Development of Novel Fluticasone/Salmeterol/Tiotropium-Loaded Dry Powder Inhaler and Bioequivalence Assessment to Commercial Products in Rats by Hyukjun Cho, Hyunji Lee, Duhyeong Hwang

“…<b>Conclusions</b>: A novel triple-combination DPI containing FP/SX/TB was successfully developed, demonstrating comparable pharmacological performance to commercial products. Optimized FP/SX/TB-loaded DPI with HPMC capsule achieved bioequivalence in rat studies, suggesting its potential for improved patient compliance and therapeutic outcomes. …”
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Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…The absence of any discernible phenotypes following the silencing of the inhibitory Wnt/β-catenin destruction complex components is consistent with low destruction complex activity in rapidly developing juvenile worms, corroborates transcriptomic expression profiles and underscores the importance of Wnt signalling as a key molecular driver of growth and development in early-stage juvenile fluke. The putative pharmacological inhibition of Wnt/β-catenin signalling using commercially available inhibitors phenocopied RNAi results and provides impetus for drug repurposing. …”
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PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction by Simon Rauterberg, Simon Rauterberg, Carmen Härdtner, Jennifer Hein, Paola Schrepf, Remi Peyronnet, Christoph Koentges, Tamara A. Vico, Carolin Ehlert, Bianca Dufner, Diana Lindner, Constantin von zur Mühlen, Dennis Wolf, Dirk Westermann, Ingo Hilgendorf, Alexander von Ehr

“…Genetic deletion of PCSK9 confers protection against post-infarct mortality, whereas pharmacological inhibition with Alirocumab fails to reproduce these benefits and may exacerbate cardiac dysfunction. …”
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Evaluating the World Health Organization’s Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala by Irmgardt Alicia Wellmann, Luis Fernando Ayala, Taryn M. Valley, Vilma Irazola, Mark D. Huffman, Michele Heisler, Peter Rohloff, Rocío Donis, Eduardo Palacios, Manuel Ramírez-Zea, David Flood

“…The pilot evaluated a package of five HEARTS-aligned implementation strategies to improve the pharmacological treatment of hypertension and diabetes. …”
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Glaucoma laser treatments: modern approaches and practice guidelines by M.H. Rabadanova, Zh.G. Oganezova, E.A. Egorov, D.V. Katz, V.V. Novoderezhkin

“…Despite a variety of pharmacological, surgical and laser treatment options, the number of patients with irreversible glaucomatous damage to visual function is continuously rising. …”
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Correction of insulin resistance in patients with chronic obstructive pulmonary disease under the influence of recovery treatment by O.I. Lemko, N.V. Vantiukh, D.V. Reshetar, S.V. Lukashchuk

“…The aim is to study the possibilities of insulin resistance correction in COPD patients, taking into account the previous COVID-19, under the influence of complex non-pharmacological treatment based on haloaero­soltherapy in connection with the applied treatment complex. …”
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Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala by Zhiguo Nie, Eric P. Zorrilla, Samuel G. Madamba, Kenner C. Rice, Marissa Roberto, George Robert Siggins

“…In whole-cell patch recordings of pharmacologically isolated GABAAergic IPSCs from slices of mouse CeA, both CRF and ethanol augmented evoked IPSCs in a concentration-dependent manner, with low EC50s. …”
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A data-driven machine learning algorithm to predict the effectiveness of inulin intervention against type II diabetes by Shuheng Yang, Ralf Weiskirchen, Wenjing Zheng, Xiangxu Hu, Aibiao Zou, Zhiguo Liu, Hualin Wang

“…Alongside traditional pharmacological treatments, nutritional therapy has emerged as a crucial aspect of T2DM management. …”
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Histologic and Endoscopic Similarity between Nodular Gastric Antral Vascular Ectasia and Gastric Hyperplastic Polyps Potentially Causing Treatment Delays by Pujitha Kudaravalli, Sheikh A. Saleem, Rachana Mandru, Sekou Rawlins

“…There is not a lot of evidence supportive of pharmacological treatment of GAVE with estrogen-progesterone, tranexamic acid, and thalidomide. …”
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Behavioural factors associated with cigarette quitting behaviour: an analysis of cross-sectional survey data collected in three low-income South African communities by Laura Rossouw, Samantha Filby

“…Being impatient reduces the odds of making a quit attempt (OR=0.814, 95% CI: 0.702 to 0.943), as does a tendency to postpone important tasks (OR=0.784, 95% CI: 0.644 to 0.956).Conclusions Non-pharmacological cessation support to low-income smokers should challenge potential lifetime quitters to practice self-control, equip them with tools to manage stress, and tackle temptations to time-discounting. …”
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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…To enable preclinical toxicology studies of CD200R1 blockade in a pharmacologically relevant non-clinical species, we engineered a surrogate antibody with high affinity toward MfCD200R1. …”
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Efficacy of defocus incorporated multiple segments (DIMS) lenses and low-dose atropine on retarding myopic shift among premyopic preschoolers: Protocol for a prospective, multicent... by Hsin-Yu Yang, Der-Chong Tsai, Yu-Chieh Yang, Chiao-Yu Wang, Chia-Wei Lee, Pei-Wei Huang

“…<h4>Methods</h4>This randomized controlled trial aims to evaluate the efficacy of optical (Defocus Incorporated Multiple Segments [DIMS] spectacle lenses) and pharmacological (0.01% atropine eye drops) interventions in preventing myopia among premyopic preschoolers. …”
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Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register by Katarina Eeg-Olofsson, Soffia Gudbjörnsdottir, Ann-Marie Svensson, Björn Eliasson, Linus Schioler, Björn Zethelius, Nils Ekström, Jan Cederholm, Junmei Miao Jonasson

“…Objective To evaluate the effectiveness and safety of metformin use in clinical practice in a large sample of pharmacologically treated patients with type 2 diabetes and different levels of renal function.Design Observational study between July 2004 and December 2010, mean follow-up 3.9 years.Setting Hospital outpatient clinics and primary care in Sweden.Participants 51 675 men and women with type 2 diabetes, registered in the Swedish National Diabetes Register, and on continuous glucose-lowering treatment with oral hypoglycaemic agents (OHAs) or insulin.Main outcome measures Risks of cardiovascular disease (CVD), all-cause mortality and acidosis/serious infection, associated with each treatment regimens, were analysed in all patients and in subgroups with different estimated glomerular filtration rate (eGFR) intervals. …”
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Comparative and Correlational Evaluation of the Phytochemical Constituents and Antioxidant Activity of Musa sinensis L. and Musa paradisiaca L. Fruit Compartments (Musaceae) by Barnabas Oluwatomide Oyeyinka, Anthony Jide Afolayan

“…Secondary metabolites and their biological activity have pharmacological relevance in the prevention and therapeutic management of disease, including the facilitation of normal physiological processes through biochemical mechanisms. …”
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Patient-derived response estimates from zero-passage organoids of luminal breast cancer by Róża K. Przanowska, Najwa Labban, Piotr Przanowski, Russell B. Hawes, Kristen A. Atkins, Shayna L. Showalter, Kevin A. Janes

“…Our goal was to adapt short-term organoids of luminal breast cancer for parallel testing of genetic and pharmacologic perturbations. Methods We freshly isolated patient-derived cells from luminal tumor scrapes, miniaturized the organoid format into 5 µl replicates for increased throughput, and set an endpoint of 14 days to minimize drift. …”
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Group Psychological Therapy Program in Adult Patients with Congenital Heart Disease and Anxious–Depressive Symptoms by Efrén Martínez-Quintana, Karen Codana-Alcántara, Hector M. Montesdeoca-Naranjo, Marta Isabel García-Suárez, María Pino Fleitas-Álvarez, María Alcántara-Castellano, Alejandro Ruiz-Castellano, Ana González-Isasi, Fayna Rodríguez-González, Esperanza Bosch-Casañas

“…<i>Methods</i>: We used non-pharmacological psychological group intervention, of six weekly sessions of 90 min each, administered by trained personnel, in adult patients with CHD. …”
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Delusions of Glass Under Skin: An Unusual Case of Somatic-Type Delusional Disorder Treated with Olanzapine by Nicholas Comardelle, Amber Edinoff, Juliana Fort

“…Accordingly, clinicians should consider the nature of the delusions along with the unique side effect profile of the pharmacological therapy as any harm might outweigh the potential benefit. …”
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Effectiveness and Safety of Dupilumab and Tralokinumab for Treating Atopic Dermatitis and Pruritic Skin Disorders in Oncological Patients: A Narrative Review by Lauletta G, Potestio L, Patruno C, De Lucia M, Napolitano M

“…In conducting this narrative review, Medical Subject Headings (MeSH) terms and medical terminology related to clinical trials and real-life studies were employed, focusing on the pharmacological agents dupilumab, and tralokinumab.Discussion: Patients with active or past cancer are typically excluded from clinical trials of new medications, complicating the evaluation of cancer progression or recurrence risks in these patients setting. …”
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Comparison of the Effects of Vitagnus, Soy, and Vitagnus-soy Capsules on Premenstrual Syndrome in University Students: A Randomized Clinical Trial by Roya Partovi Golshan, Maryam Moradi, Hasan Rakhshandeh, Vahid Ghavami, Seyed Mostafa Moshirian Farahi

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A scoping review on the psychosocial interventions used in day care service for people living with dementia. by Dympna Tuohy, Liz Kingston, Eileen Carey, Margaret Graham, Liz Dore, Owen Doody

“…Psychosocial interventions are important non-pharmacological interventions which support people's wellbeing.…”
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