Deficiency of ATF3 facilitates both angiotensin II‐induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway by Yifan Du, Poyi Hu, Xiangchao Ding, Dashuai Wang, Jingjing Luo, Sheng Le, Lingyun Ren, Manhua Chen, Ping Ye, Jiahong Xia

“…Impaired DNA repair in VSMCs resulted in micronuclei formation in the cytoplasm, activating the  cyclicGMP‐AMP synthase‐ stimulator of interferon genes (cGAS–STING) pathway and inducing VSMC phenotypic switching and apoptosis. Finally, both pharmacological complementation of P21 function and knockdown of STING expression alleviated ATF3 deficiency‐induced AAD. …”
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Single, double, and triple-hit strategies to establish a long-term premature rabbit model of bronchopulmonary dysplasia by Chiara Catozzi, Francesca Stretti, Enrica Scalera, Matteo Storti, Angelo Modena, Giorgio Aquila, Gino Villetti, Erica Ferrini, Andrea Grandi, Franco Fabio Stellari, Francesca Ravanetti, Luisa Ragionieri, Roberta Ciccimarra, Matteo Zoboli, Christina Brandenberger, Henri Schulte, Xabier Murgia, Maurizio Civelli, Francesca Ricci

“…Abstract Background Bronchopulmonary dysplasia (BPD) is a chronic lung condition of premature neonates, yet without an established pharmacological treatment. The BPD rabbit model exposed to 95% oxygen has been used in recent years for drug testing. …”
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Significant room for improvement in the prehospital assessment and treatment of acute abdominal pain: a retrospective observational study by Rasmus Bjerén, Carl Magnusson, Johan Herlitz, Denise Bäckström

“…Of those, 62% (n = 249) received pharmacological treatment. In 50% (n = 158) of all cases receiving treatment, pain was reassessed afterwards. …”
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A randomized controlled interventional study for analgesic effects of intrathecal versus intravenous dexmedetomidine on subarachnoid anesthesia with hyperbaric bupivacaine by Manu Dadhwal, Anupama Gupta, Ajay Kurian

“…Background: Various pharmacologic agents such as opioids, benzodiazepines, ketamine, and alpha2 adrenergic agonists are commonly used to increase the duration of subarachnoid block. …”
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Standardization and Quality Control of the Herbal Medicine Mist Nibima, Employed to Treat Malaria and COVID-19, Using Physicochemical and Organoleptic Parameters and Quantification... by Emmanuel Kofi Kumatia, Francis Ofosu-Koranteng, Alfred Ampomah Appiah, Kofi Bobi Barimah

“…These results could now serve as tools for authentication, standardization, and quality control of Mist Nibima to ensure its chemical and pharmacological consistency and safety.…”
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Protective and Ameliorative Effects of Hydroethanolic Extract of Piper nigrum (L.) Stem against Antiretroviral Therapy-Induced Hepatotoxicity and Dyslipidemia in Wistar Rats by Doreen Enyang, Mubo A. Sonibare, Armelle D. Tchamgoue, Lauve R. Y. Tchokouaha, Fanta S. Yadang, Gael N. Nfor, Christelle W. Kom, Patrick D. H. Betote, Cedric F. Tchinda, Steveng S. K. Tiogo, Gabriel A. Agbor

“…This study reported on the phytochemical and pharmacological profile of hydroethanolic extracts of Piper nigrum stem (PNS) and evaluated its protective effect against tenofovir/lamivudine/efavirenz (TLE)-induced hepatotoxicity and dyslipidemia in Wistar rats. …”
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Economic evaluation of Maternal Depression Treatment in HIV (M-DEPTH) for perinatal depression among women living with HIV in Uganda: a cost-effectiveness analysis by Ryan McBain, Adeyemi Okunogbe, Rhoda K Wanyenze, Violet Gwokyalya, Glenn Wagner

“…Objective We conducted a cost-effectiveness analysis of an evidence-based collaborative care model for treatment of perinatal depression among women living with HIV in Uganda.Design Maternal Depression Treatment in HIV (M-DEPTH) is a cluster randomised controlled trial implemented from July 2019 to August 2023, during which 391 pregnant women with mild-to-severe depressive symptoms were randomised to receive stepped care for depression (M-DEPTH: behavioural and pharmacological treatments) or care as usual (CAU: hospital referral for severe cases), at one of eight public health facilities in Uganda.Methods We implemented time-driven, activity-based costing to determine the economic cost of M-DEPTH from a societal perspective, compared with CAU. …”
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Cancer Risk in Inflammatory Bowel Disease by Anders M Ekbom

“…Different treatment strategies could be an explanation, a hypothesis that was substantiated in a study of 102 cases of colorectal cancer among patients with ulcerative colitis compared with 196 controls. Pharmacological therapy with sulfasalazine entailed a strong protective effect against colorectal cancer (relative risk of 0.34, 95% CI 0.190 to 0.62).…”
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Non-apical plateau potentials and persistent firing induced by metabotropic cholinergic modulation in layer 2/3 pyramidal cells in the rat prefrontal cortex. by Nicholas Hagger-Vaughan, Daniel Kolnier, Johan F Storm

“…The non-apical L2/3 PPs depended on metabotropic cholinergic (mAChR) or glutamatergic (mGluR) modulation, which is probably essential also for conscious brain states and experience, in both wakefulness and dreaming. Pharmacological tests indicated that the non-apical L2/3 PPs depend on transient receptor potential (TRP) cation channels, both TRPC4 and TRPC5, and require external calcium (Ca2+) and internal Ca2+ stores, but not voltage-gated Ca2+ channels, unlike Ca2+-dependent PPs in other cortical pyramidal neurons. …”
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Phase II randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of MLC1501 in patients with stroke: the MLC1501 study Assessing Efficacy in post-STrOk... by Narayanaswamy Venketasubramanian, Deidre Anne De Silva, Christopher P L H Chen, Cyrus G Escabillas, John Harold Hiyadan, Johnny K Lokin, Romulo U Esagunde, Joel M Advincula, Christian Oliver C Co, Maria Epifania V Collantes, Annabelle Y Lao, Yeow-Hoay Koh, Carol Huilian Tham

“…Background MLC1501, consisting of four herbs, that is, Radix Astragali, Radix Angelicae sinensis, Rhizoma Chuanxiong, Radix Polygalae, has the same pharmacological properties as its precursors MLC601 and MLC901 which contain extracts of nine herbs and showed neuroprotective, anti-inflammatory and neurorestorative properties in non-clinical models, as well as clinical benefits in improving functional and neurological recovery after brain injuries.Aims To determine the efficacy of MLC1501 on motor recovery as measured by Fugl-Meyer motor Assessment (FMA) total score at 24 weeks in patients with ischaemic stroke (IS).Design A total of 300 patients aged >18 years, diagnosed with IS in the prior 2–10 days, with National Institute of Health Stroke Scale (NIHSS) total score of 8–18 and a combined score of ≥3 on NIHSS motor items 5A, 5B, 6A and/or 6B, will be randomised in a 1:1:1 ratio to receive oral placebo, MLC1501 low dose or MLC1501 high dose for 6 months. …”
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EVALUATION OF ANTIBACTERIAL ACTIVITY OF TRICHILIA DREGEANA SOND (MELIACEAE) CRUDE EXTRACTS AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA by Tesfa Mossie, Temesgen Kasa, Bekesis Urge, Hilena Yifred

“…The findings are promising and encourage further investigation of the crude extracts’ phytochemical, toxicological, and pharmacological aspects to support their potential rational use in antimicrobial therapy. …”
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A study of mydriatic effect on intraocular pressure and anterior chamber angle morphology by anterior segment optical coherence tomography by Srinivasapuram Krishnacharya Prabhakar, Meghana Hiremath

“…Context Pharmacological mydriasis possibly is associated with intraocular pressure (IOP) rise and anterior chamber angle changes. …”
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Higher frequency of interstate over international transmission chains of SARS-CoV-2 virus at the Rio Grande do Sul - Brazil state borders by Filipe Zimmer Dezordi, José Valter Joaquim Silva Júnior, Terimar Facin Ruoso, Angela Giovana Batista, Pedro Mesquita Fonseca, Larissa Paim Bernardo, Richard Steiner Salvato, Tatiana Schäffer Gregianini, Thaísa Regina Rocha Lopes, Eduardo Furtado Flores, Rudi Weiblen, Patrícia Chaves Brites, Mônica de Medeiros Silva, João Batista Teixeira da Rocha, Gustavo de Lima Barbosa, Lais Ceschini Machado, Alexandre Freitas da Silva, Marcelo Henrique Santos Paiva, Matheus Filgueira Bezerra, Tulio de Lima Campos, Tiago Gräf, Daniel Angelo Sganzerla Graichen, Elgion Lucio da Silva Loreto, Gabriel da Luz Wallau

“…These findings suggest that while non-pharmacological interventions were effective to mitigate transmission across international RS land borders, they were insufficient to contain transmission at the domestic level.…”
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Community-based model for management and follow-up by non-physician healthcare workers to improve awareness, treatment, and control of hypertension: The COTRACO study protocolDetai... by A.J. Lora Mantilla, L.A. Parra Gomez, P.A. Camacho-López, J. Otero-Wandurraga, B. Novella, A. González-Medina, O. Valdez-Tiburcio, F. Lanas, M.C. Rocha-Lezama, J. Alonzo-Arias, C. Rivilla-Piñango, C. Cáceres-Ramírez, S.J. Villabona-Flórez, Y.M. Giraldo-Castrillón, P. López-Jaramillo

“…A community-based model will be implemented in 600 patients in Colombia and the Dominican Republic, involving NPHWs to: 1) apply standardized treatment algorithms, 2) promote adherence to healthy lifestyles, and 3) provide standardized pharmacological treatment. Propensity Score Matching will be used to select 300 patients in Chile and 1200 in Spain for comparison with standard care in these populations. …”
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Phenolic Content and Antioxidant and Antimicrobial Activities of Malva sylvestris L., Malva oxyloba Boiss., Malva parviflora L., and Malva aegyptia L. Leaves Extract by Khalid A. Shadid, Ashok K. Shakya, Rajashri R. Naik, Nidal Jaradat, Husni S. Farah, Naeem Shalan, Nooman A. Khalaf, Ghaleb A. Oriquat

“…The methanolic extract of M. oxyloba has a pharmacological potential as a valuable natural product that can be utilized as a main ingredient in the design and development of new therapeutic formulations. …”
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An untargeted metabolomic analysis of acute AFB1 treatment in liver, breast, and lung cells. by Heidi H Cao, Sabrina Molina, Susan Sumner, Blake R Rushing

“…A better understanding of how AFB1 disrupts metabolism would provide insight into how this mycotoxin leads to carcinogenesis, growth impairment, and/or immunomodulation, and may reveal potential targets for pharmacological or nutritional interventions to protect against these effects. …”
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How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel? A Narrative Review by Luke Gray, Peter Ladlow, Russell J Coppack, Robyn P Cassidy, Lynn Kelly, Sarah Lewis, Nick Caplan, Robert Barker-Davies, Alexander N Bennett, Luke Hughes

“…Conventional resistance training is commonly contraindicated in load compromised and/or persistent pain populations, compromising rehabilitation progression and potentially leading to extensive pharmacological intervention, invasive procedures, and reduced occupational status. …”
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Why is the New York Times Writing so Much about Alzheimer's Disease Therapies? by Tamas Bartfai

“…This will provide the pharmacological evidence needed to show that it is worth fighting amyloidosis because it saves memory. …”
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Electrophysiological properties of vestibular hair cells isolated from human crista by Nesrien Mohamed, Mohammad Al-Amin, Frances L. Meredith, Olivia Kalmanson, Anna Dondzillo, Stephen Cass, Samuel Gubbels, Katherine J. Rennie

“…Here, we obtained freshly harvested vestibular neuroepithelia from adult translabyrinthine surgical patients to obtain electrophysiological recordings from human hair cells.MethodsWhole cell patch clamp recordings were performed on hair cells mechanically isolated from human cristae to characterize voltage-dependent and pharmacological properties of membrane currents. Hair cells were classified as type I or type II according to morphological characteristics and/or their electrophysiological properties.ResultsType I hair cells exhibited low voltage-activated K+ currents (IKLV) at membrane potentials around the mean resting membrane potential (-63 mV) and large slowly activating outward K+ currents in response to depolarizing voltage steps. …”
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Treatment Options for Advanced Non-Small Cell Lung Cancer After Failure of Previous Immune Checkpoint Inhibitors and Chemotherapy: Meta-Analysis of Five Randomized Controlled Trial... by Andrea Messori, Andrea Ossato, Lorenzo Gasperoni, Luna Del Bono, Alessandro Inno, Vera Damuzzo

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