Southeast Nigeria by Chibuike Agu, Chinyere Ojiugo Mbachu, Ifunanya Clara Agu, Godstime Eigbiremolen, Ugenyi Iloabachie, Ozioma Nwankpa, Obinna Onwujekwe

Get full text

L-Borneol 7-O-[β-D-Apiofuranosyl-(1→6)]-β-D-Glucopyranoside Alleviates Myocardial Ischemia-Reperfusion Injury in Rats and Hypoxic/Reoxygenated Injured Myocardial Cells via Regulati... by Ziyi Tong, Gaowen Li, Chengxiao Su, Liyan Zhou, Ling Zhang, Qun Chen, Qing Xia

Get full text

Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions by Alessandra Bitto, Francesco Squadrito, Natasha Irrera, Gabriele Pizzino, Giovanni Pallio, Anna Mecchio, Federica Galfo, Domenica Altavilla

Get full text

New Insights Into Hepatic Impairment (HI) Trials by Sebastian Haertter, Maximilian Lobmeyer, Brian C. Ferslew, Pallabi Mitra, Thomas Arnhold

“…ABSTRACT Hepatic impairment (HI) trials are traditionally part of the clinical pharmacology development to assess the need for dose adaptation in people with impaired metabolic capacity due to their diseased liver. …”
Get full text

Impact of Metabolic States on SARS-CoV-2 Vaccine Responses in Mouse Models of Obesity and Diabetes by Olivia A. Smith, Brent Fujimoto, Teri Ann S. Wong, Albert To, Troy Odo, Aquena Ball, Brien K. Haun, Hiromi Muramatsu, Ying K Tam, Norbert Pardi, Axel T. Lehrer

Get full text

A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice by Fangfang Wu, Chenxi Gu, Rui Xu, Junwei Ma, Lei Gao, Youjiao Zhang, Siyuan Bu, Qingbo Lu, Te Zhao, Yijun Han, Chen Guo, Yihui Cui, Jianhua Ding, Gang Hu, Zhijun Zhang

Get full text

Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model by José Sereno, Belmiro Parada, Flávio Reis, Fernanda X. Cunha, Edite Teixeira-Lemos, Patrícia Garrido, Rui Pinto, Petronila Rocha-Pereira, Paula Neto, José Ruivo, Paulo Rodrigues-Santos, Sara Nunes, Alfredo Mota, Arnaldo Figueiredo, Frederico Teixeira

Get full text

Preclinical Evidences for an Antimanic Effect of Carvedilol by Greicy Coelho de Souza, Julia Ariana de S. Gomes, Ana Isabelle de Góis Queiroz, Maíra Morais de Araújo, Lígia Menezes Cavalcante, Michel de Jesus Souza Machado, Aline Santos Monte, David Freitas de Lucena, João Quevedo, André Ferrer Carvalho, Danielle Macêdo

Get full text

NLRP3: a key regulator of skin wound healing and macrophage-fibroblast interactions in mice by Jiamin Zhao, Shuangyi Zhang, Zhiguo Gong, Wei Mao, Wenhui Bao, Qianru Li, Yunjie Bai, Feifei Gao, Shuang Feng

Get full text

Pro-inflammatory effects of inhaled Great Salt Lake dust particles by Jacob M. Cowley, Cassandra E. Deering-Rice, John G. Lamb, Erin G. Romero, Marysol Almestica-Roberts, Samantha N. Serna, Lili Sun, Kerry E. Kelly, Ross T. Whitaker, Jenna Cheminant, Alessandro Venosa, Christopher A. Reilly

Get full text

Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue by Ashraf I. Khasawneh, Sofian Al Shboul, Nisreen Himsawi, Amani Al Rousan, Nisreen Abu Shahin, Mohammed El-Sadoni, Ahmad Alhesa, Ala’ Abu Ghalioun, Suzan Khawaldeh, Bayan Shawish, Salem Abu Mahfouz, Mais Al-Shayeb, Shatha Abo Dawoud, Raghad Tlilan, Mohammad Nuseir, Moureq R. Alotaibi, Ola Abu Al Karsaneh, Fida Asali, Marcos Yébenes Mayordomo, Raghda Barham, Rame Khasawneh, Tareq Saleh

Get full text

Targeting UGT2B15 and NR1H4 interaction: a novel therapeutic strategy for polycystic ovary syndrome using naftopidil enantiomers by Xiufen Zheng, Zikai Chen, Miao Liang, Liting Zhou, Miaoru Wang, Silin Zhang, Shuyun Zhang, Lei Ma, Wei Yi, Xiawen Liu

Get full text

Larval Cytotoxic and Subacute Toxicity of Gardenia ternifolia, Rourea coccinea, and Cassytha filiformis Used in Traditional Medicine of Benin (West Africa) by E. Agbodjento, J. R. Klotoé, T. I. Sacramento, T. V. Dougnon, E. Déguenon, J. Agbankpé, K. Fabiyi, P. Assogba, M.-P. Hounkanrin, R. Akotegnon, T. J. Dougnon, J.-M. Atègbo

Get full text