State-of-the-art of loading and unloading tests for glaucoma: potentialities and informative value by O.S. Myakonkaya, A.S. Sarkisyan, A.V. Seleznev, A.V. Kuroyedov, I.R. Gazizova

“…Stress tests include water-drinking test, position test, dark room test, dentation test, pharmacological mydriasis, corticosteroid provocative test, etc. …”
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Synergy of rehabilitation for stress-related disorders and ARIs in school-age children under the war condition in Ukraine by I.O. Mityuryayeva-Kornijko, Ie.A. Burlaka, T.D. Klets, O.A. Panchenko, A.V. Kabantseva, E.S. Sukhodolska

“…The purpose of the study: to increase the effectiveness of the rehabilitation for stress-related disorders and acute respiratory infections (ARIs) in school-age children under the conditions of martial law in Ukraine by means of synergistic pharmacological correction with the inclusion of immunocorrective and sedative agents. …”
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Crinum jagus (J. Thomps. Dandy): Antioxidant and protective properties as a medicinal plant on toluene-induced oxidative stress damages in liver and kidney of rats by Mariama, Salihu, Gaber, El-Saber Batiha, Keneth Iceland, Kasozi, George D., Zouganelis, Souty M.Z., Sharkawi, Eman, Ibrahim Ahmed, Ibe Michael, Usman, Halima, Nalugo, Juma J., Ochieng, Ibrahim, Ssengendo, Olatayo Segun, Okeniran, Theophilus, Pius, Kyobe Ronald, Kimanje, Eric Simidi, Kegoye, Ritah, Kenganzi, Fred Ssempijja

“…Dandy (Liliaceae) is a pantropical plant known for its medicinal values and pharmacological properties. The study assessed the protective effects and changes in oxidative stress indices due to C. jagus leaf extracts on the toluene-induced liver and kidney injuries in rats. …”
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Medical therapy to treat obesity and optimize fertility in women of reproductive age: a narrative review by Janelle Duah, David B. Seifer

“…However, with the advent of novel pharmacologic agents, significant weight loss can be achieved, improving the chances of healthy pregnancies, and their use should be considered during periconceptual counseling. …”
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Pengaruh Kompres Panas dan Dingin terhadap Penurunan Nyeri Kala I Fase Aktif Persalinan Fisiologis Ibu Primipara by Mutia Felina, Masrul ., Detty Iryani

“…Even, some mother choose sectio caesarea without medical implication as a labor choice.Hot and cold compress therapy is one of non-pharmacological approach to reduce pain. The objective of this study was to determine the difference of the effect of hot and cold compress pain relief during active first stage of physiologic labor in primiparous women.This is an experimental study with one group pretest posttest design. …”
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Effect of JumpstartMD, a Commercial Low-Calorie Low-Carbohydrate Physician-Supervised Weight Loss Program, on 22,407 Adults by Sean Bourke, John Magaña Morton, Paul Williams

“…The effectiveness of JumpstartMD, a commercial pay-as-you-go program that emphasizes a low-to-very-low-carbohydrate real-food diet and optional pharmacologic treatment without prepackaged meals or meal replacement, has not previously been described. …”
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Hipofosfatemia tras la administración de hierro intravenoso by Nicolás Alcalá-Rivera, Anxela Crestelo Vieitez, María del Mar García Andreu, Fabiola Diez Massó, Martín Gericó Aseguinolaza, Raúl Martínez Murgui, Paula Aragonés Pequerul, Isabel Fiteni Mera, Santiago Rubio Félix, Jesús Díez-Manglano

“…Introduction: Intravenous iron administration is a frequent procedure in wards and day-hospitals due to the existence of new pharmacological preparations and more therapeutic indications. …”
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Longitudinal Utilization of Invasive Pain Treatment Procedures Among Veterans with Chronic Pain Following Use of Whole Health Services and Complementary and Integrative Health Ther... by Zeliadt SB, DeFaccio R, Carey EP, Etingen B, Rosser EW, Suri P, Chen JA, Bokhour BG, Coggeshall S

“…School of Public Health, UT Southwestern Medical Center, Dallas, TX, USA; 6Seattle Epidemiologic Research and Information Center (ERIC), VA Puget Sound Healthcare System, Seattle, WA, USA; 7Center for Healthcare Organization and Implementation Research, VA Bedford Healthcare System, Bedford, MA, USA; 8Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School, Worcester, MA, USACorrespondence: Steven B Zeliadt, VA Center of Innovation (COIN) for Veteran-Centered and Value-Driven Care, VA Puget Sound Healthcare System, 1660 South Columbian Way, S-15, Seattle, WA, 98108, USA, Tel +1 206 277-4175, Fax +1 206 764-2935, Email steven.zeliadt@va.govObjective: To assess whether Whole Health, a system of care that emphasizes non-pharmacological approaches for chronic pain management, is associated with changes in downstream utilization of invasive pain treatment procedures.Methods: Longitudinal retrospective cohort analysis of VHA administrative data. …”
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Effects of Intrathecal Bupivacaine with Adjuvants Midazolam versus Magnesium Sulphate in Tibia Fibula Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Aanal Sha, Dushyant Chavda, Dinesh K Chauhan

“…Magnesium sulphate is a pharmacological agent used in a variety of clinical conditions. …”
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Effect of Tiaoxin Recipe on Memory Learning and Synaptic Plasticity in APP/PS1 Double Transgenic Alzheimer's Disease Mice based on αCaMKⅡ-CREB-BDNF Signal Pathway by Xiaowen WANG, Hong QIAN, Chunjuan SHEN, Yanjun LI, Haixin YUAN, Jian WANG

“…According to the conversion standard of equivalent dose between animal and human in pharmacological test, the drug dose was converted according to human equivalent dose (body mass:60 kg) in Donepezil group and Tiaoxin recipe group. …”
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HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis by Michio Sato, Tsuyoshi Kadomatsu, Jun Morinaga, Yuya Kinoshita, Daisuke Torigoe, Haruki Horiguchi, Sumio Ohtsuki, Shuji Yamamura, Ryoko Kusaba, Takanori Yamaguchi, Goro Yoshioka, Kimi Araki, Tomohiko Wakayama, Keishi Miyata, Koichi Node, Yuichi Oike

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Improving Growth Performance, Biochemical Parameters and Reducing Mortality due to Ascites in Broilers by Propranolol Inclusion by Shahriar Saidian, Somaya Farahmand, Mokhtar Fathi, Salar Saifi

“…Further studies indicated that the antioxidant activity of propranolol was independent of its pharmacological activity and was related to its intrinsic chemical properties rather than to its quinidine-like membrane stabilization effect. …”
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Potential Antidepressant Effects of Omeprazole Introduced Through Network Analysis and Systems Biology Should Be Interpreted with Caution in the Clinical Environment by Seyed-Ali Mostafavi

“…I hope that the gut-brain axis and the complexity of the effects of pharmacological treatments and their interaction with nutrients in the patients gastro intestinal system would be taken into account when suggesting anti-depressant agents; noting that sufficient clinical research is needed before interpreting the effects of therapeutic agents in the clinical environment. …”
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Clinical and experimental rationale for using phenylephrine with hypromellose for the treatment of extra accommodation strain in patients with myopia by M.V. Makhova, E.V. Shikh, V.V. Strakhov, D.S. Blinov, G.K. Poluosmak, E.V. Semeleva, E.V. Blinova

“…Ogarev National Research Mordovia State University, Saransk, Russian Federation </p> <p> <br> </p> <p> <b>Aim</b>: to perform a comparative analysis of the clinical efficacy of 2.5% phenylephrine with and without hypromellose for the treatment of extra accommodation strain in schoolchildren with myopia and to perform an experimental evaluation of the pharmacological effective of active ingredient of the finished dosage form (FDF) of preparations containing 2.5% phenylephrine with and without excipients. …”
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Ultrasensitive interferons quantification reveals different cytokine profile secretion in inflammatory myopathies and can serve as biomarkers of activity in dermatomyositis by Loïs Bolko, Loïs Bolko, Loïs Bolko, Céline Anquetil, Céline Anquetil, Alba Llibre, Solène Maillard, Damien Amelin, Karim Dorgham, Vincent Bondet, Océane Landon-Cardinal, Océane Landon-Cardinal, Océane Landon-Cardinal, Ségolène Toquet, Ségolène Toquet, Kuberaka Mariampillai, Samuel Malatre, Alexandrine Mahoudeau, Baptiste Hervier, Mathieu Rodero, Guy Gorochov, Darragh Duffy, Olivier Benveniste, Olivier Benveniste, Yves Allenbach, Yves Allenbach

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Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo... by Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…The goals of phase I research are primarily to collect short-term safety, toxicity, dosing, and pharmacologic data, not to provide efficacious treatment.…”
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