Predictive Role of IL-2R and IL-10 in the Anti-inflammatory Response and Antiplatelet Therapy of Kawasaki Disease: A Retrospective Study by Chun Zhang, Lun Chen, Sun Chen, Yan Bian, Jia Shen, Peng Zhang, JiaNi Song

“…In conclusion, dynamically monitoring the levels of IL-2R and IL-10 has the potential to provide indications of the intensity and development of the inflammatory response in children with KD and may contribute to the early prediction and adjustment of pathological and pharmacological effects of therapy.…”
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Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors by Yousef Sabah Ali, Monther Faisal Mahdi, Basma Monjid Abd Razik, Talal Aburjai

“…The findings of the cytotoxicity investigation and molecular docking analysis of these final derivatives (5a-5g) demonstrated a strong correlation, indicating the importance of a comprehensive pharmacological study to comprehend the anti-cancer mechanisms of these newly synthesized compounds fully. …”
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Efficacy and safety of a generic remifentanil formulation versus fentanyl and Ultiva during general anaesthesia: A phase III, prospective, multi-centric, observer-blind, randomised... by Indrani Hemantkumar, Ashok Kumar Swain, Manjaree Mishra, Swati Singh, Challakere Lakshminarain Gurudatt, Janampet Bekkam Giridhar

“…Background and Aims: Remifentanil and fentanyl are potent opioid analgesics commonly used during surgery due to their distinct pharmacological profiles. This study aimed to compare the efficacy and safety of a generic remifentanil (test drug) with fentanyl and Ultiva (innovator formulation) during general anaesthesia in the Indian population. …”
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Retrospective database analysis on the demographics and resource utilization of patients with Parkinson’s disease in Quebec, Canada by Véronique Baribeau, Shawn Mohammed, Amnah Awan, Diana Parison, Jean Lachaine

“…Conclusion: Many pharmacological options exist for PD patients and, though patients are adherent while on therapy, treatment discontinuation rates are high. …”
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Carboplatin in combination with etoposide for advanced small cell lung cancer complicated with idiopathic interstitial pneumonia: a single-arm phase II study by Masaru Matsumoto, Yuji Minegishi, Katsuyuki Higa, Aya Fukuizumi, Naomi Onda, Susumu Takeuchi, Akihiko Miyanaga, Akihiko Gemma, Masahiro Seike

“…Abstract Background Acute exacerbation (AEx) of interstitial pneumonia is the most common lethal adverse event related to the pharmacological treatment of patients with lung cancer complicated with interstitial pneumonia. …”
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The link between hyperuricemia and diabetes: insights from a quantitative analysis of scientific literature by Lili Ma, Jing Wang, Li Ma, Xian Min Wang

“…Exploring pathological mechanisms and pharmacological interventions linked to diabetes concomitant with HUA has emerged as a focal point of research and a burgeoning trend within the field.ConclusionThis study is the first scientometric analysis to synthesize research trends on HUA and diabetes, revealing molecular mechanisms and treatment strategies and providing theoretical insights for future clinical use.…”
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A systematic review of the clinical practice guidelines for the assessment, management and treatment of eating disorders during the perinatal period by Chantelle Ecob, Debbie M. Smith, Zoe Tsivos, Noora Hossain, Sarah Peters

“…Six overall recommendations were formed from the narrative synthesis of data: 1) Early detection: recognising the signs and symptoms, 2) Assessment and screening: a three-pronged approach, 3) Educating and supporting the mother: the importance of knowledge, 4) Cross-system collaboration, 5) Psychological, pharmacological and medical treatment, and 6) Continued monitoring. …”
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Sleep Promotion among Critically Ill Patients: Earplugs/Eye Mask versus Ocean Sound—A Randomized Controlled Trial Study by Abhilasha Chaudhary, Vinay Kumari, Neetu Neetu

“…Earplugs, eye mask, and ocean sound are safe and cost effective, which could be used as an adjuvant to pharmacological interventions to improve sleep quality among ICU patients. …”
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Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…Oridonin (Ori) is a diterpenoid derived from rubescens that has diverse pharmacological properties. Our previous study showed that Ori can protect against DN by decreasing the inflammatory response. …”
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Schistosome feeding and regurgitation. by Patrick J Skelly, Akram A Da'dara, Xiao-Hong Li, William Castro-Borges, R Alan Wilson

“…Our conclusions have major implications for worm survival under immunological or pharmacological pressure.…”
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Ketogenic metabolic therapy for schizoaffective disorder: a retrospective case series of psychotic symptom remission and mood recovery by Nicole Laurent, Erin L. Bellamy, Katherine A. Tague, Donika Hristova, Ally Houston

“…Standard treatments, primarily pharmacological, often fail to control symptoms fully and can lead to significant metabolic side effects. …”
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Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia by Hang Zhang, Sheng Yang, Yi-Lin Lu, Luo-Qi Zhou, Ming-Hao Dong, Yun-Hui Chu, Xiao-Wei Pang, Lian Chen, Lu-Lu Xu, Lu-Yang Zhang, Li-Fang Zhu, Ting Xu, Wei Wang, Ke Shang, Dai-Shi Tian, Chuan Qin

“…In addition, high loads of myelin debris promoted lipid peroxidation and ferroptosis in microglia with diminished antioxidant function. Microglia with pharmacologically or genetically stimulated Nrf2 expression exhibited enhanced resistance to ferroptosis and pro-regenerative properties to myelination due to lipid and iron metabolism reprogramming. …”
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On Ve-Degree and Ev-Degree Topological Properties of Hyaluronic Acid‐Anticancer Drug Conjugates with QSPR by Syed Ajaz K. Kirmani, Parvez Ali, Faizul Azam, Parvez Ahmad Alvi

“…These results allow researchers to better understand the physicochemical properties and pharmacological characteristics of these conjugates.…”
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Study on the Therapeutic Effects of Bisdemethoxycurcumin on a Cerebral Amyloid Angiopathy Mouse Model Established via Chronic Treatment With Five Vascular Risk Factors by Shudong Lin, Guanghua Zhu, Juan Xie, Xuanwei Wen, Limin Deng, Sijing Li, Guozhi Liu, Feiyan Wang, Shuangxi Chen, Zijian Xiao

“…Bisdemethoxycurcumin (BDMC) has been demonstrated to exhibit pharmacological effects with anti‐Aβ toxicity properties. …”
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Treatment Challenges in a Tourette Syndrome Patient with Self-Injurious Behaviour: Case Report and Literature Review by G. Asadauskaitė, G. Jasionytė, M. Karnickas

“…Tourette syndrome is commonly treated with psychotherapy, pharmacological treatment, or a combination of these methods. …”
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Prioritization of biological processes based on the reconstruction and analysis of associative gene networks describing the response of plants to adverse environmental factors by P. S. Demenkov, E. A. Oshchepkova, T. V. Ivanisenko, V. A. Ivanisenko

“…Methods for prioritizing or ranking candidate genes according to their importance based on specific criteria via the analysis of gene networks are widely used in biomedicine to search for genes associated with diseases and to predict biomarkers, pharmacological targets and other clinically relevant molecules. …”
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Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled... by Eva Skovlund, Rune Haaverstad, Henrik Zetterberg, Jorunn L Helbostad, Rolf Busund, Johan Raeder, Theis Tønnessen, Torgeir Bruun Wyller, Melanie R Simpson, Nils Kristian Skjærvold, Bjørn Erik Neerland, Svein Aslak Landsverk, Ieva Martinaityte, Hilde Margrethe Norum, Geir Selbaek, Elisabeth Skaar, Arjen JC Slooter, Øyvind Sverre Svendsen, Alexander Wahba

“…Clonidine has similar pharmacological properties and can be administered both parenterally and orally. …”
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COLORATION AND DISCOLORATION OF OLVEOLAR BONE AND TOOTH ENAMEL CAUSED BY MEDICATION by Giurgiu Cristian Levente, George Morarasu, Nicolae Baranov, Pogăcian-Maier Alexandra-Camelia, Radu-Mircea Sireteanu-Cucui, Cristina Pipa, Alina Monica Miftode, Alina Stefanache

“…Aim of the Study: This review aims to investigate the pharmacologically induced discoloration of teeth and bones, focusing on how various medications affect the coloration of tooth enamel and dentin. …”
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Prevalence of Osteoporosis in Women Over 50 Years of Age: Preventive and Therapeutic Management Skills by Enrique Rodríguez Reyes, Carlos Alberto Valverde González, Walter Alberto Vayas Valdiviezo

“…Among the predisposing and causing factors of osteoporosis in the study group were poor diet and lack of exercise. 48 % knew the meaning of the densitometry test, the use of all necessary ingredients in the diet was confirmed by 36 % of women, the use of pharmacological preparations for calcium supplementation was reported by only 33 % of women. …”
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Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations by Diana-Andreea Blaj, Catalina A. Peptu, Mihaela Balan-Porcarasu, Cristian Peptu, Cristina Gabriela Tuchilus, Lacramioara Ochiuz

“…<b>Background:</b> Magnolol (MG) and honokiol (HK) are bioactive compounds extracted from <i>Magnolia obovata</i> and <i>Magnolia Officinalis</i> trees with significant pharmacological properties, including antioxidant and antibacterial activity. …”
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