HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice by Bang-Xia Liu, Juan Zheng, Zhan-Wei Tang, Lei Gao, Meng Wang, Ying Sun, Chen Chen, Heng-Chen Yao

“…However, the adverse effects were almost completely eliminated by pharmacological blockade of the dynamin-related protein 1 (Drp1) inhibitor, Mdivi-1, which inhibits mitochondrial fission during cardiac I/R(P < 0.05). …”
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Effects of intranasal oxytocin on neural reward processing in children and adolescents with reactive attachment disorder: A randomized controlled trial by Shinichiro Takiguchi, Shinichiro Takiguchi, Kai Makita, Takashi X. Fujisawa, Takashi X. Fujisawa, Shota Nishitani, Shota Nishitani, Akemi Tomoda, Akemi Tomoda, Akemi Tomoda

“…Children and adolescents with RAD show aberrant attachment behaviors, and existing psychotherapies are difficult to maintain; therefore, pharmacological interventions to aid and boost treatment responses are needed. …”
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Exploring the Chemopreventive Potential of <i>Artemisia annua</i> Methanolic Extract in Colorectal Cancer Induced by Azoxymethane in Mice by Faris Alrumaihi

“…<i>Artemisia annua</i> (<i>A. annua</i>), known for its extensive pharmacological properties, has shown potential in cancer therapy. …”
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Study on the absorption characteristics of euscaphic acid and tiliroside in fruits of Rosa laxa Retz. by Ning Wang, Li Tian

“…(FRL) have a long history of medicinal use, known for their rich composition of flavonoids, polyphenols, amino acids, sugars, and other bioactive compounds. FRL exhibits pharmacological effects such as antioxidant, antiviral, antibacterial, and antitumor activities, making it a valuable resource with significant development potential in both the food and pharmaceutical industries. …”
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Efficacy of halopeRIdol to decrease the burden of Delirium In adult Critically ill patiEnts (EuRIDICE): study protocol for a prospective randomised multi-centre double-blind placeb... by John W Devlin, Zoran Trogrlic, Mathieu van der Jagt, Lisa Smit, Robert-Jan Osse, Huibert H Ponssen, Arjen J C Slooter, Nicole G M Hunfeld, Wim J R Rietdijk, Diederik Gommers, M. van den Boogaard, A.J.B.W. Brouwers, J.A. Lens, B.J.M. van der Meer, H. Ponssen, F.J. Schoonderbeek, K.S. Simons, E. Berger, A. Bouman, M. Campo, D. van Duijn, H. Embden – van Donk, D. van de Graaf, E. Hoogendoorn, P. Ormskerk, N. Roovers, E. Toscano, A. Vileito, T. van Zuylen, C. Exler, E. van den Berg, J. van Meeteren, M. Koopmanschap, I. Nutma, E. Kuijper

“…Current practice guideline recommendations advocate the use of non-pharmacological strategies to reduce delirium. The routine use of scheduled haloperidol to treat delirium is not recommended given a lack of evidence regarding its ability to resolve delirium nor improve relevant short-term and longer-term outcomes. …”
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PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer by Jiacheng Li, Jia Liu, Shifeng Yang, Yu Xia, Qingzhe Meng, Biying Sun, Yansong Liu, Bin Zhao, Jiaqi Jin, Hui Xu, Lihong Wang, Pengxia Zhang, Zhuoxin Cheng

“…Animal experiments revealed that antiplatelet pharmacological agents and genetic knockout of platelets potentiated the antitumour effect of the PD-L1 mAb treatment in a CD8 + T cell dependent manner. …”
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Potential Medicinal Fungi from Freshwater Environments as Resources of Bioactive Compounds by Ilenia Cicero, Giulia Mirabile, Giuseppe Venturella

“…Moreover, many of these mushrooms are also known as medicinal mushrooms since they possess several pharmacological properties attributable to a huge number of bioactive compounds derived from their sporophores. …”
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Prevention of Acute Radiation-Induced Skin Reaction with NPE® Camellia Sinensis Nonfermentatum Extract in Female Breast Cancer Patients Undergoing Postoperative Radiotherapy: A Sin... by Gabriela Näf, Urs E. Gasser, Hans E. Holzgang, Sandra Schafroth, Christoph Oehler, Daniel R. Zwahlen

“…This pilot study provides the first evidence on the potential pharmacological effectiveness of CSNF extract in prevention of RT-induced ARSR and recovery of skin irritation in patients undergoing postoperative whole breast RT and may reflect a novel concept for prevention of RT-induced ARSR and care of irritated skin.…”
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Adenosine A2A receptor activation is necessary to gate the TrkB-dependent intramuscular nerve sprouting during muscle reinnervation after a nerve crush by Michael Di Palma, Davide Lattanzi, Patrizia Ambrogini, Stefano Sartini

“…We confirmed that A2A immunoreactivity is mainly localized at the axonal level and provided evidence that A2ARs may form heteroreceptor complexes with TrKb at muscle plasmalemma. The pharmacological activation of either TrkBs or A2ARs mirrored the effect of motor activity on target muscle reinnervation after a nerve crush. …”
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Review: cell mechanisms in the control of inflammatory foundations of obesity and secondary metabolic disorders by Kristin Goldstone, Keelin Irwin, Ava O' Meara-Cushen, Cathy Brougham

“…The most common approach to obesity management and treatment includes clinical and pharmacological interventions, focusing on avenues such as surgery, weight loss management programs, and synthetic medications like semaglutides (e.g. …”
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Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages. by Judith A Smith, Mike Khan, Diogo D Magnani, Jerome S Harms, Marina Durward, Girish K Radhakrishnan, Yi-Ping Liu, Gary A Splitter

“…Finally, tauroursodeoxycholic acid, a pharmacologic chaperone that ameliorates the UPR, significantly impaired Brucella replication in macrophages. …”
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Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial by Judith Bellapart, Vinesh Appadurai, Melissa Lassig-Smith, Janine Stuart, Christopher Zappala, Rob Boots

“…Melatonin has been proposed as a pharmacological strategy to improve sleep, but studies have shown that the increase in plasma levels of melatonin do not correlate to a beneficial clinical effect; in addition, melatonin’s short half-life may be a major limitation to achieving therapeutic levels. …”
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Outcomes of an Emergency Department opioid alternatives Program implemented within a safety-net hospital system by Magda Montague, Charlotte Hopson, Claire Layton, Jennifer Fishe, Ashley Norse, L. Kendall Webb, Petra Duran-Gehring, Andrew Bertrand, Jennifer Brailsford, Taylor Munson, Rui Wang, Nolan Menze, Katelyn Perl, Phyllis Hendry, Sophia Sheikh

“…The PAMI-ED ALT program employed a multifaceted approach in the Emergency Department (ED) developing electronic health record (EHR) pain management order panels and discharge panels, as well as educating patients, clinicians, and ED staff on opioid alternatives, including non-pharmacologic interventions. The primary objective of this analysis was to compare changes in opioid and non-opioid analgesic administrations and prescribing in ED patients with select pain conditions (renal colic, headache, low back, and non-low back musculoskeletal pain) before and after implementation of PAMI ED-ALT. …”
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MFG-E8 Exerts Neuroprotection in Neural Stem Cells Induced by Anesthetic Sevoflurane via Regulating the PI3K/AKT Pathways by Minmin Cai, Liufang Sheng

“…Western blot analysis was applied for assessing the expression of MFG-E8, BCL2, BAX, cleaved caspase-3, GRP-78, XBP-1, ATF-6, ATF-4, CHOP, p-PI3K, PI3K, p-AKT, and AKT. The pharmacological experiments suggested that both mRNA and protein expression of MFG-E8 were significantly decreased after 24 h, 48 h, and 72 h treatment with SEV, and the Western blot results displayed that 50 and 100 μg/ml rhMFG-E8 could evidently promote the expression of MFG-E8 in NSCs induced by SEV. …”
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JinQi Jiangtang Tablet Regulates Gut Microbiota and Improve Insulin Sensitivity in Type 2 Diabetes Mice by Ying Cao, Guowang Yao, Yuanyuan Sheng, Li Yang, Zixuan Wang, Zhen Yang, Pengwei Zhuang, Yanjun Zhang

“…However, the low bioavailability of its chemical compositions makes it hard to explain the pharmacological mechanisms. Method. Diabetic mice were orally treated with JQJT tablets for 5 weeks. …”
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Diabetes control in public assistance recipients and free/low-cost medical care program beneficiaries in Japan: a retrospective cross-sectional study by Daisuke Nishioka, Mitsuhiko Funakoshi, Seiji Haruguchi, Sakae Yonemura, Takashi Takebe, Misato Nonaka, Sanae Iwashita

“…This study aimed to elucidate the blood glucose control status among individuals with low income (ie, recipients of public assistance (PARs) and free/low-cost medical care (FLCMC) programme beneficiaries) and to investigate the effects of public subsidies for medical expenses on treatment adherence among low-income patients with diabetes.Methods We conducted a secondary analysis of medical records from 910 outpatients with diabetes who underwent pharmacological treatment for &gt;90 days. Data on predictive variables, such as glycated haemoglobin (HbA1c) level and control variables, including sex, age and insurance type, were obtained retrospectively. …”
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Diagnosing and managing patients with heart failure with preserved ejection fraction: a consensus survey by Christi Deaton, Robin Fox, Ian Wellwood, Carolyn Chew-Graham, Katherine Brown, Sharon Dixon, Thomas Blakeman, Alistair Brown, Julie Smith, Nick Thomas, Adam Jones, Basilio Hernandez-Diaz, Christopher Keast, Heather Rutter, Kyle Knox, Matthew Gaw, Nick Wooding, Christine A'Court, Hannah Swayze, Helen Ashdown, Victoria Glover, Rosalynn Austin, Eva Khair, Muhammad Zakir Hossain, Emma Sowden, Faye Forsyth, Mollika Chakravorty, Sophie Maclachlan, Edward Kane, Jessica Odone, Natasha Thorley, Susana Borja-Boluda, Muhammed Hossain, John Sharpley, Brain Gordon, Joanna Taffe, Aaron Long, Affan Aziz, Chris Schramm, Sine MacDonald, Helena Papworth, Craig Needs, David Cronk, Chris Newark, Duncan Blake, Amman Basuita, Emma Gayton, Jonathan Crawshaw, Rachael Ayerst, Shamila Wanninayake, Elisabetta Angeleri-Rand

“…Aim As heart failure (HF) with preserved ejection fraction (HFpEF) prevalence increases, it remains frequently underdiagnosed and poorly managed. Recent positive pharmacological trials have increased interest in HFpEF but challenges of diagnosis and management remain. …”
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Quality Evaluation of Bioactive Ingredients in Lianhua Qingwen Capsule Based on Quantitative Analysis of Multicomponent by the Single Marker Method and the Chemical Recognition Pat... by Qianqian Zhou, Lin Yang, Yiwu Wang, Jiajia Zou, Shuya Li, Lei Dai, Yan Li, Dan He

“…More importantly, compared to previous work, the simultaneous determination of the content of ten pharmacologically important active ingredients at one detection wavelength with only one reference substance has been achieved. …”
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Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU by Xin Hu, Yikang Ji, Mi Zhang, Zhihui Li, Xinhua Pan, Zhen Zhang, Xu Wang

“…Supplementary IL-8 stimulated TAMs to synthesize CLU, and CLU counteracted oxidative stress in HNSCC cells under conditions of glucose deficiency. Moreover, pharmacological blockade of CXCL8 signaling (reparixin) sensitized HNSCC cells to nutrient-starvation therapy (anlotinib) in two xenograft models. …”
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Deletion of sphingosine 1-phosphate receptor 1 in myeloid cells reduces hepatic inflammatory macrophages and attenuates MASH by Gopanandan Parthasarathy, Nanditha Venkatesan, Guneet Singh Sidhu, Myeong Jun Song, Chieh-Yu Liao, Fanta Barrow, Amy Mauer, Tejasav Sehrawat, Yasuhiko Nakao, P. Vineeth Daniel, Debanjali Dasgupta, Kevin Pavelko, Xavier S. Revelo, Harmeet Malhi

“…We have previously demonstrated that pharmacological sphingosine 1-phosphate (S1P) receptor modulation ameliorates MASH and is associated with attenuated accumulation of intrahepatic macrophage and T-cell subsets. …”
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